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Human organoids: model systems for human biology and medicine
Open accessAbstract
The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids - which are stem cell-derived 3D culture systems - it is now possible to re-create the architecture and physiology of human organs in remarkable detail. Human organoids provide unique opportunities for the study of human disease and complement animal models. Human organoids have been used to study infectious diseases, genetic disorders and cancers through the genetic engineering of human stem cells, as well as directly when organoids are generated from patient biopsy samples. This Review discusses the applications, advantages and disadvantages of human organoids as models of development and disease and outlines the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments.
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“In particular, for cancer treatment, several different patient-derived organoid models tested, including but not limited to: pancreas, colorectal and liver cancer all exhibit heterogeneous responses to known chemotherapeutic and anticancer agents49,132,212.”
From Organoids (2022) · cites this paper as [212]
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“Meanwhile, being entirely derived from human cells, these organoids can fully replicate human biology and potentially reduce the translational barriers from experimental findings to therapeutic applications (20–22), offering advantages over animal models (23–25).”
From Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems (2025) · cites this paper as [20]
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“The versatile skin OTC-based platform is ideally suited for investigating a broad range of physiological and pathological scenarios, presenting significant potential for advancing our understanding of skin developmental biology, disease modeling, and applications in regenerative medicine [69–71].”
From Diversity of human skin three-dimensional organotypic cultures (2024) · cites this paper as [71]
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,745
Research works printed but not linked: 1
- Rotavirus vaccines. WHO position paper—January 2013. Wkly. Epidemiol. Rec. 88, 49–64 (2013).
Cited by
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Items 401–500 of 1,003
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Mulaudzi, P. E., Abrahamse, H., & Crous, A. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10655-6 · Cited by 38
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Casanova, J., & Abel, L. (2024) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092123-022855 · Cited by 33
Harlaar, N., Dekker, S. O., Zhang, J., Snabel, R. R., Veldkamp, M. W., Verkerk, A. O., Fabres, C. C., Schwach, V., Lerink, L. J. S., Rivaud, M. R., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00827-5 · Cited by 32
Human Kidney Organoids and Tubuloids as Models of Complex Kidney Disease
Nunez-Nescolarde, A. B., Nikolic‐Paterson, D. J., & Combes, A. N. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.01.009 · Cited by 32
Park, S. B., Jung, W. H., Choi, K. J., Koh, B., & Kim, K. Y. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00496-8 · Cited by 33
ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming
Kim, T. M., Lee, R. H., Kim, M. S., Lewis, C. A., & Park, C. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03267-x · Cited by 32
EP300 facilitates human trophoblast stem cell differentiation
van Voorden, J., Keijser, R., Veenboer, G. J. M., Cardozo, S. L., Diek, D., Vlaardingerbroek, J. A., van Dijk, M., Ris‐Stalpers, C., van Pelt, A. M. M., & Afink, G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217405120 · Cited by 32
Decellularization and Their Significance for Tissue Regeneration in the Era of 3D Bioprinting
Gadre, M. A., Kasturi, M., Agarwal, P., & Vasanthan, K. S. (2024) · ACS Omega · doi:10.1021/acsomega.3c08930 · Cited by 34
Evaluation of Drug Blood-Brain-Barrier Permeability Using a Microfluidic Chip
Yang, J. Y., Shin, D., Jeong, M., Kim, S. S., Jeong, H. N., Lee, B. H., Hwang, K.-S., Son, Y., Jeong, H. C., Choi, C., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050574 · Cited by 31
Graß, T., Dokuzluoglu, Z., Buchner, F., Rosignol, I., Thomas, J. D., Caldarelli, A., Dalinskaya, A., Becker, J., Rost, F., Marass, M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101659 · Cited by 33
Sun, D., Zhang, K., Zheng, F., Yang, G., Yang, M., Xu, Y., Qin, Y., Lin, M., Li, Y., Tan, J., et al. (2024) · Advanced Materials · doi:10.1002/adma.202410802 · Cited by 32
Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics
Brancati, G., Treutlein, B., & Camp, J. G. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.001 · Cited by 32
Endometrial Organoids: A Rising Star for Research on Endometrial Development and Associated Diseases
Song, Y., & Fazleabas, A. T. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00471-z · Cited by 31
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Mahapatra, C., Lee, A., & Paul, M. K. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.11.007 · Cited by 31
