The DOI matches its Crossref record; 207 of the 210 references it cites were found in a registry or an index.
Human organoids: model systems for human biology and medicine
Open accessAbstract
The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids - which are stem cell-derived 3D culture systems - it is now possible to re-create the architecture and physiology of human organs in remarkable detail. Human organoids provide unique opportunities for the study of human disease and complement animal models. Human organoids have been used to study infectious diseases, genetic disorders and cancers through the genetic engineering of human stem cells, as well as directly when organoids are generated from patient biopsy samples. This Review discusses the applications, advantages and disadvantages of human organoids as models of development and disease and outlines the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In particular, for cancer treatment, several different patient-derived organoid models tested, including but not limited to: pancreas, colorectal and liver cancer all exhibit heterogeneous responses to known chemotherapeutic and anticancer agents49,132,212.”
From Organoids (2022) · cites this paper as [212]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Meanwhile, being entirely derived from human cells, these organoids can fully replicate human biology and potentially reduce the translational barriers from experimental findings to therapeutic applications (20–22), offering advantages over animal models (23–25).”
From Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems (2025) · cites this paper as [20]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The versatile skin OTC-based platform is ideally suited for investigating a broad range of physiological and pathological scenarios, presenting significant potential for advancing our understanding of skin developmental biology, disease modeling, and applications in regenerative medicine [69–71].”
From Diversity of human skin three-dimensional organotypic cultures (2024) · cites this paper as [71]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,745
Research works printed but not linked: 1
- Rotavirus vaccines. WHO position paper—January 2013. Wkly. Epidemiol. Rec. 88, 49–64 (2013).
Cited by
Sorted by citations
Items 701–800 of 1,003
Zhao, W., Li, B., Hao, J., Sun, R., He, P., Lv, H., He, M., Shen, J., & Han, Y. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108652 · Cited by 18
EphA3 CAR T cells are effective against glioblastoma in preclinical models
Martins, J. P., D’Souza, R. C. J., Skarne, N., Lekieffre, L., Horsefield, S., Ranjankumar, M., Li, X. O., Le, T. T., Smith, F., Smith, C., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009403 · Cited by 19
He, Y., Liu, D., Ling, A., Han, Z., Cui, J., Cheng, J., Feng, Y., Liu, W., Gong, W., Xia, Y., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07789-5 · Cited by 18
Manokawinchoke, J., Limraksasin, P., Okawa, H., Pavasant, P., Egusa, H., & Osathanon, T. (2022) · International Journal of Oral Science · doi:10.1038/s41368-021-00151-3 · Cited by 18
Research Advances in Gametogenesis and Embryogenesis Using Pluripotent Stem Cells
Luo, Y., & Yu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.801468 · Cited by 18
Development of patient derived organoids for cancer drug screening applications
Baskar, G., Palaniyandi, T., Viswanathan, S., Rajendran, B. K., Ravi, M., & Sivaji, A. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151895 · Cited by 18
Lou, X., Zhou, Q., Dong, Z., Bai, L., Su, J., & Yue, H. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.07.010 · Cited by 17
Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids
Wan, L., Kral, A. J., Voss, D., Schäfer, B., Sudheendran, K., Danielsen, M., Caruthers, M. H., & Krainer, A. R. (2024) · Nucleic Acid Therapeutics · doi:10.1089/nat.2023.0070 · Cited by 17
Celotti, M., Derks, L. L. M., van Es, J., van Boxtel, R., Clevers, H., & Geurts, M. H. (2024) · STAR Protocols · doi:10.1016/j.xpro.2024.103189 · Cited by 17
Establishment and characterization of endometrial organoids from different placental types
Kwon, D.-H., Lim, B., Lee, S.-Y., Won, S., & Jang, G. (2025) · BMB Reports · doi:10.5483/bmbrep.2024-0141 · Cited by 17
Microvascularization in 3D Human Engineered Tissue and Organoids
Shin, Y. J., Safina, D., Zheng, Y. Y., & Levenberg, S. (2025) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-103023-115236 · Cited by 18
Marconi, G. D., Mazzone, A., Rocca, Y. D., Trubiani, O., Pizzicannella, J., & Diomede, F. (2025) · Biology · doi:10.3390/biology14070875 · Cited by 17
Ariño, S., Ferrer‐Lorente, R., Serrano, G., Zanatto, L., de la Torre, R. A. M. G., Gratacós‐Ginès, J., Rubio, A. B., Pérez-Guasch, M., Mateos-Sánchez, C., Aguilar‐Bravo, B., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.07.014 · Cited by 19
Biomineralization empowers bone organoids
Zhu, M., Fan, Z., Chen, M., Xu, K., Jiang, Y., & Su, J. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123703 · Cited by 17
van Tienderen, G. S., Willemse, J., van Loo, B., van Hengel, E. V. A., de Jonge, J., van der Laan, L. J. W., Leijten, J., & Verstegen, M. M. A. (2022) · Cells · doi:10.3390/cells11223657 · Cited by 17
Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids
Ouchi, R., & Koike, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1133534 · Cited by 17
Preclinical Models of Neuroendocrine Prostate Cancer
Cacciatore, A., Albino, D., Catapano, C. V., & Carbone, G. M. (2023) · Current Protocols · doi:10.1002/cpz1.742 · Cited by 17
Proteomics-wise, how similar are mouse and human platelets?
Martínez-Botía, P., Villar, P., Carbajo-Argüelles, G., Jaiteh, Z., Acebes‐Huerta, A., & Gutiérrez, L. (2023) · Platelets · doi:10.1080/09537104.2023.2220415 · Cited by 17
Organoids as complex (bio)systems
Fernandes, T. G. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1268540 · Cited by 18
Endothelialized Bronchioalveolar Lung Organoids Model Endothelial Cell Responses to Injury
Ament, A.-L., Heiner, M., Hessler, M. C., Alexopoulos, I., Steeg, K., Gärtner, U., Vazquez-Armendariz, A. I., & Herold, S. (2025) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0373ma · Cited by 17
Emerging biotechnologies for engineering liver organoids
Zhao, J., Zhi, Y., Ren, H., Wang, J., & Zhao, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.11.002 · Cited by 19
Generation, interrogation, and future applications of microglia-containing brain organoids
Stefano, J. D., Marco, F. D., Cicalini, I., FitzGerald, U., Pieragostino, D., Verhoye, M., Ponsaerts, P., & Breedam, E. V. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00921 · Cited by 17
Cho, J., Park, J. J., Seo, E., Lee, O., Cho, T.-J., Kim, J. Y., Bae, H. C., Lee, E., Park, Y., Jang, H., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.028 · Cited by 17
Self-citationRole of NDE1 in the Development and Evolution of the Gyrified Cortex
Soto‐Perez, J., Baumgartner, M., & Kanadia, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.617513 · Cited by 17
Yoo, G., Park, D., Kim, Y., & Chung, C. (2021) · Cancers · doi:10.3390/cancers13123069 · Cited by 17
Zeidler, M., Kummer, K. K., Schöpf, C. L., Kalpachidou, T., Kern, G., Cader, M. Z., & Kress, M. (2021) · Advanced Science · doi:10.1002/advs.202102354 · Cited by 18
Organoid Models for Cancer Research—From Bed to Bench Side and Back
Kastner, C., Hendricks, A., Deinlein, H., Hankir, M. K., Germer, C., Schmidt, S., & Wiegering, A. (2021) · Cancers · doi:10.3390/cancers13194812 · Cited by 18
Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?
