Human organoids: model systems for human biology and medicine

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

THE GENETICS OF CAENORHABDITIS ELEGANS

Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,745

Recent Insights into Organoid-Derived Extracellular Vesicles and Their Biomedical Applications

Dayem, A. A., Kwak, Y., Jeun, H., & Cho, S. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15100492 · Cited by 12

Modeling neurodegenerative diseases with brain organoids: from development to disease applications

Larriba-González, T., García-Martín, M., Ojeda-Hernández, D. D., Rincón-Cerrada, P., Martín-Blanco, L., Benito‐Martín, M. S., Selma-Calvo, B., de la Fuente-Martín, S., Matías‐Guiu, J. A., Matías‐Guiu, J., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1663286 · Cited by 12

The evolving landscape of pharmacogenomics: Current achievements and future directions

Lauschke, V. M., & Ingelman‐Sundberg, M. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100122 · Cited by 13

Generalist biological artificial intelligence in modeling the language of life

Rao, V. M., Zhang, S., Plosky, B. S., Hsu, P. D., Wang, B., Zou, J., Žitnik, M., Topol, E. J., & Rajpurkar, P. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03064-w · Cited by 14

Building blocks to the future of regenerative medicine: Organoid bioprinting

Tan, N., & Yang, Y. Y. (2021) · Matter · doi:10.1016/j.matt.2021.06.042 · Cited by 12

Bioactive Porous Particles as Biological and Physical Stimuli for Bone Regeneration

Kim, M. J., Park, J., Lee, J., Kim, H., Choi, H., Lee, H., Lee, J. H., Byun, J., & Oh, S. H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00664 · Cited by 12

Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy

Sarmah, H., Sawada, A., Hwang, Y., Miura, A., Shimamura, Y., Tanaka, J., Yamada, K., & Mori, M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1070560 · Cited by 12

Pluripotent stem cells for target organ developmental toxicity testing

Wu, X., Chen, Y., Kreutz, A., Silver, B., & Tokar, E. J. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae037 · Cited by 12

Impact of Micro‐ and Nano‐Plastics on Human Intestinal Organoid‐Derived Epithelium

Wang, B., Iglesias‐Ledon, L., Bishop, M., Chadha, A., Rudolph, S., Longo, B. N., Cairns, D. M., Chen, Y., & Kaplan, D. L. (2024) · Current Protocols · doi:10.1002/cpz1.1027 · Cited by 12

Comparative Analysis of Olive-Derived Phenolic Compounds’ Pro-Melanogenesis Effects on B16F10 Cells and Epidermal Human Melanocytes

Cho, J., Bejaoui, M., Tominaga, K., & Isoda, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084479 · Cited by 12

Palladium(II)-Indenyl Complexes Bearing N-Heterocyclic Carbene (NHC) Ligands as Potent and Selective Metallodrugs toward High-Grade Serous Ovarian Cancer Models

Bortolamiol, E., Mauceri, M., Piccolo, R., Cavarzerani, E., Demitri, N., Donati, C., Gandin, V., Kranjc, S., Kamenšek, U., Čemažar, M., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01203 · Cited by 12

Generation of human-pig chimeric renal organoids using iPSC technology

Fujimori, K., Yamanaka, S., Shimada, K., Matsui, K., Kawagoe, S., Kuroda, T., Ikeda, A., Inoue, M., Kobayashi, E., & Yokoo, T. (2024) · Communications Biology · doi:10.1038/s42003-024-06986-w · Cited by 12

Exploring human pancreatic organoid modelling through single-cell RNA sequencing analysis

Cherubini, A., Rusconi, F., Piras, R., Wächtershäuser, K. N., Dossena, M., Barilani, M., Mei, C., Hof, L., Sordi, V., Pampaloni, F., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07193-3 · Cited by 13

Targeting fibroblast–endothelial cell interactions in LAM pathogenesis using 3D spheroid models and spatial transcriptomics

Koç-Günel, S., Liu, E. C., Gautam, L. K., Calvert, B. A., Murthy, S., Harriott, N. C., Nawroth, J. C., Zhou, B., Krymskaya, V. P., & Ryan, A. L. (2025) · JCI Insight · doi:10.1172/jci.insight.187899 · Cited by 12

Cost-reduction strategy to culture patient derived bladder tumor organoids

Sisakht, M. M., Gholizadeh, F., Hekmatirad, S., Mahmoudi, T., Montazeri, S., Sharifi, L., Daemi, H., Romal, S., Yazdi, M. H., Faramarzi, M. A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-87509-3 · Cited by 12

