Signalling mechanisms and cellular functions of SUMO

Molecular mechanisms and cellular functions of cGAS–STING signalling

Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052

Deep proteome and transcriptome mapping of a human cancer cell line

Nagaraj, N., Wisniewski, J. R., Geiger, T., Cox, J., Kircher, M., Kelso, J., Pääbo, S., & Mann, M. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.81 · Cited by 979

A framework for understanding the functions of biomolecular condensates across scales

Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895

SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia

Cheng, J., Kang, X., Zhang, S., & Yeh, E. T. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.045 · Cited by 624

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

Fukuda, I., Ito, A., Hirai, G., Nishimura, S., Kawasaki, H., Saitoh, H., Kimura, K.-I., Sodeoka, M., & Yoshida, M. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.01.009 · Cited by 355

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

Galanty, Y., Belotserkovskaya, R., Coates, J., & Jackson, S. P. (2012) · Genes & Development · doi:10.1101/gad.188284.112 · Cited by 314

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

Yin, Y., Seifert, A., Chua, J. S., Maure, J.-F., Golebiowski, F., & Hay, R. T. (2012) · Genes & Development · doi:10.1101/gad.189274.112 · Cited by 237

The Leukemia-Associated Gene TEL Encodes a Transcription Repressor Which Associates with SMRT and mSin3A

Chakrabarti, S. R., & Nucifora, G. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1605 · Cited by 149

USP7 is a SUMO deubiquitinase essential for DNA replication.

Lecona, E., Rodriguez-Acebes, S., Specks, J., Lopez-Contreras, A. J., Ruppen, I., Murga, M., Muñoz, J., Mendez, J., & Fernandez-Capetillo, O. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3185 · Cited by 148

SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

Hu, Z., Teng, X.-L., Zhang, T., Yu, X., Ding, R., Yi, J., Deng, L., Wang, Z., & Zou, Q. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.024 · Cited by 123

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442

The Multiple Roles of Interferon Regulatory Factor family in Health and Disease

Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178

Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms

Acuña, M. L., García-Morin, A., Orozco-Sepúlveda, R., Ontiveros, C., Flores, A., Diaz, A. V., Gutiérrez-Zubiate, I., Patil, A. R., Alvarado, L. A., Roy, S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-29357-7 · Cited by 19

Fasting‐sensitive SUMO‐switch on Prox1 controls hepatic cholesterol metabolism

Alfaro, A. J., Dittner, C., Becker, J., Loft, A., Mhamane, A., Maida, A., Georgiadi, A., Tsokanos, F., Klepac, K., Molocea, C., et al. (2023) · The EMBO Reports · doi:10.15252/embr.202255981 · Cited by 14

A SUMO interacting motif in the replication initiator protein of tomato yellow leaf curl virus is required for viral replication

Gaertner, N. F., Maio, F., Arroyo-Mateos, M., Luna, A. P., Sabarit, B., Kwaaitaal, M., Eltschkner, S., Prins, M., Bejarano, E. R., & van den Burg, H. A. (2025) · Journal of Virology · doi:10.1128/jvi.01286-25 · Cited by 1

An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer

Cheng, C., Sun, L., Yang, J., Liu, Z., Zhang, F., Qiu, L., Yu, M., Wang, T., Huang, J., Wang, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73682-0

Improved Peptide Search for Identification of SUMO and Sequence-Based Modifiers, in MaxSBM

Lennartsson, C., Kyriakidou, P., Nielsen, M. L., Olsen, J. V., Cox, J., & Hendriks, I. A. (2026) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2026.101589