Mechanisms underlying T cell ageing

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Molecular and cellular insights into T cell exhaustion

Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652

Aging, Cellular Senescence, and Cancer

Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954

Cellular senescence: from physiology to pathology

Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086

Neurodegeneration and aging: pathophysiology, diagnosis, and therapeutic targets

Thakur, A., Sharma, R., Sharma, R. R., & Devi, A. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01991-9 · Cited by 4

Immunosenescence and human healthspan. Lessons from centenarians

Anaya, J., Lozada-Martínez, I. D., Acosta‐Ampudia, Y., & Tobon, G. (2026) · Current Opinion in Immunology · doi:10.1016/j.coi.2026.102777 · Cited by 4

Restraining the killers: regulation of T cell quiescence

Lumnitzer, M. E., Lovell, S. A., Condotta, S. A., & Richer, M. J. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.04.008 · Cited by 4

A clinical nomogram based on absolute count of lymphocyte subsets for predicting overall survival in patients with non-small cell lung cancer

Liu, A., Zhang, G., Yang, Y., Xia, Y., Li, W., Liu, Y., Cui, Q., Wang, D., Zhao, J., & Yu, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109391 · Cited by 5

Mulibrey nanism and immunological complications: a comprehensive case report and literature review

Gazzin, A., Pala, F., Bosticardo, M., Niemela, J. E., Stoddard, J. L., Biasin, E., Quarello, P., Carli, D., Ferroni, F., Delmonte, O. M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1303251 · Cited by 4

Choroidal macrophages in homeostasis, aging and age-related macular degeneration

Khan, A. H., & Mulfaul, K. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110159 · Cited by 4

Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis

O’Byrne, A. M., de Jong, T. A., & van Baarsen, L. G. M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.820232 · Cited by 4

An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted GerotherapeuticsPreprint

Anderson, P. L., Pang, A. P. S., Coyle, R. P., Schlachetzki, J. C. M., Molina, A. J. A., Bushman, L. R., Aguado, J., Hill, R. B., Liu, A., Brooks, K. M., et al. (2026) · medRxiv · doi:10.64898/2026.03.23.26349105 · Cited by 4

Natural killer cell-based senotherapy: a promising strategy for healthy aging

中澤務, Yamanishi, R., Morimoto, T., & Matusda, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1737572 · Cited by 3

T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases

Richter, L., Dias-Ferreira, J., Ramos, G. C., & Ashour, D. (2026) · Immunological Reviews · doi:10.1111/imr.70125 · Cited by 3

Immunological features of ESRD patients undergoing hemodialysis of various ages

Chen, X., Xiang, F., Cao, X., Lv, W., Shen, B., Zou, J., & Ding, X. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03683-1 · Cited by 3

CD8+ T-cell metabolism is related to cerebrovascular reactivity in middle-aged adults

DeConne, T. M., Fancher, I. S., Edwards, D. G., Trott, D. W., & Martens, C. R. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00267.2023 · Cited by 3

Assessing the causal role of immune traits in rheumatoid arthritis by bidirectional Mendelian randomization analysis

Qiu, M., Shen, H., Ji, W., & Fan, Q. (2024) · Aging · doi:10.18632/aging.205833 · Cited by 3

T cell-Intrinsic Peripheral Tolerance: A Checkpoint Target to Treat Autoimmunity

Gholijani, N., Daryabor, G., & Kahmini, F. R. (2024) · Journal of Cellular Immunology · doi:10.33696/immunology.6.194 · Cited by 3

FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription

Xie, Y., Yan, F., Liu, X., Yu, L., Yan, H., Shang, Z., Kong, Y., & Yang, Z. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s492576 · Cited by 3

Hepatitis B Vaccine Nonresponse and Associated Risk Factors: Insights From a Cohort Study

Hudu, S. A., Jimoh, A. O., Shinkafi, S. A., Tahir, A., Alshrari, A. S., Umar, M. T., Yunusa, A., Bello, N., & Abubakar, N. (2025) · Journal of Tropical Medicine · doi:10.1155/jotm/3879562 · Cited by 3

