Defining circadian disruption in neurodegenerative disorders

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Stability, precision, and near-24-hour period of the human circadian pacemaker

Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705 · see citing works

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

Soto, C., & Pritzkow, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0235-9 · Cited by 1,180 · see citing works

Glymphatic failure as a final common pathway to dementia

Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145 · cited 2× · see citing works

The Circadian Clock and Human Health

Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004 · see citing works

Light as a central modulator of circadian rhythms, sleep and affect

LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001 · see citing works

Mechanisms linking circadian clocks, sleep, and neurodegeneration

Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878 · see citing works

The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia

Swaab, D. F., Fliers, E., & Partiman, T. S. (1985) · Brain Research · doi:10.1016/0006-8993(85)91350-2 · Cited by 847 · see citing works

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., et al. (2019) · Science · doi:10.1126/science.aav2546 · Cited by 813 · see citing works

Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock

Liu, C., Weaver, D. R., Jin, X., Shearman, L. P., Pieschl, R. L., Gribkoff, V. K., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80350-5 · Cited by 723 · see citing works

Circadian control of brain glymphatic and lymphatic fluid flow

Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18115-2 · Cited by 704 · cited 1× · see citing works

Association between circadian rhythms and neurodegenerative diseases

Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 660 · see citing works

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia

Hablitz, L. M., Vinitsky, H. S., Sun, Q., Stæger, F. F., Sigurdsson, B., Mortensen, K. N., Lilius, T. O., & Nedergaard, M. (2019) · Science Advances · doi:10.1126/sciadv.aav5447 · Cited by 629 · see citing works

Protein transmission in neurodegenerative disease

Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0333-7 · Cited by 625 · see citing works

Implications of sleep disturbance and inflammation for Alzheimer's disease dementia

Irwin, M. R., & Vitiello, M. V. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30450-2 · Cited by 587 · see citing works

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

Brehme, M., Voisine, C., Rolland, T., Wachi, S., Soper, J. H., Zhu, Y., Orton, K., Villella, A., Garza, D., Vidal, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.042 · Cited by 584 · see citing works

Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions

Schmidt, T. M., Chen, S., & Hattar, S. S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.001 · Cited by 553 · see citing works

The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548 · see citing works

Circadian clock control of endocrine factors

Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 529 · see citing works

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524 · see citing works

Circadian Mechanisms in Medicine

Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519 · see citing works

Circadian rhythm as a therapeutic target

Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 501 · see citing works

Circadian clock genes and the transcriptional architecture of the clock mechanism

Cox, K. H., & Takahashi, J. S. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0153 · Cited by 481 · see citing works

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Breen, D. P., Vuono, R., Nawarathna, U., Fisher, K., Shneerson, J. M., Reddy, A. B., & Barker, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.65 · Cited by 440 · see citing works

Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease

Morton, A. J., Wood, N. I., Hastings, M. H., Hurelbrink, C., Barker, R. A., & Maywood, E. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3842-04.2005 · Cited by 403 · see citing works

Circadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease

Videnovic, A., Noble, C., Reid, K. J., Peng, J., Turek, F. W., Marconi, A., Rademaker, A. W., Simuni, T., Zadikoff, C., & Zee, P. C. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6239 · Cited by 390 · see citing works

Sundowning and Circadian Rhythms in Alzheimer’s Disease

Volicer, L., Harper, D. G., Manning, B. C., Goldstein, R., & Satlin, A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.5.704 · Cited by 382 · see citing works

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 373 · see citing works

CONTRIBUTION OF CIRCADIAN PHYSIOLOGY AND SLEEP HOMEOSTASIS TO AGE-RELATED CHANGES IN HUMAN SLEEP

Dijk, D., Duffy, J. F., & Czeisler, C. A. (2000) · Chronobiology International · doi:10.1081/cbi-100101049 · Cited by 373 · see citing works

Medicine in the Fourth Dimension

Cederroth, C. R., Albrecht, U., Bass, J. T., Brown, S. A., Dyhrfjeld‐Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich‐Förster, C., Hogenesch, J. B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.019 · Cited by 363 · see citing works

Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics

Lucey, B. P., Hicks, T. J., McLeland, J. S., Toedebusch, C. D., Boyd, J., Elbert, D. L., Patterson, B. W., Baty, J., Morris, J. C., Ovod, V., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25117 · Cited by 362 · see citing works

Contrasting Effects of Ibotenate Lesions of the Paraventricular Nucleus and Subparaventricular Zone on Sleep–Wake Cycle and Temperature Regulation

Lu, J., Zhang, Y.-H., Chou, T. C., Gaus, S. E., Elmquist, J. K., Shiromani, P. J., & Saper, C. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04864.2001 · Cited by 335 · see citing works

Circadian disruption: what do we actually mean?

Vetter, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14255 · Cited by 333 · see citing works

Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus

Wen, S., Ma, D., Zhao, M., Xie, L., Wu, Q., Gou, L., Zhu, C., Fan, Y., Wang, H., & Yan, J. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0586-x · Cited by 328 · see citing works

Immunity around the clock

Man, K., Loudon, A., & Chawla, A. (2016) · Science · doi:10.1126/science.aah4966 · Cited by 325 · see citing works

Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia

Hatfield, C. F. (2004) · Brain · doi:10.1093/brain/awh129 · Cited by 323 · see citing works

Twenty-Four Hour Cortisol Release Profiles in Patients With Alzheimer's and Parkinson's Disease Compared to Normal Controls: Ultradian Secretory Pulsatility and Diurnal Variation

Hartmann, A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)80309-0 · Cited by 319 · see citing works

Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype¹

Liu, R.-Y., Zhou, J.-N., van Heerikhuize, J., Hofman, M. A., & Swaab, D. F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5394 · Cited by 304 · see citing works

Circadian Rhythm Generation and Entrainment in Astrocytes

Prolo, L. M., Takahashi, J. S., & Herzog, E. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4133-04.2005 · Cited by 298 · see citing works

Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation

Chung, S., Lee, E. J., Yun, S., Choe, H. K., Park, S., Son, H. J., Kim, K., Dluzen, D. E., Lee, I., Hwang, O., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.039 · Cited by 298 · see citing works

Microglia inflammatory responses are controlled by an intrinsic circadian clock

Fonken, L. K., Frank, M. G., Kitt, M. M., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.009 · Cited by 280 · see citing works

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen, C.-Y., Logan, R. W., Ma, T., Lewis, D. A., Tseng, G. C., Sibille, E., & McClung, C. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508249112 · Cited by 277 · see citing works