Marrazzo, P., Cricca, M., & Nastasi, C. (2021) · Pathogens · doi:10.3390/pathogens10101233 · Cited by 17
Bekhite, M. M., & Schulze, P. C. (2021) · Cells · doi:10.3390/cells10123483 · Cited by 21
Tischler, J., Swank, Z., Hsiung, H.-A., Vianello, S., Lutolf, M., & Maerkl, S. J. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100244 · Cited by 15
Ding, X., Pu, Y., Tang, M., & Zhang, T. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159329 · Cited by 17
Standard: Human intestinal organoids
Wang, Y., Lin, H., Zhao, L., Hong, F., Hao, J., Zhang, Z., Sheng, W., Song, L., Deng, C., Zhao, B. T., et al. (2023) · Cell Regeneration · doi:10.1186/s13619-023-00168-5 · Cited by 19
Rogulska, O. Y., Havelkova, J., & Petrenko, Y. (2023) · Cryoletters · doi:10.54680/fr23210110112 · Cited by 17
The challenge of making the right choice: patient avatars in the era of cancer immunotherapies
Kayser, C., Bräuer, A., Susanne, S., & Wandmacher, A. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1237565 · Cited by 17
Organoids as a new approach for improving pediatric cancer research
Lampis, S., Galardi, A., Paolo, V. D., & Giannatale, A. D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1414311 · Cited by 16
Bjerring, J. S., Khodour, Y., Peterson, E. A., Sachs, P. C., & Bruno, R. D. (2025) · FEBS Journal · doi:10.1111/febs.70002 · Cited by 16
Skeletal muscle, neuromuscular organoids and assembloids: a scoping review
Yang, J.-L., Qian, S.-Y., Chen, M.-L., Wang, L., Wang, Y., Liu, J., Xi, C., Yang, Y., Li, Y., Gao, C., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105825 · Cited by 16
Zeng, J., Hu, K., Wang, Z., Huang, Y.-C., Zhang, Y., Peng, H., & Ma, S. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00086 · Cited by 18
Ringnalda, F. C. A. S., van Son, G. J. F., Verweij, L. H. G., Kim, S., Amo-Addae, V., Flucke, U. E., Hiemcke‐Jiwa, L. S., Langenberg, K. P. S., Bramer, J. A. M., Heimans, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62673-2 · Cited by 20
Iteration of Tumor Organoids in Drug Development: Simplification and Integration
Zhao, R., Feng, Q., Xia, Y., Liao, L., & Xie, S. (2025) · Pharmaceuticals · doi:10.3390/ph18101540 · Cited by 17
Qin, Y., Li, J., Heng, Y., Wang, Z., Wu, D., Rahman, M., Hu, P., Plötz, T., Hopp, A. V., Kurniawan, N. A., et al. (2025) · BMC Biology · doi:10.1186/s12915-025-02411-8 · Cited by 16
Hou, C., Sha, W., Xu, Z., Hu, Y., Amakye, W. K., Yao, M., & Ren, J. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131634 · Cited by 16
Toward Human Models of Cardiorenal Syndrome in vitro
Gabbin, B., Meraviglia, V., Mummery, C. L., Rabelink, T. J., van Meer, B. J., van den Berg, C. W., & Bellin, M. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.889553 · Cited by 16
Kim, Y., Jung, S., Park, G., Shin, H., Heo, S. C., & Kim, Y. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109248 · Cited by 16
Advances in Tumor Organoids for the Evaluation of Drugs: A Bibliographic Review
Londoño-Berrío, M., Castro, C. I., Cañas, A. I., Ortiz, I., & Osorio, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122709 · Cited by 16
3D Models of Sarcomas: The Next-generation Tool for Personalized Medicine
Xu, R., Chen, R., Tu, C., Gong, X. Y., Liu, Z., Mei, L., Ren, X., & Li, Z. (2023) · Phenomics · doi:10.1007/s43657-023-00111-3 · Cited by 16
Intranasal mask for protecting the respiratory tract against viral aerosols
Hu, X., Wang, S., Fu, S., Qin, M., Lyu, C., Ding, Z., Wang, Y., Wang, Y., Wang, D., Zhu, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44134-w · Cited by 17
A clustering and graph deep learning-based framework for COVID-19 drug repurposing
