Human organoids: model systems for human biology and medicine

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,745

Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials

Amorim, M. J. B., Peijnenburg, W. J. G. M., Greco, D., Saarimäki, L. A., Dumit, V. I., Bahl, A., Haase, A., Tran, L., Hackermüller, J., Canzler, S., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101735 · Cited by 27

Animal Models of Human Disease

Green, S. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009025836 · Cited by 27

Modelling Mitochondrial Disease in Human Pluripotent Stem Cells: What Have We Learned?

McKnight, C. L., Low, Y. C., Elliott, D. A., Thorburn, D. R., & Frazier, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147730 · Cited by 27

A pillar/perfusion plate enhances cell growth, reproducibility, throughput, and user friendliness in dynamic 3D cell culture

Lekkala, V. K. R., Kang, S.-Y., Liu, J., Shrestha, S., Acharya, P., Joshi, P., Zolfaghar, M., Lee, M., Vanga, M. G., Jamdagneya, P., et al. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00179 · Cited by 25

The composition and roles of gastric stem cells in epithelial homeostasis, regeneration, and tumorigenesis

Liu, M., Liu, Q., Zou, Q., Li, J., Chu, Z., Xiang, J., Chen, W., Miao, Z., & Wang, B. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00802-z · Cited by 25

Modeling lung adenocarcinoma metastases using patient-derived organoids

Liu, Y., Lankadasari, M. B., Rosiene, J. A., Johnson, K. E., Zhou, J., Bapat, S., Chow-Tsang, L.-F., Tian, H., Mastrogiacomo, B., He, D., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101777 · Cited by 25

Patient-Derived Organoids: A Game-Changer in Personalized Cancer Medicine

Abbasian, M. H., Sobhani, N., Sisakht, M. M., D’Angelo, A., Sirico, M., & Roudi, R. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10805-4 · Cited by 28

Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids

Scalise, M., Cianflone, E., Quercia, C., Pagano, L., Chiefalo, A., Stincelli, A., Torella, A., Puccio, B., Santamaria, G., Guzzi, H. P., et al. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.112007 · Cited by 27

Droplet-based 3D bioprinting for drug delivery and screening

Xu, H., Zhang, S., Song, K., Yang, H., Yin, J., & Huang, Y. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115486 · Cited by 25

Perspective of 3D culture in medicine: transforming disease research and therapeutic applications

Park, C. H., Park, J. H., & Suh, Y. J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1491669 · Cited by 26

The Life of a Kidney Podocyte

Loreth, D., Sachs, W., & Meyer‐Schwesinger, C. (2025) · Acta Physiologica · doi:10.1111/apha.70081 · Cited by 27

Artificial intelligence-, organoid-, and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges

Elfatimi, E., Lekbach, Y., Prakash, S., Karan, S., Dorotta, J. C., Garcia, A., Suoth, B. S., Maurya, C., Omorogieva, E., Ng, S. X. L., et al. (2025) · Frontiers in Artificial Intelligence · doi:10.3389/frai.2025.1681106 · Cited by 28

Characterization of an in vitro 3D intestinal organoid model by using massive RNAseq-based transcriptome profiling

Lu, J. N., Křepelová, A., Rasa, S. M. M., Annunziata, F., Husak, O., Adam, L., Nunna, S., & Neri, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-96321-8 · Cited by 26

Scientific Validation and Clinical Application of Lung Cancer Organoids

Lee, D., Kim, Y., & Chung, C. (2021) · Cells · doi:10.3390/cells10113012 · Cited by 25

Paclitaxel resistance is mediated by NF‑κB on mesenchymal primary breast cancer cells

Esparza‐López, J., Longoria, O., la Cruz-Escobar, E. N. D., Garibay-Díaz, J. C., León‐Rodríguez, E., & Ibarra-Sánchez, M. D. J. (2021) · Oncology Letters · doi:10.3892/ol.2021.13168 · Cited by 25

Organoid Studies in COVID-19 Research

Kim, J., Koo, B., & Clevers, H. C. (2022) · International Journal of Stem Cells · doi:10.15283/ijsc21251 · Cited by 27

Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation

Pitstick, A. L., Poling, H. M., Sundaram, N., Lewis, P. L., Kechele, D. O., Sanchez, J. G., Scott, M. A., Broda, T. R., Helmrath, M. A., Wells, J. M., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.06.011 · Cited by 25

Immune Checkpoint Inhibitors: Recent Clinical Advances and Future Prospects

Banday, A. H., & Abdalla, M. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220819115849 · Cited by 25

Star Polymer Nanomedicines─Challenges and Future Perspectives

Forgham, H., Zhu, J., Qiao, R., & Davis, T. P. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.2c01291 · Cited by 26

Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease

Colozza, G., Park, S., & Koo, B. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00854-5 · Cited by 26

Lung Organoids in Smoking Research: Current Advances and Future Promises

Agraval, H., & Chu, H. W. (2022) · Biomolecules · doi:10.3390/biom12101463 · Cited by 25

Organoid technology and applications in lung diseases: Models, mechanism research and therapy opportunities

Chen, J., & Na, F. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1066869 · Cited by 25

Therapeutic Potential of Human Intestinal Organoids in Tissue Repair Approaches in Inflammatory Bowel Diseases

Rutherford, D. G., & Ho, G. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad044 · Cited by 26

Cutoff value of IC50 for drug sensitivity in patient-derived tumor organoids in colorectal cancer

Tang, Y., Wang, T., Hu, Y., Ji, H., Yan, B., Hu, X., Zeng, Y., Hao, Y., Xue, W., Chen, Z., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107116 · Cited by 26

Cell Culture Model Evolution and Its Impact on Improving Therapy Efficiency in Lung Cancer

Roman, V., Mihaila, M. A., Radu, N., Marineata, S., Diaconu, C. C., & Bostan, M. (2023) · Cancers · doi:10.3390/cancers15204996 · Cited by 26

Use and application of organ-on-a-chip platforms in cancer research

Yu, Y., Zhou, T., & Cao, L.-L. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00790-7 · Cited by 28

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells

Grau-Expósito, J., Perea, D., Suppi, M., Massana, N., Vergara, A., Soler, M. J., Trinité, B., Blanco, J., García‐Pérez, J., Alcamı́, J., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010171 · Cited by 27

Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects

Morais, A. S., Mendes, M., Cordeiro, M. A., Sousa, J., Pais, A. A. C. C., Mihaila, S. M., & Vitorino, C. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050615 · Cited by 25

Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs

Jin, Y., Li, F., Li, Z., Ikezu, T. C., O’Leary, J., Selvaraj, M., Zhu, Y., Martens, Y. A., Koga, S., Santhakumar, H., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk3700 · Cited by 26

The deLIVERed promises of gene therapy: Past, present, and future of liver-directed gene therapy

Puzzo, F., & Kay, M. A. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.041 · Cited by 26

Cell reprogramming: methods, mechanisms and applications

Zhu, F., & Nie, G. (2025) · Cell Regeneration · doi:10.1186/s13619-025-00229-x · Cited by 26

Human Organoids as an Emerging Tool for Genome Screenings

Andreatta, F., Hendriks, D. F. G., & Artegiani, B. (2025) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-103023-122327 · Cited by 24

Patient-Derived Organoid Biobanks for Translational Research and Precision Medicine: Challenges and Future Perspectives

Paola, F. J. D., Calafato, G., Piccaluga, P. P., Tallini, G., & Rhoden, K. J. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15080394 · Cited by 25

A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer

Chan, B. K. C., Zhang, C., Poon, C. H., Lee, M. H. Y., Chu, H. Y., Wang, B., Chen, S.-G., Yan, H. H. N., Leung, S. Y., & Wong, A. S. L. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.08.006 · Cited by 25

Three-Dimensional Culture Models to Study Innate Anti-Tumor Immune Response: Advantages and Disadvantages

