Human organoids: model systems for human biology and medicine

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,745

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex

Vuong, C. K., Weber, A., Seong, P., Matoba, N., Chen, Y.-J., Peyer, J., Younesi, S., Salinda, A., Gomez, D., Rivas, G., et al. (2026) · Science · doi:10.1126/science.aea1259 · Cited by 18

Microplastic accumulation in endometrial cancer tissues and its metabolic impact

Dong, C., Xu, H., Zhang, B., Lin, Y., Song, J. C., Yu, J., & Ma, D. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127005 · Cited by 14

Multiscale Construction, Evaluation, and Application of Organoids

Ma, W., Dong, Z., Zheng, Z., Bai, L., Zhang, X., & Su, J. (2025) · Advanced Science · doi:10.1002/advs.202508534 · Cited by 15

Organoids for disease modeling and treatment: state-of-the-art

Xu, M., Kong, D., Sun, S., Wang, Y., Su, G., Zhang, S., Yan, J., Han, Z., Li, J., & Zhang, L. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00743-x · Cited by 14

Application of Hexanoyl Glycol Chitosan as a Non-cell Adhesive Polymer in Three-Dimensional Cell Culture

Kim, D., Lee, Y. B., Shim, H., Song, J. J., Han, J., Moon, K., Huh, K. M., & Kang, S. (2022) · ACS Omega · doi:10.1021/acsomega.2c00890 · Cited by 14

Nutritional assessment models for diabetes and aging

Wen, Y., Liu, Y., Huang, Q., Farag, M. A., Li, X., Wan, X., & Zhao, C. (2022) · Food Frontiers · doi:10.1002/fft2.168 · Cited by 14

How do scientists model humanness? A qualitative study of human organoids in biomedical research

Hinterberger, A., & Bea, S. (2023) · Social Science & Medicine · doi:10.1016/j.socscimed.2023.115676 · Cited by 14

Induction of toxicity in human colon cells and organoids by size- and composition-dependent road dust

Park, S. B., Kim, E.-A., Kim, K. Y., & Koh, B. (2023) · RSC Advances · doi:10.1039/d2ra07500h · Cited by 14

Analysis of the Application of Pedagogical Technology to the Learning of Children with ASD

Khasawneh, M. A. S. (2023) · International Journal of Special Education (IJSE) · doi:10.52291/ijse.2023.38.8 · Cited by 14

Organoid models of the pituitary gland in health and disease

Laporte, E., & Vankelecom, H. E. J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1233714 · Cited by 15

Spectroscopic techniques for monitoring stem cell and organoid proliferation in 3D environments for therapeutic development

Mao, W., Bui, H. D., Cho, W., & Yoo, H. S. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115074 · Cited by 14

Application of organoids in precision immunotherapy of lung cancer (Review)

Tian, H., Ren, J., Mou, R., & Jia, Y. (2023) · Oncology Letters · doi:10.3892/ol.2023.14071 · Cited by 14

Development of heart organoid cryopreservation method through Fe3O4 nanoparticles based nanowarming system

Lee, S., Kim, J., Seok, J., Kim, M. W., Rhee, J., Song, G., Park, S., Lee, S., Jeong, Y., Chung, H., et al. (2023) · Biotechnology Journal · doi:10.1002/biot.202300311 · Cited by 14

Three-Dimensional Tumor Models to Study Cancer Stemness-Mediated Drug Resistance

Lamichhane, A., & Tavana, H. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00798-y · Cited by 16

Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations

Zdyrski, C., Gabriel, V., Gessler, T. B., Ralston, A., Sifuentes‐Romero, I., Kundu, D., Honold, S. T., Wickham, H., Topping, N. E., Sahoo, D. K., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05818-1 · Cited by 15

LATS1 controls CTCF chromatin occupancy and hormonal response of 3D-grown breast cancer cells

Ramírez-Cuéllar, J., Ferrari, R., Sanz, R. T., Valverde-Santiago, M., García-García, J., Nacht, A. S., Castillo, D., Dily, F. L., Neguembor, M. V., Malatesta, M., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00080-x · Cited by 14

Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids

Bustamante‐Madrid, P., Barbáchano, A., Albandea‐Rodríguez, D., Rodríguez‐Cobos, J., Rodrı́guez-Salas, N., Prieto, I., Burgos, A., de Villarreal, J. M., Real, F. X., González‐Sancho, J. M., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06680-z · Cited by 14

