The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies
Open accessAbstract
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-threatening. The continued emergence of antibiotic resistance, together with our increasing understanding of the detrimental effects conferred by broad-spectrum antibiotic use on the health of the beneficial microbiota of the host, has underscored the weaknesses in our current treatment paradigm for UTIs. In this Review, we discuss how recent microbiological, structural, genetic and immunological studies have expanded our understanding of host–pathogen interactions during UTI pathogenesis. These basic scientific findings have the potential to shift the strategy for UTI treatment away from broad-spectrum antibiotics targeting conserved aspects of bacterial replication towards pathogen-specific antibiotic-sparing therapeutics that target core determinants of bacterial virulence at the host–pathogen interface. In this Review, Klein and Hultgren discuss recent advances in our understanding of the interplay between pathogens and the host during urinary tract infections, and how the insights into host–pathogen interactions and pathogenesis are guiding the development of antibiotic-sparing therapeutics.
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Cites
1 retracted
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Cited by
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics
Timm, M. R., Russell, S. K., & Hultgren, S. J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01092-4 · Cited by 190
Self-citationImpact of bacterial persisters on their host
Moldoveanu, A. L., Rycroft, J. A., & Helaine, S. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.07.006 · Cited by 44
Gilbert, N. M., O’Brien, V. P., Waller, C., Batourina, E., Mendelsohn, C. L., & Lewis, A. L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.909799 · Cited by 23
From mucosal infection to successful cancer immunotherapy
Goubet, A.-G., Rouanne, M., Derosa, L., Kroemer, G., & Zitvogel, L. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00784-5 · Cited by 11
Paudel, S., Severin, G. B., Pirani, A., Pearson, M. M., Anderson, M. T., Snitkin, E. S., & Mobley, H. L. T. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.02382-24 · Cited by 2
Metadata
- Authors
- Klein, R. D., & Hultgren, S. J.
- Venue
- Nature Reviews Microbiology
- Published
- 2020-02-18
- Volume
- 18
- Issue
- 4
- Pages
- 211-226
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W3007390255
- Cited by
- 557
- References
- 10
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- green
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