Mechanisms underlying T cell ageing

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Molecular and cellular insights into T cell exhaustion

Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652

Aging, Cellular Senescence, and Cancer

Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954

Cellular senescence: from physiology to pathology

Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086

Understanding vertebrate immunity through comparative immunology

Boehm, T. L. J. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01083-9 · Cited by 42

Metabolic checkpoints in rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2024) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2024.152586 · Cited by 38

Reference range of naïve T and T memory lymphocyte subsets in peripheral blood of healthy adult

Xia, Y., Liu, A., Li, W., Liu, Y., Zhang, G., Ye, S., Zhao, Z.-R., Shi, J., Jia, Y., Liu, X., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab038 · Cited by 34

Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching

Mkhikian, H., Hayama, K. L., Khachikyan, K. M., Li, C., Zhou, R. W., Pawling, J., Klaus, S. M., Tran, P. Q. N., Ly, K. M., Gong, A. D., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00187-y · Cited by 34

Central tolerance is impaired in the middle‐aged thymic environment

Lancaster, J. N., Keatinge-Clay, D. L., Srinivasan, J., Li, Y., Selden, H. J., Nam, S., Richie, E. R., & Ehrlich, L. I. R. (2022) · Aging Cell · doi:10.1111/acel.13624 · Cited by 33

Heterogeneity of memory T cells in aging

Jain, A. K., Sturmlechner, I., Weyand, C. M., & Goronzy, J. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250916 · Cited by 34

PI3K/AKT/mTOR and PD‑1/CTLA‑4/CD28 pathways as key targets of cancer immunotherapy (Review)

Wang, S., Liu, C., Yang, C., Jin, Y., Cui, Q., Wang, D., Ge, T., He, G., Li, W., Zhang, G., et al. (2024) · Oncology Letters · doi:10.3892/ol.2024.14700 · Cited by 35

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

Webb, L. M. C., Fra-Bidó, S., Innocentin, S., Matheson, L. S., Attaf, N., Bignon, A., Novarino, J., Fazilleau, N., & Linterman, M. A. (2021) · Aging Cell · doi:10.1111/acel.13295 · Cited by 34

Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm

Peng, X., Wang, Y., Xi, X., Jia, Y., Tian, J., Yu, B., & Tian, J. (2021) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07120-8 · Cited by 32

T cell aging and Alzheimer’s disease

Guo, L., Li, X., Gould, T. M., Wang, Z., & Cao, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154699 · Cited by 35

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Zhang, M., Cui, J., Chen, H., Cheng, Y., Chen, Q., Zong, F., Lu, X. J., Qin, L., Han, Y., Kuai, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56002-w · Cited by 37

Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases

Rickenbach, C., & Gericke, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.806260 · Cited by 33

T-cell surveillance of the human brain in health and multiple sclerosis

Smolders, J., van Luijn, M. M., Hsiao, C., & Hamann, J. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00926-8 · Cited by 37

Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults

Semelka, C., DeWitt, M., Blevins, M. W., Holbrook, B. C., Sanders, J. W., & Alexander‐Miller, M. A. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00327-x · Cited by 35

Circulating senescent angiogenic T cells are linked with endothelial dysfunction and systemic inflammation in hypertension

Zhang, G., Liu, Y., Qiu, Y., Zhang, J., Sun, J., Zhou, Z., Wang, Z., Zeng, P., Tao, J., & He, J. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002715 · Cited by 31

Aging is accompanied by T‐cell stiffening and reduced interstitial migration through dysfunctional nuclear organization

González‐Bermúdez, B., Kobayashi, H., Abarca‐Ortega, A., Córcoles‐Lucas, M., González-Sánchez, M., la Fuente, M. D., Guinea, G. V., Elices, M., & Plaza, G. R. (2022) · Immunology · doi:10.1111/imm.13559 · Cited by 29

