A road map for understanding molecular and genetic determinants of osteoporosis
Open accessAbstract
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density, osteoporosis and osteoporotic fracture are highly heritable; however, determining the genetic architecture, and especially the underlying genomic and molecular mechanisms, of osteoporosis in vivo in humans is still challenging. In addition to susceptibility loci identified in genome-wide association studies, advances in various omics technologies, including genomics, transcriptomics, epigenomics, proteomics and metabolomics, have all been applied to dissect the pathogenesis of osteoporosis. However, each technology individually cannot capture the entire view of the disease pathology and thus fails to comprehensively identify the underlying pathological molecular mechanisms, especially the regulatory and signalling mechanisms. A change to the status quo calls for integrative multi-omics and inter-omics analyses with approaches in 'systems genetics and genomics'. In this Review, we highlight findings from genome-wide association studies and studies using various omics technologies individually to identify mechanisms of osteoporosis. Furthermore, we summarize current studies of data integration to understand, diagnose and inform the treatment of osteoporosis. The integration of multiple technologies will provide a road map to illuminate the complex pathogenesis of osteoporosis, especially from molecular functional aspects, in vivo in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
WGCNA: an R package for weighted correlation network analysis
Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252 · see citing works
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116 · see citing works
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · see citing works
Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368 · see citing works
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works
Giambartolomei, C., Vukcevic, D., Schadt, E. E., Franke, L., Hingorani, A. D., Wallace, C., & Plagnol, V. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004383 · Cited by 4,261 · see citing works
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962 · see citing works
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Maurano, M. T., Humbert, R., Rynes, E., Thurman, R. E., Haugen, E., Wang, H., Reynolds, A. P., Sandstrom, R., Qu, H., Brody, J., et al. (2012) · Science · doi:10.1126/science.1222794 · Cited by 3,716 · see citing works
Multi-omics approaches to disease
Hasin, Y., Seldin, M., & Lusis, A. (2017) · Genome Biology · doi:10.1186/s13059-017-1215-1 · Cited by 2,953 · see citing works
An Expanded View of Complex Traits: From Polygenic to Omnigenic
Boyle, E. A., Li, Y. I., & Pritchard, J. K. (2017) · Cell · doi:10.1016/j.cell.2017.05.038 · Cited by 2,851 · see citing works
Metabolomics: beyond biomarkers and towards mechanisms
Johnson, C. H., Ivanisevic, J., & Siuzdak, G. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.25 · Cited by 2,829 · see citing works
Annotation of functional variation in personal genomes using RegulomeDB
Boyle, A. P., Hong, E. L., Hariharan, M., Cheng, Y., Schaub, M. A., Kasowski, M., Karczewski, K. J., Park, J., Hitz, B. C., Weng, S., et al. (2012) · Genome Research · doi:10.1101/gr.137323.112 · Cited by 2,722 · see citing works
(1994) · PubMed · Cited by 2,533 · see citing works
Wright, N. C., Looker, A. C., Saag, K. G., Curtis, J. R., Delzell, E. S., Randall, S., & Dawson-Hughes, B. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2269 · Cited by 1,801 · see citing works
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779 · see citing works
The support of human genetic evidence for approved drug indications
Nelson, M. R., Tipney, H., Painter, J. L., Shen, J., Nicoletti, P., Shen, Y., Floratos, A., Sham, P. C., Li, M. J., Wang, J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3314 · Cited by 1,666 · see citing works
Predictive Value of BMD for Hip and Other Fractures
Johnell, O., Kanis, J. А., Odén, A., Johansson, H., Laet, C. E. D. H. D., Delmas, P. D., Eisman, J. A., Fujiwara, S., Kröger, H., Mellström, D., et al. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050304 · Cited by 1,448 · see citing works
Untargeted Metabolomics Strategies—Challenges and Emerging Directions
Schrimpe‐Rutledge, A. C., Codreanu, S. G., Sherrod, S. D., & MCLEAN, J. A. J. (2016) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1469-y · Cited by 1,391 · see citing works
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366 · see citing works
New approaches to population stratification in genome-wide association studies
Price, A. L., Zaitlen, N., Reich, D., & Patterson, N. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2813 · Cited by 1,181 · see citing works
Estrada, K., Styrkársdóttir, U., Εvangelou, Ε., Hsu, Y., Duncan, E. L., Ntzani, E., Oei, L., Albagha, O., Amin, N., Kemp, J. P., et al. (2012) · Nature Genetics · doi:10.1038/ng.2249 · Cited by 1,177 · see citing works
Building strong bones: molecular regulation of the osteoblast lineage
Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,149 · see citing works
Riggs, B. L., Khosla, S., & Melton, L. J. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.5.763 · Cited by 1,143 · see citing works
Scotti, M. M., & Swanson, M. S. (2015) · Nature Reviews Genetics · doi:10.1038/nrg.2015.3 · Cited by 1,130 · see citing works
What makes UK Biobank special?
