Cited by 281T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Tissue regulatory T cells: regulatory chameleons

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Muñoz-Rojas, Andrés R., Mathis, Diane·2021·Nature Reviews Immunology

DOI 10.1038/s41577-021-00519-wPMC PMC8403160

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Abstract

The FOXP3+CD4+ regulatory T (T reg) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue T reg cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor dependencies that arm them to survive and operate in their home tissue. Their functions extend beyond immune surveillance to tissue homeostasis, including regulation of local and systemic metabolism, promotion of tissue repair and regeneration, and control of the proliferation, differentiation and fate of non-lymphoid cell progenitors. T reg cells in diverse tissues share a common FOXP3+CD4+ precursor located within lymphoid organs. This precursor undergoes definitive specialization once in the home tissue, following a multilayered array of common and tissue-distinct transcriptional programmes. Our deepening knowledge of tissue T reg cell biology will inform ongoing attempts to harness T reg cells for precision immunotherapeutics.

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Authors: Muñoz-Rojas, A. R., & Mathis, D.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Mathis, Diane
ORCID: Muñoz-Rojas, Andrés R.
Mathis, Diane
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2021-03-26
Volume: 21
Issue: 9
Pages: 597-611
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-021-00519-w
PMC: PMC8403160
OpenAlex: W3136492352
Cited by: 281
References: 123
Citations by year: 2026: 59 · 2025: 61 · 2024: 61 · 2023: 47 · 2022: 40 · 2021: 13
FWCI: 4.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (RC2DK116691, R01DK092541)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR070334)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: CD4+ Foxp3+ T cells, non-lymphoid tissues, T cell receptor repertoire, immune surveillance, tissue homeostasis, local metabolism, tissue repair and regeneration, immunotherapy
MeSH terms: Animals, Female, Homeostasis, Humans, Male, Receptors, Antigen, T-Cell, Skin, Models, Immunological, Muscle, Skeletal, Intra-Abdominal Fat, T-Lymphocytes, Regulatory, Mice, Transcriptome

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Tissue regulatory T cells: regulatory chameleons

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