Advances in T Cell-Based Cancer Immunotherapy: From Fundamental Mechanisms to Clinical Prospects

Zhang, K., Zhang, Y., Pan, X., Wang, Y., Li, Y., Jiang, S., Zhang, Y., Chen, M., Su, W., Li, X., et al. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c01502 · Cited by 3

CD8+ T–cell Exhaustion Phenotype in Human Asymptomatic and Ocular Toxoplasmosis

García-López, L. L., Vargas-Montes, M., Osorio-Méndez, J. F., Cardona, N., Hernández-de-los-Ríos, A., Toro-Acevedo, C. A., Arenas-García, J. C., Mantilla-Muriel, L. E., Torres, E., Hernández, J. D. V., et al. (2023) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2023.2217906 · Cited by 4

Tumor metabolic crosstalk and immunotherapy

Zhang, Y., Nie, Y., Liu, X., Wan, X., Shi, Y., Zhang, K., Wu, P., & He, J. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03304-4 · Cited by 3

Loss of immune regulation in aged T-cells: A metabolic review to show lack of ability to control responses within the self

Singh, B., & Rai, A. K. (2022) · Human Immunology · doi:10.1016/j.humimm.2022.10.002 · Cited by 3

Senescence blurs the line between innate and adaptive immune cells

Quinn, K. M., & Linterman, M. A. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12341 · Cited by 3

T cell aging in hypertension

Weyand, C. M., & Goronzy, J. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa185 · Cited by 3

Aging trajectories of memory CD8 + T cells differ by their antigen specificityPreprint

Sturmlechner, I., Jain, A. K., Hu, B., Jadhav, R. R., Cao, W., Okuyama, H., Tian, L., Weyand, C. M., & Goronzy, J. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.26.605197 · Cited by 3

Exploring TREC and KREC Levels in Nursing Home Residents and Staff and Their Association with SARS-CoV-2 Antibody Response After Vaccination

Meyers, E., Biesen, N. V., Rop, L. D., Burghgraeve, T. D., Digregorio, M., Buret, L., Coenen, S., Scholtes, B., Verbakel, J. Y. J., Heytens, S., et al. (2025) · Vaccines · doi:10.3390/vaccines13080874 · Cited by 2

Advancing nanotheranostics for neuro-immunological disorders: current status and future prospects

Rai, S., Nair, A., Saleem, Z., Ray, S. K., Kanwar, J. R., & Mukherjee, S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.051 · Cited by 2

Lymph node paracortex-inspired on-a-chip recapitulating immunosenescence: a cancer vaccine immunogenicity and antitumoral efficacy screening platform

Maity, S., Najafabadi, A. H., Kawakita, S., Khorsandi, D., Yilgor, C., Jewell, C., Mohaghegh, N., Dokmeci, M. R., Khademhosseini, A., & Jucaud, V. (2025) · Lab on a Chip · doi:10.1039/d5lc00533g · Cited by 5

Recent advances in exercise effects on immunosenescence and management of diseases

Saleh, M. Y., Saleh, A. Y., Abbas, R., Hiali, T. A., Mohamed, A. F., & Al-Nuaimi, A. M. A. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115971 · Cited by 2

The cellular senescence–metabolism axis: emerging insights into T cell dynamics in the context of biological aging

Garza‐Martinez, L., & Fitzgerald-Bocarsly, P. A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02525-0 · Cited by 2

Single‐Cell Transcriptome‐Wide Mendelian Randomization and Colocalization Analyses Uncover Cell‐Specific Mechanisms in Epigenetic Age Acceleration

Hong, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202503032r · Cited by 1

CD8+ T cell aging, senescence, and related disease

He, Z., Guo, F., Zhao, Q., & Lu, W. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3101-7 · Cited by 3