Collins, R. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60404-8 · Cited by 1,128 · see citing works
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Jaffe, A. E., & Irizarry, R. A. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r31 · Cited by 1,067 · see citing works
Udagawa, N., Takahashi, N., Akatsu, T., Tanaka, H., Sasaki, T., Nishihara, T., Koga, T., Martin, T. J., & Suda, T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.7260 · Cited by 1,048 · see citing works
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works
From genome-wide associations to candidate causal variants by statistical fine-mapping
Schaid, D. J., Chen, W., & Larson, N. B. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0016-z · Cited by 897 · see citing works
FINEMAP: efficient variable selection using summary data from genome-wide association studies
Benner, C., Spencer, C. C. A., Havulinna, A. S., Salomaa, V., Ripatti, S., & Pirinen, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw018 · Cited by 815 · see citing works
An atlas of genetic influences on osteoporosis in humans and mice
23andMe Research Team, Morris, J. A., Kemp, J. P., Youlten, S. E., Laurent, L., Logan, J. G., Chai, R. C., Vulpescu, N. A., Forgetta, V., Kleinman, A., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0302-x · Cited by 773 · see citing works
Rivadeneira, F., Estrada, K., Zillikens, M. C., van Meurs, J. B. J., Pols, H. A. P., Uitterlinden, A. G., Amin, N., Aulchenko, Y. S., Albert Hofman, D., van Duijn, C. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.446 · Cited by 706 · see citing works
Colocalization of GWAS and eQTL Signals Detects Target Genes
Hormozdiari, F., van de Bunt, M., Segrè, A. V., Li, X., Joo, J. W. J., Bilow, M., Sul, J. H., Sankararaman, S., Pasaniuc, B., & Eskin, E. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.10.003 · Cited by 697 · see citing works
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
Richards, J. B., Rivadeneira, F., Inouye, M., Pastinen, T., Soranzo, N., Wilson, S. G., Andrew, T., Falchi, M., Gwilliam, R., Ahmadi, K. R., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60599-1 · Cited by 680 · see citing works
Multiple Genetic Loci for Bone Mineral Density and Fractures
Styrkársdóttir, U., Halldórsson, B. V., Grétarsdóttir, S., Gudbjartsson, D. F., Walters, G. B., Ingvarsson, Þ., Jónsdóttir, Þ., Saemundsdottir, J., Nguyen, T. V., Bagger, Y. Z., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801197 · Cited by 629 · see citing works
Identification of the Human Skeletal Stem Cell
Chan, C. K. F., Gulati, G. S., Sinha, R., Vincent-Tompkins, J., Lopez, M., Carter, A. C., Ransom, R. C., Reinisch, A., Wearda, T. L., Murphy, M. P., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.029 · Cited by 602 · see citing works
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
Zheng, H., Forgetta, V., Hsu, Y., Estrada, K., Roselló‐Díez, A., Leo, P. J., Dahia, C. L., Park‐Min, K. H., Tobias, J. H., Kooperberg, C. L., et al. (2015) · Nature · doi:10.1038/nature14878 · Cited by 593 · see citing works
Crockett, J. C., Rogers, M. J., Coxon, F. P., Hocking, L. J., & Helfrich, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.063032 · Cited by 504 · see citing works
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
Eskildsen, T. V., Taipaleenmäki, H., Stenvang, J., Abdallah, B. M., Ditzel, N., Nossent, A. Y., Bak, M., Kauppinen, S., & Kassem, M. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016758108 · Cited by 476 · see citing works
Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
Kichaev, G., Yang, W.-Y., Lindström, S., Hormozdiari, F., Eskin, E., Price, A. L., Kraft, P., & Paşaniuc, B. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004722 · Cited by 476 · see citing works
Peacock, M., Turner, C. H., Econs, M. J., & Foroud, T. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0464 · Cited by 461 · see citing works
Sun, Y. V., & Hu, Y.-J. (2016) · Advances in Genetics · doi:10.1016/bs.adgen.2015.11.004 · Cited by 459 · see citing works
Kemp, J. P., Morris, J. A., Medina‐Gómez, C., Forgetta, V., Warrington, N. M., Youlten, S. E., Zheng, J., Gregson, C. L., Grundberg, E., Trajanoska, K., et al. (2017) · Nature Genetics · doi:10.1038/ng.3949 · Cited by 457 · see citing works
Genetic architecture: the shape of the genetic contribution to human traits and disease
Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.101 · Cited by 434 · see citing works
Estimating prevalence of osteoporosis: examples from industrialized countries
Wade, S. W., Strader, C., Fitzpatrick, L. A., Anthony, M. S., & O’Malley, C. D. (2014) · Archives of Osteoporosis · doi:10.1007/s11657-014-0182-3 · Cited by 389 · see citing works
New sequence variants associated with bone mineral density
Styrkársdóttir, U., Halldórsson, B. V., Grétarsdóttir, S., Gudbjartsson, D. F., Walters, G. B., Ingvarsson, Þ., Jónsdóttir, Þ., Saemundsdottir, J., Snorradóttir, S., Nguyen, T. V., et al. (2008) · Nature Genetics · doi:10.1038/ng.284 · Cited by 362 · see citing works
Medina‐Gómez, C., Kemp, J. P., Trajanoska, K., Luan, J., Chesi, A., Ahluwalia, T. S., Mook-Kanamori, D. O., Ham, A. C., Hartwig, F. P., Evans, D. S., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.12.005 · Cited by 346 · see citing works
Prevalence of osteoporosis in China: a meta-analysis and systematic review
Chen, P., Li, Z., & Hu, Y. (2016) · BMC Public Health · doi:10.1186/s12889-016-3712-7 · Cited by 317 · see citing works
The Relationship Between the Human Genome and Microbiome Comes into View
Goodrich, J. K., Davenport, E. R., Clark, A. G., & Ley, R. E. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155532 · Cited by 311 · see citing works
Genetics of osteoporosis from genome-wide association studies: advances and challenges
Richards, J. B., Zheng, H., & Spector, T. D. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3228 · Cited by 310 · see citing works
Tate, M. L. K., Adamson, J., Tami, A., & Bauer, T. W. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00241-3 · Cited by 310 · see citing works
Zheng, H., Tobias, J. H., Duncan, E. L., Evans, D. M., Eriksson, J., Paternoster, L., Yerges-Armstrong, L. M., Lehtimäki, T. J., Bergström, U., Kähönen, M. A. P., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002745 · Cited by 293 · see citing works
Replication in Genome-Wide Association Studies
Kraft, P. L., Zeggini, E., & Ioannidis, J. P. A. (2009) · Statistical Science · doi:10.1214/09-sts290 · Cited by 292 · see citing works
Richards, J. B., Kavvoura, F. K., Rivadeneira, F., Styrkársdóttir, U., Estrada, K., Halldórsson, B. V., Hsu, Y., Zillikens, M. C., Wilson, S. G., Mullin, B. H., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-8-200910200-00006 · Cited by 280 · see citing works
Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture
Greene, C. S., Penrod, N. M., Williams, S. M., & Moore, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005639 · Cited by 266 · see citing works
Trajanoska, K., Morris, J. A., Oei, L., Zheng, H.-F., Evans, D. M., Kiel, D. P., Ohlsson, C., Richards, J. B., & Rivadeneira, F. (2018) · BMJ · doi:10.1136/bmj.k3225 · Cited by 262 · see citing works
Benner, C., Havulinna, A. S., Järvelin, M., Salomaa, V. V., Ripatti, S., & Pirinen, M. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.08.012 · Cited by 244 · see citing works
Diversity analysis of gut microbiota in osteoporosis and osteopenia patients
Wang, J., Wang, Y., Gao, W., Wang, B., Zhao, H., Zeng, Y. H., Ji, Y., & Hao, D. (2017) · PeerJ · doi:10.7717/peerj.3450 · Cited by 240 · see citing works
Glutamate Receptors Are Expressed by Bone Cells and Are Involved in Bone Resorption
Chenu, C., Serre, C., Raynal, C., Burt‐Pichat, B., & Delmas, P. D. (1998) · Bone · doi:10.1016/s8756-3282(97)00295-0 · Cited by 239 · see citing works
Genome-wide Copy-Number-Variation Study Identified a Susceptibility Gene, UGT2B17, for Osteoporosis
Yang, T., Chen, X., Guo, Y., Lei, S., Wang, J.-T., Zhou, Q., Pan, F., Chen, Y., Zhang, Z.-X., Dong, S.-S., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.10.006 · Cited by 216 · see citing works
Self-citationSingle-Cell (Multi)omics Technologies
Chappell, L., Russell, A. J. C., & Voet, T. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091416-035324 · Cited by 206 · see citing works
Xiong, D., Liu, X.-G., Guo, Y.-F., Tan, L., Wang, L., Sha, B., Tang, Z., Pan, F., Yang, T., Chen, X., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.01.025 · Cited by 203 · see citing works
Self-citationCell-type deconvolution in epigenome-wide association studies: a review and recommendations
Teschendorff, A. E., & Zheng, S. (2017) · Epigenomics · doi:10.2217/epi-2016-0153 · Cited by 200 · see citing works
Association between gut microbiota and bone health: Potential mechanisms and prospective