Replicating Host–Microbiome Interactions: Harnessing Organ-on-a-Chip and Organoid Technologies to Model Vaginal and Lung Physiology

Coxon, J., Linder, E., Sweet, C. W., Magness, S. T., & Green, L. N. (2025) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110122-122343 · Cited by 12

High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins

Skowronek, D., Pilz, R. A., Saenko, V. V., Mellinger, L., Singer, D., Ribback, S., Weise, A., Claaßen, K., Büttner, C., Brockmann, E. M., et al. (2025) · Angiogenesis · doi:10.1007/s10456-025-09985-5 · Cited by 12

A Concise Review of Organoid Tissue Engineering: Regenerative Applications and Precision Medicine

Makesh, K. Y., Navaneethan, A., Ajay, M., Munuswamy‐Ramanujam, G., Chinnasamy, A., Gnanasampanthapandian, D., & Palaniyandi, K. (2025) · Organoids · doi:10.3390/organoids4030016 · Cited by 12

Emerging roles of epigenetic regulators during lung development

Meng, G., Yin, W., Hong, Y., & Oliviero, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07823-6 · Cited by 13

Prenatal Development and Function of Human Mononuclear Phagocytes

Miah, M., Goh, I., & Haniffa, M. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.649937 · Cited by 13

Of form and function: Early cardiac morphogenesis across classical and emerging model systems

Shewale, B., & Dubois, N. C. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.025 · Cited by 12

An Improved Scalable Hydrogel Dish for Spheroid Culture

Valdoz, J. C., Jacobs, D. J., Cribbs, C. G., Johnson, B. C., Hemeyer, B. M., Dodson, E. L., Saunooke, J. A., Franks, N. A., Poulson, P. D., Garfield, S. R., et al. (2021) · Life · doi:10.3390/life11060517 · Cited by 12

Cytosine and adenosine base editing in human pluripotent stem cells using transient reporters for editing enrichment

Tekel, S. J., Brookhouser, N., Standage-Beier, K., Wang, X., & Brafman, D. A. (2021) · Nature Protocols · doi:10.1038/s41596-021-00552-y · Cited by 12

Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids—A New Method to Characterize the Metabolism of Brain Organoids?

Sapir, G., Steinberg, D. J., Aqeilan, R. I., & Katz‐Brull, R. (2021) · Pharmaceuticals · doi:10.3390/ph14090878 · Cited by 12

Plumbing our organs: Lessons from vascular development to instruct lab generated tissues

Ryan, A. R., & Cleaver, O. B. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.02.013 · Cited by 12

Concept development of an on-chip PET system

Clement, C., Birindelli, G., Pizzichemi, M., Pagano, F., Julio, M. K., Ziegler, S. I., Rominger, A., Auffray, E., & Shi, K. (2022) · EJNMMI Physics · doi:10.1186/s40658-022-00467-x · Cited by 13

Tissue Sampling and Homogenization with NIRL Enables Spatially Resolved Cell Layer Specific Proteomic Analysis of the Murine Intestine

Voß, H., Moritz, M., Pelczar, P., Gagliani, N., Huber, S., Nippert, V., Schlüter, H., & Hahn, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116132 · Cited by 12

Progress, prospects, and limitations of organoid technology

Park, J. H., Byeun, D. G., & Choi, J. K. (2022) · Organoid · doi:10.51335/organoid.2022.2.e9 · Cited by 12

A Bloody Conspiracy— Blood Vessels and Immune Cells in the Tumor Microenvironment

Terrassoux, L., Claux, H., Bacari, S., Meignan, S., & Furlan, A. (2022) · Cancers · doi:10.3390/cancers14194581 · Cited by 12

Animal Model Alternatives in Filovirus and Bornavirus Research

Widerspick, L., Steffen, J. F., Tappe, D., & Muñoz‐Fontela, C. (2023) · Viruses · doi:10.3390/v15010158 · Cited by 12

Cell-free DNA as a potential biomarker of differentiation and toxicity in cardiac organoids

Silver, B., Gerrish, K., & Tokar, E. J. (2023) · eLife · doi:10.7554/elife.83532 · Cited by 12

Advanced 3D In Vitro Lung Fibrosis Models: Contemporary Status, Clinical Uptake, and Prospective Outlooks