T-Cell “Rejuvenation” Nanovaccine: Enhancing Immunological Memory and Antitumor Responses through Telomere Extension

Cao, X., Zeng, T., Bai, S., Li, S., Liu, Y., Fang, L., Fang, X. J., Chen, Q., Lü, C., & Hh, Y. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c21977 · Cited by 2

Immune Aging as a Failure of Programmed Cell Death Coordination

Lee, H.-M., Kim, E.-J., Hasan, A., & Kang, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031554 · Cited by 3

Mapping the immune landscape of PCa: From tumor microenvironment to therapeutics

Huang, S., Ou, Y., Zhuang, W., Huang, J., Wang, B., Li, Z., & Huang, H. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189586 · Cited by 2

Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions

Zhang, Y., Yu, X., Li, P., Ouyang, Y., Zhu, L., & Luo, F. (2026) · BMC Medicine · doi:10.1186/s12916-026-04833-9 · Cited by 2

Endothelial Elavl1 Is Required for CD8 T-Cell Persistence in Atherosclerosis

Nicholas, S.-A. E., Helming, S. B., Ménoret, A., Pathoulas, C. L., Xu, M. M., Hensel, J. A., Kimble, A. L., Heineman, B. D., Jellison, E. R., Reese, B., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323674 · Cited by 4

T-Cell Immunosenescence in Systemic Lupus Erythematosus: Molecular Mechanisms and Therapeutic Perspectives

Zhou, S., Jian, L., Chen, H., Yin, H., Ji, F., Yang, M., & Wu, H. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09164-4 · Cited by 2

Rapid progression of methotrexate-associated lymphoproliferative disorder presenting with multiple pulmonary masses in rheumatoid arthritis patient: A case report

Minta, M., Matsuoka, H., & Kuroki, Y. (2026) · Modern Rheumatology Case Reports · doi:10.1093/mrcr/rxag036 · Cited by 2

T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy

van den Broecke, L., der Vreken, A. V., Watté, F., Meeus, F., Veirman, K. D., Breckpot, K., Bruyne, E. D., & Menu, E. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02923-x · Cited by 3

Immune system rejuvenation—approaches and real achievements

Pishel, I. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00105 · Cited by 2

Senescent T Cells: The Silent Culprit in Acute Myeloid Leukemia Progression?

Zhang, X., & Liu, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312550 · Cited by 2

Acute effects of FLT3L treatment on T cells in intact mice

Wolf, G. S., Gerber, A. N., Fasana, Z., Rosenberg, K., & Singh, N. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-24126-4 · Cited by 2

Ageing of the Gut Microbiome and Its Potential Contribution Towards Immunesenescence and Inflammaging

Conway, J., Rees, N. P., & Duggal, N. A. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_3 · Cited by 2

Potential role of mesenchymal stem cells in T cell aging

Zhong, X., Chen, J., Bo, W., Wu, X., Li, M., Du, F., Chen, Y., Deng, S., Zhao, Y., Shen, J., et al. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02371-y · Cited by 4

Humoral immunity to SARS-CoV-2 in kidney transplant recipients and dialysis patients: IgA and IgG patterns unraveled after SARS-CoV-2 infection and vaccination

Bouver, C. D., Bouziotis, J., Wijtvliet, V. P. W. M., Ariën, K. K., Mariën, J., Heyndríckx, L., Couttenye, M. M., de Fijter, H. J. W., Mestrez, F., Treille, S., et al. (2024) · Virology Journal · doi:10.1186/s12985-024-02410-1 · Cited by 2

Dysregulation of adipose ILC2 underlies thermogenic failure in agingPreprint

Goldberg, E. L., Shchukina, I., Youm, Y., Camell, C. D., Dlugos, T., Artyomov, M. N., & Dixit, V. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.08.288431 · Cited by 2