Son, J., Park, S. J., Ha, T., Lee, S., Cho, H., & Choi, J. (2022) · ACS Sensors · doi:10.1021/acssensors.1c02279 · Cited by 32
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Schmidt, S. C., Alt, Y., Deoghare, N., Krüger, S., Kern, A., Rockel, A. F., Wagner, N., Ergün, S., & Wörsdörfer, P. (2022) · Organoids · doi:10.3390/organoids1010005 · Cited by 31
Establishment of a patient-derived organoid model and living biobank for nasopharyngeal carcinoma
Wang, X., Xia, T., Tang, H., Liu, X., Han, R., Zou, X., Zhao, Y.-T., Chen, M., & Li, G. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-1076 · Cited by 31
Alginate-based bioink for organoid 3D bioprinting: A review
Leonardo, M., Prajatelistia, E., & Judawisastra, H. (2022) · Bioprinting · doi:10.1016/j.bprint.2022.e00246 · Cited by 33
Corridon, P. R., Wang, X., Shakeel, A., & Chan, V. (2022) · Biomedicines · doi:10.3390/biomedicines10102445 · Cited by 32
Asif, K., Adeel, M., Rahman, M. M., Sfriso, A., Bartoletti, M., Canzonieri, V., Rizzolio, F., & Caligiuri, I. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.03.005 · Cited by 31
Pandamooz, S., Jurek, B., Meinung, C.-P., Baharvand, Z., Shahem-abadi, A. S., Haerteis, S., Miyan, J. A., Downing, J. R., Dianatpour, M., Borhani‐Haghighi, A., et al. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-121120-012309 · Cited by 31
Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era
Singh, B., Mal, G., Verma, V., Tiwari, R., Khan, M. I., Mohapatra, R. K., Mitra, S., Alyami, S. A., Emran, T. B., Dhama, K., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02334-5 · Cited by 30
Advances in organoid technology for veterinary disease modeling
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Nanomaterials in Organoids: From Interactions to Personalized Medicine
Shi, Y., Han, X., Zou, S., & Liu, G. (2024) · ACS Nano · doi:10.1021/acsnano.4c13330 · Cited by 30
Kim, K., Lee, Y., Jung, K. B., Kim, Y., Jang, E., Lee, M., Son, M., & Lee, H. J. (2024) · Advanced Materials · doi:10.1002/adma.202412953 · Cited by 30
Ege, N., Bouguenina, H., Tatari, M. N., & Chopra, R. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.02.011 · Cited by 31
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‘Consciousnessoids’: clues and insights from human cerebral organoids for the study of consciousness
Lavazza, A. (2021) · Neuroscience of Consciousness · doi:10.1093/nc/niab029 · Cited by 30
Mechanical Control of Cell Differentiation: Insights from the Early Embryo
Nelson, C. M. (2022) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-060418-052527 · Cited by 33
Su, T., Liang, L., Zhang, L., Wang, J., Chen, L., Su, C., Cao, J., Yu, Q., Deng, S., Chan, H. F., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.939774 · Cited by 31
Human mini-blood–brain barrier models for biomedical neuroscience research: a review
Tran, M., Heo, C., Lee, L. P., & Cho, H. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00332-z · Cited by 31
Living Anisotropic Structural Color Hydrogels for Cardiotoxicity Screening
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Cartilage organoids and osteoarthritis research: a narrative review
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A decade of liver organoids: Advances in disease modeling
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Lee, W., Lee, S., Yoon, J.-K., Lee, D., Kim, Y., Han, Y. B., Kim, R., Moon, S., Park, Y. J., Park, K., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01076-z · Cited by 31
Self-citationTardito, S., Matis, S., Zocchi, M. R., Benelli, R., & Poggi, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137131 · Cited by 30
Jørgensen, C., & Simon, M. (2021) · Cells · doi:10.3390/cells10030596 · Cited by 29
de Dios-Figueroa, G. T., Aguilera-Márquez, J. D. R., Camacho-Villegas, T. A., & Lugo-Fabres, P. H. (2021) · Biomedicines · doi:10.3390/biomedicines9060602 · Cited by 29
Altmaier, S., Meiser, I., Lemesre, E., Chanrion, B., Steeg, R., Leonte, L. E., Holst, B., Nielsen, B. S., Clausen, C., Schmidt, K., et al. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.05.005 · Cited by 29
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Gao, Z., Wang, S., Sui, Y., Zhang, Q., Yang, Y., Huang, J., Xiong, Y., Ma, T., Zhang, X., & Zheng, H. (2023) · Small Structures · doi:10.1002/sstr.202200288 · Cited by 29
Cryobiopsy: A Breakthrough Strategy for Clinical Utilization of Lung Cancer Organoids
Park, D., Lee, D., Kim, Y., Park, Y., Lee, Y.-J., Lee, J. E., Yeo, M., Kang, M., Chong, Y., Han, S. J., et al. (2023) · Cells · doi:10.3390/cells12141854 · Cited by 30
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Krebs, C. E., Lam, A., McCarthy, J., Constantino, H., & Sullivan, K. (2023) · ALTEX · doi:10.14573/altex.2210212 · Cited by 31
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Yousafzai, M. S., & Hammer, J. A. (2023) · Biosensors · doi:10.3390/bios13100905 · Cited by 30
Phouphetlinthong, O., Partiot, E., Bernou, C., Sebban, A., Gaudin, R., & Charlot, B. (2023) · Lab on a Chip · doi:10.1039/d3lc00294b · Cited by 29
