Human organoids: model systems for human biology and medicine

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Items 301–400 of 1,003

1. Modelling the tumor immune microenvironment for precision immunotherapy
   Nathan J. Mackenzie, Clarissa Nicholls, Abby R. Templeton, Omattage Mahasha Perera, Penny L. Jeffery, Kate Zimmermann, Arutha Kulasinghe, Tony Kenna, Ian Vela, Elizabeth D. Williams et al. · 2022 · Clinical & Translational Immunology
2. Proteins and Transcriptional Dysregulation of the Brain Extracellular Matrix in Parkinson’s Disease: A Systematic Review
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3. In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models
   Laure Mahieu, Laurence Van Moll, Linda De Vooght, Peter Delputte, Paul Cos · 2024 · FEMS Microbiology Reviews
4. Organoids meet microfluidics: recent advancements, challenges, and future of organoids-on-chip
   Talha Chauhdari, Syeda Armana Zaidi, Jilei Su, Yongsheng Ding · 2025 · In vitro models
5. Patient-Derived Tumor Organoids for Drug Repositioning in Cancer Care: A Promising Approach in the Era of Tailored Treatment
   Silvia Vivarelli, Saverio Candido, Giuseppe Caruso, Luca Falzone, Massimo Libra · 2020 · Cancers
6. Artificial intelligence in cancer research: learning at different levels of data granularity
   Davide Cirillo, Iker Núñez‐Carpintero, Alfonso Valencia · 2021 · Molecular Oncology
7. Human neural organoids: Models for developmental neurobiology and disease
   Brian Guy, Jingliang Simon Zhang, Leighton H. Duncan, Robert J. Johnston · 2021 · Developmental Biology
8. Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle
   Youhei Uchida, Jennifer Gherardini, Karin Pappelbaum, Jérémy Chéret, Andreas Schulte‐Mecklenbeck, Catharina C. Groß, Nataša Štrbo, Amos Gilhar, Alfredo Rossi, Wolfgang Funk et al. · 2021 · Journal of Autoimmunity
9. Cardiac Organoids: A 3D Technology for Modeling Heart Development and Disease
   Liyuan Zhu, K.Y. Liu, Qi Feng, Yingnan Liao · 2022 · Stem Cell Reviews and Reports
10. Gene therapy for primary mitochondrial diseases: experimental advances and clinical challenges
    Micol Falabella, Michal A. Minczuk, Michael G. Hanna, Carlo Fiore Viscomi, Robert D. S. Pitceathly · 2022 · Nature Reviews Neurology
11. Fourier light-field imaging of human organoids with a hybrid point-spread function
    Wenhao Liu, Ge-Ah R Kim, Shuichi Takayama, Shu Jia · 2022 · Biosensors and Bioelectronics