Poggi, A. D., Villa, F., Fernandez, J. L. C., Costa, D., Zocchi, M. R., & Benelli, R. (2021) · Cancers · doi:10.3390/cancers13143417 · Cited by 25

3D printed porous microgel for lung cancer cells culture in vitro

Hu, Q., Liu, X., Liu, H., Yang, L., Yuan, X., Chen, Y., Wu, W., Luo, J. C., Long, J., Huang, M., et al. (2021) · Materials & Design · doi:10.1016/j.matdes.2021.110079 · Cited by 24

Designing highly customizable human based platforms for cell culture using proteins from the amniotic membrane

Deus, I. A., Santos, S. C., Custódio, C. A., & Mano, J. F. (2021) · Biomaterials Advances · doi:10.1016/j.msec.2021.112574 · Cited by 24

Evaluation of immunotherapies improving macrophage anti-tumor response using a microfluidic model

Chernyavska, M., Hermans, C. K. J. C., Chan, C., Baumann, N., Rösner, T., Leusen, J. H. W., Valerius, T., & Verdurmen, W. P. R. (2022) · Organs-on-a-Chip · doi:10.1016/j.ooc.2022.100019 · Cited by 25

Upgrading a Consumer Stereolithographic 3D Printer to Produce a Physiologically Relevant Model with Human Liver Cancer Organoids

Breideband, L., Wächtershäuser, K. N., Hafa, L., Wieland, K., Frangakis, A. S., Stelzer, E. H. K., & Pampaloni, F. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202200029 · Cited by 24

Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes

Pietrobon, A., Yockell‐Lelièvre, J., Flood, T. A., & Stanford, W. L. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111048 · Cited by 24

Next generation patient derived tumor organoids

Podaza, E., Kuo, H., Nguyen, J., Elemento, O., & Martín, M. L. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.003 · Cited by 26

Bio-chemo-mechanical coupling models of soft biological materials: A review

Sun, S.-Y., Zhang, H., Fang, W. P., Chen, X., Li, B., & Feng, X. (2022) · Advances in applied mechanics · doi:10.1016/bs.aams.2022.05.004 · Cited by 24

All‐in‐one microfluidic design to integrate vascularized tumor spheroid into high‐throughput platform

Kim, Y., Ko, J., Shin, N., Park, S., Lee, B., Kim, S., Song, J., Lee, S.-J., Kang, K., Lee, J., et al. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28221 · Cited by 24

Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host–pathogen interactions in the bat airway epithelium

Chan, L., Gamage, A. M., Tan, C. W., Tan, K. S., Liu, J., Tay, D. J. W., Foo, R., Rénia, L., Wang, D. Y., & Wang, L. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2148561 · Cited by 24

Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson’s disease patient-derived iPSCs

Patikas, N., Ansari, R. A., & Metzakopian, E. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.06.001 · Cited by 24

Recent advances in lung-on-a-chip technology for modeling respiratory disease

Negrete, J. A. T., Das, P., Najafikhoshnoo, S., Zanganeh, S., & Esfandyarpour, R. (2023) · Bio-Design and Manufacturing · doi:10.1007/s42242-023-00241-7 · Cited by 24

Antitumor effect of luteolin proven by patient‐derived organoids of gastric cancer

Hao, X., Zu, M., Ning, J., Zhou, X., Gong, Y., Han, X., Meng, Q., Li, D., & Ding, S. (2023) · Phytotherapy Research · doi:10.1002/ptr.7963 · Cited by 24

In vivo biological analysis of cold plasma on allergenicity reduction of tropomyosin in shrimp

Cheng, J., Li, J., & Sun, D. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.137210 · Cited by 24

Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings

Milky, B., Zabolocki, M., Al‐Bataineh, S. A., van den Hurk, M., Greenberg, Z., Turner, L., Mazzachi, P., Williams, A., Illeperuma, I., Adams, R., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.01.013 · Cited by 24

Human‐based new approach methodologies to accelerate advances in nutrition research

