Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

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The metabolism-immune axis in colorectal cancer: remodeling the tumor microenvironment through metabolite signaling

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Apoptosis-mediated anticancer activity in prostate cancer cells of a chestnut honey (Castanea sativa L.) quinoline–pyrrolidine gamma-lactam alkaloid

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Tryptophan‐Kynurenine Pathway in COVID‐19‐Dependent Musculoskeletal Pathology: A Minireview

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Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and PROTAC-based degraders for cancer therapy

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Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress

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The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma

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Tryptophan metabolism regulates inflammatory macrophage polarization as a predictive factor for breast cancer immunotherapy

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Expanding the Therapeutic World of Tryptophan Metabolism

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Insight of a Metabolic Prognostic Model to Identify Tumor Environment and Drug Vulnerability for Lung Adenocarcinoma

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Prediction of hepatocellular carcinoma prognosis and immunotherapeutic effects based on tryptophan metabolism-related genes

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Current Status and Challenges of Oncolytic Virotherapy for the Treatment of Glioblastoma

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Indoleamine 2,3-Dioxygenase (IDO) Activity: A Perspective Biomarker for Laboratory Determination in Tumor Immunotherapy

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Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice

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Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy

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Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms

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Glial cell nutrient sensing: mechanisms of nutrients regulating Alzheimer’s pathogenesis and precision intervention

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Renal fibrosis is induced by hyperactive Wnt/β-catenin pathway via microbial-mediated tryptophan metabolism-driven AhR signaling in rodents and humans

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Analysis of Immune Checkpoint Drug Targets and Tumor Proteotypes in Non-Small Cell Lung Cancer

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A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics

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IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration

Yu, K., Li, D., Xu, F., Guo, H., Feng, F., Ding, Y., Wan, X., Sun, N., Zhang, Y., Fan, J., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107446 · Cited by 27

Tryptophan Metabolism via Kynurenine Pathway: Role in Solid Organ Transplantation

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Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway

Duan, R., Yang, C.-L., Du, T., Ai, L., Wang, A.-R., Sun, W.-J., Li, X., Li, J.-X., Yan, C., & Liu, Q. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02193-0 · Cited by 28

Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis

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Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase

Liu, J., Ren, J. X., Yang, K., Chen, S., Yang, X., & Zhao, Q. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114294 · Cited by 27

Characterizing microbiota and metabolomics analysis to identify candidate biomarkers in lung cancer

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The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression

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Programmed Cell Death-Ligand 1 in Head and Neck Squamous Cell Carcinoma: Molecular Insights, Preclinical and Clinical Data, and Therapies

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DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota

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Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases

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Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma

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Metabolomics Distinguishes DOCK8 Deficiency from Atopic Dermatitis: Towards a Biomarker Discovery

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Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

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IL4I1 Is Expressed by Head–Neck Cancer-Derived Mesenchymal Stromal Cells and Contributes to Suppress T Cell Proliferation

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Role of indoleamine 2, 3-dioxygenase 1 in immunosuppression of breast cancer

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Microbial metabolites and their influence on the tumor microenvironment

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Mahuang Decoction Antagonizes Acute Liver Failure via Modulating Tricarboxylic Acid Cycle and Amino Acids Metabolism

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X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease

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Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner

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Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies

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Tryptophan hydroxylase 1 drives glioma progression by modulating the serotonin/L1CAM/NF-κB signaling pathway

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Gut Microbiome and Serum Metabolome Profiles of Capsaicin with Cognitive Benefits in APP/PS1 Mice

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The evolution of small molecule enzyme activators

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Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD

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Kynurenine Pathway in Respiratory Diseases

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Micro-/nano-plastics as vectors of heavy metals and stress response of ciliates using transcriptomic and metabolomic analyses

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Simultaneous Analysis of Tryptophan and Its Metabolites in Human Plasma Using Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry

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Immunometabolism: A ‘Hot’ Switch for ‘Cold’ Pediatric Solid Tumors

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A feasible and efficient voltammetric sensor based on electropolymerized L-arginine for the detection of L-tryptophan in dietary supplements

Lima, D., Pessôa, C. A., Wohnrath, K., Junior, L. H. M., & Bergamini, M. F. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107709 · Cited by 25

The association of kynurenine pathway metabolites with symptom severity and clinical features of bipolar disorder: An overview

Bartoli, F., Cioni, R. M., Cavaleri, D., Callovini, T., Crocamo, C., Misiak, B., Savitz, J. B., & Carrà, G. (2022) · European Psychiatry · doi:10.1192/j.eurpsy.2022.2340 · Cited by 27

Gut microbiota in COVID-19: new insights from inside

Zhou, B., Pang, X., Wu, J., Liu, T., Wang, B., & Cao, H. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2201157 · Cited by 27

Effects of different chronic restraint stress periods on anxiety- and depression-like behaviors and tryptophan-kynurenine metabolism along the brain-gut axis in C57BL/6N mice