Chen, Y.-C., Greenbaum, J., Shen, H., & Deng, H.-W. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00513 · Cited by 165 · see citing works
Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066944 · Cited by 158 · see citing works
Chesi, A., Wagley, Y., Johnson, M. E., Manduchi, E., Su, C., Lu, S., Leonard, M. E., Hodge, K. M., Pippin, J. A., Hankenson, K. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09302-x · Cited by 158 · see citing works
Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis
Ding, C., Cicuttini, F., & Jones, G. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.01.003 · Cited by 156 · see citing works
Delgado-Calle, J., Fernández, A., Sainz, J., Zarrabeitia, M. T., Sañudo, C., García-Renedo, R., Pérez-Núñez, M. I., García-Ibarbia, C., Fraga, M., & Riancho, J. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37753 · Cited by 153 · see citing works
Genome-wide expression profiles of subchondral bone in osteoarthritis
Chou, C., Wu, C., Song, I.-W., Chuang, H.-P., Lu, L.-S., Chang, J.-H., Kuo, S., Lee, C., Wu, J., Chen, Y.-T., et al. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4380 · Cited by 139 · see citing works
Kanis, J. A. (1997) · Osteoporosis International · doi:10.1007/bf03194355 · Cited by 139 · see citing works
Deng, H., Deng, H., Mahaney, M. C., et al. (2001) · Genetic Epidemiology · doi:10.1002/gepi.1040 · Cited by 136 · see citing works
Self-citationWang, Q., Chen, R., Cheng, F., Wei, Q., Ji, Y., Hai, Y., Zhong, X. Y., Tao, R., Wen, Z., Sutcliffe, J. S., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0382-7 · Cited by 130 · see citing works
Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways
Sims, N. A., & Walsh, N. C. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0096-1 · Cited by 126 · see citing works
Liu, Y.-Z., Dvornyk, V., Lü, Y., Shen, H., Lappe, J. M., Recker, R. R., & Deng, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501164200 · Cited by 126 · see citing works
Self-citationEpigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?
Marini, F., Cianferotti, L., & Brandi, M. L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081329 · Cited by 121 · see citing works
Zhang, L., Guo, Y.-F., Liu, Y.-Z., Liu, Y.-J., Xiong, D.-H., Liu, X.-G., Wang, L., Yang, T.-L., Lei, S.-F., Guo, Y., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.36 · Cited by 119 · see citing works
Self-citationSerum Sclerostin and Risk of Hip Fracture in Older Caucasian Women
Arasu, A., Cawthon, P. M., Lui, L., Do, T. P., Arora, P. S., Cauley, J. A., Ensrud, K. E., & Cummings, S. R. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3419 · Cited by 119 · see citing works
Genome-Wide Association Study Identifies ALDH7A1 as a Novel Susceptibility Gene for Osteoporosis
Guo, Y., Tan, L., Lei, S., Yang, T., Chen, X., Zhang, F., Chen, Y., Pan, F., Yan, H., Liu, X., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000806 · Cited by 118 · see citing works
Self-citationThe Long Non-coding RNA-ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Fate
Yang, L., Li, Y., Gong, R., Gao, M., Feng, C., Liu, T., Sun, Y., Jin, M., Wang, D., Yuan, Y., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.11.019 · Cited by 117 · see citing works
Self-citationCalabrese, G. M., Mesner, L. D., Stains, J. P., Tommasini, S. M., Horowitz, M. C., Rosen, C. J., & Farber, C. R. (2016) · Cell Systems · doi:10.1016/j.cels.2016.10.014 · Cited by 114 · see citing works
Liu, Y., Pei, Y., Liu, J., Yang, F., Guo, Y., Zhang, L., Liu, X.-G., Yan, H., Wang, L., Zhang, Y., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006827 · Cited by 105 · see citing works
Self-citationKoller, D. L., Zheng, H., Karasik, D., Yerges‐Armstrong, L. M., Liu, C., McGuigan, F. E., Kemp, J. P., Giroux, S., Lai, D., Edenberg, H. J., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1796 · Cited by 104 · see citing works
Reppe, S., Noer, A., Grimholt, R. M., Halldórsson, B. V., Medina‐Gómez, C., Gautvik, V. T., Olstad, O. K., Berg, J. P., Datta, H. K., Estrada, K., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2342 · Cited by 102 · see citing works
詫摩, 敦., Kaneda, T., Sato, T., Ninomiya, S., Kumegawa, M., & Hakeda, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300213200 · Cited by 100 · see citing works