Jain, N., Bhushan, B. L. S., Natarajan, M., Mehta, R., Saini, D. K., & Chatterjee, K. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01499 · Cited by 13

Revolutionizing biomedical research: The imperative need for heart–kidney-connected organoids

Song, S.-S., Park, H., Kim, Y. K., & Kang, S. (2024) · APL Bioengineering · doi:10.1063/5.0190840 · Cited by 12

Reference method for off-line analysis of nitrogen oxides in cell culture media by an ozone-based chemiluminescence detector

Chmayssem, A., Monsalve, K., Alias, M., Mourier, V., Vignoud, S., Scomazzon, L., Muller, C. B., Barthes, J., Vrana, N. E., & Mailley, P. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-03102-9 · Cited by 12

Harnessing the power of microphysiological systems for COVID-19 research

Kleinstreuer, N., & Holmes, A. M. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.06.020 · Cited by 12

Direct Electromembrane Extraction‐Based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids

Skottvoll, F. S., Aizenshtadt, A., Hansen, F. A., Martinez, M. A., Andersen, J. M., Bogen, I. L., Kutter, J. P., Pedersen‐Bjergaard, S., Lundanes, E., Krauss, S. J. K., et al. (2021) · Analysis & Sensing · doi:10.1002/anse.202100051 · Cited by 12

High content 3D imaging method for quantitative characterization of organoid development and phenotypePreprint

Béghin, A., Grenci, G., Rajendiran, H., Delaire, T., Raffi, S. B. M., Blanc, D., Mets, R. D. M. D., Ong, H. T., Acharya, V., Sahini, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.26.437121 · Cited by 12

Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?

Galvan, A., Pellicciari, C., & Calderan, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021165 · Cited by 11

Artificial intelligence-enhanced bioavailability studies: Advancing the quality of food

Cheng, H., Liu, L., Zhang, H., Yang, Y., Bai, Y., Wang, S., Yang, M., Lu, W., Cheng, J., & Jin, Y. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105203 · Cited by 11

Organoids: physiologically relevant ex vivo models for viral disease research

Wang, Y., Peng, D., Li, M., Meng, Y., Li, T., Li, S., Qiu, H., & Li, L. (2025) · Journal of Virology · doi:10.1128/jvi.01132-25 · Cited by 11

The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic Diseases

Ma, Z., Xu, Q., & Xu, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s534574 · Cited by 12

Next-generation discovery: empowering organoid research with machine learning, artificial intelligence, and mathematical modeling

Ramesan, S. P., Poonacha, J. B., Pathirana, D., Merkt, S. J., Maaß, C., Hasenauer, J., & Reckzeh, E. S. (2026) · Trends in biotechnology · doi:10.1016/j.tibtech.2026.01.009 · Cited by 12

Assessment of Normal Tissue Radiosensitivity by Evaluating DNA Damage and Repair Kinetics in Human Brain Organoids

Bojcevski, J., Wang, C., Liu, H., Abdollahi, A., & Đokić, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413195 · Cited by 12

Modeling placental development and disease using human pluripotent stem cells

Morey, R. E., Bui, T., Fisch, K. M., & Horii, M. (2022) · Placenta · doi:10.1016/j.placenta.2022.10.011 · Cited by 11

Creation of EGD-Derived Gastric Cancer Organoids to Predict Treatment Responses

McDonald, H. G., Harper, M. M., Hill, K. S., Gao, A., Solomon, A. L., Bailey, C. J., Lin, M., Barry-Hundeyin, M., Cavnar, M. J., Mardini, S. H., et al. (2023) · Cancers · doi:10.3390/cancers15113036 · Cited by 11

Functional genomics in stem cell models: considerations and applications

Shevade, K., Peddada, S., Mader, K., & Przybyla, L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1236553 · Cited by 11

The NAD + Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease

Hong, Y., Zhang, Z., Yangzom, T., Chen, A., Lundberg, B. C., Fang, E. F., Siller, R., Sullivan, G. J., Zeman, J., Tzoulis, C., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91624 · Cited by 11

Establishment of a human organoid-based evaluation system for assessing interspecies infection risk of animal-borne coronaviruses

Gong, Q.-C., Jiang, R.-D., Ji, L., Lin, H., Liu, M., Tang, X., Yang, Y., Han, W., Chen, J., Guo, Z., et al. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2327368 · Cited by 11

Application and prospect of organoid technology in breast cancer

Huang, S., Mei, Z., Wan, A., Zhao, M., & Qi, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1413858 · Cited by 11