TRIB2 safeguards naive T cell homeostasis during aging

Cao, W., Sturmlechner, I., Zhang, H., Jin, J., Hu, B., Jadhav, R. R., Fang, F., Weyand, C. M., & Goronzy, J. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112195 · Cited by 33

MicroRNA miR-181—A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function

Grewers, Z., & Krueger, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176200 · Cited by 30

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

Khan, A. H., Chowers, I., & Lotery, A. J. (2023) · Cells · doi:10.3390/cells12131708 · Cited by 31

The immunological pathogenesis of IgG4-related disease categorized by clinical characteristics

Akiyama, M., Alshehri, W., Ishigaki, S., Saito, K., & Kaneko, Y. (2024) · Immunological Medicine · doi:10.1080/25785826.2024.2407224 · Cited by 33

Immunosenescence promotes cancer development: from mechanisms to treatment strategies

Wang, L., & Tang, D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02082-6 · Cited by 32

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Amoriello, R., Mariottini, A., & Ballerini, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.799380 · Cited by 31

An adjuvanted zoster vaccine elicits potent cellular immune responses in mice without QS21

Nam, H. J., Hong, S. J., Lee, A., Kim, J., Lee, S.-H., Casper, C., Carter, D., Reed, S. G., Simeon, G., & Shin, E. (2022) · npj Vaccines · doi:10.1038/s41541-022-00467-z · Cited by 29

Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components

Sharma, R., Diwan, B., Sharma, A., & Witkowski, J. M. (2022) · Biogerontology · doi:10.1007/s10522-022-09995-6 · Cited by 30

The ageing immune system as a driver of systemic ageing

Jang, I. H., Niedernhofer, L. J., Robbins, P. D., & Camell, C. D. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01269-3 · Cited by 35

Biomaterial-based immunoengineering to fight COVID-19 and infectious diseases

Zarubova, J., Zhang, X., Hoffman, T., Hasani‐Sadrabadi, M. M., & Li, S. (2021) · Matter · doi:10.1016/j.matt.2021.02.025 · Cited by 28

Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant

Higdon, L. E., Gustafson, C. E., Ji, X., Sahoo, M. K., Pinsky, B. A., Margulies, K. B., Maecker, H. T., Goronzy, J. J., & Maltzman, J. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661551 · Cited by 30

Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8+ EMRA T Cells During Type 2 Diabetes

Callender, L. A., Carroll, E. C., Garrod-Ketchley, C., Schroth, J., Byström, J., Berryman, V., Pattrick, M., Campbell-Richards, D., Hood, G., Hitman, G. A., et al. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.681428 · Cited by 30

Lysosomes in T Cell Immunity and Aging

Jin, J., Zhang, H., Weyand, C. M., & Goronzy, J. J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.809539 · Cited by 30

Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands

Trujillo-Vargas, C. M., Mauk, K. E., Hernandez, H., de Souza, R. G., Yu, Z., Galletti, J. G., Dietrich, J., Paulsen, F. P., & de Paiva, C. S. (2022) · GeroScience · doi:10.1007/s11357-022-00529-z · Cited by 27

T-cell Senescence in the Tumor Microenvironment

Huang, L., Zhang, C., Jiang, A., Lin, A., Zhu, L., Mou, W., Zeng, D., Liu, Z., Tang, B., Zhang, J., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0894 · Cited by 29

Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome

Martini, A. C., Gross, T. J., Head, E., & Mapstone, M. E. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.001 · Cited by 26

Correlation between COVID-19 vaccination and diabetes mellitus: A systematic review

He, Y., Ouyang, J., Hu, X.-D., Ni, W., Jiang, Z., Bian, N., & Wang, J. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i6.892 · Cited by 27

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 30

Two types of human TCR differentially regulate reactivity to self and non-self antigens

Trofimov, A., Brouillard, P., Larouche, J., Séguin, J., Laverdure, J., Brasey, A., Ehx, G., Roy, D., Busque, L., Lachance, S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104968 · Cited by 30