DJ-1 depletion prevents immunoaging in T-cell compartments

Zeng, N., Capelle, C., Baron, A. G., Kobayashi, T., Ciré, S., Tslaf, V., Leonard, C. A., Coowar, D., Koseki, H., Westendorf, A. M., et al. (2022) · immuneACCESS · doi:10.21417/nz2022embor · Cited by 2

Distinct Heterogeneity in the Naive T cell Compartments of Children and AdultsPreprint

Gustafson, C. E., Thomson, Z., He, Z., Swanson, E. G., Henderson, K., Pebworth, M.-P., Okada, L. Y., Heubeck, A. T., Roll, C. R., Hernandez, V., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.04.510869 · Cited by 2

COVID-19 INDUCES SENESCENCE AND EXHAUSTION OF T CELLS IN PATIENTS WITH MILD/MODERATE AND SEVERE DISEASE DURING A SEVEN-DAY INTERVALPreprint

Pedroso, R. B., Ventura, L. H. D. A., Torres, L., Camatta, G. C., Caixeta, F., Nascimento, L. S., Mota, C., Mendes, A. C., Ribeiro, F., Guimarães, H. C., et al. (2023) · medRxiv · doi:10.1101/2023.01.16.23284612 · Cited by 2

The immunology and cell biology of T cell aging

Goronzy, J. J., & Weng, N. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101843 · Cited by 2

Endothelial Immunosuppression in Atherosclerosis : Translational Control by Elavl1/HuRPreprint

Nicholas, S.-A. E., Helming, S. B., Ménoret, A., Pathoulas, C. L., Xu, M. M., Hensel, J. A., Kimble, A. L., Heineman, B. D., Jellison, E. R., Reese, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.02.605922 · Cited by 2

Biological Age and Age Acceleration Predict Alzheimer’s Disease Plasma Biomarker LevelsPreprint

Eissman, J. M., Ma, Y., Qiao, M., Reyes‐Dumeyer, D., Piriz, A. L., Lee, A., Lantigua, R., Medrano, M. Z., Mejía, D. R., Honig, L. S., et al. (2025) · medRxiv · doi:10.1101/2025.05.22.25328181 · Cited by 2

Patients with Chronic Spinal Cord Injury Display a Progressive Alteration over the Years of the Activation Stages of the T Lymphocyte Compartment

Haro, S., Gomez-Lahoz, A. M., Monserrat, J., Atienza-Pérez, M., Fraile‐Μartinez, O., Ortega, M. A., Montero, C. G., Díaz, D., López‐Dolado, E., & Álvarez‐Mon, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417596 · Cited by 1

The effector function of mucosal associated invariant T cells alters with aging and is regulated by RORγt

Yang, Z., Luo, B., Li, M., He, Z., Ren, C., Chen, X., Kang, X., Chen, H., Xu, E., Guan, W., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1504806 · Cited by 1

Risk factors for mortality in patients with primary biliary cholangitis: a nomogram to predict 5-year survival

Liu, Y., Gao, M., Li, B., Liu, L., Liu, Y., Feng, Y., Wang, X., Wang, X., & Zhou, G. (2025) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2025.1534145 · Cited by 1

In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8+ T cells from old mice

Dahlquist, K. J. V., Dehm, E. M., Smith, D. M., Lucas, E. D., Pierson, M. J., Hamilton, S. E., & Camell, C. D. (2025) · GeroScience · doi:10.1007/s11357-025-01723-5 · Cited by 1

Psychosocial Theories

Waite‐Jones, J. M., & Rodriguez, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-88177-0_2 · Cited by 1

Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance

Buckley, D. J., Zahedi, S., Velusamy, P., Sharma, S., Sabnani, M. K., Flores, L. C., Tandukar, G., Ikeno, Y., Fadel, P. J., Lesniewski, L. A., et al. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00531-x · Cited by 1

Hirsutella sinensis Fungus Enhances CD8+ T Cell Anti-Tumor Activity in NSCLC via Modulating the IL-10/STAT3/STAT1 Axis