Melatonin rhythmicity: effect of age and Alzheimer's disease

Skene, D. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00198-5 · Cited by 270 · see citing works

Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep–waking

Mishima, K., Tozawa, T., Satoh, K., Matsumoto, Y., Hishikawa, Y., & Okawa, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00510-6 · Cited by 269 · see citing works

Pathologic Evaluation of the Human Suprachiasmatic Nucleus in Severe Dementia

Stopa, E. G., Volicer, L., Kuo-Leblanc, V., Harper, D., Lathi, D., Tate, B., & Satlin, A. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199901000-00004 · Cited by 265 · see citing works

Circadian clock protein Rev-erbα regulates neuroinflammation

Griffin, P., Dimitry, J. M., Sheehan, P. W., Lananna, B. V., Guo, C., Robinette, M. L., Hayes, M. E., Cedeño, M. R., Nadarajah, C. J., Ezerskiy, L. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812405116 · Cited by 263 · see citing works

Sleep-wake cycles drive daily dynamics of synaptic phosphorylation

Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, M., Brown, S. A., & Robles, M. S. (2019) · Science · doi:10.1126/science.aav3617 · Cited by 261 · see citing works

High-accuracy determination of internal circadian time from a single blood sample

Wittenbrink, N., Ananthasubramaniam, B., Münch, M. Y., Koller, B., Maier, B., Weschke, C., Bes, F., de Zeeuw, J., Nowozin, C., Wahnschaffe, A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120874 · Cited by 260 · see citing works

CYCLOPS reveals human transcriptional rhythms in health and disease

Anafi, R. C., Francey, L. J., Hogenesch, J. B., & Kim, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619320114 · Cited by 252 · see citing works

The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, M., Tyagarajan, S. K., Robles, M. S., & Brown, S. A. (2019) · Science · doi:10.1126/science.aav2642 · Cited by 248 · see citing works

VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease

Zhou, J. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00043-e · Cited by 243 · see citing works

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

Nakajima, A., & Ohizumi, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143380 · Cited by 239 · see citing works

Temporal orchestration of circadian autophagy rhythm by C/EBPβ

Ma, D., Panda, S., & Lin, J. D. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.322 · Cited by 234 · see citing works

Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease

Satlin, A., Volicer, L., Stopa, E. G., & Harper, D. G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00059-n · Cited by 232 · see citing works

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factorPreprint

Reinke, H., Saini, C., Fleury-Olela, F., Dibner, C., Benjamin, I. J., & Schibler, U. (2008) · Genes & Development · doi:10.1101/gad.453808 · Cited by 228 · see citing works

Light and the Human Circadian Clock

Roenneberg, T., Kantermann, T., Juda, M., Vetter, C., & Allebrandt, K. V. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_13 · Cited by 220 · see citing works

Suprachiasmatic neuron numbers and rest–activity circadian rhythms in older humans

Wang, J. L., Lim, A. S., Chiang, W., Hsieh, W., Lo, M., Schneider, J. A., Buchman, A. S., Bennett, D. A., Hu, K., & Saper, C. B. (2015) · Annals of Neurology · doi:10.1002/ana.24432 · Cited by 217 · see citing works

Regulation of amyloid-β dynamics and pathology by the circadian clock

Kress, G. J., Liao, F., Dimitry, J. M., Cedeño, M. R., FitzGerald, G. A., Holtzman, D. M., & Musiek, E. S. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172347 · Cited by 206 · see citing works

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

Di Meco, A., Joshi, Y. B., & Praticò, D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.011 · Cited by 205 · see citing works

Disturbance of Endogenous Circadian Rhythm in Aging and Alzheimer Disease

Harper, D. G., Volicer, L., Stopa, E. G., McKee, A. C., Nitta, M., & Satlin, A. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.5.359 · Cited by 199 · see citing works

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

Sterniczuk, R., Dyck, R. H., LaFerla, F. M., & Antle, M. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.013 · Cited by 198 · see citing works

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S

Hayashi, Y., Koyanagi, S., Kusunose, N., Okada, R., Wu, Z., Tozaki‐Saitoh, H., Ukai, K., Kohsaka, S., Inoue, K., Ohdo, S., et al. (2013) · Scientific Reports · doi:10.1038/srep02744 · Cited by 192 · see citing works

How to fix a broken clock

Schroeder, A., & Colwell, C. S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.002 · Cited by 190 · see citing works

Circadian dysfunction in a mouse model of Parkinson's disease

Kudo, T., Loh, D. H., Truong, D., Wu, Y., & Colwell, C. S. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.003 · Cited by 188 · see citing works

Study of Circadian Melatonin Secretion Pattern at Different Stages of Parkinson's Disease

Bordet, R., Devos, D., Brique, S., Touitou, Y., Guieu, J. D., Libersa, C., & Destée, A. (2003) · Clinical Neuropharmacology · doi:10.1097/00002826-200303000-00005 · Cited by 184 · see citing works

A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice.

An, K., Zhao, H., Miao, Y., Xu, Q., Li, Y.-F., Ma, Y.-Q., Shi, Y.-M., Shen, J.-W., Meng, J.-J., Yao, Y.-G., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0640-8 · Cited by 176 · see citing works

Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the “master clock”

Wu, Y., Fischer, D. F., Kalsbeek, A., Garidou, M., van der Vliet, J., Heijningen, C. L. V., Liu, R., Zhou, J., & Swaab, D. F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4446fje · Cited by 175 · see citing works

Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects

Cermakian, N., Waddington Lamont, E., Boudreau, P., & Boivin, D. B. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730410395732 · Cited by 175 · see citing works

Elimination of circadian rhythms in drinking, activity, sleep, and temperature by isolation of the suprachiasmatic nuclei

Stephan, F. K., & Nunez, A. A. (1977) · Behavioral Biology · doi:10.1016/s0091-6773(77)90397-2 · Cited by 171 · see citing works

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

Lananna, B. V., Nadarajah, C. J., Izumo, M., Cedeño, M. R., Xiong, D. D., Dimitry, J. M., Tso, C. F., McKee, C. A., Griffin, P. Y., Sheehan, P. W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.015 · Cited by 170 · see citing works

Molecular Interactions Between Components of the Circadian Clock and the Immune System

Hergenhan, S. M., Holtkamp, S., & Scheiermann, C. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.044 · Cited by 170 · see citing works

Universal method for robust detection of circadian state from gene expression

Braun, R., Kath, W. L., Iwanaszko, M., Kula-Eversole, E., Abbott, S. M., Reid, K. J., Zee, P. C., & Allada, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800314115 · Cited by 168 · see citing works

Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia

Harper, D. G., Stopa, E. G., Kuo-LeBlanc, V., McKee, A. C., Asayama, K., Volicer, L., Kowall, N. W., & Satlin, A. (2008) · Brain · doi:10.1093/brain/awn049 · Cited by 165 · see citing works

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

Kudo, T., Schroeder, A., Loh, D. H., Kuljis, D. A., Jordan, M. C., Roos, K. P., & Colwell, C. S. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.12.011 · Cited by 163 · see citing works

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

Song, H., Moon, M., Choe, H. K., Han, D.-H., Jang, C., Kim, A., Cho, S., Kim, K., & Mook‐Jung, I. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0007-x · Cited by 154 · see citing works

Assessment of Circadian Rhythms

Reid, K. J. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.05.001 · Cited by 152 · see citing works

Melanopsin, Ganglion-Cell Photoreceptors, and Mammalian Photoentrainment

Rollag, M. D., Berson, D. M., & Provencio, I. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403018003005 · Cited by 147 · see citing works

The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration

Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 145 · see citing works

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1

Cronin, P., McCarthy, M. J., Lim, A. S. P., Salmon, D. P., Galasko, D. R., Masliah, E., Jager, P. L. D., Bennett, D. A., & Desplats, P. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.10.003 · Cited by 140 · see citing works

Disruption of Bmal1 Impairs Blood–Brain Barrier Integrity via Pericyte Dysfunction

Nakazato, R., Kawabe, K., Yamada, D., Ikeno, S., Mieda, M., Shimba, S., Hinoi, E., Yoneda, Y., & Takarada, T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3639-16.2017 · Cited by 139 · see citing works

Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease

Bolitho, S. J., Naismith, S. L., Rajaratnam, S. M. W., Grunstein, R. R., Hodges, J. R., Terpening, Z., Rogers, N., & Lewis, S. J. G. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.10.016 · Cited by 139 · see citing works

Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease

Pugh, P. L., Richardson, J. C., Bate, S. T., Upton, N., & Sunter, D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.044 · Cited by 138 · see citing works

Understanding systems-level properties: timely stories from the study of clocks

Hogenesch, J. B., & Ueda, H. R. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2972 · Cited by 136 · see citing works

Disruption of Peripheral Circadian Timekeeping in a Mouse Model of Huntington's Disease and Its Restoration by Temporally Scheduled Feeding

Maywood, E. S., Fraenkel, E., McAllister, C., Wood, N. I., Reddy, A. B., Hastings, M. H., & Morton, A. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1694-10.2010 · Cited by 135 · see citing works

Circadian and sleep disorder in Huntington's disease

Morton, A. J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.014 · Cited by 133 · see citing works

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

Banerjee, S., Wang, Y., Solt, L. A., Griffett, K., Kazantzis, M., Amador, A., Elgendy, B., Huitrón‐Reséndiz, S., Roberts, A. J., Shin, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms6759 · Cited by 132 · see citing works

Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington’s Disease

Aziz, N. A., Pijl, H., Frölich, M., van der Graaf, A. W. M., Roelfsema, F., & Roos, R. A. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2543 · Cited by 131 · see citing works

Neuroendocrine Disturbances in Huntington's Disease

Saleh, N., Moutereau, S., Dürr, A., Krystkowiak, P. C., Azulay, J., Tranchant, C., Broussolle, E., Morin, F., Bachoud‐Lévi, A., & Maison, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004962 · Cited by 131 · see citing works

Mammalian Inner Retinal Photoreception

Lucas, R. J. (2013) · Current Biology · doi:10.1016/j.cub.2012.12.029 · Cited by 126 · see citing works

Circadian Rhythm Sleep–Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease

Steele, T. A., Louis, E. K. S., Videnović, A., & Auger, R. R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01031-8 · Cited by 123 · see citing works

Plasma melatonin is reduced in Huntington's disease

Kalliolia, E., Silajdžić, E., Nambron, R., Hill, N. R., Doshi, A., Frost, C. D., Watt, H., Hindmarsh, P. C., Björkqvist, M., & Warner, T. T. (2014) · Movement Disorders · doi:10.1002/mds.26003 · Cited by 118 · see citing works

Light-Induced Pupillary Responses in Alzheimer's Disease

Chougule, P. S., Najjar, R. P., Finkelstein, M. T., Kandiah, N., & Miléa, D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00360 · Cited by 117 · see citing works

Effects of a Tailored Lighting Intervention on Sleep Quality, Rest–Activity, Mood, and Behavior in Older Adults With Alzheimer Disease and Related Dementias: A Randomized Clinical Trial

Figueiro, M. G., Plitnick, B., Roohan, C., Sahin, L., Kalsher, M. J., & Rea, M. S. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8078 · Cited by 116 · see citing works

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., & Carelli, V. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00162 · Cited by 111 · see citing works

Searching for Genes Underlying Behavior: Lessons from Circadian Rhythms

Takahashi, J. S., Shimomura, K., & Kumar, V. (2008) · Science · doi:10.1126/science.1158822 · Cited by 105 · see citing works

The circadian system and the balance of the autonomic nervous system

Buijs, R. M., Escobar, C., & Swaab, D. F. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00015-8 · Cited by 100 · see citing works

Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature

Scheer, F. A. J. L., Pirovano, C., Someren, E. J. W. V., & Buijs, R. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.012 · Cited by 98 · see citing works

Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities

Duffy, J. F., Abbott, S. M., Burgess, H. J., Crowley, S. J., Emens, J. S., Epstein, L. J., Gamble, K. L., Hasler, B. P., Kristo, D. A., Malkani, R. G., et al. (2021) · SLEEP · doi:10.1093/sleep/zsaa281 · Cited by 98 · see citing works

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

Cunningham, P. S., Meijer, P., Nazgiewicz, A., Anderson, S. G., Borthwick, L. A., Bagnall, J., Kitchen, G. B., Lodyga, M., Begley, N., Venkateswaran, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912109117 · Cited by 97 · see citing works

The Hypothalamus in Alzheimer’s Disease

Balogiannis, S., Mavroudis, I. A., Mitilineos, D., Baloyannis, I. S., & Costa, V. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317514556876 · Cited by 95 · see citing works

Circadian rhythms in innate immunity and stress responses

Baxter, M. D., & Ray, D. W. (2019) · Immunology · doi:10.1111/imm.13166 · Cited by 95 · see citing works

Melanopsin-mediated pupil function is impaired in Parkinson’s disease

Joyce, D. S., Feigl, B., Kerr, G., Roeder, L., & Zele, A. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-26078-0 · Cited by 90 · see citing works

Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease

Ortuño‐Lizarán, I., Esquiva, G., Beach, T. G., Serrano, G. E., Adler, C. H., Lax, P., & Cuenca, N. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0596-z · Cited by 87 · see citing works

Disruption of normal circadian clock function in a mouse model of tauopathy

Stevanovic, K. D., Yunus, A., Joly‐Amado, A., Gordon, M. N., Morgan, D., Gulick, D., & Gamsby, J. J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.015 · Cited by 86 · see citing works

A Histologic Study of the Circadian System in Parkinson Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy

Pablo‐Fernández, E. D., Courtney, R. J., Warner, T. T., & Holton, J. L. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0640 · Cited by 86 · see citing works

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep

Loh, D. H., Kudo, T., Truong, D. A., Wu, Y., & Colwell, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069993 · Cited by 84 · see citing works

Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington’s disease

Fisher, S. P., Black, S. W., Schwartz, M. D., Wilk, A. J., Chen, T.-M., Lincoln, W. U., Liu, H. W., Kilduff, T. S., & Morairty, S. R. (2013) · Brain · doi:10.1093/brain/awt132 · Cited by 82 · see citing works

The Relationship between Thermoregulation and REM Sleep Behaviour Disorder in Parkinson’s Disease

Zhong, G., Bolitho, S., Grunstein, R. R., Naismith, S. L., & Lewis, S. J. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072661 · Cited by 81 · see citing works

Suprachiasmatic Nucleus Neuropeptide Expression in Patients with Huntington's Disease

van Wamelen, D. J., Aziz, N. A., Anink, J. J., van Steenhoven, R., Angeloni, D., FRASCHINI, F., Jockers, R., Roos, R. A. C., & Swaab, D. F. (2012) · SLEEP · doi:10.5665/sleep.2314 · Cited by 77 · see citing works

The Suprachiasmatic Nucleus Is Essential for Circadian Body Temperature Rhythms in Hibernating Ground Squirrels

Ruby, N. F., Dark, J. G., Burns, D. E., Heller, H. C., & Zucker, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00357.2002 · Cited by 75 · see citing works

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging

Gloston, G. F., Yoo, S. H., & Chen, Z. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00100 · Cited by 73 · see citing works

Chronotherapy

Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819975-6.00023-6 · Cited by 73 · see citing works

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

Griffin, P., Sheehan, P. W., Dimitry, J. M., Guo, C., Kanan, M. F., Lee, J., Zhang, J., & Musiek, E. S. (2020) · eLife · doi:10.7554/elife.58765 · Cited by 73 · see citing works

Human Peripheral Clocks: Applications for Studying Circadian Phenotypes in Physiology and Pathophysiology

Saini, C., Brown, S. A., & Dibner, C. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00095 · Cited by 71 · see citing works

The limbic-hypothalamic-pituitary-adrenal axis in Huntington's disease

Heuser, I. J. E., Chase, T. N., & Mouradian, M. M. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90007-9 · Cited by 68 · see citing works

Nocturnal body core temperature falls in Parkinson's disease but not in multiple‐system atrophy

Pierangeli, G., Provini, F., Maltoni, P., Barletta, G., Contin, M., Lugaresi, E., Montagna, P., & Cortelli, P. (2001) · Movement Disorders · doi:10.1002/mds.1039 · Cited by 66 · see citing works

Efficient Screening and Selection of Post-Combustion CO2 Capture Solvents

Παπαδόπουλος, Α. Ι., Badr, S., Chremos, A., Forte, E., Zarogiannis, T., Seferlis, P., Papadokonstantakis, S., Adjiman, C. S., Galindo, A., & Jackson, G. (2014) · Chemical engineering transactions · doi:10.3303/cet1439036 · Cited by 62 · see citing works

Age-related changes in core body temperature and activity in triple-transgenic Alzheimer’s disease (3xTgAD) mice

Knight, E. M., Brown, T. M., Gümüsgöz, S., Smith, J., Waters, E. J., Allan, S. M., & Lawrence, C. B. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010173 · Cited by 59 · see citing works

Chronotherapies for Parkinson’s disease

Fifel, K., & Videnović, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.002 · Cited by 58 · see citing works

Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington's disease mouse

Fahrenkrug, J., Popović, N., Georg, B., Brundin, P., & Hannibal, J. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn/31:02:139 · Cited by 56 · see citing works

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease

Whittaker, D. S., Loh, D. H., Wang, H. B., Tahara, Y., Kuljis, D. A., Cutler, T., Ghiani, C. A., Shibata, S., Block, G. D., & Colwell, C. S. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418790401 · Cited by 55 · see citing works

Interacting influences of aging and Alzheimer's disease on circadian rhythms

Duncan, M. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14358 · Cited by 55 · see citing works

Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease

Bartlett, D. M., D, J. F. D., Reyes, A. P., Zaenker, P., Feindel, K. W., Newton, R. U., Hannan, A. J., Slater, J. A., Eastwood, P. R., Lázár, A. S., et al. (2018) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2018.07.001 · Cited by 50 · see citing works

Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington’s Disease

Kuljis, D. A., Gad, L., Loh, D. H., Kaswan, Z. A. M., Hitchcock, O. N., Ghiani, C. A., & Colwell, C. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147583 · Cited by 48 · see citing works

Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease

Oh, A. J., Amore, G., Sultan, W., Asanad, S., Park, J. C., Romagnoli, M., Morgia, C. L., Karanjia, R., Harrington, M. G., & Sadun, A. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226197 · Cited by 45 · see citing works

Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s disease

Zhou, L., Gao, Q., Nie, M., Gu, J., Hao, W., Wang, L., & Cao, J. (2016) · Scientific Reports · doi:10.1038/srep36335 · Cited by 44 · see citing works

Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

Xu, F., Kula-Eversole, E., Iwanaszko, M., Hutchison, A. L., Dinner, A. R., & Allada, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.015 · Cited by 44 · see citing works

Hypothalamic–pituitary–adrenal axis functioning in Huntington's disease mutation carriers compared with mutation-negative first-degree controls

van Duijn, E., Selis, M. A., Giltay, E. J., Zitman, F. G., Roos, R. A. C., van Pelt, H., & van der Mast, R. C. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.08.006 · Cited by 42 · see citing works

Evening melatonin timing secretion in real life conditions in patients with Alzheimer disease of mild to moderate severity

Manni, R., Cremascoli, R., Perretti, C., Icco, R. D., Picascia, M., Ghezzi, C., Cerri, S., Sinforiani, E., & Terzaghi, M. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.04.018 · Cited by 42 · see citing works

Circadian rhythms of melatonin and cortisol in manifest Huntington's disease and in acute cortical ischemic stroke.

