Cited by 474Gut microbiota and healthClostridium difficile and Clostridium perfringens researchPlant-Microbe Interactions and Immunity

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Microbiota-mediated colonization resistance: mechanisms and regulation

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Caballero-Flores, Gustavo, Pickard, Joseph M., Núñez, Gabriel·2023·Nature Reviews Microbiology

DOI 10.1038/s41579-022-00833-7PMC PMC10249723

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Abstract

A dense and diverse microbial community inhabits the gut and many epithelial surfaces. Referred to as the microbiota, it co-evolved with the host and is beneficial for many host physiological processes. A major function of these symbiotic microorganisms is protection against pathogen colonization and overgrowth of indigenous pathobionts. Dysbiosis of the normal microbial community increases the risk of pathogen infection and overgrowth of harmful pathobionts. The protective mechanisms conferred by the microbiota are complex and include competitive microbial-microbial interactions and induction of host immune responses. Pathogens, in turn, have evolved multiple strategies to subvert colonization resistance conferred by the microbiota. Understanding the mechanisms by which microbial symbionts limit pathogen colonization should guide the development of new therapeutic approaches to prevent or treat disease.

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Authors: Caballero-Flores, G., Pickard, J. M., & Núñez, G.
Affiliations: University of Michigan (US)
Corresponding author: Caballero-Flores, Gustavo
Núñez, Gabriel
ORCID: Caballero-Flores, Gustavo
Pickard, Joseph M.
Núñez, Gabriel
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2022-12-20
Volume: 21
Issue: 6
Pages: 347-360
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/s41579-022-00833-7
PMC: PMC10249723
OpenAlex: W4312065785
Cited by: 474
References: 196
Citations by year: 2026: 160 · 2025: 182 · 2024: 100 · 2023: 32
FWCI: 8.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (K99-R00)
National Institute of Allergy and Infectious Diseases (K99AI159620, R00AI159620)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK095782)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Keywords: gut microbiota, colonization resistance, pathogen colonization, dysbiosis, pathobionts, microbial competition, host immune response, host-microbe interactions, microbiota-based therapy
MeSH terms: Immunity, Microbiota

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