Zhang, L., Xu, Y., Luo, J., Lin, H., Xia, L., & Zhu, X. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s531106 · Cited by 1

Estimation of biological aging based on T-cell differentiation trajectories: emerging and future avenues

Bhasin, A. M., Marwaha, I. K., & Nooka, L. S. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1684051 · Cited by 1

Neutrophil-to-Lymphocyte Ratio and Mortality in Cardiovascular Disease or Cancer

Morsy, M. I., Friday, J. M., Pell, J. P., Lewsey, J., Mackay, D., Dundas, R., Tran, T., Brown, D., Ho, F. K. W., Hastie, C. E., et al. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.102362 · Cited by 3

Single-cell multi-omics dissects transcript isoform and immune repertoire dynamics in human immunosenescence

Zheng, Y., Ren, Z.-H., Yang, Y., Liu, W., Li, F., Zuo, Y., Zeng, T., Wang, X., Lin, X., Zhu, X., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3398-8 · Cited by 1

Beyond the hallmarks of aging: Rethinking what aging is and how we measure it

Keshavarz, M., & Ehninger, D. (2025) · Genomic psychiatry : · doi:10.61373/gp025i.0119 · Cited by 2

Age-associated differences in XBB.1.5 trivalent booster vaccine-induced adaptive responses revealed by single-cell RNA sequencing

Chen, S., Liu, T., Chen, J., Yin, S., Ran, J., Zhang, W., Zhang, W., Zhang, J., Li, C., Wang, X., et al. (2026) · Emerging Microbes & Infections · doi:10.1080/22221751.2026.2627067 · Cited by 1

Immunometabolic resistors of aging in long-lived golden spiny mice

Kim, H., Sagiv, T., Youm, Y., Vardi-Naim, H., Dlugos, T., Strino, F., Kazavchinsky-Bar, M., Egulsky, L., Bodogai, M., Biragyn, A., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec9991 · Cited by 2

Recurrent cytokine release syndrome in patients receiving bispecific antibody therapy for multiple myeloma: a case series

Pepa, R. D., Leone, A., Grimaldi, F., Avilia, S., Memoli, M., Rossini, B., Liberatore, C., & Pane, F. (2026) · Annals of Hematology · doi:10.1007/s00277-026-06966-6 · Cited by 1

Immunosenescence in elderly patients with advanced non-small cell lung cancer: Mechanisms and therapeutic implications

Wang, N., Wang, C., Wang, X., Meng, Y., Cui, S., Zhao, K., Jia, Y., & Kong, F. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189587 · Cited by 1

Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence

Zaongo, S. D., Yang, Q., Han, M., Xi, T., Luo, Z., Wang, X., Yang, J., & Ouyang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792954 · Cited by 2

Risk Factors for Secondary Immunodeficiency in the Aged

Lang, A., Grammatikos, A. P., Ballow, M. C., Otani, I. M., & Barmettler, S. (2026) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2026.05.022 · Cited by 3

Pharmacological Modulation of Immunosenescence and Inflammaging: Senolytics, Senomorphics, and Emerging Therapies

Bhavya, R., & Sandur, R. (2026) · Immunological Investigations · doi:10.1080/08820139.2026.2695165 · Cited by 1

Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets

Gong, Y., Zeng, W., Liao, Y., Xie, X., Qin, Z., Li, C., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1926935 · Cited by 1

Aging-related transcriptomic signatures associated with recurrence following resection of stage I lung adenocarcinoma

Darawshy, F., Bayrak, Ç. S., Zhou, X., Wong, K. K., Sulaiman, I., Kwok, B., Chung, C. J., Lukovnikova, A., Roldan, S., Wu, B. G., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00470-x · Cited by 1

Lymph node contraction links sex-biased naive CD8+ T cell decline to compromised antigen recognition during middle age

Menzel, L., Zschummel, M., O’Melia, M. J., Sandstedt, M., Zhou, H., Lei, P.-J., Liu, L., Lee, H., Sen, D. R., Munn, L. L., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01238-4 · Cited by 1