Adamczak-Ratajczak, A., Kupsz, J., Owecki, M. K., Zielonka, D., Sowińska, A., Chęcińska-Maciejewska, Z., Krauss, H., Michalak, S., & Gibas-Dorna, M. (2017) · PubMed · Cited by 42 · see citing works

A multi‐level assessment of the bidirectional relationship between aging and the circadian clock

Buijink, M. R., & Michel, S. H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15286 · Cited by 41 · see citing works

Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice

Oyegbami, O., Collins, H. M., Pardon, M., Ebling, F. J. P., Heery, D. M., & Moran, P. M. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113159 · Cited by 38 · see citing works

Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease

Fisher, S. P., Schwartz, M. D., Wurts, S. W., Thomas, A. M., Chen, T.-M., Miller, M. A., Palmerston, J. B., Kilduff, T. S., & Morairty, S. R. (2016) · SLEEP · doi:10.5665/sleep.5448 · Cited by 37 · see citing works

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

Neueder, A., Gipson, T. A., Batterton, S., Lazell, H., Farshim, P. P., Paganetti, P., Housman, D. E., & Bates, G. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-12897-0 · Cited by 35 · see citing works

Assessing the role of nocturnal core body temperature dysregulation as a biomarker of neurodegeneration

Raupach, A. K., Martens, K. A. E., Memarian, N., Zhong, G., Matar, E., Halliday, G. M., Grunstein, R. R., & Lewis, S. J. G. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12939 · Cited by 35 · see citing works

Circadian alterations in patients with neurodegenerative diseases: Neuropathological basis of underlying network mechanisms

Fifel, K., & Videnović, A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105029 · Cited by 35 · see citing works

Distinct contribution of cone photoreceptor subtypes to the mammalian biological clock

van Diepen, H. C., Schoonderwoerd, R. A., Ramkisoensing, A., Janse, J. A. M., Hattar, S. S., & Meijer, J. H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024500118 · Cited by 35 · see citing works

Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment

Lin, M.-S., Liao, P., Chen, H., Chang, C., Chen, S., & Chern, Y. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0571-18.2018 · Cited by 31 · see citing works

Chromatic Pupillometry Findings in Alzheimer’s Disease

Romagnoli, M., Maserati, M. S., Matteis, M. D., Capellari, S., Carbonelli, M., Amore, G., Cantalupo, G., Zenesini, C., Liguori, R., Sadun, A. A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00780 · Cited by 31 · see citing works

Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts

Desvergne, A., Ugarte, N., Radjei, S., Gareil, M., Petropoulos, I., & Friguet, B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.037 · Cited by 29 · see citing works

Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease

Ouk, K., Hughes, S., Pothecary, C. A., Peirson, S. N., & Morton, A. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw359 · Cited by 26 · see citing works

Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer’s Disease

Hulme, B., Didikoğlu, A., Bradburn, S., Robinson, A., Canal, M. M., Payton, A., Pendleton, N., & Murgatroyd, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200634 · Cited by 25 · see citing works

Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease

Paul, J. R., Munir, H. A., van Groen, T., & Gamble, K. L. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.03.007 · Cited by 23 · see citing works

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease

Cutler, T., Park, S., Loh, D. H., Jordan, M. C., Yokota, T., Roos, K. P., Ghiani, C. A., & Colwell, C. S. (2017) · Physiological Reports · doi:10.14814/phy2.13289 · Cited by 22 · see citing works

Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease

Whittaker, D. S., Wang, H. B., Loh, D. H., Cachope, R., & Colwell, C. S. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.344 · Cited by 22 · see citing works

Autonomic dysregulation as an early pathologic feature of Huntington Disease

Schultz, J. L., Harshman, L. A., Kamholz, J. A., & Nopoulos, P. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102775 · Cited by 18 · see citing works

Normalizing glucocorticoid levels attenuates metabolic and neuropathological symptoms in the R6/2 mouse model of huntington's disease

Dufour, B. D., & McBride, J. L. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.025 · Cited by 17 · see citing works

Melatonin secretion in patients with Parkinson's disease receiving different-dose levodopa therapy

Kataoka, H., Saeki, K., Kurumatani, N., Sugie, K., & Obayashi, K. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.07.043 · Cited by 17 · see citing works

The PDB and protein homeostasis: From chaperones to degradation and disaggregase machines

Saibil, H. R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100744 · Cited by 11 · see citing works

Psychological Screening for Exceptional Environments: Laboratory Circadian Rhythm and Sleep Research

Amira, S. A., Bressler, B. L., Lee, J. H., Czeisler, C. A., & Duffy, J. F. (2020) · Clocks & Sleep · doi:10.3390/clockssleep2020013 · Cited by 10 · see citing works

Role of neuroinflammation in neurodegeneration development

Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works

Circadian disruption and sleep disorders in neurodegeneration

Shen, Y., Lv, Q.-K., Xie, W.-Y., Gong, S.-Y., Zhuang, S., Liu, J.-Y., Mao, C.-J., & Liu, C.-F. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00340-6 · Cited by 171 · see citing works

Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease

Whittaker, D. S., Akhmetova, L., Carlin, D., Romero, H., Welsh, D. K., Colwell, C. S., & Desplats, P. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.014 · Cited by 147 · see citing works

Aging, circadian disruption and neurodegeneration: Interesting interplay

Verma, A. K., Singh, S., & Rizvi, S. I. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2022.112076 · Cited by 55 · see citing works

The circadian clock and extracellular matrix homeostasis in aging and age-related diseases

Dudek, M., Swift, J., & Meng, Q. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00122.2023 · Cited by 47 · see citing works

Pathogenesis of Neurodegenerative Diseases and the Protective Role of Natural Bioactive Components

Samanta, S., Chakraborty, S., & Bagchi, D. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2203235 · Cited by 43 · see citing works

Alzheimer’s disease and sleep disorders: A bidirectional relationship

Chen, J., Peng, G., & Sun, B. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.08.008 · Cited by 43 · see citing works

Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review

Xiao, X., Rui, Y., Jin, Y., & Chen, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04086-5 · Cited by 35 · see citing works

Chronobiology of Parkinson's disease: Past, present and future

Asadpoordezaki, Z., Coogan, A. N., & Henley, B. M. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15859 · Cited by 31 · see citing works

Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment

Keihani, A., Mayeli, A., & Ferrarelli, F. (2022) · Advanced Biology · doi:10.1002/adbi.202200237 · Cited by 32 · see citing works

Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective

Trujillo-Rangel, W. Á., Acuña-Vaca, S., Padilla-Ponce, D. J., García-Mercado, F. G., Torres-Mendoza, B. M., Pacheco-Moisés, F. P., Escoto-Delgadillo, M., García‐Benavides, L., & Delgado-Lara, D. L. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084401 · Cited by 27 · see citing works

Examination of Diurnal Variation and Sex Differences in Hippocampal Neurophysiology and Spatial Memory

Goode, L. K., Fusilier, A. R., Remiszewski, N., Reeves, J. M., Abiraman, K., Defenderfer, M. K., Paul, J. R., McMahon, L. L., & Gamble, K. L. (2022) · eNeuro · doi:10.1523/eneuro.0124-22.2022 · Cited by 26 · see citing works

Regulation of headache response and transcriptomic network by the trigeminal ganglion clock

Han, C., Lim, J. Y., Koike, N., Kim, S. Y., Ono, K., Tran, C. K., Mangutov, E., Kim, E., Zhang, Y., Li, L., et al. (2024) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14670 · Cited by 25 · see citing works

Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions

Madhamanchi, K., Zhang, J., & Melkani, G. C. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.011 · Cited by 30 · see citing works

Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health

Kim, E., Yoo, S. H., & Chen, Z. (2022) · F1000Research · doi:10.12688/f1000research.126364.1 · Cited by 21 · see citing works

Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases

Hussain, Y., Dar, M. I., & Pan, X. (2024) · Metabolites · doi:10.3390/metabo14120723 · Cited by 21 · see citing works

Impact of circadian clock dysfunction on human health

Samanta, S., & Ali, S. A. (2022) · Exploration of neuroscience · doi:10.37349/en.2022.00002 · Cited by 20 · see citing works

Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease

Whittaker, D. S., Tamai, K. T., Bains, R. S., Villanueva, S. A. M. B., Luk, S. H. C., Dell’Angelica, D., Block, G. D., Ghiani, C. A., & Colwell, C. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1034743 · Cited by 21 · see citing works

FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function

Gerstner, J. R., Flores, C. C., Lefton, M., Rogers, B., & Davis, C. J. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1212213 · Cited by 22 · see citing works

The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites

Dong, Y., Lam, S. M., Li, Y., Li, M., & Shui, G. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.04.014 · Cited by 18 · see citing works

Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease

Khandayataray, P., & Murthy, M. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.066 · Cited by 18 · see citing works

Outdoor nighttime light exposure (light pollution) is associated with Alzheimer’s disease

Voigt, R. M., Ouyang, B., & Keshavarzian, A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1378498 · Cited by 18 · see citing works

Glucocorticoids, synaptic plasticity and Alzheimer’s disease

Klyubin, I., Ondrejcak, T., Hu, N.-W., & Rowan, M. J. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100365 · Cited by 16 · see citing works

Fall Risk, Sleep Behavior, and Sleep-Related Movement Disorders in Young Urbanites Exposed to Air Pollution

Calderón‐Garcidueñas, L., Kulesza, R. J., Greenough, G. P., García-Rojas, E., Revueltas-Ficachi, P., Villanueva, A. R., Flores-Vázquez, J. O., Brito-Aguilar, R., Ramírez-Sánchez, S., Vacaseydel-Aceves, N., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220850 · Cited by 16 · see citing works

Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer’s Disease

Shukla, M., & Vincent, B. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230314142505 · Cited by 15 · see citing works

The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

Huang, W., Zong, J., Zhang, Y. L., Zhou, Y., Zhang, L., Wang, Y., Shan, Z., Xie, Q., Li, M., Pan, S., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0921 · Cited by 16 · see citing works

Melatonin as a Chronobiotic/Cytoprotective Agent in REM Sleep Behavior Disorder

Cardinali, D. P., & Garay, A. D. C. (2023) · Brain Sciences · doi:10.3390/brainsci13050797 · Cited by 14 · see citing works

Neuron-Astrocyte Interactions and Circadian Timekeeping in Mammals

Smyllie, N. J., Hastings, M. H., & Patton, A. P. (2024) · The Neuroscientist · doi:10.1177/10738584241245307 · Cited by 12 · see citing works

Melatonin as a Chronobiotic and Cytoprotector in Non-communicable Diseases: More than an Antioxidant

Cardinali, D. P., Pandi-Perumal, S. R., & Brown, G. M. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_11 · Cited by 12 · see citing works

Time for circadian medicine

Kramer, A. (2023) · Acta Physiologica · doi:10.1111/apha.13984 · Cited by 12 · see citing works

Restoration of Sleep and Circadian Behavior by Autophagy Modulation in Huntington's Disease

Sharma, A., Narasimha, K., Manjithaya, R. R., & Sheeba, V. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1894-22.2023 · Cited by 12 · see citing works

Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer’s disease

Muñoz‐Moreno, E., Simoes, R. V., Tudela, R., López-Gil, X., & Sòria, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-20962-6 · Cited by 11 · see citing works

Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease

Silva, A. C., Lemos, C., Silva, H. B. L., Ferreira, I. L., Tomé, Â. R., Rego, A. C., & Cunha, R. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.835885 · Cited by 11 · see citing works

Circadian Rhythms in Aging and Age-Related Neurogenerative Disease

Zitting, K.-M., & Yuan, R. K. (2025) · Current Sleep Medicine Reports · doi:10.1007/s40675-025-00336-w · Cited by 10 · see citing works

Sex differences in sleep architecture in a mouse model of Huntington's disease

Chiem, E., Zhao, K., Stark, G., Ghiani, C. A., Colwell, C. S., & Paul, K. N. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25290 · Cited by 9 · see citing works

Retinal dysfunction in Huntington’s disease mouse models concurs with local gliosis and microglia activation

Cano-Cano, F., Martín-Loro, F., Gallardo-Orihuela, A., González-Montelongo, M. D. C., Ortuño‐Miquel, S., Hervás-Corpión, I., de la Villa, P., Ramón-Marco, L., Navarro-Calvo, J., Gómez-Jaramillo, L., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-54347-8 · Cited by 9 · see citing works

REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage

Wang, X., Zhi, H., Zhang, Z., Li, J., & Guo, D. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02264-w · Cited by 8 · see citing works

Circadian clocks and their role in kidney and eye diseases across organ systems

Chen, X., Zhang, W., Gu, Y., & Huang, S. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1583502 · Cited by 8 · see citing works

The 4E-BPs as Translational Regulators in Neurological Disorders: Molecular Mechanisms and Therapeutic Potential