Mitochondria as disease-relevant organelles in rheumatoid arthritis

Weyand, C. M., Wu, B., Huang, T., Hu, Z., & Goronzy, J. J. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac107 · Cited by 29

A Comprehensive Review of Hepatitis B Vaccine Nonresponse and Associated Risk Factors

Tahir, A., Shinkafi, S. A., Alshrari, A. S., Yunusa, A., Umar, M. T., Hudu, S. A., & Jimoh, A. O. (2024) · Vaccines · doi:10.3390/vaccines12070710 · Cited by 26

Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Georgiev, P., Han, S., Huang, A. Y., Nguyen, T. H., Drijvers, J. M., Creasey, H., Pereira, J. A., Yao, C.-H., Park, J. S., Conway, T. S., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0463 · Cited by 27

Immunological biomarkers of aging

Wu, F., Mu, W., Markov, N. T., Fuentealba, M., Halaweh, H., Senchyna, F., Manwaring-Mueller, M., Winer, D. A., & Furman, D. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae036 · Cited by 28

Aging reshapes the adaptive immune system from healer to saboteur

Delgado-Pulido, S., Yousefzadeh, M. J., & Mittelbrunn, M. (2025) · Nature Aging · doi:10.1038/s43587-025-00906-1 · Cited by 29

Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality

Anderson, J. J., Susser, E., Arbeev, K. G., Yashin, A. I., Levy, D. A., Verhulst, S., & Aviv, A. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103978 · Cited by 26

cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

Fukushima, Y., Sakamoto, K., Matsuda, M., Yoshikai, Y., Yagita∥, H., Kitamura, D., Chihara, M., Minato, N., & Hattori, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111373 · Cited by 28

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression

Wang, Y., Lih, T. M., Lee, J. W., Ohtsuka, T., Hozaka, Y., Mino-Kenudson, M. A., Adsay, N. V., Luchini, C., Scarpa, A., Maker, A. V., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.08.001 · Cited by 26

Optimising vaccine immunogenicity in ageing populations: key strategies

Jiang, G., Zou, Y., Zhao, D., & Yu, J. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00497-3 · Cited by 27

Targeting immunosenescence for improved tumor immunotherapy

Liu, Z., Zuo, L., Zhou, Z., Liu, S., Ba, Y., Zuo, A., Ren, Y., Zhang, C., Chen, Y., Ma, H., et al. (2024) · MedComm · doi:10.1002/mco2.777 · Cited by 24

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites

Lam, N., Angel, J. C., Buchholz, B. A., Lee, Y. S., Weisberg, S. P., Hampton, B. K., Davis‐Porada, J., Caron, D. P., Jensen, I. J., Szabo, P. A., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.07.001 · Cited by 26

The Involvement of Glucose and Lipid Metabolism Alteration in Rheumatoid Arthritis and Its Clinical Implication

Luo, T.-T., Wu, Y., Yin, Q., Chen, W.-G., & Zuo, J. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s398291 · Cited by 25

Translational Frontiers and Clinical Opportunities of Immunologically Fitted Radiotherapy

Morel, D., Robert, C., Nikos Paragios, A., Grégoire, V., & Deutsch, É. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3632 · Cited by 29

Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals

Chen, S., Chu, C., Wang, C., Yang, Y., Xu, Z.-Y., Qu, Y., & Man, Y. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122685 · Cited by 23

Metabolic regulation of immunological aging

Kim, H., & Dixit, V. D. (2025) · Nature Aging · doi:10.1038/s43587-025-00921-2 · Cited by 30

Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation

Lin, R. J., Elias, H. K., & van den Brink, M. R. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674093 · Cited by 22

Senescence and Aging: Does It Impact Cancer Immunotherapies?

