Glycolysis in the tumor microenvironment: a driver of cancer progression and a promising therapeutic target
Open accessAbstract
Even with sufficient oxygen, tumor cells use glycolysis to obtain the energy and macromolecules they require to multiply, once thought to be a characteristic of tumor cells known as the “Warburg effect”. In fact, throughout the process of carcinogenesis, immune cells and stromal cells, two major cellular constituents of the tumor microenvironment (TME), also undergo thorough metabolic reprogramming, which is typified by increased glycolysis. In this review, we provide a full-scale review of the glycolytic remodeling of several types of TME cells and show how these TME cells behave in the acidic milieu created by glucose shortage and lactate accumulation as a result of increased tumor glycolysis. Notably, we provide an overview of putative targets and inhibitors of glycolysis along with the viability of using glycolysis inhibitors in combination with immunotherapy and chemotherapy. Understanding the glycolytic situations in diverse cells within the tumor immunological milieu will aid in the creation of subsequent treatment plans.
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Glycolysis is a canonical hallmark of cancer metabolism and plays a pivotal role in tumor initiation, progression, and adaptation to microenvironmental stress.
“Glycolysis constitutes a canonical hallmark of cancer metabolism and plays a pivotal role in tumor initiation, progression, and adaptation to microenvironmental stress (9).”
From Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma (2026) · cites this paper as [9]
The Introduction (page unavailable) describes aerobic glycolysis as a characteristic of tumors and a crucial indicator of malignant transformation. Section 4 says enhanced glycolysis promotes tumor development, while Section 2.3.8 links it to the hypoxic tumor microenvironment. These passages support its role in cancer metabolism, progression, and response to microenvironmental stress, but do not establish a role in tumor initiation. (LLM, conf=0.83)
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Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma
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- Authors
- Zhao, J., Jin, D., Huang, M., Ji, J., Xu, X., Wang, F., Zhou, L., Bao, B., Jiang, F., Xu, W., Lu, X., & Xiao, M.
- Affiliations
- Nantong University (CN)
- Corresponding author
- Xu, Weisong
- Lu, Xiaomin
- Xiao, Mingbing
- ORCID
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2024-06-12
- Volume
- 12
- Pages
- 1416472-1416472
- ISSN
- 2296-634X (ISSN-L)
- PMC
- PMC11199735
- OpenAlex
- W4399592964
- Cited by
- 84
- References
- 165
- Citations by year
- 2026: 38 · 2025: 42 · 2024: 4
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82272624, YJXYY202204)
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK20211105)
- Nantong University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- glycolysis, tumor microenvironment, Warburg effect, metabolic reprogramming, tumor progression, tumor acidosis, lactate accumulation, tumor-infiltrating immune cells, tumor stromal cells, glycolysis inhibitors, combination therapy, immunotherapy, chemotherapy
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