The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Fungal secondary metabolism: regulation, function and drug discovery
Open accessAbstract
One of the exciting movements in microbial sciences has been a refocusing and revitalization of efforts to mine the fungal secondary metabolome. The magnitude of biosynthetic gene clusters (BGCs) in a single filamentous fungal genome combined with the historic number of sequenced genomes suggests that the secondary metabolite wealth of filamentous fungi is largely untapped. Mining algorithms and scalable expression platforms have greatly expanded access to the chemical repertoire of fungal-derived secondary metabolites. In this Review, I discuss new insights into the transcriptional and epigenetic regulation of BGCs and the ecological roles of fungal secondary metabolites in warfare, defence and development. I also explore avenues for the identification of new fungal metabolites and the challenges in harvesting fungal-derived secondary metabolites. In this Review, Nancy P. Keller describes the classification and genetics of secondary metabolites and biosynthetic gene clusters, cluster regulation and the ecological roles of secondary metabolites, and she explores avenues for the discovery of new fungal metabolites and current challenges in their identification.
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Cites
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
Nierman, W. C., Pain, A., Anderson, M. J., Wortman, J. R., Kim, H. S., Arroyo, J., Berriman, M., Abe, K., Archer, D. B., Bermejo, C., et al. (2005) · Nature · doi:10.1038/nature04332 · Cited by 1,391
Self-citationTranscriptional Regulation of Chemical Diversity in Aspergillus fumigatus by LaeA
Perrin, R. M., Fedorova, N. D., Bok, J. W., Cramer, R. A., Wortman, J. R., Kim, H. S., Nierman, W. C., & Keller, N. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030050 · Cited by 352
Self-citationInglis, D. O., Binkley, J., Skrzypek, M. S., Arnaud, M. B., Cerqueira, G. C., Shah, P., Wymore, F., Wortman, J. R., & Sherlock, G. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-91 · Cited by 293
Gacek-Matthews, A., Berger, H., Sasaki, T., Wittstein, K., Gruber, C., Lewis, Z. A., & Strauss, J. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006222 · Cited by 105
Lind, A. L., Lim, F. Y., Soukup, A. A., Keller, N. P., & Rokas, A. (2018) · mSphere · doi:10.1128/msphere.00050-18 · Cited by 64
Self-citationBiofilms and beyond: Expanding echinocandin utility
Larkin, E. L., Dharmaiah, S., & Ghannoum, M. A. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx451 · Cited by 31
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Ultraviolet Radiation From a Plant Perspective: The Plant-Microorganism Context
Vanhaelewyn, L., Van Der Straeten, D., De Coninck, B., & Vandenbussche, F. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.597642 · Cited by 188
Evolutionary Histories of Type III Polyketide Synthases in Fungi
Navarro-Muñoz, J. C., & Collemare, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03018 · Cited by 59
“Access to this hidden biodiversity is hampered by the strict regulation of SM biosynthetic pathways under specific conditions that are difficult to reproduce in the laboratory (Keller, 2019).”
BackgroundFu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48
Chen, X., Zhu, C., Na, Y., Ren, D., Zhang, C., He, Y., Wang, Y., Xiang, S., Ren, W., Jiang, Y., et al. (2021) · mBio · doi:10.1128/mbio.00007-21 · Cited by 39
Carboué, Q., Rébufa, C., Hamrouni, R., Roussos, S., & Bombarda, I. (2020) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-020-02413-6 · Cited by 35
Metadata
- Authors
- Keller, N. P.
- Venue
- Nature Reviews Microbiology
- Published
- 2018-12-10
- Volume
- 17
- Issue
- 3
- Pages
- 167-180
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2905340019
- Cited by
- 1,390
- References
- 6
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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