The Role of Peptides in Combatting HIV Infection: Applications and Insights

Helmy, N. M., & Parang, K. (2024) · Molecules · doi:10.3390/molecules29204951 · Cited by 11

Synthetic hydrogel substrate for human induced pluripotent stem cell definitive endoderm differentiation

Mulero‐Russe, A., Mora‐Boza, A., Marquez, E. N., Ziegelski, M. C., Helmrath, M., & Garcı́a, A. J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122920 · Cited by 11

Construction of a lung cancer 3D culture model based on alginate/gelatin micro-beads for drug evaluation

Zhao, Z., Feng, X., Wu, H., Chen, S., Ma, C., Guan, Z., Lei, L., Tang, K., Chen, X., Dong, Y. Q., et al. (2024) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-490 · Cited by 11

Noncanonical Amino Acid Incorporation in Animals and Animal Cells

Kim, J., Kim, Y., Cho, S., & Park, H. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00955 · Cited by 13

Exploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids

Lederer, A., Görrissen, N., Nguyen, T. T., Kreutz, C., Rasel, H., Bartsch, F., Lang, H., & Endres, K. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06012-x · Cited by 11

Breast Morphogenesis: From Normal Development to Cancer

Ingþórsson, S., Traustadóttir, G. Á., & Guðjónsson, Þ. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-70875-6_3 · Cited by 11

Advances in lacrimal gland organoid development: Techniques and therapeutic applications

Dayem, A. A., Jang, S. B., Lim, N., Yeo, H. C., Kwak, Y., Lee, S., Shin, H. J., & Cho, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117870 · Cited by 12

Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling

Pagliaro, A., Andreatta, F., Finger, R., Artegiani, B., & Hendriks, D. F. G. (2025) · Nature Protocols · doi:10.1038/s41596-024-01107-7 · Cited by 12

Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research

Wei, S., Thi, P. L., Zhang, Y., Park, M.-Y., Do, K.-H., Thi, T. T. H., Morgan, N., Dao, T., Heo, J., Jo, Y., et al. (2025) · Biomaterials Research · doi:10.34133/bmr.0161 · Cited by 11

Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and Ethics

Taglieri, M., Gregorio, L. D., Matis, S., Uras, C. R. M., Ardy, M., Casati, S., Marchese, M., Poggi, A. D., Raffaghello, L., & Benelli, R. (2025) · Cells · doi:10.3390/cells14060457 · Cited by 12

Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip

Fredrikson, J. P., Roth, D. M., Cosgrove, J. A., Şener, G., Crow, L. A., Eckenstein, K. H., Wu, L., Hosseini, M., Thomas, G., Eksi, S. E., et al. (2025) · Lab on a Chip · doi:10.1039/d5lc00134j · Cited by 13

Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer

Zhou, D., Tang, E., Wang, W., Xiao, Y., Huang, J., Liu, J., Zheng, C., Zhang, K., Hu, R., Wang, F., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102158 · Cited by 11

Engineering pancreatic islet-loaded microfibers via pneumatically-controlled microfluidic spinning for the assembly of a microphysiological system

Shi, J., Li, J., Ma, J., Yang, X., Xue, C., Zhang, Y., & Gao, X. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123480 · Cited by 12

Frontier technologies for investigating endothelial heterogeneity and function in diabetic vascular disease: An updated review

Guan, H., Zhao, S., Fang, X., Miao, R., Zhang, Y., Zhang, Y., & Tian, J. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118445 · Cited by 11

Stem cell-based human embryo models: current knowledge and open questions

Rosner, M., Horer, S., Kiss, I., & Hengstschläger, M. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04581-2 · Cited by 11

Hypoxia and Multilineage Communication in 3D Organoids for Human Disease Modeling

Ehab, S., Gaser, O. A., & Dayem, A. A. (2025) · Biomimetics · doi:10.3390/biomimetics10090624 · Cited by 13

Immunosenescence and organoids: pathophysiology and therapeutic opportunities

Kamroo, A., Kakroudi, M. H., Sarmadian, A. J., Firouzabadi, A., Mousavi, S., Yazdanpanah, N., Saleki, K., & Rezaei, N. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00530-y · Cited by 12

From variants to mechanisms: Neurogenomics in the post-GWAS era

Margolis, M. P., Tang, M., Gagliardi, M., Wen, C. H., Wu, Y., Wray, N. R., Ziller, M. J., & Gandal, M. J. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.014 · Cited by 14