Baskarapantula, S. S., Kumar, V. S., Changdar, P., Chakraborty, D., Nayak, Y., Spada, A. R. L., Bennett, C. L., & Dastidar, S. G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05553-6 · Cited by 8 · see citing works

Implications from proteomic studies investigating circadian rhythm disorder-regulated neurodegenerative disease pathology

Liu, W., Ma, R., Sun, C., Xu, Y., Liu, Y., Hu, J., Ma, Y., Wang, D., Wen, D., & Yu, Y. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101789 · Cited by 8 · see citing works

Fine-tuning the circadian system with light treatment for Parkinson’s disease: an in-depth, critical review

Willis, G. L., & Armstrong, S. M. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0026 · Cited by 7 · see citing works

Circadian clocks: It’s time for chronobiology

Merrow, M. W. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002426 · Cited by 7 · see citing works

Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

Linhares, S. S. G., Meurer, Y. D. S. R., de Aquino, A. C. Q., Câmara, D. D. A., Brandão, L. E. M., Dierschnabel, A. L., Fiuza, F. P., Lima, R. H., Engelberth, R. C. G. J., & Cavalcante, J. S. (2022) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10189 · Cited by 7 · see citing works

Evaluating the Genetic Role of Circadian Clock Genes in Parkinson’s Disease

Xiang, Y., Huang, J., Wang, Y., Huang, X., Zeng, Q., Li, L., Zhao, Y., Pan, H., Xu, Q., Liu, Z., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03243-9 · Cited by 6 · see citing works

Circadian disruption during fetal development promotes pathological cardiac remodeling in male mice

Yu, Y., Liu, J., Yang, H.-J., Luo, X.-Q., Gao, X.-P., Huang, X., Tang, A.-X., Cheng, H. M., Liu, W., & Zhang, P. (2024) · iScience · doi:10.1016/j.isci.2024.109008 · Cited by 6 · see citing works

Melatonin’s role in ameliorating perturbed circadian immune molecular links with aging and sleep deprivation in central and peripheral clocks in male Wistar rats

Khan, Z. A., & Jagota, A. (2025) · Biogerontology · doi:10.1007/s10522-025-10321-z · Cited by 5 · see citing works

Circadian rhythms are disrupted in patients and preclinical models of Machado-Joseph disease

Ribeiro, R. F. N., Pereira, D., Lopes, S., Reis, T., Silva, P., Lobo, D. D., Gaspar, L. S., Durães, J., Fernandes, A. R., Ferreira‐Marques, M., et al. (2025) · Brain · doi:10.1093/brain/awaf199 · Cited by 5 · see citing works

Circadian disruption promotes the neurotoxicity of oligomeric alpha-synuclein in mice

Zhang, J., Wan, X.-J., Duan, W.-X., Dai, X.-Q., Xia, D., Fu, X., Hu, L., Wang, F., & Liu, C. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00798-9 · Cited by 5 · see citing works

Circadian Intervention Improves Parkinson’s Disease and May Slow Disease Progression: A Ten Year Retrospective Study

Willis, G. L., Endo, T., & Waldman, M. (2024) · Brain Sciences · doi:10.3390/brainsci14121218 · Cited by 5 · see citing works

IL ‐ 17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease

Liu, T., Mao, T., Fan, J., Shen, Y., Xue, L., Du, K., Yang, L., Wang, L., & Wang, X. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70546 · Cited by 5 · see citing works

Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders

Panda, M., Fakitsa, M., Markaki, M., & Tavernarakis, N. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115655 · Cited by 4 · see citing works

Exploring the connection between the Mitochondrial DNA and the Circadian Rhythm: Insights into Mitochondrial Biogenesis and its Dynamics

Anand, S., Balgote, P. J., & Jayanthi, S. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11010-3 · Cited by 4 · see citing works

Is it time to think about chronotherapy in migraine

Holland, P. R., & Fronczek, R. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00823 · Cited by 4 · see citing works

Scheduled feeding improves sleep in a mouse model of Huntington’s disease

Chiem, E., Zhao, K., Dell’Angelica, D., Ghiani, C. A., Paul, K. N., & Colwell, C. S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1427125 · Cited by 4 · see citing works

A Neural-Glial Model of the ApoE-SORT1-FABP7 Axis Tied to Sleep Disruption and Alzheimer’s Disease Pathophysiology

Flores, C. C., Lee, Y., Davis, C. J., Solverson, P. M., & Gerstner, J. R. (2025) · Biomolecules · doi:10.3390/biom15101432 · Cited by 3 · see citing works

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Singh, B., Pigazzani, F., & Manfredini, R. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70046 · Cited by 3 · see citing works

Stress and the risk of Alzheimer dementia: Can deconstructed engrams be rebuilt?

Jeanneteau, F. D. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13235 · Cited by 3 · see citing works

Circadian rhythm disruption exacerbates neurodegeneration and alters proteomic profiles in a 6-OHDA induced Parkinson's disease model

Koç, H. I., Dogan, E., Yelkenci, H. E., Bayraktaroğlu, Ç., Ozpinar, A., Balaban, B., Altunay, S., Beker, M., Kılıç, E., & Beker, M. Ç. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115356 · Cited by 3 · see citing works

Melatonin as a Chronobiotic and Cytoprotector in Healthy Aging

Cardinali, D. P., Pandi-Perumal, S. R., & Brown, G. M. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_14 · Cited by 3 · see citing works

Effects of DNA methylation inhibitors on light-induced circadian clock plasticity

Kim, S., & McMahon, D. G. (2025) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2025.100134 · Cited by 2 · see citing works

Dysregulation of the molecular clock by blood-borne factors in Alzheimer’s disease patients

Zhao, C., Li, T., Hao, S., Zhao, L., Han, Y., & Cai, Y. (2025) · Journal of Neurology · doi:10.1007/s00415-024-12824-0 · Cited by 2 · see citing works

Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a Drosophila model of Huntington's disease

Prakash, P., Pradhan, A. K., & Sheeba, V. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049447 · Cited by 2 · see citing works

Missing the Dark: Malediction for the Environment and Human Health

Samanta, S. (2023) · Asian Journal of Environment & Ecology · doi:10.9734/ajee/2023/v22i4516 · Cited by 1 · see citing works

Circadian timing and entrainment properties of the SCN pacemaker in the PS19 mouse model of tau pathology

Halloy, N. R., Formanowicz, M., Pham, N. N. L., Hoyt, K. R., & Obrietan, K. H. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115458 · Cited by 1 · see citing works

Enhancing Animal Welfare Through Home Cage Monitoring Systems

Potschka, H., Martinez-Garcia, F. D., Meulen, M. V. D., Prins, J., Cevik, Ö. S., & Stiedl, O. (2026) · Springer eBooks · doi:10.1007/978-3-032-19781-8_3 · Cited by 1 · see citing works