Dynamic 3D in vitro lung models: applications of inorganic nanoparticles for model development and characterization

Fallert, L., Urigoitia-Asua, A., Cipitria, A., & de Aberasturi, D. J. (2024) · Nanoscale · doi:10.1039/d3nr06672j · Cited by 14

Melatonin alleviates myocardial dysfunction through inhibition of endothelial‐to‐mesenchymal transition via the NF‐κB pathway

Kim, R., Kim, M., Jeong, S., Kim, S., Moon, H., Kim, H., Lee, M. Y., Kim, J., Kim, H., Choi, M., et al. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12958 · Cited by 14

Validating Well-Functioning Hepatic Organoids for Toxicity Evaluation

Choi, S. Y., Kim, T. H., Kim, M. J., Mun, S. J., Kim, T., Jung, K. K., Oh, I. U., Oh, J. H., Son, M. J., & Lee, J. H. (2024) · Toxics · doi:10.3390/toxics12050371 · Cited by 14

In silico study of heterogeneous tumour-derived organoid response to CAR T-cell therapy

Luque, L. M., Carlevaro, C. M., Rodríguez‐Lomba, E., & Lomba, E. (2024) · Scientific Reports · doi:10.1038/s41598-024-63125-5 · Cited by 14

Development and Optimization of a Lactate Dehydrogenase Assay Adapted to 3D Cell Cultures

Castiglione, H., Madrange, L., Lemonnier, T., Deslys, J., Yates, F., & Vigneron, P.-A. (2024) · Organoids · doi:10.3390/organoids3020008 · Cited by 14

The mouse multi-organ proteome from infancy to adulthood

Wang, Q., Ding, X., Xu, Z., Wang, A., Wang, A., Wang, L., Ding, Y., Song, S., Chen, Y., Zhang, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50183-6 · Cited by 14

AUTS2 disruption causes neuronal differentiation defects in human cerebral organoids through hyperactivation of the WNT/β-catenin pathway

Geng, Z., Tai, Y. T., Wang, Q., & Gao, Z. (2024) · Scientific Reports · doi:10.1038/s41598-024-69912-4 · Cited by 14

Bioengineering Tooth and Periodontal Organoids from Stem and Progenitor Cells

Torizal, F. G., Noorintan, S. T., & Gania, Z. (2024) · Organoids · doi:10.3390/organoids3040015 · Cited by 14

Advancing Glioblastoma Research with Innovative Brain Organoid-Based Models

Correia, C. D., Calado, S. M., Matos, A., Esteves, F., Sousa‐Coelho, A. L. D., Campinho, M. A., & Fernandes, M. T. (2025) · Cells · doi:10.3390/cells14040292 · Cited by 16

Organoid: Biomedical application, biobanking, and pathways to translation

Sinha, A., Maibam, M., Jain, R., Aggarwal, K., Sahu, A. K., Gupta, P. K., Paul, S., Bisht, B., & Paul, M. K. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e43028 · Cited by 16

Characterization of extracellular vesicles and miRNA released by cerebral organoids

Silver, B. B., Fannin, R. D., Gerrish, K., & Tokar, E. J. (2025) · Current Research in Toxicology · doi:10.1016/j.crtox.2025.100229 · Cited by 14

Precision Spatial Control of Tumor‐Stroma Interactions in Cancer Models via 3D Bioprinting for Advanced Research and Therapy

Li, Y., Cui, H., & Cui, H. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202503391 · Cited by 15

The Toxicological Profile of Active Pharmaceutical Ingredients–Containing Nanoparticles: Classification, Mechanistic Pathways, and Health Implications

Muhaimin, M., Chaerunisaa, A. Y., Dewi, M. K., Khatib, A., & Hazrina, A. (2025) · Pharmaceuticals · doi:10.3390/ph18050703 · Cited by 15

Human reconstructed kidney models

Kishi, S., Matsumoto, T., Ichimura, T., & Brooks, C. R. (2021) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-021-00548-8 · Cited by 14

Harnessing pluripotent stem cells as models to decipher human evolution

Dannemann, M., & Romero, I. G. (2021) · FEBS Journal · doi:10.1111/febs.15885 · Cited by 14