Review of studies of severe acute respiratory syndrome related coronavirus–2 pathogenesis in human organoid models

Egilmezer, E., & Rawlinson, W. D. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2227 · Cited by 11

Defense of COVID-19 by Human Organoids

Lv, T., Meng, F., Yu, M., Huang, H., Lin, X., & Zhao, B. T. (2021) · Phenomics · doi:10.1007/s43657-021-00015-0 · Cited by 11

Protein overexpression of toll‑like receptor 4 and myeloid differentiation factor 88 in oral squamous cell carcinoma and clinical significance

Li, L., Zhou, Z., Mai, K., Li, P., Wang, Z., Wang, Y., Cao, Y., Ma, X., Zhang, T., & Wang, D. (2021) · Oncology Letters · doi:10.3892/ol.2021.13047 · Cited by 11

Disease Modeling of Rare Neurological Disorders in Zebrafish

Son, M., Kim, D. Y., & Kim, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073946 · Cited by 12

Histone Chaperones as Cardinal Players in Development

Rajam, S. M., Varghese, P. C., & Dutta, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.767773 · Cited by 11

Maximizing the integration of virtual and experimental screening in hit discovery

Bajusz, D., & Keserű, G. M. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2085685 · Cited by 11

Coplanar embedding of multiple 3D cell models in hydrogel towards high-throughput micro-histology

Heub, S., Navaee, F., Migliozzi, D., Ledroit, D., Pasche, S., Goldowsky, J., Vuille-dit-Bille, E., Hofer, J., Gaiser, C., Revol, V., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-13987-4 · Cited by 11

Acute radiation syndrome drug discovery using organ-on-chip platforms

Singh, V. K., & Seed, T. M. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2099833 · Cited by 11

Challenges in genomic analysis of model systems and primary tumors of pancreatic ductal adenocarcinoma

Hyun, S., & Park, D. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.064 · Cited by 11

Pancreatic cancer derived 3D organoids as a clinical tool to evaluate the treatment response

Shukla, H. D., Đukić, T., Roy, S. K., Bhandary, B., Gerry, A., Poirier, Y. P., Lamichhane, N., Molitoris, J. K., Carrier, F., Banerjee, A., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1072774 · Cited by 11

Organ mimicking technologies and their applications in drug discovery

Qu, Y., Ye, J., Lin, B., Luo, Y., & Zhang, X. (2023) · Intelligent Pharmacy · doi:10.1016/j.ipha.2023.05.003 · Cited by 11

Collagen-based biomaterials for tissue engineering applications

Amirthalingam, S., & Hwang, N. S.-Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98827-8.00025-4 · Cited by 11

Human Retinal Organoids in Therapeutic Discovery: A Review of Applications

Cheng, L. Z., & Kuehn, M. H. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_691 · Cited by 11

Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Silvestri, A., Vicente, F., Vicent, M. J., Stechmann, B., & Fecke, W. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.02.024 · Cited by 12

The History of Gene Hunting in Hereditary Spinocerebellar Degeneration: Lessons From the Past and Future Perspectives

Yahia, A., & Stévanin, G. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.638730 · Cited by 11

Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential

Thomas, J., Zimmerlin, L., Huo, J. S., Considine, M., Cope, L., & Zambidis, E. T. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00135-1 · Cited by 13

A Novel Organoid Model of In Vitro Spermatogenesis Using Human Induced Pluripotent Stem CellsPreprint

Robinson, M., Witherspoon, L., Willerth, S. M., & Flannigan, R. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.04.447122 · Cited by 11

Engineering Biomimetic Microenvironment for Organoid

Chen, S., Wang, L., Yang, L., Rana, A. S., & He, C. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300223 · Cited by 10

In vitro laboratory models of proliferative vitreoretinopathy

Gao, A. Y., Haak, A. J., & Bakri, S. J. (2023) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2023.05.007 · Cited by 10

Advancing Point-of-Care Applications with Droplet Microfluidics: From Single-Cell to Multicellular Analysis

Sharkey, C., White, R., Finocchiaro, M. A., Thomas, J., Estevam, J., & Konry, T. (2024) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110222-102142 · Cited by 11

Advances and Challenges in Cerebral Organoids Research

Luo, D., Xu, J., Liu, F., & Gu, Z. (2024) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300126 · Cited by 11