Maggiorani, D., & Beausejour, C. M. (2021) · Cells · doi:10.3390/cells10071568 · Cited by 25

Shaping Heterogeneity of Naive CD8+ T Cell Pools

Lee, S., Lee, G.-W., Kim, H.-O., & Cho, J.-H. (2023) · Immune Network · doi:10.4110/in.2023.23.e2 · Cited by 23

Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure

Wu, F., & Simonetti, F. R. (2023) · Current HIV/AIDS Reports · doi:10.1007/s11904-023-00674-w · Cited by 23

The Role of T Cell Senescence in Neurological Diseases and Its Regulation by Cellular Metabolism

Fessler, J., & Angiari, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706434 · Cited by 25

T-Cell Immune Responses to SARS-CoV-2 Infection and Vaccination

Notarbartolo, S. (2024) · Vaccines · doi:10.3390/vaccines12101126 · Cited by 23

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells

Sturmlechner, I., Jain, A. K., Hu, B., Jadhav, R. R., Cao, W., Okuyama, H., Tian, L., Weyand, C. M., & Goronzy, J. J. (2025) · Nature Communications · doi:10.1038/s41467-025-61627-y · Cited by 22

Involvement of NRF2 and AMPK signaling in aging and progeria: a digest

Petsouki, E., Gerakopoulos, V., Gianniou, D. D., Heiß, E. H., & Trougakos, I. P. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103782 · Cited by 22

T cells mediate cell non‐autonomous arterial ageing in mice

Trott, D. W., Machin, D. R., Phuong, T. T. T., Adeyemo, A. O., Bloom, S. I., Bramwell, R. C., Sorensen, E. S., Lesniewski, L. A., & Donato, A. J. (2021) · The Journal of Physiology · doi:10.1113/jp281698 · Cited by 22

The epidemiologic and biologic basis for classifying older age as a high-risk, immunocompromising condition for pneumococcal vaccine policy

Grant, L. R., Slack, M., Yan, Q., Trzciński, K., Barratt, J., Sobczyk, E. A., Appleby, J. C., Cane, A. D., Jódar, L., Istúriz, R., et al. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1921579 · Cited by 22

Applying causal discovery to single-cell analyses using CausalCell

Wen, Y., Huang, J., Zhang, H., Guo, S., Elyahu, Y., Monsonego, A., Ding, Y., & Zhu, H. (2023) · eLife · doi:10.7554/elife.81464 · Cited by 24

Sporadic Inclusion Body Myositis at the Crossroads between Muscle Degeneration, Inflammation, and Aging

Guglielmi, V., Cheli, M., Tonin, P., & Vattemi, G. N. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052742 · Cited by 21

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

van der Heiden, M., Shetty, S. A., Bijvank, E., Beckers, L., Çevirgel, A., van Sleen, Y., Tcherniaeva, I., Ollinger, T., Burny, W., van Binnendijk, R. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50760-9 · Cited by 21

Sex differences in sepsis outcomes across the lifespan: a population-based cohort study in Germany

Rose, N., Agrama, I., Nachtigall, I., Pletz, M. W., Rosendahl, J., Chung, H., Zielinski, C. E., Dudziak, D., Spoden, M., Dröge, P., et al. (2025) · Critical Care · doi:10.1186/s13054-025-05657-4 · Cited by 21

Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals

Jo, N., Zhang, R., Ueno, H., Yamamoto, T., Weiskopf, D., Nagao, M., Yamanaka, S., & Hamazaki, Y. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.719342 · Cited by 20

Autophagy takes it all – autophagy inducers target immune aging

Zinecker, H., & Simon, A. K. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049345 · Cited by 22

Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses

Hirai, T., & Yoshioka, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918611 · Cited by 21

Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis

Zhang, T., Liu, X., Zhao, Y. C., Xu, X., Liu, Y., & Wu, X. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00305-9 · Cited by 21

Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis

Phillips, E. J., & Simons, M. J. P. (2023) · GeroScience · doi:10.1007/s11357-022-00691-4 · Cited by 21