12. Somatic Mutation: What Shapes the Mutational Landscape of Normal Epithelia?
    Joanna C. Fowler, Philip H. Jones · 2022 · Cancer Discovery
13. Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
    Sara G. Romeo, Ilaria Secco, Edoardo Schneider, Christina Maria Reumiller, Célio X.C. Santos, Anna Zoccarato, Vishal Musale, Aman Pooni, Xiaoke Yin, Konstantinos Theofilatos et al. · 2023 · Nature Communications
14. Engineered Synthetic Matrices for Human Intestinal Organoid Culture and Therapeutic Delivery
    Adriana Mulero‐Russe, Andrés J. Garcı́a · 2023 · Advanced Materials
15. Patient‐Derived Microphysiological Systems for Precision Medicine
    Jihoon Ko, Jiyoung Song, Nakwon Choi, Hong Nam Kim · 2023 · Advanced Healthcare Materials
16. A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs
    Changwen Wang, Meng Juan Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider et al. · 2024 · npj Precision Oncology
17. IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11
    Manli Miao, Min Pan, Xu Chen, Jiapan Shen, Ling Zhang, Xiaoxia Feng, Mengting Chen, Guofeng Cui, Huaiyuan Zong, Wen Zhang et al. · 2024 · Redox Biology
18. Toward developing human organs via embryo models and chimeras
    Jun Wu, Jianping Fu · 2024 · Cell
19. Standardization and quality assessment for human intestinal organoids
    Hana Lee, Seunghye Yang, Kyung Jin Lee, Si-Na Kim, Ji‐Seon Jeong, Ki Young Kim, Cho‐Rok Jung, Sooyeon Jeon, Dayeon Kwon, Sungin Lee et al. · 2024 · Frontiers in Cell and Developmental Biology
20. Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids
    Henrik Renner, Katharina Becker, Theresa Kagermeier, Martha Grabos, Farsam Eliat, Patrick S. Günther, Hans Robert Schöler, Jan M. Bruder · 2021 · Frontiers in Molecular Neuroscience
21. Tiered testing of micro- and nanoplastics using intestinal in vitro models to support hazard assessments
    Gerrit Bredeck, Blanka Halamoda‐Kenzaoui, Alessia Bogni, Dorelia Lipsa, Susanne Bremer‐Hoffmann · 2021 · Environment International
22. Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts
    Yoon-Ha Go, Woo Hee Choi, Won Jung Bae, Sook‐In Jung, Chang‐Hoon Cho, Seung Ah Lee, Joon Seong Park, Ji Mi Ahn, Sung Won Kim, Kyung Jin Lee et al. · 2022 · Cancers
23. Silk scaffolding drives self-assembly of functional and mature human brain organoids
    Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar et al. · 2022 · Frontiers in Cell and Developmental Biology
24. Venom-derived peptides for breaking through the glass ceiling of drug development
    Lou Freuville, Chloé Matthys, Loïc Quinton, Jean‐Pierre Gillet · 2024 · Frontiers in Chemistry
25. Examining the gut-liver axis in liver cancer using organoid models
    Dmitrii Shek, Dishen Chen, Scott A. Read, Golo Ahlenstiel · 2021 · Cancer Letters
26. Recent Advancements in Regenerative Approaches for Thymus Rejuvenation
    Himal Sharma, Lorenzo Moroni · 2021 · Advanced Science
27. The integration of spheroids and organoids into organ-on-a-chip platforms for tumour research: A review
    Violeta Meneses Carvalho, Manuel Bañobre‐López, Graça Maria Henriques Minas, Senhorinha Teixeira, Rui A. Lima, Raquel O. Rodrigues · 2022 · Bioprinting
28. Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids
    Chansu Lee, Joo Hye Song, Yeo-Eun Cha, Dong Kyung Chang, Young‐Ho Kim, Sung Noh Hong · 2022 · Journal of Crohn s and Colitis
29. Industry 5.0 in Orthopaedics
    Madhan Jeyaraman, Arulkumar Nallakumarasamy, Naveen Jeyaraman · 2022 · Indian Journal of Orthopaedics
30. Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo
    Whee-Soo Kim, Sungjin Min, Su Kyeom Kim, Sunghwi Kang, Soohwan An, Ernesto Criado-Hidalgo, Hunter C. Davis, Avinoam Bar‐Zion, Dina Malounda, Yu Heun Kim et al. · 2023 · Nature Materials