Bansal, C., Deepa, P. R., Agarwal, V., & Chandra, R. (2024) · Expert Systems with Applications · doi:10.1016/j.eswa.2024.123560 · Cited by 16
Lin, X., Guan, T., Xu, Y., Li, Y., Lin, Y., Chen, S., Chen, Y., Wei, X., Li, D., Cui, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1337489 · Cited by 17
Kim, H.-Y., Charton, C., Shim, J. H., Lim, S. Y., Kim, J.-H., Lee, S., Ohn, J. H., Kim, B., & Heo, C. Y. (2024) · Cells · doi:10.3390/cells13090729 · Cited by 18
Self-citationModeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Kim, J.-T., Song, K., Han, S. W., Youn, D. H., Jung, H., Kim, K., Lee, H., Hong, J. Y., Cho, Y.-J., Kang, S., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01252-2 · Cited by 16
Self-citationPharmacological Approaches to Hearing Loss
Cederroth, C. R., Dyhrfjeld‐Johnsen, J., & Canlon, B. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001195 · Cited by 18
A novelin vitrotubular model to recapitulate features of distal airways: the bronchioid
Maurat, É., Raasch, K., Leipold, A. M., Henrot, P., Zysman, M., Prével, R., Trian, T., Krammer, T., Bergeron, V., Thumerel, M., et al. (2024) · European Respiratory Journal · doi:10.1183/13993003.00562-2024 · Cited by 16
Seyfoori, A., Amereh, M., Dabiri, S. M. H., Askari, E., Walsh, T., & Akbari, M. (2020) · Biomaterials Science · doi:10.1039/d0bm01616k · Cited by 16
Functional patient-derived cellular models for neuropsychiatric drug discovery
Lago, S. G., Tomasik, J., & Bahn, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01243-8 · Cited by 16
Polydopamine-based biofunctional substrate coating promotes mesenchymal stem cell migration
Deng, Z., Wang, W., Xu, X., Ma, N., & Lendlein, A. (2021) · MRS Advances · doi:10.1557/s43580-021-00091-4 · Cited by 16
Microwell bag culture for large-scale production of homogeneous islet-like clusters
Suenaga, R., Konagaya, S., Yamaura, J., Ito, R., Tanaka, S., Ishizaki, Y., & Toyoda, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-09124-w · Cited by 16
Dyer, L., Parker, A. J., Paphiti, K., & Sanderson, J. (2022) · Current Protocols · doi:10.1002/cpz1.448 · Cited by 17
The use of organoids in food research
Stanton, J. E., & Grabrucker, A. M. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100977 · Cited by 16
Irrechukwu, O. (2023) · ALTEX · doi:10.14573/altex.2204071 · Cited by 18
Kusakabe, M., Taguchi, A., Tanikawa, M., Hoshi, D., Tsuchimochi, S., Qian, X., Toyohara, Y., Kawata, A., Wagatsuma, R., Yamaguchi, K., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.5588 · Cited by 16
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes
Wang, C., Khatun, M. S., Zhang, Z., Allen, M. J., Chen, Z., Ellsworth, C. R., Currey, J. M., Dai, G., Tian, D., Bach, K., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05626-z · Cited by 16
From NAFLD to MAFLD: Aligning Translational In Vitro Research to Clinical Insights
Gatzios, A., Rombaut, M., Buyl, K., De Kock, J., Rodrigues, R. M., Rogiers, V., Vanhaecke, T., & Boeckmans, J. (2022) · Biomedicines · doi:10.3390/biomedicines10010161 · Cited by 15
Omran, M. M., Vafaei, S., Alkhrait, S., Ali, F. L., Bariani, M. V., Bai, T., Thompson, W. E., Yang, Q., Ali, M. R., & Al-Hendy, A. A. (2025) · Cell Proliferation · doi:10.1111/cpr.70025 · Cited by 15
Vascular microphysiological systems (MPS): biologically relevant and potent models
Breuil, L., Kitada, A., Yadav, S., Zhou, H., Fujimoto, K., & Yokokawa, R. (2025) · Lab on a Chip · doi:10.1039/d5lc00014a · Cited by 15