Cassotta, M., Cianciosi, D., Elexpuru-Zabaleta, M., Elío, I., Cano, S. S., Giampieri, F., & Battino, M. A. (2024) · Food Frontiers · doi:10.1002/fft2.369 · Cited by 23

Design approaches for 3D cell culture and 3D bioprinting platforms

Sreepadmanabh, M., Arun, A. B., & Bhattacharjee, T. (2024) · Biophysics Reviews · doi:10.1063/5.0188268 · Cited by 23

Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium

Herms, A., Fernández‐Antorán, D., Alcolea, M. P., Kalogeropoulou, A., Banerjee, U., Piedrafita, G., Abby, E., Valverde-Lopez, J. A., Ferreira, I. S. D. S. R., Caseda, I., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01875-8 · Cited by 26

Cyborg organoids integrated with stretchable nanoelectronics can be functionally mapped during development

Lin, Z., Wang, W., Liu, R., Li, Q., Lee, J., Hirschler, C., & Jia Liu, B. (2025) · Nature Protocols · doi:10.1038/s41596-025-01147-7 · Cited by 26

Dynamic Hydrogels with Tunable Mechanics for 3D Organoid Derivation

Xie, X., Chen, X., Zhou, J. X., Wang, T., Yang, G., Han, F., & Zhao, W. (2025) · Small · doi:10.1002/smll.202501862 · Cited by 23

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

Song, Y., Jo, H., Jeong, S., Kim, I., & Lee, S. S. (2026) · Cell Proliferation · doi:10.1111/cpr.70161 · Cited by 23

Collective behaviours in organoids

Yang, Q., & Liberali, P. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.06.006 · Cited by 24

Beyond Mendelian Inheritance: Genetic Buffering and Phenotype Variability

Rossi, A., & Kontarakis, Z. (2021) · Phenomics · doi:10.1007/s43657-021-00030-1 · Cited by 23

Acoustically manipulating internal structure of disk-in-sphere endoskeletal droplets

Shakya, G., Yang, T., Gao, Y., Fajrial, A. K., Li, B., Ruzzene, M., Borden, M. A., & Ding, X. (2022) · Nature Communications · doi:10.1038/s41467-022-28574-4 · Cited by 23

A Green Synthesis of Carbene‐Metal‐Amides (CMAs) and Carboline‐Derived CMAs with Potent in vitro and ex vivo Anticancer Activity

Tzouras, N. V., Scattolin, T., Gobbo, A., Bhandary, S., Rizzolio, F., Cavarzerani, E., Canzonieri, V., Hecke, K. V., Vougioukalakis, G. C., Cazin, C. S. J., et al. (2022) · ChemMedChem · doi:10.1002/cmdc.202200135 · Cited by 24

Cell and Animal Models for SARS-CoV-2 Research

Bestion, E., Halfon, P., Mezouar, S., & Mège, J. (2022) · Viruses · doi:10.3390/v14071507 · Cited by 24

Brain organoid-on-a-chip: A next-generation human brain avatar for recapitulating human brain physiology and pathology

Song, J., Bang, S., Choi, N., & Kim, H. N. (2022) · Biomicrofluidics · doi:10.1063/5.0121476 · Cited by 25

Organoids of the male reproductive system: Challenges, opportunities, and their potential use in fertility research

Patrício, D., Santiago, J., Mano, J. F., & Fardilha, M. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1590 · Cited by 26

Step-by-step fabrication of heart-on-chip systems as models for cardiac disease modeling and drug screening

Deir, S., Mofrad, Y. M., Mashayekhan, S., Shamloo, A., & Mansoori-Kermani, A. (2023) · Talanta · doi:10.1016/j.talanta.2023.124901 · Cited by 23

Cellular agriculture for milk bioactive production

Yart, L., Wijaya, A. W., Lima, M. J., Haller, C., van der Beek, E. M., Carvalho, R. S., Kraus, M. R.-C., & Mashinchian, O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00112-x · Cited by 23

Developing 3D bioprinting for organs-on-chips

Wu, Z., Liu, R., Shao, N., & Zhao, Y. (2025) · Lab on a Chip · doi:10.1039/d4lc00769g · Cited by 24

