Mechanisms underlying T cell ageing

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Molecular and cellular insights into T cell exhaustion

Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652

Aging, Cellular Senescence, and Cancer

Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954

Cellular senescence: from physiology to pathology

Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086

Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients

Rodríguez, I. J., Bernal-Estévez, D. A., Llano-León, M., Bonilla, C., & Parra-López, C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280851 · Cited by 16

Inclusion Body Myositis and Neoplasia: A Narrative Review

Damian, L. O., Login, C., Solomon, C. M., Belizna, C. C., Encică, S., Urian, L. G., Jurcuț, C., Stancu, B., & Vulturar, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137358 · Cited by 15

Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Durand, A., Bonilla, N., Level, T., Ginestet, Z., Lombès, A., Guichard, V., Germain, M., Jacques, S., Letourneur, F., Cruzeiro, M. D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45984-8 · Cited by 20

The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk

Li, S., Wang, K., Wu, J., & Zhu, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102653 · Cited by 18

Immunoinflammation and post-translational modifications in the aging process

Xiao, J., Qin, X., Chen, W., Que, X., Ma, Y., Huang, W., Ou, H., Bao, Y., Qu, L., & Shan, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06892-7 · Cited by 15

Mycobacterium tuberculosis: Implications of Ageing on Infection and Maintaining Protection in the Elderly

Bonavida, V., Frame, M., Nguyen, K., Rajurkar, S., & Venketaraman, V. (2022) · Vaccines · doi:10.3390/vaccines10111892 · Cited by 15

Excessive apoptosis of Rip1‐deficient T cells leads to premature aging

Wang, L., Zhang, X., Zhang, H., Lu, K., Li, M., Li, X., Ou, Y., Zhao, X., Wu, X., Wu, X., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357925 · Cited by 14

Senescent T Cells in Age-Related Diseases

Yu, P.-J., Zhou, M. L., Liu, Y., & Du, J. (2024) · Aging and Disease · doi:10.14336/ad.2024.0219 · Cited by 16

Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults

Urban, B. C., Gonçalves, A. N. A., Loukov, D., Passos, F. M., Reiné, J., Gonzalez‐Dias, P., Solórzano, C., Mitsi, E., Nikolaou, E., O’Connor, D., et al. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.06.010 · Cited by 14

Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapy

Wu, H., Li, J., Zhang, Z., & Zhang, Y. (2024) · European Journal of Immunology · doi:10.1002/eji.202451093 · Cited by 14

Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults

Kometani, K., Yorimitsu, T., Jo, N., Yamaguchi, E., Kikuchi, O., Fukahori, M., Sawada, T., Tsujimoto, Y., Sunami, A., Li, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1455334 · Cited by 15

Mechanisms and strategies of immunosenescence effects on non-small cell lung cancer (NSCLC) treatment: A comprehensive analysis and future directions

Zhou, H., Zheng, Z., Fan, C., & Zhou, Z. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.01.001 · Cited by 15

Gzmk+ CD8 T cells in inflammatory diseases

Cui, X., Liu, P., Zhan, Q., & Cao, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1661755 · Cited by 16

Lymphoma accelerates T cell and tissue aging

Hesterberg, R. S., Davis, J. T., Handoo, K. J., Elmarsafawi, A. G., Augello, A. C., Cheng, C., Atkins, R. M., Lee, D. H., Yang, C., Yao, J., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.07.023 · Cited by 14

Relevance of tissue-resident memory CD8 T cells in the onset of Parkinson’s disease and examination of its possible etiologies: infectious or autoimmune?

de Fàbregues, O., Sellés, M. C., Ramos-Vicente, D., Roch, G., Vila, M., & Bové, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106308 · Cited by 12

Deciphering the impact of TERT/telomerase on immunosenescence and T cell revitalization

Huang, L., Zhang, M., Bai, D., & Qu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1465006 · Cited by 13