Richards, C., Chen, H., O’Rourke, M. B., Bannister, A., Owen, G., Volkerling, A. M., Ghosh, A., Gorrie, C. A., Gallego‐Ortega, D., Bottomley, A. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62996-0 · Cited by 15
Li, Q., Nikolova, M. T., Zhang, G., Červenka, I., Valigi, F., Bürri, D., Plantier, E., Mazzoleni, A., Lamouline, A., Schwaller, J., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.009 · Cited by 16
Temporal tissue dynamics from a spatial snapshot
Somer, J., Mannor, S., & Alon, U. (2026) · Nature · doi:10.1038/s41586-025-09876-1 · Cited by 20
FRC-QE: a robust and comparable 3D microscopy image quality metric for cleared organoids
Preußer, F., dos Santos, N., Contzen, J., Stachelscheid, H., Costa, É. T., Mergenthaler, P., & Preibisch, S. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btab160 · Cited by 17
Nii, T., & Tabata, Y. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.11.006 · Cited by 16
A cryopreservation method for bioengineered 3D cell culture models
Herrero-Gómez, A., Azagra, M., & Marco‐Rius, I. (2022) · Biomedical Materials · doi:10.1088/1748-605x/ac76fb · Cited by 15
Ngo, H. T., Amartumur, S., Tran, V. T. A., Tran, M., Diep, Y. N., Cho, H., & Lee, L. P. (2023) · Biosensors · doi:10.3390/bios13020231 · Cited by 15
Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids
Co, J. Y., Klein, J. A., Kang, S., & Homan, K. A. (2023) · Advanced Biology · doi:10.1002/adbi.202200333 · Cited by 15
Ito, F., Kato, K., Yanatori, I., Maeda, Y. K., Murohara, T., & Toyokuni, S. (2023) · BMC Cancer · doi:10.1186/s12885-023-10966-4 · Cited by 15
Kim, J. Y., Rosenberger, M. G., Rutledge, N. S., & Esser-Kahn, A. P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061687 · Cited by 15
Self-citationBioengineering translational models of lymphoid tissues
Michaels, Y. S., Buchanan, C. F., Gjorevski, N., & Moisan, A. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00101-0 · Cited by 16
Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing
Fashemi, B., van Biljon, L., Rodriguez, J., Graham, O., Mullen, M., & Khabele, D. (2023) · Journal of Visualized Experiments · doi:10.3791/65068 · Cited by 15
Bioengineering toolkits for potentiating organoid therapeutics
Park, S., & Cho, S. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115238 · Cited by 18
Şenkal, S., Okumuş, E. B., Aydın, M., Türkmen, N. B., Taşlıdere, A., Şahi̇n, F., Yılmaz, Ş., Süt, P. A., & Doğan, A. (2024) · Advanced Science · doi:10.1002/advs.202407567 · Cited by 15
Chen, D., Li, G., Luo, L., Liu, K., Chu, X., Liu, K., Lai, T., Liao, Y., Lin, X., & Chen, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156155 · Cited by 15
OrganoLabeler: A Quick and Accurate Annotation Tool for Organoid Images
Kahveci, B., Polatlı, E., Baştanlar, Y., & Güven, S. (2024) · ACS Omega · doi:10.1021/acsomega.4c06450 · Cited by 15
Model Organoids: Integrated Frameworks for the Next Frontier of Healthcare Advancements
Bhattacharya, R., Bose, D., Kaur, T., Patel, R., Renuka, O., & Rodriguez, R. V. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10814-3 · Cited by 15
Liu, C., Dong, F., Sun, J., Li, G., Du, R., Zuo, X., Zhang, K., Zhang, W., Wang, S., Li, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03021-2 · Cited by 15
Cougnoux, A., Mahmoud, L., Johnsson, P. A., Eroğlu, A., Gsell, L., Rosenbauer, J., Sandberg, R., & Hausser, J. (2025) · Scientific Reports · doi:10.1038/s41598-024-83989-x · Cited by 17
Organoids in cancer therapies: a comprehensive review
Xin-Yi, J., Yan-Ran, W., Pin-Ru, D., Shi-Yi, Q., & Jiang, H. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1607488 · Cited by 17
Challenges and Opportunities in NUT Carcinoma Research