Targeting Sirtuin Signaling in Parkinson’s Disease and Neurodegeneration: Molecular Insights and Translational Potential

Kumari, S., Singh, H., Kamiya, A., & Taliyan, R. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06062-w · Cited by 2 · see citing works

Yogic Interventions in Clock Dysfunction, Neurodegeneration and Ageing

Jagota, A., Khan, Z. A., Sharma, S. A., & Dalai, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-2855-8_4 · Cited by 1 · see citing works

Rhythms under tension: Circadian clocks in an Unsynced Society

Kattner, A. A. (2025) · Biomedical Journal · doi:10.1016/j.bj.2025.100873 · Cited by 1 · see citing works

Circadian modulation by time-restricted feeding restores brain transcription and slows amyloid deposition in a mouse model of Alzheimer’s diseasePreprint

Whittaker, D. S., Akhmetova, L., Romero, H. K., Welsh, D. K., Colwell, C. S., & Desplats, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.07.511346 · Cited by 1 · see citing works

Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington’s DiseasePreprint

Chiem, E., Zhao, K., Stark, G., Ghiani, C. A., Colwell, C. S., & Paul, K. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.28.538324 · Cited by 1 · see citing works

Disrupted Diurnal Phase Variation in Circulating Factors as a Predictor of Disease and MortalityPreprint

Melamud, E., Mrčela, A., Lahens, N. F., Skarke, C., & FitzGerald, G. A. (2026) · medRxiv · doi:10.64898/2026.01.16.26344298 · Cited by 1 · see citing works

Measuring circadian rhythms in patients with dementia: protocol for a scoping reviewPreprint

Gabb, V. G., Ince, L. M., Rudd, S., & Coulthard, E. J. (2022) · medRxiv · doi:10.1101/2022.06.06.22275886

Retinal affectation in Huntington’s disease mouse models concurs with a local innate immune responsePreprint

Arroba, A. I., Gallardo-Orihuela, A., Cano-Cano, F., Martín-Loro, F., González-Montelongo, M. D. C., Hervás-Corpión, I., de la Villa, P., Ramón-Marco, L., Gómez-Jaramillo, L., & Valor, L. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.17.523578

Disruptions of Circadian Rhythms and Sleep/Wake Cycles in Neurologic Disorders

Walker, W. H., Liu, J. A., & Nelson, R. J. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_22

COVID-19 AS A TRIGGER FOR THE ONSET AND PROGRESSION OF NEURODEGENERATIVE PATHOLOGY PREDOMINANTLY IN ELDERLY AND SENILE POPULATION

Арьев, А. Л., & Лаптева, Е. С. (2024) · Успехи геронтологии · doi:10.34922/ae.2023.36.6.006

Sleep Disorders and Neurodegeneration

de Almondes, K. M., & Paiva, T. (2024) · Advances in medical technologies and clinical practice book series · doi:10.4018/979-8-3693-0851-6.ch011

Neurodegenerative diseases and circadian rhythm dysfunction: A bidirectional nexus

Samanta, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95735-9.00033-4

Microglial Circadian Rhythms and Neurodegenerative Diseases

Xia, Y. F. (2024) · Current Alzheimer Research · doi:10.2174/0115672050336499240903113255

Light and Sleep

Nelson, R. J. (2025) · Oxford University Press eBooks · doi:10.1093/9780197639979.003.0004

Diverse Aspects of Chrono-nutrition and Brain Function

Shiuchi, T. (2025) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.78.87

Role of circadian rhythm disruption and dietary polyphenols in the prognosis of neoadjuvant therapy for locally advanced colorectal cancer

Wang, G. (2025) · American Journal of Cancer Research · doi:10.62347/dizo2176

Circadian clock: Epigenetic regulators (sirtuins), metabolism, and diseases

Meyer‐Ficca, M. L., & Meyer, R. G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00303-4

Increased neuronal activity restores circadian function in Drosophila models of C9orf72-ALS/FTD

Inami, S., Jenny, B. P., Akpoghiran, O., Gallagher, S. I., Strich, A. K., Tonoki, A., Trotti, D., Haeusler, A. R., & Koh, K. (2026) · iScience · doi:10.1016/j.isci.2026.114798

Regulating Kynurenine-Mediated Suppression of CLOCK by miR-30b-5p in Knee Osteoarthritis

Liu, J., & Duan, Z. (2025) · Molecular Biology · doi:10.1134/s0026893325601983

Timing the decline: Cellular circadian rhythms and Alzheimer’s disease

Colwell, C. S. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2604049123

Circadian Health Training in Latin America: Translating Chronobiology into Clinical Practice

de Andrade, T. G., & Silva, A. C. (2026) · Sleep Science · doi:10.1055/s-0046-1819594

Sleep spindle alterations as a novel biomarker for phenotypic stratification in sporadic amyotrophic lateral sclerosis

Li, M., Han, M., Li, X., Yu, N., Zhang, X., Zhao, L., Liu, Q., Liu, H., Wu, J., Han, Z., et al. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108961

Dynamic integration of metabolic, circadian and neuroendocrine axes in ageing and regeneration from the cellular and molecular perspectives

Salma, U., Islam, M. M., Islam, M. M., Ali, M. H., Mawya, J., Mohtasim, M., Sharmi, N. S., & Haque, N. (2026) · Biological Rhythm Research · doi:10.1080/09291016.2026.2717696

Health impacts of atypical working hours: an updated review of scientific evidence and re-evaluation of risk classifications

Bacha, A., & Liani, N. (2026) · Journal of Public Health and Community Medicine · doi:10.5455/jphcm.20260302032211

Circadian aging and neurodegeneration: the emerging role of the melatonin-cortisol axis in brain homeostasis, disease progression, and precision chronomedicine

Chakraborty, W., Anand, A., Kumar, S., & Roy, K. K. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101292

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update

Fifel, K., & Videnović, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.627330 · Cited by 68 · see citing works

Circadian rhythm in neurodegenerative diseases

Videnović, A. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.10.121 · Cited by 1 · see citing works

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 373 · see citing works

Circadian disruption as a driver and target in neurodegenerative diseases: from molecular mechanisms to chronotherapeutic strategies

Maidh, A., Kalra, P., Khan, H., Silakari, P., & Grewal, A. K. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01813-z · Cited by 2 · see citing works

Circadian clock disruption in neurodegenerative diseases: cause and effect?

Musiek, E. S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00029 · Cited by 120 · see citing works