31. Developmental basis of trachea-esophageal birth defects
    Nicole A. Edwards, Vered Shacham-Silverberg, Leelah Weitz, Paul S. Kingma, Yufeng Shen, James M. Wells, Wendy K. Chung, Aaron M. Zorn · 2021 · Developmental Biology
32. Indenyl and Allyl Palladate Complexes Bearing N ‐Heterocyclic Carbene Ligands: an Easily Accessible Class of New Anticancer Drug Candidates
    Thomas Scattolin, Ilenia Pessotto, Enrico Cavarzerani, Vincenzo Canzonieri, Laura Orian, Nicola Demitri, Claudia S. Schmidt, Angela Casini, Enrica Bortolamiol, Fabiano Visentin et al. · 2022 · European Journal of Inorganic Chemistry
33. TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn’s Disease
    Chansu Lee, Minae An, Je‐Gun Joung, Woong‐Yang Park, Dong Kyung Chang, Young‐Ho Kim, Sung Noh Hong · 2021 · Cellular and Molecular Gastroenterology and Hepatology
34. Establishment of Patient-Derived Organoids Using Ascitic or Pleural Fluid from Cancer Patients
    Wonyoung Choi, Yun‐Hee Kim, Sang Myung Woo, Yebeen Yu, Mi Rim Lee, Woo Jin Lee, Jung Won Chun, Sung Hoon Sim, Heejung Chae, Hyoeun Shim et al. · 2023 · Cancer Research and Treatment
35. Optimization of Vascularized Intestinal Organoid Model
    Zhang Wen, Mariabelen Orduno, Zixie Liang, Xiangyu Gong, Michael Mak · 2024 · Advanced Healthcare Materials
36. A Perspective on Organoids for Virology Research
    Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja C. Wolthers · 2020 · Viruses
37. Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer
    Tet Woo Lee, Amy Lai, Julia K. Harms, Dean C. Singleton, Benjamin D. Dickson, Andrew Macann, Michael P. Hay, Stephen M. F. Jamieson · 2020 · Cancers
38. Tissues and Tumor Microenvironment (TME) in 3D: Models to Shed Light on Immunosuppression in Cancer
    Teresa Ho, Rasha Msallam · 2021 · Cells
39. Mechanobiology of the female reproductive system
    Sachiko Matsuzaki · 2021 · Reproductive Medicine and Biology
40. Soluble ECM promotes organotypic formation in lung alveolar model
    Jonard Corpuz Valdoz, Nicholas A. Franks, Collin G. Cribbs, Dallin J. Jacobs, Ethan L. Dodson, Connor J. Knight, Peter Daniel Poulson, Seth R. Garfield, Benjamin C. Johnson, Brandon M. Hemeyer et al. · 2022 · Biomaterials
41. The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling
    Jamison Beiriger, Ahmed Habib, Nicolina Jovanovich, Chowdari V. Kodavali, Lincoln Edwards, Nduka Amankulor, Pascal Olivier Zinn · 2022 · Frontiers in Oncology
42. Intestinal organoids and organoids extracellular vesicles for inflammatory bowel disease treatment
    Han Liu, Jinru Sun, Mingkai Wang, Sicheng Wang, Jiacan Su, Can Xu · 2023 · Chemical Engineering Journal
43. Organic electronic transmembrane device for hosting and monitoring 3D cell cultures
    Charalampos Pitsalidis, Douglas C. van Niekerk, Chrysanthi‐Maria Moysidou, Alexander J. Boys, Aimee M. Withers, Romane Vallet, Róisı́n M. Owens · 2022 · Science Advances
44. Genome Editing, A Superior Therapy for Inherited Retinal Diseases
    Alexander L. Yan, Samuel W. Du, Krzysztof Palczewski · 2022 · Vision Research
45. Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity
    Pelin Saglam‐Metiner, Ender Yıldırım, Can Dincer, Onur Başak, Özlem Yeşil-Çeliktaş · 2024 · Microchimica Acta
46. Lipid Rafts: The Maestros of Normal Brain Development
    Barbara Viljetić, Senka Blažetić, Irena Labak, Vedrana Ivić, Milorad Zjalić, Marija Heffer, Marta Balog · 2024 · Biomolecules
47. Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