Gu, B., & Hakun, M. (2021) · Genes · doi:10.3390/genes12020235 · Cited by 15
Okita, Y., Zheng, L., Kawanishi, K., Miyoshi, H., Yanagihara, K., & Kato, M. (2021) · Genes to Cells · doi:10.1111/gtc.12843 · Cited by 15
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids
Trevisan, M., Riccetti, S., Sinigaglia, A., & Barzon, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052356 · Cited by 16
Esmail, S., & Danter, W. R. (2021) · Biomedicines · doi:10.3390/biomedicines9040440 · Cited by 15
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19
Barrantes, F. J. (2021) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-102620-080956 · Cited by 15
Miloradović, D., Pavlović, D., Gazdic, M., Nikolić, S., Papić, M., Milivojević, N. N., Stojković, M., & Ljujić, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.709183 · Cited by 15
Lee, H., Im, J. S., Choi, D. B., & Woo, D. (2021) · Organoid · doi:10.51335/organoid.2021.1.e11 · Cited by 17
Multicellular modules as clinical diagnostic and therapeutic targets
Baertsch, M., Nolan, G. P., & Hickey, J. W. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.11.004 · Cited by 16
Patient-derived organoids as a model for tumor research
Wang, J., Feng, X., Li, Z., Chen, Y., & Huang, W. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.03.004 · Cited by 15
Bokhari, R. S., Beheshti, A., Blutt, S. E., Bowles, D. E., Brenner, D., Britton, R. A., Bronk, L. F., Cao, X., Chatterjee, A., Clay, D. E., et al. (2022) · Life Sciences in Space Research · doi:10.1016/j.lssr.2022.08.003 · Cited by 15
Lung organoids: current strategies for generation and transplantation
Demchenko, A. G., Лавров, А. В., & Smirnikhina, S. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03686-x · Cited by 15
Shim, J. Y., Chung, J. O., Jung, D., Kang, P. S., Park, S., Kendi, A. T., Lowe, V. J., & Lee, S. B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281496 · Cited by 16
Microfabricated sensors for non-invasive, real-time monitoring of organoids
Kim, Y., Chica, E., & Lee, H. J. (2024) · Micro and Nano Systems Letters · doi:10.1186/s40486-024-00216-y · Cited by 14
Current Development of iPSC-Based Modeling in Neurodegenerative Diseases
Guo, X., Wang, X., Wang, J., Ma, M., & Ren, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083774 · Cited by 15
A systems view of cellular heterogeneity: Unlocking the “wheel of fate”
Movasat, H., Giacopino, E., Shahdoost, A., Nokoorani, Y. D., Abrbekouh, A. H., Tahamtani, Y., & Shakiba, N. (2025) · Cell Systems · doi:10.1016/j.cels.2025.101300 · Cited by 15
Metadata
- Authors
- Kim, J., Koo, B.-K., & Knoblich, J. A.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Corresponding author
- Koo, Bon-Kyoung
- Knoblich, Juergen A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-07-07
- Volume
- 21
- Issue
- 10
- Pages
- 571-584
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC7339799
- OpenAlex
- W3040646360
- Cited by
- 2,187
- References
- 210
- Citations by year
- 2026: 311 · 2025: 410 · 2024: 409 · 2023: 381 · 2022: 352 · 2021: 291 · 2020: 31
- FWCI
- 25.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund (Z_153_B09)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- human organoids, stem cell-derived organoids, alternative to animal models, disease modeling, organogenesis, infectious diseases, genetic disorders, tumor models, patient-derived organoids, drug discovery
- MeSH terms
- Animals, Biology, Communicable Diseases, Genetic Engineering, Humans, Medicine, Neoplasms, Organoids, Stem Cells, Genetic Diseases, Inborn
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