Brommage, R., Liu, J., Hansen, G. M., Kirkpatrick, L., Potter, D., Sands, A., Zambrowicz, B., Powell, D. R., & Vogel, P. (2014) · Bone Research · doi:10.1038/boneres.2014.34 · Cited by 100 · see citing works
Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption
Xiong, L., Jung, J.-U., Wu, H.-T., Xia, W.-F., Pan, J.-X., Shen, C.-Y., Mei, L., & Xiong, W.-C. (2015) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1419714112 · Cited by 100 · see citing works
Moayyeri, A., Hsu, Y., Karasik, D., Estrada, K., Xiao, S., Nielson, C. M., Srikanth, P., Giroux, S., Wilson, S. G., Zheng, H., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt675 · Cited by 97 · see citing works
Gene-Based Tests of Association
Huang, H., Chanda, P., Alonso, Á., Bader, J. S., & Arking, D. E. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002177 · Cited by 95 · see citing works
Population genomics in a disease targeted primary cell modelPreprint
Grundberg, E., Kwan, T., Ge, B., Lam, K. C. L., Koka, V., Kindmark, A., Mallmin, H., Dias, J., Verlaan, D. J., Ouimet, M., et al. (2009) · Genome Research · doi:10.1101/gr.095224.109 · Cited by 94 · see citing works
Chen, X., Zhu, D., Yang, M. G., Hu, W., Duan, Y.-Y., Lü, B.-J., Rong, Y., Dong, S., Hao, R.-H., Chen, J., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.03.001 · Cited by 94 · see citing works
Self-citationFitzpatrick, L. A., Buzás, E. I., Gagne, T. J., Nagy, A., Horvath, C., Ferencz, V., Mester, A., Kari, B., Ruan, M., Falus, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0934373100 · Cited by 92 · see citing works
You, Y., Lin, C., Liang, H., Lee, S.-H., Tsai, K., Chiou, J., Chen, Y., Tsao, C.-K., & Chen, J. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2018 · Cited by 91 · see citing works
Medina‐Gómez, C., Kemp, J. P., Dimou, N. L., KREINER, E. B., Chesi, A., Zemel, B. S., Bønnelykke, K., Boer, C. G., Ahluwalia, T. S., Bisgaard, H. F., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00108-3 · Cited by 91 · see citing works
Xia, W.-F., Jung, J.-U., Cui, S., Xiong, S., Xiong, L., Shi, X., Mei, L., & Xiong, W. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1954 · Cited by 89 · see citing works
Inactivation of estrogen receptor α in bone‐forming cells induces bone loss in female mice
Määttä, J. A., Büki, K. G., Gu, G., Alanne, M. H., Vääräniemi, J. P., Liljenbäck, H., POUTANEN, M. H., Härkönen, P. L., & Väänänen, K. (2012) · The FASEB Journal · doi:10.1096/fj.12-213587 · Cited by 87 · see citing works
Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis
Zhao, K., Zhao, Q., Guo, Z., Chen, Z., Hu, Y., Su, J., Chen, L., He, Z., Cai, X., Chen, M., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489657 · Cited by 86 · see citing works
Self-citationOsteomicrobiology: The influence of gut microbiota on bone in health and disease
Jones, R. M., Mullé, J. G., & Pacifici, R. (2017) · Bone · doi:10.1016/j.bone.2017.04.009 · Cited by 77 · see citing works
Metabolomic profiles associated with bone mineral density in US Caucasian women
Zhao, Q., Shen, H., Su, K., Zhang, J.-G., Tian, Q., Zhao, L., Qiu, C., Zhang, Q., Garrett, T. J., Liu, J., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0296-5 · Cited by 76 · see citing works
Self-citationDistinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women
Reppe, S., Lien, T. G., Hsu, Y., Gautvik, V. T., Olstad, O. K., Yu, R., Bakke, H. G., Lyle, R., Kringen, M. K., Glad, I. K., et al. (2017) · Epigenetics · doi:10.1080/15592294.2017.1345832 · Cited by 74 · see citing works
Cornelius, C., Koverech, G., Crupi, R., Paola, R. D., Koverech, A., Lodato, F., Scuto, M., Salinaro, A., Cuzzocrea, S., Calabrese, E., et al. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00120 · Cited by 70 · see citing works
Role of Epigenomics in Bone and Cartilage Disease
van Meurs, J. V., Boer, C. G., López-Delgado, L., & Riancho, J. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3662 · Cited by 69 · see citing works
Peripheral Blood Monocyte-expressed ANXA2 Gene is Involved in Pathogenesis of Osteoporosis in Humans
Deng, F., Lei, S., Zhang, Y., Zhang, Y.-L., Zheng, Y.-P., Zhang, L.-S., Pan, R., Wang, L., Tian, Q., Shen, H., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.011700 · Cited by 68 · see citing works
Self-citationGenome-wide Association Studies for Osteoporosis: A 2013 Update
Liu, Y., Zhang, L., Papasian, C. J., & Deng, H. (2014) · Journal of Bone Metabolism · doi:10.11005/jbm.2014.21.2.99 · Cited by 62 · see citing works