Immunosenescence: A new direction in anti-aging research

Li, H., Lin, S., Wang, Y., Shi, Y., Fang, X., Wang, J., Cui, H., Bian, Y., & Qi, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112900 · Cited by 21

Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy

Shasha, C., Glass, D. R., Moelhman, E., Islas, L., Tian, Y., Chour, T., Xu, G., Szeto, G. L., Peng, T., Song, X., et al. (2025) · Blood · doi:10.1182/blood.2024025655 · Cited by 21

The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a

Ye, Z., Gould, T. M., Zhang, H., Jin, J., Weyand, C. M., & Goronzy, J. J. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00056-9 · Cited by 19

Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis

Song, J., Zhang, X., Yin, Y., Guo, M., Zhao, X., Wang, L., Ren, C., Yin, Y., Zhang, X., Deng, X., et al. (2023) · Advanced Science · doi:10.1002/advs.202206344 · Cited by 23

Memory B cell development elicited by mRNA booster vaccinations in the elderly

Wang, Z., Muecksch, F., Raspe, R., Johannsen, F., Turroja, M., Canis, M., ElTanbouly, M. A., Santos, G. S. S., Johnson, B., Baharani, V. A., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230668 · Cited by 19

SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

Choy, C., Chen, J., Li, J., Gallagher, D. T., Lü, J., Wu, D., Zou, A., Hemani, H., Baptiste, B. A., Wichmann, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42430-z · Cited by 21

Recent advances in influenza vaccines

Pawelec, G., & McElhaney, J. E. (2020) · F1000Research · doi:10.12688/f1000research.22611.1 · Cited by 20

Understanding T cell aging to improve anti-viral immunity

Zhang, H., Weyand, C. M., Goronzy, J. J., & Gustafson, C. E. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.09.017 · Cited by 18

Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils

Sureshchandra, S., Henderson, J., Levendosky, E., Bhattacharyya, S., Kastenschmidt, J. M., Sorn, A. M., Mitul, M. T., Yates, T. B., Cheng, E., Benchorin, A. I., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.025 · Cited by 26

Induction of T Cell Senescence by Cytokine Induced Bystander Activation

Abbas, A. A., & Akbar, A. N. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.714239 · Cited by 23

The Role of the Gut Microbiome in Health and Disease in the Elderly

Chen, L. A., & Boyle, K. (2024) · Current Gastroenterology Reports · doi:10.1007/s11894-024-00932-w · Cited by 22

Senescent CD8+ T cells: a novel risk factor in atrial fibrillation

Li, X., Bao, Y., Zhang, N., Lin, C., Xie, Y., Wei, Y. Z., Luo, Q., Liu, J., Sha, Z., Wu, G., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae222 · Cited by 18

B cells drive CD4 T cell immunosenescence and age-associated health decline

Khan, S., Chakraborty, M., Wu, F., Chen, N., Wang, T., Chan, Y. T., Sayad, A., Vásquez, J. D. S., Kotlyar, M., Nguyen, K., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.adv7615 · Cited by 37

Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives

Ganguly, P., Toghill, B. J., & Pathak, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212225 · Cited by 17

Decreased thymic output predicts progression of chronic kidney disease

Iio, K., Kabata, D., Iio, R., Shibamoto, S., Watanabe, Y., Morita, M., Imai, Y., Hatanaka, M., Omori, H., & Isaka, Y. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00333-z · Cited by 19

Geriatric syndromes, chronic inflammation, and advances in the management of frailty: A review with new insights

Li, N., Liu, G., Gao, H., Wu, Q., Meng, J., Wang, F., Jiang, S., Chen, M., Xu, W., Zhang, Y., et al. (2023) · BioScience Trends · doi:10.5582/bst.2023.01184 · Cited by 18

Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments

Sitnikova, S. I., Walker, J. A., Prickett, L. B., Morrow, M., Valge-Archer, V., Robinson, M. J., Wilkinson, R. W., & Dovedi, S. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1258291 · Cited by 19

Immunity to acute virus infections with advanced age

Nikolich‐Žugich, J., Bradshaw, C. M., Uhrlaub, J. L., & Watanabe, M. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.09.007 · Cited by 19

Allotransplantation Is Associated With Exacerbation of CD8 T-Cell Senescence: The Particular Place of the Innate CD8 T-Cell Component

Daniel, L., Tassery, M., Lateur, C., Thierry, A., Herbelin, A., Gombert, J., & Barbarin, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674016 · Cited by 17

Early age–related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging

Sonar, S. A., Uhrlaub, J. L., Coplen, C. P., Sempowski, G. D., Dudakov, J. A., van den Brink, M. R. M., LaFleur, B., Jergović, M., & Nikolich‐Žugich, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121028119 · Cited by 18

Repertoire-scale measures of antigen binding

Arora, R., & Arnaout, R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203505119 · Cited by 16

Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging

Sonar, S. A., Watanabe, M., & Nikolich‐Žugich, J. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101835 · Cited by 19

The inter-link of ageing, cancer and immunity: findings from real-world retrospective study

Fu, X., Qin, P., Li, F., Zhu, H., You, H., Zhang, Y., Xu, B., Li, T., Zhang, F., Han, L., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00399-9 · Cited by 19

An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases

Xu, Y., Wang, Z., Li, S., Su, J., Gao, L., Ou, J., Lin, Z., Luo, O. J., Xiao, C., & Chen, G. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2695-x · Cited by 20

Fungi, immunosenescence and cancer

Xu, B., Luo, Z., Niu, X., Li, Z., Lu, Y., & Li, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.002 · Cited by 17

Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting

Hong, Y., Wang, Y., Shu, W., Li, J., Mi, Y., Chen, H., & Chen, C. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102835 · Cited by 17

Exhausted but Not Senescent T Lymphocytes Predominate in Lupus Nephritis Patients

Λιούλιος, Γ., Mitsoglou, Z., Fylaktou, A., Xochelli, A., Christodoulou, M., Stai, S., Moysidou, E., Konstantouli, A., Nikolaidou, V., Papagianni, A. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213928 · Cited by 18

Single‐Cell Transcriptomics Reveals Longevity Immune Remodeling Features Shared by Centenarians and Their Offspring

Dong, C., Miao, Y., Zhao, R. Z., Yang, M., Guo, A., Xue, Z., Li, T., Zhang, Q., Bao, Y., Shen, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202204849 · Cited by 16

Aging of lymphoid stromal architecture impacts immune responses

Lancaster, J. N. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101817 · Cited by 16

Proteostasis in T cell aging

Gressler, A. E., Leng, H., Zinecker, H., & Simon, A. K. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101838 · Cited by 15

The Regulation of Cellular Senescence in Cancer

Zhang, X., Gao, Y., Zhang, S., Wang, Y., Du, Y., Hao, S., & Ni, T. (2025) · Biomolecules · doi:10.3390/biom15030448 · Cited by 17

Healthy ageing: the struggle for maintaining T cells young

Frieser, D., Gensous, N., & Appay, V. (2026) · International Immunology · doi:10.1093/intimm/dxag042

Immunosenescence: Analysis and Genetic Modulation of Replicative Senescence in T Cells

Effros, R. B., & Valenzuela, H. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.305 · Cited by 2

T cell function in the aged: Lessons learned from animal models

Linton, P., Lustgarten, J., & Thoman, M. L. (2006) · Clinical and Applied Immunology Reviews · doi:10.1016/j.cair.2006.06.001 · Cited by 10

T cells and ageing

Pawelec, G., Remarque, E. J., Barnett, Y., & Solana, R. (1998) · Cited by 21

T cells and aging

Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357