The obese adipose tissue microenvironment in cancer development and progression

Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies

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Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

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Microenvironmental regulation of tumor progression and metastasis

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6-Shogaol Antagonizes the Adipocyte-Conditioned Medium-Initiated 5-Fluorouracil Resistance in Human Colorectal Cancer Cells through Controlling the SREBP-1 Level

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Adipocyte-derived extracellular vesicles: bridging the communications between obesity and tumor microenvironment

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An adhesive hydrogel implant combining chemotherapy and tumor microenvironment remodeling for preventing postoperative recurrence and metastasis of breast cancer

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Periprostatic Adipose Tissue: A New Perspective for Diagnosing and Treating Prostate Cancer

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Strengthening the Combinational Immunotherapy from Modulating the Tumor Inflammatory Environment via Hypoxia‐Responsive Nanogels

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Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots

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Dissecting the emerging role of cancer-associated adipocyte-derived cytokines in remodeling breast cancer progression

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Dual-responsive near-infrared fluorescent probe for monitoring viscosity and mitochondria-generated peroxynitrite-induced lipid droplet migration in live cells and non-alcoholic fatty liver

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Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes.

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Cohesive cancer invasion of the biophysical barrier of smooth muscle

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Identifying Key Genes and Functionally Enriched Pathways of Diverse Adipose Tissue Types in Cattle

Pan, C., Yang, C., Wang, S., & Ma, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.790690 · Cited by 18

Characteristic and fate determination of adipose precursors during adipose tissue remodeling

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Neoadjuvant Gastric Cancer Treatment and Associated Nutritional Critical Domains for the Optimization of Care Pathways: A Systematic Review

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High-Density Lipoprotein in Metabolic Disorders and Beyond: An Exciting New World Full of Challenges and Opportunities

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Obesity-Associated Breast Cancer: Analysis of Risk Factors and Current Clinical Evaluation

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Adipogenesis in Different Body Depots and Tumor Development

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Adipose tissue-associated cancer risk: Is it the fat around the liver, or the fat inside the liver?

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Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP

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The Lipoprotein Transport System in the Pathogenesis of Multiple Myeloma: Advances and Challenges

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Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

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The crosstalk within the breast tumor microenvironment in type II diabetes: Implications for cancer disparities

Ennis, C. S., Llévenes, P., Qiu, Y., Dries, R., & Denis, G. V. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1044670 · Cited by 20

High visceral fat-to-muscle ratio is an independent factor that predicts worse overall survival in patients with primary epithelial ovarian, fallopian tube, and peritoneal cancer

Ham, S., Choi, J. H., Shin, S. G., & Lee, E. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01098-1 · Cited by 17

Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer

Zhu, Q., Cao, Y., Yuan, J., & Hu, Y. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03584-3 · Cited by 17

Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma

Birts, C. N., Savva, C., Laversin, S. A., Lefas, A. Y., Krishnan, J. V., Schapira, A., Ashton‐Key, M., Crispin, M., Johnson, P., Blaydes, J. P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11696-6 · Cited by 17

Obesity and Infection: What Have We Learned From the COVID-19 Pandemic

Vassilopoulou, Ε., Bumbăcea, R. S., Pappa, A. K., Papadopoulos, A. N., & Bumbăcea, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931313 · Cited by 17

Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: Implications for atherogenic, tumorigenic, and obesogenic processes

Lee‐Rueckert, M., Jauhiainen, M., Kovanen, P. T., & Escolá‐Gil, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.008 · Cited by 16

Genome Profiling of H3k4me3 Histone Modification in Human Adipose Tissue during Obesity and Insulin Resistance

Castellano‐Castillo, D., Ramos‐Molina, B., Oliva‐Olivera, W., Ocaña-Wilhelmi, L., Queipo‐Ortuño, M. I., & Cardona, F. (2021) · Biomedicines · doi:10.3390/biomedicines9101363 · Cited by 17

Omental Macrophagic “Crown-like Structures” Are Associated with Poor Prognosis in Advanced-Stage Serous Ovarian Cancer

Liang, Y., Lin, C.-N., Tsai, H.-F., Wu, P., Lin, S., Hong, T.-M., & Hsu, K. (2021) · Current Oncology · doi:10.3390/curroncol28050359 · Cited by 16

Two‐sided roles of adipose tissue: Rethinking the obesity paradox in various human diseases from a new perspective

Pan, J., Yin, J., Gan, L., & Xue, J. (2022) · Obesity Reviews · doi:10.1111/obr.13521 · Cited by 21

Obesity, the Adipose Organ and Cancer in Humans: Association or Causation?