The Potential of Pancreatic Organoids for Diabetes Research and Therapy

Bittenglová, K., Habart, D., Saudek, F., & Koblas, T. (2021) · Islets · doi:10.1080/19382014.2021.1941555 · Cited by 16

High-throughput screening for drug discovery targeting the cancer cell-microenvironment interactions in hematological cancers

Giri, A. K., & Ianevski, A. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.1991306 · Cited by 15

Capturing the third dimension in drug discovery: Spatially-resolved tools for interrogation of complex 3D cell models

Simão, D. F., Gomes, C. M., Alves, P. M., & Brito, C. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107883 · Cited by 15

Transcriptional Factor Repertoire of Breast Cancer in 3D Cell Culture Models

Özkan, H., Öztürk, D. G., & Korkmaz, G. (2022) · Cancers · doi:10.3390/cancers14041023 · Cited by 14

Organoids as a tool for understanding immune-mediated intestinal regeneration and development

Jowett, G. M., Coales, I., & Neves, J. F. (2022) · Development · doi:10.1242/dev.199904 · Cited by 14

Recent Advances in 3D-Cultured Brain Tissue Models Derived from Human iPSCs

Choi, N. Y., Lee, M., & Jeong, S. (2022) · BioChip Journal · doi:10.1007/s13206-022-00075-y · Cited by 14

Organoids: A New Chapter in Sarcoma Diagnosis and Treatment

Psilopatis, I., Kokkali, S., Palamaris, K., Digklia, A., Vrettou, K., & Theocharis, S. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911271 · Cited by 14

The Power of Gene Technologies: 1001 Ways to Create a Cell Model

Karagyaur, M. N., Primak, A. L., Efimenko, A. Y., Никитична, С. М., & Va, T. (2022) · Cells · doi:10.3390/cells11203235 · Cited by 14

Organ-On-A-Chip Database Revealed—Achieving the Human Avatar in Silicon

Jiang, L., Li, Q., Liang, W., Du, X., Yang, Y., Zhang, Z., Xu, L., Zhang, J., Li, J., Chen, Z., et al. (2022) · Bioengineering · doi:10.3390/bioengineering9110685 · Cited by 15

Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease

Ahn, J., Kang, M., Seo, Y., & Kim, H. (2022) · BMB Reports · doi:10.5483/bmbrep.2022-0182 · Cited by 16

Human iPSC-derived brain organoids: A 3D mini-brain model for studying HIV infection

Wei, Z., Bodnar, B. H., Zhao, R.-T., Xiao, Q., Saribas, S., Wang, X., Ho, W., & Hu, W. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114386 · Cited by 14

Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation

Koh, I., & Hagiwara, M. (2023) · Communications Biology · doi:10.1038/s42003-023-04694-5 · Cited by 14

The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

Jörg, M., & Madden, K. S. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00022e · Cited by 14

Modelling adult stem cells and their niche in health and disease with epithelial organoids

Szabó, L., Seubert, A. C., & Kretzschmar, K. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.09.006 · Cited by 14

A modular platform to generate functional sympathetic neuron-innervated heart assembloidsPreprint

Zeltner, N., Wu, H., Saito‐Diaz, K., Sun, X., Song, M., Saini, T., Grant, C., James, C., Thomas, K. S., Abate, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3894397/v1 · Cited by 14

Modeling epithelial-mesenchymal transition in patient-derived breast cancer organoids

Bar-Hai, N., Ben-Yishay, R., Arbili-Yarhi, S., Herman, N., Noy, V., Menes, T. S., Mansour, A., Awwad, F., Balint‐Lahat, N., Goldinger, G., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1470379 · Cited by 13

Uterine organoids reveal insights into epithelial specification and plasticity in development and disease

Rizo, J. A., Ahmad, V., Pru, J. M., Winuthayanon, S., Challa, S., Kim, T. H., Jeong, J., Spencer, T. E., & Kelleher, A. M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422694122 · Cited by 15

Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis

Vincent, D., Heuer, K., Raluy, L. P., Hagens, J., Kolman, J. P., Bunders, M. J., Wesche, J., Knopf, J., i, M. H., Reinshagen, K., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582526 · Cited by 13

Defining cellular diversity at the swine maternal–fetal interface using spatial transcriptomics and organoids

McCutcheon, C. R., Caldwell, A., Yang, L., Crisci, E., Pasternak, J. A., & Coyne, C. B. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003302 · Cited by 14