    Dominik Lindenhofer, Simon Haendeler, Christopher Esk, Jamie B. Littleboy, Clarisse Brunet Avalos, Julia Naas, Florian Pflug, Eline G. P. van de Ven, Daniel Reumann, Alexandre D. Baffet et al. · 2024 · Nature Cell Biology
48. Electrophysiological Analysis of Retinal Organoid Development Using 3D Microelectrodes of Liquid Metals
    Sanghoon Lee, Won Gi Chung, Han Jeong, Gang Cui, Enji Kim, Jeong Ah Lim, Hunkyu Seo, Yong Won Kwon, Suk Ho Byeon, Junwon Lee et al. · 2024 · Advanced Materials
49. Imaging 3D cell cultures with optical microscopy
    Huai-Ching Hsieh, Qinghua Han, David Brenes, Kevin W. Bishop, Rui Wang, Yuli Wang, Chetan Poudel, Adam K. Glaser, Benjamin Freedman, Joshua C. Vaughan et al. · 2025 · Nature Methods
50. Reimagining human-centric drug development with new approach methodologies
    Xuekun Wu, Matthew A. Wu, James Zou, Nicole Kleinstreuer, Joseph C. Wu · 2026 · Science
51. Engineering microcapsules to construct vascularized human brain organoids
    Yujuan Zhu, Lingyu Sun, Xiao Fu, Junying Liu, Zhenjiang Liang, Huı Tan, Weiping Li, Yuanjin Zhao · 2021 · Chemical Engineering Journal
52. Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids
    Margalida Torrens‐Mas, Catalina M. Perelló-Reus, Cayetano Navas-Enamorado, Lesly Ibargüen-González, Andrés Sánchez-Polo, Juan José Segura‐Sampedro, Lluís Masmiquel, Carles Barceló, Marta González‐Freire · 2021 · International Journal of Molecular Sciences
53. Regenerative Engineering: Current Applications and Future Perspectives
    Dana Goldenberg, Caroline McLaughlin, Srinivas V. Koduru, Dino J. Ravnic · 2021 · Frontiers in Surgery
54. Hypes and Hopes of Stem Cell Therapies in Dentistry: a Review
    Alessandra Rodriguez y Baena, Andrea Casasco, Manuela Monti · 2022 · Stem Cell Reviews and Reports
55. Multimodal microscale mechanical mapping of cancer cells in complex microenvironments
    Miloš Nikolić, Giuliano Scarcelli, Kandice Tanner · 2022 · Biophysical Journal
56. Public perceptions and expectations: Disentangling the hope and hype of organoid research
    Tine Ravn, Mads P. Sørensen, Emma Capulli, Panagiotis Kavouras, Renzo Pegoraro, Mario Picozzi, Louise Isgaard Saugstrup, Eleni Spyrakou, Vana Stavridi · 2023 · Stem Cell Reports
57. In vitro and in vivo experimental models for cancer immunotherapy study
    Chunye Zhang, Yuxiang Sui, Shuai Liu, Ming Jun Yang · 2024 · Current Research in Biotechnology
58. The Future Exploring of Gut Microbiome-Immunity Interactions: From In Vivo/Vitro Models to In Silico Innovations
    Sara Bertorello, Francesco Cei, Dorian Fink, Elena Niccolai, Amedeo Amedei · 2024 · Microorganisms
59. Organoid-based tissue engineering for advanced tissue repair and reconstruction
    Nancy Hsiung, Yikun Ju, Kai Chiang Yang, Yang Pu, Weiliang Zeng, Hongli Zhao, Pei Zou, Jiandong Ye, Kemin Yi, Xiancheng Wang · 2025 · Materials Today Bio
60. Intestinal organoid-based 2D monolayers mimic physiological and pathophysiological properties of the pig intestine
    Pascal Hoffmann, Nadine Schnepel, Marion Langeheine, Katrin Künnemann, Guntram A. Graßl, Ralph Brehm, Bettina Seeger, Gemma Mazzuoli‐Weber, G. Breves · 2021 · PLoS ONE
61. Human three‐dimensional dental pulp organoid model for toxicity screening of dental materials on dental pulp cells and tissue
    Xiao‐Qi Xu, Zheng Li, Xiaoqing Ai, Yin Tang, Deqin Yang, Lei Dou · 2021 · International Endodontic Journal
62. 3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening
    Ana Ivonne Vazquez‐Armendariz, Margarida Maria Barroso, Elie El Agha, Susanne Herold · 2022 · Cells
63. Advances of Engineered Hydrogel Organoids within the Stem Cell Field: A Systematic Review
    Zheng Li, Muxin Yue, Yunsong Liu, Ping Zhang, Jia Qing, Hao Liu, Yongsheng Zhou · 2022 · Gels