Immune senescence: A key player in cancer biology

Yang, Y., Fan, L., Li, M., & Wang, Z. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.12.001 · Cited by 15

Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients

Moysidou, E., Λιούλιος, Γ., Xochelli, A., Nikolaidou, V., Christodoulou, M., Mitsoglou, Z., Stai, S., Fylaktou, A., Papagianni, A. A., & Stangou, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314688 · Cited by 13

T-cell lymphocytes’ aging clock: telomeres, telomerase and aging

Chebly, A., Khalil, C., Kuzyk, A. C., Beylot-Barry, M., & Chevret, E. (2023) · Biogerontology · doi:10.1007/s10522-023-10075-6 · Cited by 13

The influence of 17β-oestradiol on lymphopoiesis and immune system ontogenesis in juvenile sea bass, Dicentrarchus labrax

Moreira, C., Paiola, M., Duflot, A., Varó, I., Sitjà‐Bobadilla, A., Knigge, T., Pinto, P. I. S., & Monsinjon, T. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104011 · Cited by 13

Ketogenesis restrains aging-induced exacerbation of COVID in a mouse modelPreprint

Ryu, S., Shchukina, I., Youm, Y., Qing, H., Hilliard, B. K., Dlugos, T., Zhang, X., Yasumoto, Y., Booth, C. J., Fernandez-Hernando, C. F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.11.294363 · Cited by 13

DJ‐1 depletion prevents immunoaging in T‐cell compartments

Zeng, N., Capelle, C., Baron, A., Kobayashi, T., Cire, S., Tslaf, V., Leonard, C., Coowar, D., Koseki, H., Westendorf, A. M., et al. (2022) · EMBO Reports · doi:10.15252/embr.202153302 · Cited by 13

Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice

Britton, R., Liu, A. T., Rege, S. V., Adams, J. M., Akrapongpisak, L., Le, D., Alcantara‐Lee, R., Estrada, R. A., Ray, R. D., Ahadi, S., et al. (2022) · Brain and Behavior · doi:10.1002/brb3.2736 · Cited by 14

B Cells Promote T Cell Immunosenescence and Mammalian Aging ParametersPreprint

Khan, S. M., Chakraborty, M., Wu, F., Chen, N., Wang, T., Chan, Y. T., Sayad, A., Vásquez, J. D. S., Kotlyar, M., Nguyen, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.12.556363 · Cited by 12

Immunosenescence and susceptibility to respiratory viruses: a state-of-the-art review

Fragkou, P. C., Skevaki, C. L., Moschopoulos, C. D., Keske, Ş., Wozniak, H., Malézieux-Picard, A., Prendki, V., & Rello, J. (2026) · European Respiratory Review · doi:10.1183/16000617.0248-2025 · Cited by 12

Efficacy of immune checkpoint inhibitors for NSCLC in patients with different age: A systematic review and meta-analysis

Zhang, Q., Liang, X., Wang, Z., Sun, A., Cao, T.-B., Zhang, Y.-P., Li, N., Yi, T., & Qu, K. (2024) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2024.03.145 · Cited by 12

LINE1 modulate human T cell function by regulating protein synthesis during the life span

Burattin, F. V., Vadalà, R., Panepuccia, M., Ranzani, V., Crosti, M., Colombo, F. A., Ruberti, C., Erba, E., Prati, D., Nittoli, T., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado2134 · Cited by 12

General and individualized changes in T cell immunity during aging

Song, N., Elbahnasawy, M. A., & Weng, N. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae033 · Cited by 11

COVID-19 Vaccine Race: Analysis of Age-Dependent Immune Responses against SARS-CoV-2 Indicates that more than Just One Strategy May Be Needed

Jiménez, M., Campillo, N. E., & Cañelles, M. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666201027153123 · Cited by 12

TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection

Nguyen, L. N. T., Nguyen, L. N., Zhao, J., Schank, M., Dang, X., Cao, D., Khanal, S., Wu, X. Y., Zhang, Y., Zhang, J., et al. (2022) · Journal of Cell Science · doi:10.1242/jcs.259481 · Cited by 11

Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both

Beitari, S., Agbayani, G., Hewitt, M., Duque, D., Bavananthasivam, J., Sandhu, J. K., Akache, B., Hadžisejdić, I., & Tran, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-48397-7 · Cited by 11

Causal relationship between immune cells and telomere length: mendelian randomization analysis

Li, Y., Lai, S.-L., & Kan, X. (2024) · BMC Immunology · doi:10.1186/s12865-024-00610-6 · Cited by 12

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

Gong, N., Pan, X., Deng, Y., Che, J., Bao, J., Wang, M., Xu, C., Liu, X., & Shi, Y. (2025) · MedComm · doi:10.1002/mco2.70515 · Cited by 14

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

Zhang, C., Ren, T., Zhao, X., Su, Y., Wang, Q., Zhang, T., He, B., Chen, Y., Wu, L., Sun, L., et al. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00479-4 · Cited by 10

Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects

Wu, J., Zhang, L., Zhao, Z., Liu, Y., Li, Z., Feng, X., Zhang, L., Yao, X., Du, J., Chen, L., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102783 · Cited by 10

A comprehensive single-cell atlas of three centenarian cohorts unveils unique natural killer cell signatures and enhanced mutual interactions among peripheral immune cells

Wang, B., Zhang, Z., Ouyang, Q., Zhang, M., Duan, M., Hu, H., Zhang, Q., Jin, X., Zhang, J., Luo, Q., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105922 · Cited by 10

An evidence-based debate on epigenetics and immunosenescence in COVID-19

Claudio Napoli, A., Coscioni, E., Trama, U., Strozziero, M. G., & Benincasa, G. (2023) · Current Research in Immunology · doi:10.1016/j.crimmu.2023.100069 · Cited by 10

Specific MiRNAs in naïve T cells associated with Hepatitis C Virus-induced Hepatocellular Carcinoma

Yan, P., Pang, P., Hu, X., Wang, A., Zhang, H., Ma, Y., Zhang, K., Ye, Y., Zhou, B., & Mao, J. (2020) · Journal of Cancer · doi:10.7150/jca.49594 · Cited by 10

High Levels of CD244 Rather Than CD160 Associate With CD8+ T-Cell Aging

Wang, X., Wang, D., Du, J., Wei, Y., Song, R., Wang, B., Qiu, S., Li, B., Zhang, L., Zeng, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.853522 · Cited by 10

AGE, AUTOIMMUNITY, AND INFLAMMATION: THE CURIOUS CASE OF IMMUNOSENESCENCE AND INFLAMM-AGING

Sundaram, T. G., & Ahmed, S. (2022) · Anti-Aging Eastern Europe · doi:10.56543/aaeeu.2022.1.1.04 · Cited by 10

Older Adults Who Maintained a Regular Physical Exercise Routine before the Pandemic Show Better Immune Response to Vaccination for COVID-19

Silva, B. R., Monteiro, F. R., Cezário, K., do Amaral, J. B., Paixão, V., Almeida, E. B., Santos, C. A. F., Amirato, G. R., Oliveira, D. B. L., Durigon, E. L., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031939 · Cited by 12

Early life thymectomy induces arterial dysfunction in mice

Buckley, D. J., Sharma, S., Joseph, B., Fayyaz, A. H., Canizales, A., Terrebonne, K. J., & Trott, D. W. (2023) · GeroScience · doi:10.1007/s11357-023-00853-y · Cited by 9

Perivascular Tertiary Lymphoid Structures in Autoimmune Disease

Goronzy, J. J., & Weyand, C. M. (2025) · Immunological Reviews · doi:10.1111/imr.70047 · Cited by 9