Redefining cellular reprogramming with advanced genomic technologies

Morris, S. A. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00899-y · Cited by 16

Increased reproducibility of brain organoids through controlled fluid dynamics

Aiello, G., Nemir, M., Vidimova, B., Ramel, C., Viguie, J., Ravera, A., Wrzesinski, K., & Bagni, C. (2025) · EMBO Reports · doi:10.1038/s44319-025-00619-x · Cited by 13

Modeling adaptive drug resistance of colorectal cancer and therapeutic interventions with tumor spheroids

Lamichhane, A., Thakuri, P. S., Nejad, P. R., & Tavana, H. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211014185 · Cited by 13

EZH2-mediated H3K27me3 is a predictive biomarker and therapeutic target in uveal melanoma

Hou, C., Xiao, L., Ren, X., Cheng, L., Guo, B., Zhang, M., & Yan, N. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1013475 · Cited by 13

Gastrointestinal organoids in the study of viral infections

Gebert, J. T., Scribano, F. J., Engevik, K. A., Perry, J. L., & Hyser, J. M. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2022 · Cited by 14

Novel, Innovative Models to Study Ischemia/Reperfusion-Related Redox Damage in Organ Transplantation

Hofmann, J. D., Pühringer, M., Steinkellner, S., Holl, A.-S., Mészáros, A., Schneeberger, S., Troppmair, J., & Hautz, T. (2022) · Antioxidants · doi:10.3390/antiox12010031 · Cited by 13

Localization of Multiple Hydrogels with MultiCUBE Platform Spatially Guides 3D Tissue Morphogenesis In Vitro

Suthiwanich, K., & Hagiwara, M. (2023) · Advanced Materials Technologies · doi:10.1002/admt.202201660 · Cited by 13

Endocytic trafficking of connexins in cancer pathogenesis

Totland, M. Z., Omori, Y., Sørensen, V., Kryeziu, K., Aasen, T., Brech, A., & Leithe, E. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166812 · Cited by 13

The anterior chamber of the eye technology and its anatomical, optical, and immunological bases

Yang, S.-N., Shi, Y., & Berggren, P. (2024) · Physiological Reviews · doi:10.1152/physrev.00024.2023 · Cited by 13

Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms

Alcala, N., Voegele, C., Mangiante, L., Sexton‐Oates, A., Clevers, H. C., Fernandez‐Cuesta, L., Dayton, T. L., & Foll, M. (2024) · GigaScience · doi:10.1093/gigascience/giae008 · Cited by 13

Live Organoid Cyclic Imaging

Reynolds, D. E., Sun, Y. Y., Wang, X., Vallapureddy, P., Lim, J., Pan, M., del Castillo, A. F., Carlson, J., Sellmyer, M. A., Nasrallah, M. P., et al. (2024) · Advanced Science · doi:10.1002/advs.202309289 · Cited by 13

Guidelines for Manufacturing and Application of Organoids: Skin

Lee, S., Rim, Y. A., Kim, J., Lee, S. H., Park, H. J., Kim, H., Ahn, S.-J., & Ju, J. H. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc24045 · Cited by 14

Spheroid-Hydrogel-Integrated Biomimetic System: A New Frontier in Advanced Three-Dimensional Cell Culture Technology

Yoo, S., & Lee, H. J. (2024) · Cells Tissues Organs · doi:10.1159/000541416 · Cited by 13

Omaveloxolone for the Treatment of Friedreich Ataxia: Efficacy, Safety, and Future Perspectives

Naghipour, S., Corben, L. A., Hulme, A. E., Dottori, M., Delatycki, M. B., Lees, J. G., & Lim, S. Y. (2024) · Movement Disorders · doi:10.1002/mds.30070 · Cited by 13

Enhanced Maturity and Functionality of Vascular Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture

Lekkala, V. K. R., Shrestha, S., Qaryoute, A. A., Dhinoja, S., Acharya, P., Raheem, A., Jagadeeswaran, P., & Lee, M. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01658 · Cited by 13

Exploring the landscape of current in vitro and in vivo models and their relevance for targeted radionuclide theranostics

Bokhout, L., Campeiro, J. D., & Dalm, S. U. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07123-3 · Cited by 13

Evolution of organoid genetics

Klompstra, T. M., Yoon, K., & Koo, B. (2025) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2025.151481 · Cited by 13

Self-targeted nanosystem for enhanced chemodynamic cancer therapy

Asif, K., Rahman, M. M., Canzonieri, V., Caligiuri, I., Rizzolio, F., & Adeel, M. (2025) · Biomaterials Science · doi:10.1039/d4bm01683a · Cited by 13

Can Caenorhabditis elegans Serve as a Reliable Model for Drug and Nutraceutical Discovery?

