Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

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Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex

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Rheum tanguticum Alleviates Cognitive Impairment in APP/PS1 Mice by Regulating Drug-Responsive Bacteria and Their Corresponding Microbial Metabolites

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Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia

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Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources

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Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT—A Systematic Review

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Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish

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Dihydroartemisinin Protects Mice from CUMS-induced Depression-like Behaviors by Regulating Gut Microbes

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Recent contributions of single-cell and spatial profiling to the understanding of bladder cancer

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Anti-inflammatory and immunomodulatory effects of mesenchymal stem cell therapy on parasitic drug resistance

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Biomimetic Hydrogel‐Mediated Mechano‐Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery

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3-Hydroxykynurenine targets kainate receptors to promote defense against infection

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Synthesis of Non‐canonical Tryptophan Variants via Rh‐catalyzed C−H Functionalization of Anilines

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The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis

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Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma

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1,25(OH)2D3 mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis

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Effect of a Single Bout of Aerobic Exercise on Kynurenine Pathway Metabolites and Inflammatory Markers in Prostate Cancer Patients—A Pilot Randomized Controlled Trial

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Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes

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Anion-controlled Zn( ii ) coordination polymers with 1-(tetrazo-5-yl)-3-(triazo-1-yl) benzene as an assembling ligand: synthesis, characterization, and efficient detection of tryptophan in water

Sun, H., Zhou, J., Zhang, Z., He, M., He, L.-C., Du, L., Xie, M., & Zhao, Q. (2021) · Dalton Transactions · doi:10.1039/d1dt03045k · Cited by 12

Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)

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Integrative Methylome and Transcriptome Characterization Identifies SERINC2 as a Tumor-Driven Gene for Papillary Thyroid Carcinoma

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Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality

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Tryptophan Prevents the Development of Non-Alcoholic Fatty Liver Disease

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Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy

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Metabolic Pathways Associated With Psychoneurological Symptoms in Children With Cancer Receiving Chemotherapy

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Ginsenoside Rg1 exerts antidepressant effect by regulating hepatic kynurenine metabolism through promoting the interaction between HNF4α and PGC1α

Jia, K., Pan, S., Wu, W., Sun, Y., & Zhang, Q. (2024) · Journal of Ginseng Research · doi:10.1016/j.jgr.2024.12.002 · Cited by 11

IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration

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Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach

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Microbial Metabolites in Allergic Diseases: Beyond Short-Chain Fatty Acids

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Microenvironmental and Molecular Pathways Driving Dormancy Escape in Bone Metastases

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Chlorogenic acid ameliorates chronic stress-induced prefrontal cortex injury through activating the 5-HT/BDNF signaling pathway in rats

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12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

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Phenotypic screening of novel probiotics with potential anti-neuroinflammation activity based on cell and zebrafish models

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Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study

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Effects of dietary tryptophan supplementation on rectal temperature, humoral immunity, and cecal microflora composition of heat-stressed broilers

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KYNU as a Biomarker of Tumor-Associated Macrophages and Correlates with Immunosuppressive Microenvironment and Poor Prognosis in Gastric Cancer

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Host-microbe tryptophan partitioning in cardiovascular diseases

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Metabolomic profile of neuroendocrine tumors identifies methionine, porphyrin, and tryptophan metabolisms as key dysregulated pathways associated with patient survival

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Tryptophan metabolism and kynurenine metabolites in cancer: systemic nutritional and metabolic implications

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Unveiling the hidden pathways: Exploring astrocytes as a key target for depression therapy

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Targeting metabolism of breast cancer and its implications in T cell immunotherapy

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The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis

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Unveiling the metabolic landscape of pulmonary hypertension: insights from metabolomics

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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence

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Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque

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Gut Microbiota and Tryptophan Metabolism in Pathogenesis of Ischemic Stroke: A Potential Role for Food Homologous Plants

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The Two Sides of Indoleamine 2,3-Dioxygenase 2 (IDO2)

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Serum neurotransmitter analysis of motor and non-motor symptoms in Parkinson’s patients

Fan, Y., Yang, W., Wu, W., Wang, X., Lin, Y., Wu, L., Wang, J., Huan, F., Ding, H., & Gao, R. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1423120 · Cited by 11

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis

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Single‐cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis‐associated mesothelial cells (EAMCs) and ectopic stromal cells may influence progesterone resistance

Hou, S., Zhang, J., Zhang, Z., Qu, H., Li, S., Jiang, Y., & Liu, C. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70216 · Cited by 12

Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production

Xu, Q., Liu, X., Heng, H., Wang, H., Chen, K., Chan, E. W., Yang, G., & Chen, S. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012979 · Cited by 11

Emerging roles of microglia and neuroinflammation in Huntington's disease: From pathophysiology to clinical trials

Abedrabbo, M., Kazemian, P., Connolly, C., & Leavitt, B. R. (2025) · Journal of Huntington s Disease · doi:10.1177/18796397251330144 · Cited by 12

Promising Gastric Cancer Biomarkers—Focus on Tryptophan Metabolism via the Kynurenine Pathway

Ożga, K., Stepuch, P., Maciejewski, R., & Sadok, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083706 · Cited by 10

The gut-tumor connection: the role of microbiota in cancer progression and treatment strategies

Wei, Z., Gao, G., He, Q., Kwok, L., & Sun, Z. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.038 · Cited by 12