Adipose Tissue Dysfunction Determines Lipotoxicity and Triggers the Metabolic Syndrome: Current Challenges and Clinical Perspectives

Carobbio, S., Pellegrinelli, V., & Vidal‐Puig, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_8 · Cited by 23

Assembly of glioblastoma tumoroids and cerebral organoids: a 3D in vitro model for tumor cell invasion

Kim, J., Kim, R., Lee, W., Kim, G. H., Jeon, S., Lee, Y. J., Lee, J. S., Kim, K. H., Won, J., Lee, W., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13740 · Cited by 26

Organoids technology in cancer research: from basic applications to advanced ex vivo models

Varinelli, L., Illescas, O., Lorenc, E., Battistessa, D., Bella, M. D., Zanutto, S., & Gariboldi, M. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1569337 · Cited by 23

New developments and applications of human organoids

Andersson-Rolf, A., & Clevers, H. C. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-00974-0 · Cited by 25

Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids

Wu, W., Yao, H., Dwivedi, I., Negraes, P. D., Zhao, H. W., Wang, J., Trujillo, C. A., Muotri, A. R., & Haddad, G. G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.593248 · Cited by 22

3-D Cell Culture Systems in Bone Marrow Tissue and Organoid Engineering, and BM Phantoms as In Vitro Models of Hematological Cancer Therapeutics—A Review

Janagama, D. G., & Hui, S. K. (2020) · Materials · doi:10.3390/ma13245609 · Cited by 22

Application of Human Induced Pluripotent Stem Cell-Derived Cellular and Organoid Models for COVID-19 Research

Luo, Y., Zhang, M., Chen, Y., Chen, Y., & Zhu, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720099 · Cited by 23

WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

Steinberg, D. J., & Aqeilan, R. I. (2021) · Cells · doi:10.3390/cells10113082 · Cited by 22

Human pluripotent stem cell registry: Operations, role and current directions

Kurtz, A., Mah, N., Chen, Y., Fuhr, A., Kobold, S., Seltmann, S., & Müller, S. C. (2022) · Cell Proliferation · doi:10.1111/cpr.13238 · Cited by 22

Systematically quantifying morphological features reveals constraints on organoid phenotypes

Beck, L. E., Lee, J., Cote, C. J., Dunagin, M. C., Lukonin, I., Salla, N., Chang, M., Hughes, A. J., Mornin, J. D., Gartner, Z. J., et al. (2022) · Cell Systems · doi:10.1016/j.cels.2022.05.008 · Cited by 22

The multifaceted role of LRRK2 in Parkinson's disease: From human iPSC to organoids

Oun, A., Sabogal-Guáqueta, A. M., Galuh, S., Alexander, A., Kortholt, A., & Dolga, A. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105837 · Cited by 23

Application of the transgenic pig model in biomedical research: A review

Wei, J., Zhang, W., Li, J., Jin, Y., & Qiu, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1031812 · Cited by 23

Bioengineering Human Pluripotent Stem Cell-Derived Retinal Organoids and Optic Vesicle-Containing Brain Organoids for Ocular Diseases

Arthur, P., Muok, L., Nathani, A., Zeng, E. Z., Sun, L. J., Li, Y., & Singh, M. S. (2022) · Cells · doi:10.3390/cells11213429 · Cited by 24

Constructing 3D In Vitro Models of Heterocellular Solid Tumors and Stromal Tissues Using Extrusion-Based Bioprinting

Flores-Torres, S., Jiang, T., Kort-Mascort, J., Yang, Y. K., Peza-Chavez, O., Pal, S., Mainolfi, A., Pardo, L. A., Ferri, L. E., Bertos, N., et al. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00998 · Cited by 25

Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

Basnayake, B. W. M. T. J., Leo, P., Rao, S., Vasani, S. S., Kenny, L., Haass, N. K., & Punyadeera, C. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02167-4 · Cited by 23

MorphoSim: an efficient and scalable phase-field framework for accurately simulating multicellular morphologies

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