Aging-related alternative splicing landscapes across human T cells

Mao, L., Zhu, Y., Zhang, B., Wu, G., Feng, Q., & Luo, O. J. (2023) · Aging Research · doi:10.26599/agr.2023.9340007 · Cited by 1

The essential elements of adaptive immunity and their relevance to cancer immunology

Bullock, T. N. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87763-3.00016-2 · Cited by 1

Tolérance et efficacité des inhibiteurs de points de contrôle immunitaire en monothérapie chez les patients âgés

Mailly-Giacchetti, L., López‐Trabada, D., Feldman, J. P., André, T., & Cohen, R. (2023) · Bulletin du Cancer · doi:10.1016/j.bulcan.2023.06.012 · Cited by 1

Sorting nexin 27–dependent regulation of Lck and CD4 tunes the initial stages of T-cell activation

Rodríguez‐Rodríguez, C., González-Mancha, N., Ochoa-Echeverría, A., & Mérida, I. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae086 · Cited by 1

Age-related outcomes in MSI/dMMR gastrointestinal cancers treated by immune checkpoint inhibitors and toxicity’s impact on efficacy: an immunoMSI cohort study

Mailly-Giacchetti, L., Colle, R., Samaille, T., Ataz, D. L.-T., Faucheux, L., Duval, A., André, T., & Cohen, R. (2024) · ESMO Gastrointestinal Oncology · doi:10.1016/j.esmogo.2024.100047 · Cited by 2

Inclusion body myositis, viral infections, and TDP-43: a narrative review

Văcăraș, V., Vulturar, R., Chiş, A., & Damian, L. O. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01353-9 · Cited by 1

Au cœur de la capacité de vitalité : l’immuno-métabolisme et sa nature holistique

Mercier, J., Colson, S. S., & Rousseau, A. (2024) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2024.04.002 · Cited by 2

iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection

Hill, B., Zak, A. J., Raja, S., Bugada, L. F., Rizvi, S. M., Roslan, S. B., Nguyen, H. N., Chen, J., Jiang, H., Ono, A., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.172140 · Cited by 1

The influence of a human macronutrient-matched diet on phenotypes in old mice

Darrah, M. A., Longtine, A. G., Greenberg, N., Mahoney, S. A., Venkatasubramanian, R., VanDongen, N. S., Reisz, J. A., D’Alessandro, A., Seals, D. R., de Quirós, Y. B., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01423-6 · Cited by 1

T Cell Aging: An Important Target for Perioperative Immunomodulation

Lan, H., Xu, S., Li, H., Guo, R., Feng, Z., & Wang, Y. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s519438

The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4 + T cell responses of older adultsPreprint

Zhang, H., Jadhav, R. R., Cao, W., Goronzy, I. N., Jin, J., Greenleaf, W. J., Weyand, C. M., & Goronzy, J. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.27.457205 · Cited by 1

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian agingPreprint

Wang, L., Zhang, X., Zhang, H., Lu, K., Li, M., Li, X., Ou, Y., Zhao, X., Wu, X., Wu, X., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529806 · Cited by 1

Multiple vaccine comparison in the same adults from the VITAL study reveals vaccine-specific and age-related humoral response patternsPreprint

van der Heiden, M., Shetty, S. A., Bijvank, E., Beckers, L., Çevirgel, A., van Sleen, Y., Tcherniaeva, I., Ollinger, T., Burny, W., van Binnendijk, R. S., et al. (2024) · medRxiv · doi:10.1101/2024.01.22.24301601 · Cited by 1

Age-related remodeling of the glycocalyx drives T cell exhaustionPreprint

Zhang, H., Tsui, C. K., Castillo, J. G., Evangelista, A., Kim, E. J. Y., Joe, L. K., Twells, N. M., Robey, E. A., Mahal, L. K., DuPage, M. J. P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.06.627213 · Cited by 1