Trevellin, E., Bettini, S., Pilatone, A., Vettor, R., & Milan, G. (2023) · Biomedicines · doi:10.3390/biomedicines11051319 · Cited by 17

Lifestyle and host determinants of antitumor immunity and cancer health disparities

Swaby, A. M., Atallah, A., Varol, O., Cristea, A., & Quail, D. F. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.08.007 · Cited by 16

Impact of body size and body composition on bladder cancer outcomes: Risk stratification and opportunity for novel interventions

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Fatty acid translocase: a culprit of lipid metabolism dysfunction in disease

Rupert, J. E., & Kolonin, M. G. (2022) · Immunometabolism · doi:10.1097/in9.0000000000000001 · Cited by 17

SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters

Bogard, G., Barthelemy, J., Hantute-Ghesquier, A., Sencio, V., Rodrigues, P. B., Séron, K., Robil, C., Flourens, A., Pinet, F., Eberlé, D., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05574-w · Cited by 16

Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte‐Rich Bone in Excess Weight Male Rodents

Gaculenko, A., Gregoric, G., Popp, V., Seyler, L., Ringer, M., Kachler, K., Wu, Z., Kisel, W., Hofbauer, C., Hofbauer, L., et al. (2021) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4422 · Cited by 13

Evolved Resistance to Placental Invasion Secondarily Confers Increased Survival in Melanoma Patients

Suhail, Y., Afzal, J. M., & Gupta, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040595 · Cited by 15

Dynamic phenotypes of preclinical and clinical obesity in relation to new‐onset cancer risk: A longitudinal analysis from the UK biobank

Xu, M., Li, M., Zhang, Y., Li, L., Shen, Y., & Hu, G. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16582 · Cited by 15

Atrial Fibrillation and Cancer: Pathophysiological Mechanism and Clinical Implications

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Association between metabolic overweight/obesity phenotypes and readmission risk in patients with lung cancer: A retrospective cohort study

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CEP55 as a Promising Immune Intervention Marker to Regulate Tumor Progression: A Pan-Cancer Analysis with Experimental Verification

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Reporting on patient’s body mass index (BMI) in recent clinical trials for patients with breast cancer: a systematic review

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Obesity Drives Delayed Infarct Expansion, Inflammation, and Distinct Gene Networks in a Mouse Stroke Model

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Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity

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Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins

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Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

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Obesity promotes immunotherapy efficacy by up-regulating the glycolytic-mediated histone lactacylation modification of CD8+ T cells

Wang, K.-X., Shi, D.-M., Shi, X., Wang, J., & Ai, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1533464 · Cited by 15

Digital analysis of distant and cancer-associated mammary adipocytes

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Adiposity and cancer: systematic review and meta-analysisPreprint

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Adipocyte-derived IL6 and triple-negative breast cancer cell-derived CXCL1 co-activate STAT3/NF-κB pathway to mediate the crosstalk between adipocytes and triple-negative breast cancer cells

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Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer

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Macrophage Phenotypic Switch and Obesity‐Associated Metabolic Risk: Mechanisms and Targets

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C(3)1-TAg in C57BL/6 J background as a model to study mammary tumor development

Sena, I. F. G., Rocha, B. G. S., Picoli, C. C., Santos, G. S. P., Costa, A. C., Gonçalves, B. Ô. P., Garcia, A. P. V., Soltani-asl, M., Coimbra-Campos, L. M. C., da Silva, W. N., et al. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-021-01995-w · Cited by 12

Advances in “adiponcosis”: Insights in the inner mechanisms at the base of adipose and tumour tissues interplay

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Biological Support to Obesity Paradox in Renal Cell Carcinoma: A Review

Li, M., & Bu, R. (2020) · Urologia Internationalis · doi:10.1159/000510245 · Cited by 12

The molecular mechanisms linking metabolic syndrome to endometrial and breast cancers

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Obesity, Type-2 Diabetes and Cancer: Mechanistic Insights

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Effects of body composition profiles on oncological outcomes and postoperative intraabdominal infection following colorectal cancer surgery