Deji-Oloruntoba, O. O., Elufioye, T. O., Adefegha, S. A., & Jang, M. (2025) · Applied Biosciences · doi:10.3390/applbiosci4020023 · Cited by 13

Lactoferrin-osteopontin complexes: insights into intestinal organoid bioavailability and gut microbiota modulation

Ceroni, C., Dayon, L., den Abbeele, P. V., Roch, A., Dervaux, J., Ernest, M., Sirugue, P., Baudot, A., Kraus, M. R.-C., Brandenberg, N., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08460-7 · Cited by 13

Human Embryo Models and Drug Discovery

Rosner, M., Reithofer, M., Fink, D., & Hengstschläger, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020637 · Cited by 16

Organ-Specific, Fibroblast-Derived Matrix as a Tool for Studying Breast Cancer Metastasis

Jensen, A. R. D., Horton, E. R., Blicher, L. H., Pietras, E. J., Steinhauer, C., Reuten, R., Schoof, E. M., & Erler, J. T. (2021) · Cancers · doi:10.3390/cancers13133331 · Cited by 13

Future Match Making: When Pediatric Oncology Meets Organoid Technology

Barbet, V., & Broutier, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.674219 · Cited by 19

To Better Generate Organoids, What Can We Learn From Teratomas?

Li, H., Gao, L., Du, J., Ma, T., Ye, Z., & Li, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.700482 · Cited by 13

An Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach

Marx, U., Accastelli, E., David, R. M., Erfurth, H., Koenig, L., Lauster, R., Ramme, A. P., Reinke, P., Volk, H., Winter, A., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.728866 · Cited by 15

Kidney development to kidney organoids and back again

Gupta, N. R., & Morizane, R. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.09.017 · Cited by 13

The potential and limitations of intrahepatic cholangiocyte organoids to study inborn errors of metabolism

Lehmann, V., Schene, I. F., Ardisasmita, A. I., Liv, N., Veenendaal, T., Klumperman, J., van der Doef, H. P. J., Verkade, H. J., Verstegen, M. M. A., van der Laan, L. J. W., et al. (2021) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12450 · Cited by 13

Why Can Organoids Improve Current Organ-on-Chip Platforms?

Sokołowska, P., Żuchowska, A., & Brzózka, Z. (2022) · Organoids · doi:10.3390/organoids1010007 · Cited by 15

Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks

Anh, N. H., Yoon, Y. C., Min, Y. J., Long, N. P., Jung, C. W., Kim, S. J., Kim, S. W., Lee, E. G., Wang, D., Wang, X. D., et al. (2022) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2022.06.006 · Cited by 13

Retinoic acid and FGF10 promote the differentiation of pluripotent stem cells into salivary gland placodes

Zhang, S., Sui, Y., Yan, S., Zhang, Y., Ding, C., Su, X., Xiong, J., & Wei, S. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03033-5 · Cited by 14

3D engineered tissue models for studying human-specific infectious viral diseases

Hwang, K. S., Seo, E. U., Choi, N., Kim, J., & Kim, H. N. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.010 · Cited by 13

Immunohistochemistry (IHC) staining of in-vitro cancer cell-generated tumoroids

Amereh, M., & Akbari, M. (2023) · MethodsX · doi:10.1016/j.mex.2023.102242 · Cited by 13

Application of colloidal photonic crystals in study of organoids

Huang, K., Li, Q., Xue, Y., Wang, Q., Chen, Z., & Gu, Z. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115075 · Cited by 13

Random Traction Yielding Transition in Epithelial Tissues

Amiri, A., Duclut, C., Jülicher, F., & Popovic, M. A. (2023) · Physical Review Letters · doi:10.1103/physrevlett.131.188401 · Cited by 13

Human fetal tissue is critical for biomedical research

Brumbaugh, J., Aguado, B. A., Lysaght, T., & Goldstein, L. S. B. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.10.008 · Cited by 13

Does the Microenvironment Hold the Hidden Key for Functional Precision Medicine in Pancreatic Cancer?