Modeling Immunosenescence on-a-chip: a platform for cancer vaccine efficacy assessmentPreprint

Maity, S., Najafabadi, A. H., Kawakita, S., Khorsandi, D., Yilgor, C., Jewell, C., Mohaghegh, N., Dokmeci, M. R., Khademhosseini, A., & Jucaud, V. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.14.654059 · Cited by 1

A importância da saúde bucal em idosos hospitalizados: revisão integrativa

Dias, W. J., Araújo, A. S., Sales, P. H. D. H., de Miranda, P. M., Gaines, A. P. L., & dos Santos-Lima, E. K. N. (2021) · Revista Eletrônica Acervo Saúde · doi:10.25248/reas.e7618.2021

Estudio celular de la inmunosenescencia en adultos mayores vacunados y en pacientes con cáncer de mama

Rodríguez, R., & Johanna, I. (2021)

Ageing Mucosal Immunity and Its Consequences for Infectious Diseases in the Aged; A First Glance

van der Heiden, M., & van Baarle, D. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-87532-9_6

Faculty Opinions recommendation of FOXO1 deficiency impairs proteostasis in aged T cells.

Chakraborty, K. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737807256.793587855

A new way to maintain CD8+ T-cell quiescence: interaction between CD8α and PILRα

Jin, K., & Wu, B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01094-9

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespanPreprint

Tong, R., Li, R., Zhao, Y., Luo, L., Zhong, J., Li, Z., Lin, W., Chen, Y., Shi, J., Gao, Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.11.498621 · Cited by 1

Delayed antigen-specific CD4 + T-cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderlyPreprint

Jo, N., Hidaka, Y., Kikuchi, O., Fukahori, M., Sawada, T., Aoki, M., Yamamoto, M., Nagao, M., Morita, S., Nakajima, T. E., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.10.490700

Crosstalk between lipoproteins and leukocytes

Bazioti, V. (2022) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.241440465

Interrogating Atherosclerotic Plaque Biology Through Responses to Cardiovascular Risk Management and Imaging

Good, E. (2022) · Linköping University medical dissertations · doi:10.3384/9789179295660

Immune Deficiencies at the Extremes of Age

Gustafson, C. E., Weyand, C. M., & Goronzy, J. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8165-1.00021-6

VACCINATION EFFECTIVENESS IN THE POPULATION OF THE ELDERLY PEOPLE AND THE AGING OF THE IMMUNE SYSTEM

Zuziak, P., Przeorski, K., Dereziński, M. M., Mendowski, M., & Kliniec, K. (2022) · Postepy Biologii Komorki · doi:10.59674/pbk3

Acceleration of Large-Scale Single Cell Differential Gene Expression Analysis with FastDEPreprint

Connolly, E. C., Aluru, M. R., Chockalingam, S. P., Dhere, V. R., Gibson, G. C., & Pan, T. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.15.545003

The Effects of Aging on Solid Organ Transplantation—Characteristics and Consequences of Immunosenescence

Rollenhagen, C., & Maltzman, J. S. (2023) · Current Transplantation Reports · doi:10.1007/s40472-023-00405-5

Healthy ageing: the struggle for maintaining T cells young

Frieser, D., Gensous, N., & Appay, V. (2026) · International Immunology · doi:10.1093/intimm/dxag042

Immunosenescence: Analysis and Genetic Modulation of Replicative Senescence in T Cells

Effros, R. B., & Valenzuela, H. (1998) · Rejuvenation Research · doi:10.1089/rej.1.1998.1.305 · Cited by 2

T cell function in the aged: Lessons learned from animal models

Linton, P., Lustgarten, J., & Thoman, M. L. (2006) · Clinical and Applied Immunology Reviews · doi:10.1016/j.cair.2006.06.001 · Cited by 10

T cells and ageing

Pawelec, G., Remarque, E. J., Barnett, Y., & Solana, R. (1998) · Cited by 21

T cells and aging

Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357