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The obese adipose tissue microenvironment in cancer development and progression
Open accessAbstract
Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These associations are driven, in part, by metabolic and inflammatory changes in adipose tissue that disrupt physiological homeostasis both within local tissues and systemically. However, the mechanisms underlying the obesity-cancer relationship are poorly understood. In this Review, we describe how the adipose tissue microenvironment (ATME) evolves during body-weight gain, and how these changes might influence tumour initiation and progression. We focus on multiple facets of ATME physiology, including inflammation, vascularity and fibrosis, and discuss therapeutic interventions that have the potential to normalize the ATME, which might be translationally relevant for cancer prevention and therapy. Given that the prevalence of obesity is increasing on an international scale, translational research initiatives are urgently needed to provide mechanistic explanations for the obesity-cancer relationship, and how to best identify high-risk individuals without relying on crude measures, such as BMI.
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“Variably increased risk has been reported for cancers of the breast (postmenopausal) endometrium ovary gall bladder, stomach and esophagus, kidney, thyroid (papillary, follicular, and anaplastic but not medullary), colon, bladder, and pancreas.1733,1734,1739–1752”
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Metadata
- Authors
- Quail, D. F., & Dannenberg, A. J.
- Affiliations
- McGill University (CA)
- Weill Cornell Medicine (US)
- Corresponding author
- Quail, Daniela F.
- Dannenberg, Andrew J.
- Venue
- Nature Reviews Endocrinology
- Published
- 2018-11-20
- Volume
- 15
- Issue
- 3
- Pages
- 139-154
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC6374176
- OpenAlex
- W2900496024
- Cited by
- 542
- References
- 203
- Citations by year
- 2026: 59 · 2025: 62 · 2024: 74 · 2023: 81 · 2022: 74 · 2021: 107 · 2020: 65 · 2019: 18 · 2018: 2
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA215797, U54CA210184)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, adipose tissue microenvironment, tumor progression, tumor initiation, adipose tissue inflammation, adipose tissue fibrosis, adipose tissue metabolism, weight gain, cancer prevention, obesity as cancer risk factor
- MeSH terms
- Adipose Tissue, Animals, Cell Transformation, Neoplastic, Female, Humans, Male, Neoplasms, Obesity, Sensitivity and Specificity, Comorbidity, Body Mass Index, Prevalence, Adipocytes, Risk Assessment, Mice, Tumor Microenvironment
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