Analyzing the N–H+…π interactions of protonated tryptophan and phenylalkylamines using QTAIM, NCI, and NBO

Rodrigues‐Oliveira, A. F., Batista, P. R., Ducati, L. C., & Correra, T. C. (2020) · Theoretical Chemistry Accounts · doi:10.1007/s00214-020-02643-7 · Cited by 11

Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance

Hoffmann, D., Dvořáková, T., Schramme, F., Stroobant, V., & den Eynde, B. J. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.601759 · Cited by 11

Simultaneous determination of serum tryptophan metabolites in an older Chinese population

Wang, S., Feng, R., Chen, G., Sang, Y., Kong, L., Yu, S., Tao, F., & Liu, K. (2022) · Biomedical Chromatography · doi:10.1002/bmc.5512 · Cited by 11

A positive feedback loop between tryptophan hydroxylase 1 and β-Catenin/ZBP-89 signaling promotes prostate cancer progression

Ge, C., Yan, J., Yuan, X., & Xu, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.923307 · Cited by 11

IL4I1 and tryptophan metabolites enhance AHR signals to facilitate colorectal cancer progression and immunosuppression.

Sun, H., Han, W., Wen, J., & Ma, X. (2022) · PubMed Central · Cited by 11

A genetically encoded ratiometric indicator for tryptophan

Tao, R., Wang, K., Chen, T.-L., Zhang, X., Cao, J.-B., Zhao, W., Du, J., & Mu, Y. (2023) · Cell Discovery · doi:10.1038/s41421-023-00608-1 · Cited by 12

A Serum Metabolomic Study Reveals Changes in Metabolites During the Treatment of Lung Cancer-Bearing Mice with Anlotinib

Pan, X., Chen, W., Nie, M., Liu, Y., Xiao, Z., Zhang, Y., Zhang, W., & Zou, X. (2021) · Cancer Management and Research · doi:10.2147/cmar.s300897 · Cited by 11

The Crucial Roles of Intermediate Metabolites in Cancer

Huang, S., Wang, Z., & Zhao, L. (2021) · Cancer Management and Research · doi:10.2147/cmar.s321433 · Cited by 11

Tryptophan Side-Chain Oxidase Enzyme Suppresses Hepatocellular Carcinoma Growth through Degradation of Tryptophan

Ai, Y., Wang, B., Xiao, S., Luo, S., & Wang, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212428 · Cited by 11

Self‐Assembled Nanovehicle for Intracellular Enzyme‐Triggered Antitumor Drug Release

Zhang, J., Chen, S., Teng, J., Li, B., Wang, L., Yang, J., & Zhao, Y. (2022) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202200028 · Cited by 11

Superior normalization using total protein for western blot analysis of human adipocytes

Westerberg, L. J. S., Dedic, B., Näslund, E. B., Thorell, A., & Spalding, K. L. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328136 · Cited by 10

AR to GR switch modulates differential TDO2-Kyn-AhR signalling to promote the survival and recurrence of treatment-induced dormant cells in prostate cancer

Li, S., Zhang, Y., Luo, M., Zhou, W., Chen, Y., Wu, D., Wei, Q., Chang, Y., & Hu, H. (2025) · Cell Discovery · doi:10.1038/s41421-025-00817-w · Cited by 12

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Lan, J., Li, H., Xue, J., Duan, Y., Sun, J., & Niu, M. (2025) · Advanced Science · doi:10.1002/advs.202518487 · Cited by 10

Metabolic characteristics in hepatocellular carcinoma: amino acid metabolic reprogramming

Zhou, R., Li, Y., Li, G., Li, Y., Luo, L., Wang, B., & Wang, L. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02492-7 · Cited by 11

Metabolomics Profiling of Age-Associated Metabolites in Malay Population

Tan, J. K., Zakaria, S. N. A., Gunasekaran, G., Sani, N. F. A., Nasaruddin, M. L., Jaafar, F., Bakar, Z. H. A., Hamzah, A. I. Z. A., Aripin, K. N. N., Rani, M. D. M., et al. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/4416410 · Cited by 10

Automated Liquid Handling Extraction and Rapid Quantification of Underivatized Amino Acids and Tryptophan Metabolites from Human Serum and Plasma Using Dual-Column U(H)PLC-MRM-MS and Its Application to Prostate Cancer Study

Kipura, T., Hotze, M., Hofer, A., Egger, A.-S., Timpen, L. E., Opitz, C. A., Townsend, P. A., Gethings, L. A., Thedieck, K., & Kwiatkowski, M. (2024) · Metabolites · doi:10.3390/metabo14070370 · Cited by 10

The role of nonesterified fatty acids in cancer biology: Focus on tryptophan and related metabolism

Badawy, A. A.-B. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159531 · Cited by 10

Role of ACSL4 in modulating farnesoid X receptor expression and M2 macrophage polarization in HBV‐induced hepatocellular carcinoma

Chen, W., Xu, H., Guo, L., Zheng, F., Yao, J., & Wang, L. (2024) · MedComm · doi:10.1002/mco2.706 · Cited by 10

Reposition: Focalizing β-Alanine Metabolism and the Anti-Inflammatory Effects of Its Metabolite Based on Multi-Omics Datasets

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(2015) · Thammasat University Digital Collections