64. Lung Organoids—The Ultimate Tool to Dissect Pulmonary Diseases?
    Veronika Bosáková, Marco De Zuani, Lucie Sládková, Zuzana Garlíková, Shyam Sushama Jose, Teresa Zelante, Marcela Hortová Kohoutková, Jan Frič · 2022 · Frontiers in Cell and Developmental Biology
65. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells
    Edoardo Sozzi, Fredrik Nilsson, Janko Kajtez, Malin Parmar, Alessandro Fiorenzano · 2022 · Current Protocols
66. Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy
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67. Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis
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68. In situ biosensing technologies for an organ-on-a-chip
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69. Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction
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70. PhaseFIT: live-organoid phase-fluorescent image transformation via generative AI
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71. Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm
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72. A 3D Bioprinted Human Neurovascular Unit Model of Glioblastoma Tumor Growth
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73. Microphysiological Systems as Organ-Specific In Vitro Vascular Models for Disease Modeling
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74. Millimetre-deep micrometre-resolution vibrational imaging by shortwave infrared photothermal microscopy
    Hongli Ni, Yuhao Yuan, Mingsheng Li, Yifan Zhu, Xiaowei Ge, Jiaze Yin, Chinmayee Vallabh Prabhu Dessai, Le Wang, Ji‐Xin Cheng · 2024 · Nature Photonics
75. Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
    Amanda Andersson-Rolf, Kelvin Groot, Jeroen Korving, Harry Begthel, Maaike A. J. Hanegraaf, Michael A. VanInsberghe, Fredrik Salmén, Stieneke van den Brink, Carmen López‐Iglesias, Peter J. Peters et al. · 2024 · Cell
76. Understanding and Treating Niemann–Pick Type C Disease: Models Matter
    Valentina Pallottini, Frank W. Pfrieger · 2020 · International Journal of Molecular Sciences
77. Using 3D in vitro cell culture models in anti-cancer drug discovery
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78. Emerging liver organoid platforms and technologies
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79. Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models
    Sharifah Anoar, Nathaniel S. Woodling, Teresa Niccoli · 2021 · Frontiers in Neuroscience
80. High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates
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81. Optical tissue clearing associated with 3D imaging: application in preclinical and clinical studies
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82. Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system
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83. Role of prostate cancer stem-like cells in the development of antiandrogen resistance
    Prem Prakash Kushwaha, Shiv Verma, Shashank Kumar, Sanjay Gupta · 2022 · Cancer Drug Resistance
84. Organoids, organ-on-a-chip, separation science and mass spectrometry: An update
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85. Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro
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86. Extracellular matrix-templating fibrous hydrogels promote ovarian tissue remodeling and oocyte growth
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87. BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network
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88. Osteochondral organoids: current advances, applications, and upcoming challenges
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89. 3D Models Currently Proposed to Investigate Human Skin Aging and Explore Preventive and Reparative Approaches: A Descriptive Review
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90. Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine
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91. Automation of Organoid Cultures: Current Protocols and Applications
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92. Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors
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93. Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection
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94. Single cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
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95. Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin
    Sumito Saeki, Kohei Kumegawa, Yoko Takahashi, Liying Yang, Tomo Osako, Mahmut Yasen, Kazutaka Otsuji, Kenichi Miyata, Kaoru Yamakawa, Jun Suzuka et al. · 2023 · Breast Cancer Research
96. Integration of organoids in peptide drug discovery: Rise of the high‐throughput screening
    Siqi Zhang, Jieting Shen, Xingkai Wang, Xiaona Sun, Yuxuan Wu, Ming‐Rong Zhang, Rui Wang, Kuan Hu · 2023 · Open Research (University of Surrey)
97. Pathogenetic mechanisms and treatment targets in cerebral malaria
    Alexandros Hadjilaou, Johannes Brandi, Mathias Riehn, Manuel Alexander Friese, Thomas Jacobs · 2023 · Nature Reviews Neurology
98. Advanced models for respiratory disease and drug studies
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99. Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity
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100. Manipulating gene expression levels in mammalian cell factories: An outline of synthetic molecular toolboxes to achieve multiplexed control
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