Self-citationSusceptibility genes for osteoporotic fracture in postmenopausal chinese women
Wang, C., Zhang, Z., Zhang, H., He, J., Gu, J., Hu, W.-W., Hu, Y.-Q., Li, M., Liu, Y., Fu, W., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1711 · Cited by 62 · see citing works
Moayyeri, A., Cheung, C., Tan, K. C. B., Morris, J. A., Cerani, A., Mohney, R. P., Richards, J. B., Hammond, C. J., Spector, T. D., & Menni, C. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3358 · Cited by 61 · see citing works
Kanis, J. А. (2016) · Osteoporosis and Bone Diseases · doi:10.14341/osteo201614-5 · Cited by 60 · see citing works
Prediction of Bone Mineral Density and Fragility Fracture by Genetic Profiling
Ho-Le, T. P., Eisman, J. A., Nguyen, H. T., & Nguyen, T. V. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2998 · Cited by 59 · see citing works
Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density
Morris, J. A., Tsai, P.-C., Joehanes, R., Zheng, J., Trajanoska, K., Soerensen, M., Forgetta, V., Fernandez, J. C., Frost, M., Spector, T. D., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3148 · Cited by 58 · see citing works
Systems Genetic Analysis of Osteoblast-Lineage Cells
Calabrese, G. M., Bennett, B. J., Orozco, L. D., Kang, H. M., Eskin, E., Dombret, C., Backer, O. D., Lusis, A. J., & Farber, C. R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003150 · Cited by 57 · see citing works
Parikka, V., Peng, Z., Hentunen, T. A., Risteli, J., Elo, T., Väänänen, H. K., & Härkönen, P. L. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01832 · Cited by 56 · see citing works
Recent advances in high-throughput approaches to dissect enhancer function
Santiago‐Algarra, D., Dao, L. T. M., Pradel, L. C., España, A. P., & Spicuglia, S. (2017) · F1000Research · doi:10.12688/f1000research.11581.1 · Cited by 56 · see citing works
Using GWAS to identify novel therapeutic targets for osteoporosis
Sabik, O. L., & Farber, C. R. (2016) · Translational research · doi:10.1016/j.trsl.2016.10.009 · Cited by 55 · see citing works
Serum Biomarker Profile Associated With High Bone Turnover and BMD in Postmenopausal Women
Bhattacharyya, S., Siegel, E. R., Achenbach, S. J., Khosla, S., & Suva, L. J. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080235 · Cited by 54 · see citing works
Long Non-coding RNAs: A New Regulatory Code for Osteoporosis
Wu, Q.-Y., Li, X., Miao, Z., Ye, J., Wang, B., Zhang, F., Xu, R., Jiang, D., Zhao, M.-D., & Yuan, F. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00587 · Cited by 54 · see citing works
Twins and the mystery of missing heritability: the contribution of gene–environment interactions
Kaprio, J. A. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02587.x · Cited by 53 · see citing works
Duan, X., Liu, J., Zheng, X., Wang, Z., Zhang, Y., Hao, Y., Yang, T., & Deng, H. (2016) · Theranostics · doi:10.7150/thno.17140 · Cited by 52 · see citing works
Self-citationNetwork‐based proteomic analysis for postmenopausal osteoporosis in Caucasian females
Zhang, L., Liu, Y., Zeng, Y., Zhu, W., Zhao, Y., Zhang, J., Zhu, J., He, H., Shen, H., Tian, Q., et al. (2015) · PROTEOMICS · doi:10.1002/pmic.201500005 · Cited by 51 · see citing works
Self-citationDeng, F., Liu, Y., Li, L., Chen, J., Wu, S., Chen, Y., Jiang, H., Yang, F., Xiong, J., Xiao, P., et al. (2008) · PROTEOMICS · doi:10.1002/pmic.200700480 · Cited by 49 · see citing works
Self-citationMetabolomics-based profiles predictive of low bone mass in menopausal women
Miyamoto, T. K., Hirayama, A., Sato, Y., Koboyashi, T., Katsuyama, E., Kanagawa, H., Fujie, A., Morita, M., Watanabe, R., Tando, T., et al. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.06.004 · Cited by 47 · see citing works
Nielson, C. M., Liu, C., Smith, A. V., Ackert‐Bicknell, C. L., Reppe, S., Jakobsdóttir, J., Wassel, C. L., Register, T. C., Oei, L., Alonso, N., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2913 · Cited by 46 · see citing works
Expression Quantitative Trait Locus Study of Bone Mineral Density GWAS Variants in Human Osteoclasts
Mullin, B. H., Zhu, K., Xu, J., Brown, S. J., Mullin, S., Tickner, J. C., Pavlos, N. J., Dudbridge, F., Walsh, J. P., & Wilson, S. G. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3412 · Cited by 46 · see citing works
Lee, K. S., Bae, S.-H., Lee, S. H., et al. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.11.1514 · Cited by 45 · see citing works