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Kim, H., Park, S., Jeong, S., Kim, J., & Cho, Y. (2023) · International Journal of Stem Cells · doi:10.15283/ijsc23090 · Cited by 28
Self-citationKalla, J., Pfneissl, J., Mair, T., Tran, L., & Egger, G. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00960-8 · Cited by 31
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Kellner, M. J., Monteil, V., Zelger, P., Pei, G., Jiao, J., Onji, M., Nayak, K., Zilbauer, M., Balkema‐Buschmann, A., Dorhoi, A., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02155-1 · Cited by 29
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Boot, R. C., Koenderink, G. H., & Boukany, P. E. (2021) · Advances in Physics X · doi:10.1080/23746149.2021.1978316 · Cited by 33
Cheaito, K. A., Bahmad, H. F., Hadadeh, O., Msheik, H., Monzer, A., Ballout, F., Dagher, C., Telvizian, T., Saheb, N., Tawil, A. N., et al. (2021) · Oncology Letters · doi:10.3892/ol.2021.13124 · Cited by 29
Choi, S., Choi, S., Choi, Y., Cho, N., Kim, S.-Y., Lee, C. H., Park, H., Oh, W. K., Kim, K. K., & Kim, E. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113094 · Cited by 28
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Maenhoudt, N., Moor, A. D., & Vankelecom, H. E. J. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071048 · Cited by 31
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Cui, K., Chen, T.-W., Zhu, Y., Shi, Y., Guo, Y., & Qin, J. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10390 · Cited by 28
Zhang, D., Jiang, C., Zheng, X., Lin, Z., Zhuang, Q., Xie, H., Liang, Y., Xu, Y. K. T., Cui, L., Liu, X., et al. (2023) · Small · doi:10.1002/smll.202207786 · Cited by 28
Duru, J., Maurer, B., Doran, C. G., Jelitto, R., Küchler, J., Ihle, S. J., Ruff, T., John, R., Genocchi, B., & Vörös, J. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115591 · Cited by 28
Ma, Q., Tao, H., Li, Q., Zhai, Z., Zhang, X., Lin, Z., Kuang, N., & Pan, J. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac942 · Cited by 27
Carvalho, S. M., Mansur, A. A. P., da Silveira, I. B., Pires, T. F. S., Victória, H. F. V., Krambrock, K., Leite, M. F., & Mansur, H. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061702 · Cited by 28
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Zhao, Y., Gong, J., Liu, H., Huang, H., Tan, W., & Cai, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136707 · Cited by 28
DeLiberty, J. M., Roach, M. K., Stalnecker, C. A., Robb, R. N., Schechter, E. G., Pieper, N. L., Taylor, K. E., Pita, L. M., Yang, R. Y., Bang, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-1757 · Cited by 27
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Sahu, S., Albaugh, M. E., Martin, B. K., Patel, N. L., Riffle, L. A., Mackem, S., Kalen, J. D., & Sharan, S. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-11224-6 · Cited by 27
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Wang, Z., Faria, J., van der Laan, L. J. W., Penning, L. C., Masereeuw, R., & Spee, B. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.868857 · Cited by 27
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Temma, K., Oketani, R., Kubo, T., Bando, K., Maeda, S., Sugiura, K., Matsuda, T., Heintzmann, R., Kaminishi, T., Fukuda, K., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02236-3 · Cited by 27
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Benn, M. C., Pot, S. A., Moeller, J., Yamashita, T., Fonta, C. M., Orend, G., Kollmannsberger, P., & Viola Vogel, B. (2023) · Science Advances · doi:10.1126/sciadv.add9275 · Cited by 26
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Marshall, L. J., Triunfol, M., & Seidle, T. (2020) · Animals · doi:10.3390/ani10101923 · Cited by 29
Shrestha, S., Lekkala, V. K. R., Acharya, P., Siddhpura, D., & Lee, M. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200150 · Cited by 28
Löffler, J., Hamp, C., Scheidhauer, E., Carlo, D. D., Solbach, C., Abaei, A., Li, H., Glatting, G., Beer, A. J., Rasche, V., et al. (2021) · Cancers · doi:10.3390/cancers13164007 · Cited by 26
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Metadata
- Authors
- Kim, J., Koo, B.-K., & Knoblich, J. A.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Corresponding author
- Koo, Bon-Kyoung
- Knoblich, Juergen A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-07-07
- Volume
- 21
- Issue
- 10
- Pages
- 571-584
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC7339799
- OpenAlex
- W3040646360
- Cited by
- 2,187
- References
- 210
- Citations by year
- 2026: 311 · 2025: 410 · 2024: 409 · 2023: 381 · 2022: 352 · 2021: 291 · 2020: 31
- FWCI
- 25.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund (Z_153_B09)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- human organoids, stem cell-derived organoids, alternative to animal models, disease modeling, organogenesis, infectious diseases, genetic disorders, tumor models, patient-derived organoids, drug discovery
- MeSH terms
- Animals, Biology, Communicable Diseases, Genetic Engineering, Humans, Medicine, Neoplasms, Organoids, Stem Cells, Genetic Diseases, Inborn
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