Aging and lung diseases: Unraveling mechanisms and therapeutic targets

Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 10

Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish

Morabito, G., Dönertaş, H. M., Sperti, L., Seidel, J., Zonouzi, A. P., Poeschla, M., & Valenzano, D. R. (2026) · Nature Aging · doi:10.1038/s43587-026-01086-2 · Cited by 19

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 10

Effect of cellular aging on memory T-cell homeostasis

Swain, A. C., Borghans, J. A. M., & de Boer, R. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947242 · Cited by 9

The influence of three-dimensional structure on naïve T cell homeostasis and aging

Lambert, S., Cao, W., Zhang, H., Colville, A., Liu, J.-Y., Weyand, C. M., Goronzy, J. J., & Gustafson, C. E. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.1045648 · Cited by 9

T Lymphocytes and Their Potential Role in Dementia with Lewy Bodies

Amin, J., Gee, C., Stowell, K., Coulthard, D., & Boche, D. (2023) · Cells · doi:10.3390/cells12182283 · Cited by 10

Cellular senescence-Related genes define the immune microenvironment and molecular characteristics in severe asthma patients

Lin, Q., Zheng, Z., Ni, H., Xu, Y., & Nie, H. (2024) · Gene · doi:10.1016/j.gene.2024.148502 · Cited by 8

Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges

Francavilla, F., Intranuovo, F., Spada, G. L., Lacivita, E., Catto, M., Graps, E. A., & Altomare, C. (2024) · ChemMedChem · doi:10.1002/cmdc.202400672 · Cited by 13

Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents

Kuhlman, K. R., Tan, E. N., Cole, S. W., & Rao, U. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.004 · Cited by 10

Epstein-Barr virus infection following allogeneic hematopoietic stem cell transplantation in the era of letermovir for cytomegalovirus prophylaxis

Huang, J., Zhou, J., Zhang, S., Zhang, R., Pan, Z., Wang, L., Jiang, C., Huang, J., Zhang, Z., Zhao, Y., et al. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00665-0 · Cited by 8

T-cell senescence: Unlocking the tumor immune “Dark Box” - A multidimensional analysis from mechanism to tumor immunotherapeutic intervention

Cheng, J., Zheng, J., Ma, C., Li, Y., & Hao, H. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.010 · Cited by 8

Sustained immune youth risks autoimmune disease in the aging host

Weyand, C. M., & Goronzy, J. J. (2025) · Nature Aging · doi:10.1038/s43587-025-00919-w · Cited by 9

Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?

Lung, T., Cesare, P. D., Risch, L., Nydegger, U. E., & Risch, M. (2021) · Gerontology · doi:10.1159/000517659 · Cited by 8

Evaluation of a gene expression biomarker to identify operationally tolerant liver transplant recipients: the LITMUS trial

Chruscinski, A. J., Rojas-Luengas, V., Moshkelgosha, S., Issachar, A., Luo, J., Yowanto, H., Lilly, L., Smith, R. W., Renner, E. L., Zhang, J., et al. (2021) · Clinical & Experimental Immunology · doi:10.1093/cei/uxab011 · Cited by 8

Transcriptome-based measurement of CD8+ T cell age and its applications

Weng, N. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.05.005 · Cited by 8

mTORC1 inhibition may improve T lymphocytes affected by aging

Asghari, F., Karimi, M. H., & Pourfathollah, A. A. (2023) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2023.2232101 · Cited by 8

Natural killer cells immunosenescence and the impact of lifestyle management

Wang, L., Mao, L., Xiao, W., & Chen, P. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149216 · Cited by 8

PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age

Zhang, H., Okuyama, H., Jain, A. K., Jadhav, R. R., Wu, B., Sturmlechner, I., Morales, J., Ohtsuki, S., Weyand, C. M., & Goronzy, J. J. (2024) · JCI Insight · doi:10.1172/jci.insight.172848 · Cited by 8

