Cited by 507T-cell and B-cell ImmunologyTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Mechanisms underlying T cell ageing

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Goronzy, Jörg J., Weyand, Cornelia M.·2019·Nature Reviews Immunology

DOI 10.1038/s41577-019-0180-1PMC PMC7584388

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Abstract

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and cancer and in impairing the response to vaccination. Easy accessibility to peripheral human T cells as well as an expanding array of tools to examine T cell biology have provided opportunities to examine major ageing pathways and their consequences for T cell function. Here, we review emerging concepts of how the body attempts to maintain a functional T cell compartment with advancing age, focusing on three fundamental domains of the ageing process, namely self-renewal, control of cellular quiescence and cellular senescence. Understanding these critical elements in successful T cell ageing will allow the design of interventions to prevent or reverse ageing-related T cell failure.

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Authors: Goronzy, J. J., & Weyand, C. M.
Affiliations: VA Palo Alto Health Care System (US)
Corresponding author: Goronzy, Jörg J.
ORCID: Goronzy, Jörg J.
Weyand, Cornelia M.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2019-06-11
Volume: 19
Issue: 9
Pages: 573-583
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-019-0180-1
PMC: PMC7584388
OpenAlex: W2950578975
Cited by: 506
References: 149
Citations by year: 2026: 90 · 2025: 80 · 2024: 90 · 2023: 76 · 2022: 71 · 2021: 62 · 2020: 32 · 2019: 5
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01 BX001669)
National Institute on Aging (R01AG045779)
National Heart, Lung, and Blood Institute (P01HL129941, R01HL142068, R01HL117913)
National Institute of Allergy and Infectious Diseases (R01AI108906, R01AI129191, R01AI108891, U19AI057266)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042527)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: cellular senescence, T cell quiescence, T cell self-renewal, T cell differentiation, immunosenescence, anti-aging interventions
MeSH terms: Immunosenescence, Cell Differentiation, Homeostasis, Humans, Immunologic Memory, Receptors, Antigen, T-Cell, T-Lymphocytes, Cellular Senescence

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