Fernandez-Rebollo, E., Eipel, M., Seefried, L., Hoffmann, P., Strathmann, K., Jakob, F., & Wagner, W. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3298 · Cited by 45 · see citing works
Dissecting the Genetics of Osteoporosis using Systems Approaches
Al-Barghouthi, B. M., & Farber, C. R. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.10.004 · Cited by 45 · see citing works
Cabrera, D. L., Kruger, M. C., Wolber, F. M., Roy, N. C., Totman, J. J., Henry, C. J., Cameron‐Smith, D., & Fraser, K. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15051045 · Cited by 42 · see citing works
Ma, B., Liu, J., Zhang, Q., Ying, H., Aa, J., Sun, J., Wu, D., Wang, Y., Li, J., & Liu, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054965 · Cited by 41 · see citing works
Chen, Y.-C., Guo, Y.-F., He, H., Xu, L., Wang, X., Zhou, R. L., Li, W.-T., Pan, D.-Y., Shen, J., & Deng, H. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2781 · Cited by 40 · see citing works
Self-citationGuo, Y., Dong, S., Chen, X., Jing, Y.-A., Yang, M. G., Yan, H., Shen, H., Chen, X., Tan, L., Tian, Q., et al. (2016) · Scientific Reports · doi:10.1038/srep30558 · Cited by 40 · see citing works
Self-citationZhu, D., Chen, X., Hu, W., Dong, S.-S., Lü, B.-J., Rong, Y., Chen, Y., Chen, H., Thynn, H. N., Wang, N., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3419 · Cited by 39 · see citing works
Self-citationSaito, A. M., Ooki, A., Nakamura, T., Onodera, S., Hayashi, K., Hasegawa, D., Okudaira, T., Watanabe, K., Kato, H., Onda, T., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0754-4 · Cited by 36 · see citing works
An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese
Deng, F., Lei, S., Chen, X., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.471 · Cited by 35 · see citing works
Self-citationHeritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families
Karasik, D., Demissie, S., Zhou, Y., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2915 · Cited by 34 · see citing works
Joint Association Analysis Identified 18 New Loci for Bone Mineral Density
Pei, Y., Liu, L., Liu, T.-L., Yang, X., Zhang, H., Wei, X., Feng, G.-J., Hai, R., Ran, S., & Zhang, L. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3681 · Cited by 34 · see citing works
Self-citationZeng, Y., Zhang, L., Zhu, W., et al. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.04.044 · Cited by 32 · see citing works
Self-citationRapid phenotyping of knockout mice to identify genetic determinants of bone strength
Freudenthal, B., Logan, J. G., _, _., Croucher, P. I., Williams, G. R., & Bassett, J. H. D. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0258 · Cited by 31 · see citing works
Greenbaum, J., Wu, K., Zhang, L., et al. (2017) · Bone · doi:10.1016/j.bone.2017.03.052 · Cited by 31 · see citing works
Self-citationYu, L., Qi, H., An, G., Bao, J., Ma, B., Zhu, J., Ouyang, G., Zhang, P., Fan, H., & Zhang, Q. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001158 · Cited by 30 · see citing works
Zhang, J., Tan, L., Xu, C., He, H., Tian, Q., Zhou, Y. G., Qiu, C., Chen, X., & Deng, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138524 · Cited by 29 · see citing works
Self-citationMeng, X.-H., Chen, X., Greenbaum, J., Zeng, Q., You, S.-L., Xiao, H., Tan, L., & Deng, H. (2018) · Bone · doi:10.1016/j.bone.2018.05.012 · Cited by 29 · see citing works
Self-citationSato, T., Enoki, Y., Sakamoto, Y., Yokota, K., Okubo, M., Matsumoto, M., Hayashi, N., Usui, M., Kokabu, S., Mimura, T., et al. (2015) · Heliyon · doi:10.1016/j.heliyon.2015.e00013 · Cited by 27 · see citing works
Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study
Liu, L., Wen, Y. F., Zhang, L., Xu, P., Liang, X., Du, Y., Li, P., He, A., Fan, Q., Hao, J., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01719 · Cited by 26 · see citing works
Self-citationVidal, C., Cachia, A., & Xuereb‐Anastasi, A. (2009) · Bone · doi:10.1016/j.bone.2009.06.027 · Cited by 24 · see citing works
Lee, S. H., Cho, E.-H., Ahn, S. H., Kim, H., Lim, K.-H., Kim, B., Kim, S., Kim, T., Kim, S., Kim, G. S., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3972 · Cited by 24 · see citing works
Zhou, X., Wu, L.-F., Wang, W.-Y., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194781 · Cited by 24 · see citing works
Is GSN significant for hip BMD in female Caucasians?