Fasting mimicking diet extends lifespan and improves intestinal and cognitive health

Wang, Q., Xu, J., Luo, M., Jiang, Y., Gu, Y., Wang, Q., He, J., Sun, Y., Lin, Y., Feng, L., et al. (2024) · Food & Function · doi:10.1039/d4fo00483c · Cited by 8

Immunosenescence in skeletal muscle: The role-play in cancer cachexia chessboard

Giovarelli, M., Mocciaro, E., Carnovale, C., Cervia, D., Perrotta, C., & Clementi, E. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.02.012 · Cited by 8

CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults

Çevirgel, A., Vos, M. W., Bijvank, E., van Beek, J., van der Heiden, M., Buisman, A., & van Baarle, D. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00504-0 · Cited by 8

HIV-Induced Thymic Insufficiency and Aging-Related Immunosenescence on Immune Reconstitution in ART-Treated Patients

Guedes, M. C. S., Carvalho‐Silva, W. H. V., Andrade‐Santos, J. L., de Castro, M. C. A. B., Souto, F. O., Montenegro, L. M. L., & Guimarães, R. L. (2024) · Vaccines · doi:10.3390/vaccines12060612 · Cited by 8

Metabolic Signaling as a Driver of T Cell Aging

Choi, M. S., Choi, S., Cho, M., & Kim, C. (2025) · Immune Network · doi:10.4110/in.2025.25.e14 · Cited by 8

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures

Nehar-Belaid, D., Thibodeau, A., Eroğlu, A., Marcheş, R., Eryilmaz, G. N., Grabauskas, T., Trinity, L., Unutmaz, D., Verschoor, C. P., Gu, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73729-2 · Cited by 10

Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

Sánchez-Menéndez, C., Rodríguez-Pérez, J., Fuertes, D., Leguizamon, V., González-Sanmartin, M., Mateos, E., Cervero, M., José, E. S., Sanz, G., Álvaro, E., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1692382 · Cited by 9

Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy

Hoi, E. T. V., Santegoets, S. J. A. M., Mooijaart, S. P., van Heemst, D., Özkan, A., Verdegaal, E. M. E., Slingerland, M., Kapiteijn, E., van der Burg, S. H., Portielje, J. E. A., et al. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00463-y · Cited by 7

The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals

Quan, X., Xu, C., Wang, R.-C., Zhang, C., Zhang, Q., & Zhou, H. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104541 · Cited by 7

Multifocal Oral Epstein–Barr Virus-Positive Mucocutaneous Ulcers Associated with Dual Methotrexate and Leflunomide Therapy: A Case Report

Kunmongkolwut, S., Amornkarnjanawat, C., & Phattarataratip, E. (2022) · European Journal of Dentistry · doi:10.1055/s-0041-1739545 · Cited by 7

Maladaptive Immune Activation in Age-Related Decline of Muscle Function

Montano, M. A., & Correa‐de‐Araujo, R. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad036 · Cited by 7

Missing Insight Into T and B Cell Responses in Dermatitis Herpetiformis

Kemppainen, E., Salmi, T. T., & Lindfors, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.657280 · Cited by 7

Uncovering the New Biology of Giant Cell Arteritis to Guide Therapeutic Strategies

Shiomi, M., Watanabe, R., Ishihara, R., Tanaka, S., Kageyama, G., & Hashimoto, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14186350 · Cited by 6

Cytomegalovirus at the crossroads of immunosenescence and oncogenesis

Bouezzedine, F., Baba, R. E., Morot-Bizot, S., Diab‐Assaf, M., & Herbein, G. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00086 · Cited by 7

Immune checkpoints in autoimmune vasculitis

Sato, Y., Tada, M., Goronzy, J. J., & Weyand, C. M. (2024) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2024.101943 · Cited by 6

Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection

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Age‐Dependent Bi‐Phasic Dynamics of Ly49+ CD8 + Regulatory T Cell Population

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