Kokkinos, J., Jensen, A., Sharbeen, G., McCarroll, J. A., Goldstein, D., Haghighi, K. S., & Phillips, P. A. (2021) · Cancers · doi:10.3390/cancers13102427 · Cited by 14

Experimental Models for SARS-CoV-2 Infection

Kim, T., Lee, J. S., & Ju, Y. S. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0094 · Cited by 13

Progress and Challenges in the Use of a Liver-on-a-Chip for Hepatotropic Infectious Diseases

Kulkeaw, K., & Pengsart, W. (2021) · Micromachines · doi:10.3390/mi12070842 · Cited by 13

Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens

Garcia, M. A., Hillion, K., Cappelier, J.-M., Neunlist, M., Mahé, M. M., & Haddad, N. (2022) · Foods · doi:10.3390/foods11010108 · Cited by 13

Advances in the use of 3D colorectal cancer models for novel drug discovery

Baião, A., Dias, S., Soares, A. F., Pereira, C. L., Oliveíra, C., & Sarmento, B. F. C. C. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2056162 · Cited by 13

Advanced Complexity and Plasticity of Neural Activity in Reciprocally Connected Human Cerebral OrganoidsPreprint

Osaki, T., & Ikeuchi, Y. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.16.431387 · Cited by 15

Editorial: Use of 3D Models in Drug Development and Precision Medicine - Advances and Outlook

Prina‐Mello, A., Bonacina, L., Staedler, D., & Movia, D. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.658941 · Cited by 13

Development of a Novel Microfluidic Co-culture model to study Organoid VascularizationPreprint

Schulla, L., Alupoaie, E. D., de Silva, L. S., Gawlitta, D., Middendorp, S., Coffer, P. J., & Roukens, M. G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.25.485813 · Cited by 13

Dynamics and plasticity of stem cells in the regenerating human colonic epitheliumPreprint

Oost, K. C., Kahnwald, M., Barbiero, S., de Medeiros, G., Suppinger, S., Kalck, V., Meylan, L. C., Smallwood, S. A., Stadler, M. B., & Liberali, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.18.572103 · Cited by 14

Standard: Human gastric organoids

Hong, F., Tan, R., Wang, T., Zhong, N., Zhao, H., Xu, R., Shen, L., Liu, Y., Yao, X., Xiang, D., et al. (2025) · Cell Regeneration · doi:10.1186/s13619-024-00218-6 · Cited by 13

Fluorescence-based Single-cell Analysis of Whole-mount-stained and Cleared Microtissues and Organoids for High Throughput Screening

Renner, H., Otto, M., Grabos, M., Schöler, H., & Bruder, J. (2021) · BIO-PROTOCOL · doi:10.21769/bioprotoc.4050 · Cited by 12

Diversity of human skin three-dimensional organotypic cultures

Jia, Y. Y., & Atwood, S. X. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102275 · Cited by 12

Organotypic cultures as aging associated disease models

Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

Chau, C. W., To, A., Au-Yeung, R. K. H., Tang, K., Xiang, Y., Ruan, D., Zhang, L., Wong, H., Zhang, S., Au, M. T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-59405-9 · Cited by 12

Organoids As Promising Tools In Therapy

Shravani, P. S. D. K. (2023) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.8278935

New developments and applications of human organoids

Andersson-Rolf, A., & Clevers, H. C. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-00974-0 · Cited by 25

Clinical applications of human organoids

Verstegen, M. M. A., Coppes, R. P., Béghin, A., Coppi, P. D., Gerli, M., de Graeff, N., Pan, Q., Saito, Y., Shi, S., ZADPOOR, A. A., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03489-3 · Cited by 230

Human organoids: a new dimension in cell biology

Lehmann, R., Lee, C. M., Shugart, E. C., Benedetti, M., Charo, R. A., Gartner, Z. J., Hogan, B. L. M., Knoblich, J. A., Nelson, C. M., & Wilson, K. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-03-0135 · Cited by 158

The organoid cell atlas

the Human Cell Atlas ‘Biological Network’ Organoids, Bock, C., Boutros, M., Camp, J. G., Clarke, L., Clevers, H., Knoblich, J. A., Liberali, P., Regev, A., Rios, A. C., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-00762-x · Cited by 171