Ye, F., Dong, M.-C., Xu, C.-X., Jiang, N., Chang, Q., Liu, X., & Pan, R. L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176301 · Cited by 25

The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain

Martos, D., Lőrinczi, B., Szatmári, I., Vécsei, L., & Tanaka, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063394 · Cited by 25

Clinical insights into the kynurenine pathway in age-related diseases

Kim, B., Lee, S. H., & Koh, J. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110793 · Cited by 26

Metabolism in the Tumor Microenvironment

Montenegro, F., & Indraccolo, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-44518-8_1 · Cited by 26

Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway

Chen, L., Zhu, S.-P., Liu, T.-P., Zhao, H., Chen, P.-F., Duan, Y., & Hu, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.628821 · Cited by 25

Identification of anoikis-related molecular patterns to define tumor microenvironment and predict immunotherapy response and prognosis in soft-tissue sarcoma

Qi, L., Chen, F., Wang, L., Yang, Z., Zhang, W., & Li, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1136184 · Cited by 24

Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance

Shen, J., Zhao, W., Cheng, J., Cheng, J., Zhao, L., Dai, C., Fu, Y., Li, B., Chen, Z., Shi, D., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131988 · Cited by 26

Urolithins: A Prospective Alternative against Brain Aging

An, L., Lu, Q., Wang, K., & Wang, Y. (2023) · Nutrients · doi:10.3390/nu15183884 · Cited by 29

Circulating tryptophan–kynurenine pathway metabolites are associated with all‐cause mortality among patients with stage I–III colorectal cancer

Damerell, V., Klaassen‐Dekker, N., Brezina, S., Ose, J., Ulvik, A., van Roekel, E. H., Holowatyj, A. N., Baierl, A., Böhm, J., Bours, M. J. L., et al. (2024) · International Journal of Cancer · doi:10.1002/ijc.35183 · Cited by 27

The Kynurenine Pathway, Aryl Hydrocarbon Receptor, and Alzheimer’s Disease

Cortés-Malagón, E. M., Ornelas, A. L., Olvera‐Gómez, I., & Bonilla‐Delgado, J. (2024) · Brain Sciences · doi:10.3390/brainsci14090950 · Cited by 27

Bladder cancer immune-related markers: diagnosis, surveillance, and prognosis

Yang, T., Luo, W., Yu, J., Zhang, H., Hu, M., & Tian, J. Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1481296 · Cited by 24

Unveiling the crossroads of STING signaling pathway and metabolic reprogramming: the multifaceted role of the STING in the TME and new prospects in cancer therapies

Wang, S., Qin, L., Liu, F., & Zhang, Z. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02169-0 · Cited by 24

A Comprehensive Review of the Role of the Microbiota–Gut–Brain Axis via Neuroinflammation: Advances and Therapeutic Implications for Ischemic Stroke

Guo, H., Tang, X., He, X., Weng, Y., Zhang, Q., Fang, Q., & Zhang, L. (2025) · Biomolecules · doi:10.3390/biom15070920 · Cited by 29

From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit

Tanaka, M., & Vécsei, L. (2025) · Biomedicines · doi:10.3390/biomedicines13082020 · Cited by 31

Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma

Fu, Y., Ding, L., Yang, X., Ding, Z., Huang, X., Zhang, L., Chen, S., Hu, Q., & Ni, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.637226 · Cited by 24

Tryptophan in the diet ameliorates motor deficits in a rotenone‐induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway

Wang, Y., Chen, S., Tan, J., Gao, Y., Yan, H., Liu, Y., Yi, S., Xiao, Z., & Wu, H. (2021) · Brain and Behavior · doi:10.1002/brb3.2226 · Cited by 24

The Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin

Vogeley, C., Rolfes, K. M., Krutmann, J., & Haarmann‐Stemmann, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841721 · Cited by 24

Non-Invasive, Topical Sampling of Potential, Low-Molecular Weight, Skin Cancer Biomarkers: A Study on Healthy Volunteers

Jankovskaja, S., Morin, M., Gustafsson, A., Anderson, C. D., Lehoczki, B., Engblom, J., Björklund, S., Rezeli, M., Marko‐Varga, G., & Ruzgas, T. A. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c05470 · Cited by 24

Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE

Anderson, E., Jin, Y., Shih, A., Arazi, A., Goodwin, S., Roeser, J., Furie, R. A., Aranow, C. B., Volpe, B. T., Diamond, B., et al. (2022) · Lupus Science & Medicine · doi:10.1136/lupus-2022-000808 · Cited by 24

Vitreous metabolomic signatures of pathological myopia with complications

Tang, Y., Zhang, X., Hu, Z., Lin, K., Lin, Z., Chen, T., Wu, R., & Chi, Z. (2023) · Eye · doi:10.1038/s41433-023-02457-4 · Cited by 24

Effects of dietary chlorogenic acid on cecal microbiota and metabolites in broilers during lipopolysaccharide-induced immune stress

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(2015) · Thammasat University Digital Collections