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Metabolomics in cancer and cancer-associated inflammatory cells

dos Santos, G. C., Saldanha-Gama, R. F. G., de Brito, N. M., Renovato‐Martins, M., & Barja‐Fidalgo, C. (2021) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.86 · Cited by 12

The Metabolomic Characteristics and Dysregulation of Fatty Acid Esters of Hydroxy Fatty Acids in Breast Cancer

Qin, L., An, N., Yuan, B., Zhu, Q., & Feng, Y. (2023) · Metabolites · doi:10.3390/metabo13111108 · Cited by 11

Influence of Chronic Low-Grade Inflammation (Obesity) on the Systemic Inflammatory Response

Balderas-Peña, L.-M.-A., Sat-Muñoz, D., Mireles-Ramírez, M. A., Martínez-Herrera, B.-E., Nava-Zavala, A. H., Cervantes-González, L.-M., Muñoz-García, M.-G., Rubio-Jurado, B., Páramo, M. S., Sánchez, E. G., et al. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1002764 · Cited by 13

HDAC11 deficiency resists obesity by converting adipose-derived stem cells into brown adipocyte-like cells

Yang, H., Li, C., Che, M., Liang, J., Tian, X., Yang, G., & Sun, C. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128852 · Cited by 11

Regulation of adipogenesis by histone methyltransferases

Zhao, Y., Skovgaard, Z., & Wang, Q. (2024) · Differentiation · doi:10.1016/j.diff.2024.100746 · Cited by 12

The association of body composition phenotypes before chemotherapy with epithelial ovarian cancer mortality

Davis, E. W., Attwood, K. M., Prunier, J., Paragh, G., Joseph, J. M., Klein, A., Roche, C. L., Barone, N., Etter, J. L., Ray, A. D., et al. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae112 · Cited by 12

Histologic Characterization of Tumor-Adjacent Mammary Adipose Tissue in Normal-Weight and Overweight/Obese Patients with Triple-Negative Breast Cancer

Wolf, M., Brochhausen, C., Ramakrishnan, V., Iberl, S., Roth, J., Seitz, S., Burkhardt, R., & Stadler, S. C. (2024) · Cancers · doi:10.3390/cancers16203515 · Cited by 11

Trends in incidence and mortality of early-onset gastrointestinal cancers: a comprehensive study

Xia, C., Liu, Y., & Qing, X. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-04015-6 · Cited by 11

Oestrogen changes at menopause: insights into obesity-associated breast risk and outcomes

Sho, M., Qureshi, R., & Slingerland, J. M. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01208-7 · Cited by 10

Activation of a non-neuronal cholinergic system in visceral white adipose tissue of obese mice and humans

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The effects of flaxseed (Linum usitatissimum) supplementation on anthropometric indices: An updated systematic review and meta-analysis of randomized clinical trials

Musazadeh, V., Abolghasemian, M., Kavyani, Z., Moridpour, A. H., Nazari, A., & Faghfouri, A. H. (2024) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2024.103066 · Cited by 11

The obese inflammatory microenvironment may promote breast DCIS progression

Habanjar, O., Nehme, R., Gonçalves-Mendes, N., Cueff, G., Blavignac, C., Aoun, J., Decombat, C., Auxenfans, C., Diab‐Assaf, M., Caldefie‐Chezet, F., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1384354 · Cited by 10

Unraveling the obesity paradox in small cell lung cancer immunotherapy: unveiling prognostic insights through body composition analysis

Fang, R., Yan, L., Xu, S., Xu, Y., Gan, T., Gong, J., Zhang, J., Xie, C., & Liao, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1439877 · Cited by 10

Effect of genistein supplementation on microenvironment regulation of breast tumors in obese mice

Jin, S., Zheng, Y., Li, D., Liu, X., Zhu, T., Wang, S., Liu, Z., & Liu, Y. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01904-8 · Cited by 12

Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk

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Which exercise interventions are more helpful in treating primary obesity in young adults: A Systematic review and Bayesian Network Meta-analysis

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High-fat diet induces C-reactive protein secretion, promoting lung adenocarcinoma via immune microenvironment modulation

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Gastric Cancer, Immunotherapy, and Nutrition: The Role of Microbiota

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Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells

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Benign non-immune cells in tumor microenvironment

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Combined variations in sleep, physical activity, and nutrition and the risk of major adverse cardiovascular events

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Blood glucose and epicardial adipose tissue at the hospital admission as possible predictors for COVID-19 severity

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