Deng, F., Zhu, W., Zeng, Y., Zhang, J., Yu, N., Liu, Y., Liu, Y.-J., Tian, Q., & Deng, H. (2014) · Bone · doi:10.1016/j.bone.2014.02.015 · Cited by 23 · see citing works
Self-citationCao, Y., Wang, B., Wang, D., Zhan, D., Mai, C., Wang, P., Wei, Q., Liu, Y., Wang, H., He, W., et al. (2019) · International Journal of Genomics · doi:10.1155/2019/7076513 · Cited by 21 · see citing works
Greenbaum, J., & Deng, H. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3154 · Cited by 18 · see citing works
Self-citationLiu, Y., Zhang, L., Pei, Y., Papasian, C. J., & Deng, H. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1637 · Cited by 16 · see citing works
Self-citationMass spectrometry based proteomics profiling of human monocytes
Zeng, Y., Deng, F., Zhu, W., Zhang, L., He, H., Xu, C., Tian, Q., Zhang, J., Zhang, L.-S., Hu, H., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0342-x · Cited by 14 · see citing works
Self-citationYao, S., Guo, Y., Dong, S., Hao, R.-H., Chen, X., Chen, Y., Chen, J., Tian, Q., Deng, H., & Yang, T. (2017) · Human Genetics · doi:10.1007/s00439-017-1825-4 · Cited by 11 · see citing works
Self-citationGene-based GWAS analysis for consecutive studies of GEFOS
Zhu, W., Xu, C., Zhang, J., He, H., Wu, K.-H., Zhang, L., Zeng, Y., Zhou, Y. G., Su, K., & Deng, H. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4654-y · Cited by 11 · see citing works
Self-citationZhang, L., Shen, Y., Hu, W., Ran, S., Lin, Y., Lei, S., Zhang, Y.-H., Papasian, C. J., Yi, N., & Pei, Y. (2015) · Human Genetics · doi:10.1007/s00439-015-1621-y · Cited by 7 · see citing works
Self-citationChemokine receptor 3 is a negative regulator of trabecular bone mass in female mice
Mohan, S., Hu, Y., & Edderkaoui, B. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28672 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics
Adejuyigbe, B., Kallini, J., Chiou, D., & Kallini, J. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914583 · Cited by 148 · see citing works
A Review of Integrative Imputation for Multi-Omics Datasets
Song, M., Greenbaum, J., Luttrell, J., Zhou, W., Wu, C., Shen, H., Gong, P., Zhang, C., & Deng, H.-W. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.570255 · Cited by 127 · see citing works
Self-citationThe Development of Molecular Biology of Osteoporosis
Gao, Y., Patil, S., & Jia, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158182 · Cited by 116 · see citing works
Depression and Osteoporosis: A Mendelian Randomization Study
He, B., Lyu, Q., Yin, L., Zhang, M., Quan, Z., & Ou, Y. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00886-5 · Cited by 44 · see citing works
- Authors
- Yang, T.-L., Shen, H., Liu, A., Dong, S.-S., Zhang, L., Deng, F.-Y., Zhao, Q., & Deng, H.-W.
- Affiliations
- Xi'an Jiaotong University (CN)
- Tulane University (US)
- Soochow University (CN)
- University of Tennessee Health Science Center (US)
- Corresponding author
- Deng, Hong-Wen
- Venue
- Nature Reviews Endocrinology
- Published
- 2019-12-02
- Volume
- 16
- Issue
- 2
- Pages
- 91-103
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC6980376
- OpenAlex
- W2990451375
- Cited by
- 341
- References
- 158
- Citations by year
- 2026: 27 · 2025: 51 · 2024: 55 · 2023: 75 · 2022: 62 · 2021: 55 · 2020: 16
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG061917, U19AG055373)
- National Institute of Mental Health (R01MH107354, R01MH104680)
- National Institute of General Medical Sciences (R01GM109068, P20GM109036)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK115679)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059781, R01AR069055)
- National Institute of Biomedical Imaging and Bioengineering (R01EB020407, R01EB006841)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- osteoporosis, osteoporotic fractures, bone mineral density, genetic susceptibility loci, heritability, multi-omics integration, systems genetics, epigenomics, transcriptomics, proteomics, metabolomics, osteoporosis pathogenesis, osteoporosis diagnosis, osteoporosis treatment
- MeSH terms
- Humans, Osteoporosis, Bone Density, Genomics, Proteomics, Fractures, Bone, Genome-Wide Association Study, Metabolomics, Epigenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