Differential beta‐coronavirus infection dynamics in human bronchial epithelial organoids

Park, D., Kim, S., Jang, H. B., Kim, K., Ji, H. Y., Yang, H., Kwon, W., Kang, Y.-L., Hwang, S., Kim, H., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29600 · Cited by 10

Colon cancer inhibitory properties of Caulerpa lentillifera polysaccharide and its molecular mechanisms based on three-dimensional cell culture model

Xia, X., Wu, Y., Chen, Z., Du, D., Chen, X., Zhang, R., Yan, J., Wong, I. N., & Huang, R. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131574 · Cited by 10

Multiple transcriptome analyses reveal mouse testis developmental dynamics

Chen, A., Ji, C., Li, C., Brand‐Saberi, B., & Zhang, S. (2024) · BMC Genomics · doi:10.1186/s12864-024-10298-y · Cited by 10

Vascular smooth muscle cells exhibit elevated hypoxia-inducible Factor-1α expression in human blood vessel organoids, influencing osteogenic performance

Feltran, G. D. S., da Silva, R. A., Fernandes, C. J. D. C., Ferreira, M. R., dos Santos, S. A. A., Justulin, L. A., Sosa, L. D. V., & Zambuzzi, W. F. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114136 · Cited by 10

Leveraging preclinical models of metastatic breast cancer

Pedroza, D. A., Gao, Y., Zhang, X. H.-F., & Rosen, J. M. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189163 · Cited by 11

Pluripotent stem cell‐derived organoids: A brief history of curiosity‐led discoveries

Lancaster, M. A. (2024) · BioEssays · doi:10.1002/bies.202400105 · Cited by 11

Interleukin-33 promotes intrauterine adhesion formation in mice through the mitogen-activated protein kinase signaling pathway

Liu, D., Yuan, L., Xu, F., Ma, Y., Zhang, H., Jin, Y., Chen, M., Zhang, Z., & Luo, S. (2024) · Communications Biology · doi:10.1038/s42003-024-06709-1 · Cited by 11

Generation and maintenance of kidney and kidney cancer organoids from patient-derived material for drug development and precision oncology

Gubała, J., Mieville, V., Benamran, D. A., Tille, J., Massimo Valerio, A., & Nowak-Sliwinska, P. M. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101368 · Cited by 10

Chemical Tomography of Cancer Organoids and Cyto‐Proteo‐Genomic Development Stages Through Chemical Communication Signals

Maity, A., Maidantchik, V. D., Weidenfeld, K., Larisch, S., Barkan, D., & Haick, H. (2025) · Advanced Materials · doi:10.1002/adma.202413017 · Cited by 10

Toxicity assessment using neural organoids: innovative approaches and challenges

Park, S.-H., & Sun, W. (2025) · Toxicological Research · doi:10.1007/s43188-025-00279-y · Cited by 10

MXene-enhanced detachable transistor neuroprobe for real-time monitoring of serotonin dynamics in human organoids and living brains

Li, J., Qi, F., Li, C., Tang, L., Li, C., Liu, Y., Li, Y., & Zhang, G. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162542 · Cited by 10

Organoids as Miniature Twins—Challenges for Comparability and Need for Data Standardization and Access

Fuhr, A., Kurtz, A., Hiepen, C., & Müller, S. (2022) · Organoids · doi:10.3390/organoids1010003 · Cited by 10

Organoids As Promising Tools In Therapy

Shravani, P. S. D. K. (2023) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.8278935

New developments and applications of human organoids

Andersson-Rolf, A., & Clevers, H. C. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-00974-0 · Cited by 25

Clinical applications of human organoids

Verstegen, M. M. A., Coppes, R. P., Béghin, A., Coppi, P. D., Gerli, M., de Graeff, N., Pan, Q., Saito, Y., Shi, S., ZADPOOR, A. A., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03489-3 · Cited by 230

Human organoids: a new dimension in cell biology

Lehmann, R., Lee, C. M., Shugart, E. C., Benedetti, M., Charo, R. A., Gartner, Z. J., Hogan, B. L. M., Knoblich, J. A., Nelson, C. M., & Wilson, K. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-03-0135 · Cited by 158

The organoid cell atlas

the Human Cell Atlas ‘Biological Network’ Organoids, Bock, C., Boutros, M., Camp, J. G., Clarke, L., Clevers, H., Knoblich, J. A., Liberali, P., Regev, A., Rios, A. C., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-00762-x · Cited by 171