Microglial phagocytosis in Alzheimer disease

Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy

Cangalaya, C., Wegmann, S., Sun, W., Diez, L., Gottfried, A., Richter, K., Stoyanov, S., Pakan, J. M. P., Fischer, K., & Dityatev, A. E. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.023 · Cited by 48

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant

Luis, E. O., Ortega-Cubero, S., Lamet, I., Razquin, C., Cruchaga, C., Benitez, B. A., Lorenzo, E., Irigoyen, J., Pastor, M. A., & Pastor, P. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.007 · Cited by 47

A limited role for microglia in antibody mediated plaque clearance in APP mice

Garcı́a-Alloza, M., Ferrara, B. J., Dodwell, S. A., Hickey, G. A., Hyman, B. T., & Bacskai, B. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.019 · Cited by 47

C5aR1 signaling promotes region‐ and age‐dependent synaptic pruning in models of Alzheimer's disease

Gómez-Arboledas, Á., Fonseca, M. I., Kramár, E. A., Chu, S., Schartz, N. D., Selvan, P., Wood, M. A., & Tenner, A. J. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13682 · Cited by 47

Therapeutic modulation of APP-CD74 axis can activate phagocytosis of TAMs in GBM

Ma, C., Chen, J., Ji, J., Zheng, Y., Liu, Y., Wang, J., Chen, T., Chen, H., Chen, Z., Zhou, Q., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167449 · Cited by 47

The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta‐mediated pathology

Samuels, J. D., Moore, K. A., Ennerfelt, H. E., Johnson, A. M., Walsh, A. E., Price, R. J., & Lukens, J. R. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13089 · Cited by 46

Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum

Uesaka, N., Abe, M., Konno, K., Yamazaki, M., Sakoori, K., Watanabe, T., Kao, T., Mikuni, T., Watanabe, M., Sakimura, K., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.018 · Cited by 45

Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes

Pantazopoulou, M., Lamprokostopoulou, A., Karampela, D. S., Alexaki, A., Delis, A. D., Coens, A., Samiotaki, M. K., Kriebardis, A. G., Melki, R., Pagakis, S. N., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04841-5 · Cited by 44

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury

Sommer, D., Corstjens, I., Sanchez, S., Dooley, D., Lemmens, S., Broeckhoven, J. V., Bogie, J. F. J., Vanmierlo, T., Vidal, P. M., Rose‐John, S., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.032 · Cited by 42

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Jacquet, R. G., González Ibáñez, F., Picard, K., Funes, L., Khakpour, M., Gouras, G. K., Tremblay, M.-È., Maxfield, F. R., & Solé-Domènech, S. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115052 · Cited by 42

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands

Greven, J. A., Wydra, J. R., Greer, R. A., Zhi, C., Price, D. A., Svoboda, J. D., Camitta, C. L. M., Washington, M., Leung, D. W., Song, Y., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00795-9 · Cited by 42

Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia

Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0856-8 · Cited by 41

Complement receptor 1 is expressed on brain cells and in the human brain

Daskoulidou, N., Shaw, B., Torvell, M., Watkins, L., Cope, E. L., Carpanini, S. M., Allen, N. D., & Morgan, B. P. (2023) · Glia · doi:10.1002/glia.24355 · Cited by 40

The Adaptor Molecule Nck Localizes the WAVE Complex to Promote Actin Polymerization during CEACAM3-Mediated Phagocytosis of Bacteria

Pils, S., Kopp, K., Peterson, L., Tascon, J. D., Nyffenegger, N., & Hauck, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032808 · Cited by 39

Does soluble TREM2 protect against Alzheimer's disease?

Brown, G. C., & St George-Hyslop, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.834697 · Cited by 39

Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction

Roy, N., Haq, I., Ngo, J. C., Bennett, D. A., Teich, A. F., Jager, P. L. D., Olah, M., & Sher, F. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02835-6 · Cited by 38

The dense-core plaques of Alzheimer’s disease are granulomas

Lemke, G., & Huang, Y. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20212477 · Cited by 37

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Eskandari‐Sedighi, G., Crichton, M. C., Zia, S., Gomez‐Cardona, E., Cortez, L. M., Patel, Z. H., Takahashi, K., Laurent, C. D. S., Sidhu, G., Sarkar, S., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00734-8 · Cited by 37

Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function

Devlin, B. A., Nguyen, D. M., Ribeiro, D., Grullon, G., Clark, M. J., Finn, A., Ceasrine, A. M., Oxendine, S. R., Deja, M., Shah, A., et al. (2024) · Immunity · doi:10.1016/j.immuni.2025.06.002 · Cited by 37

A novel role for SHARPIN in amyloid-β phagocytosis and inflammation by peripheral blood-derived macrophages in Alzheimer's disease

Krishnan, D., Menon, R. N., Mathuranath, P. S., & Gopala, S. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.001 · Cited by 36

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion

Butler, C. A., Thornton, P., & Brown, G. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15349 · Cited by 36

Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia

Andoh, M., Shinoda, N., Taira, Y., Araki, T., Kasahara, Y., Takeuchi, H., Miura, M., Ikegaya, Y., & Koyama, R. (2025) · Nature Communications · doi:10.1038/s41467-025-56342-7 · Cited by 35

Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate

Allendorf, D. H., & Brown, G. C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.917884 · Cited by 34

P2Y6 receptor‐dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging

Dundee, J. M., Puigdellívol, M., Butler, R., Cockram, T. O. J., & Brown, G. C. (2022) · Aging Cell · doi:10.1111/acel.13761 · Cited by 34

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

Matera, A., Compagnion, A.-C., Pedicone, C., Kotah, J. M., Ivanov, A., Monsorno, K., Labouèbe, G., Leggio, L., Pereira-Iglesias, M., Beule, D., et al. (2025) · Immunity · doi:10.1016/j.immuni.2024.11.003 · Cited by 34

Loss of microglial EED impairs synapse density, learning, and memory

Wang, Y.-Y., Deng, Y.-S., Dai, S.-K., Mi, T.-W., Li, R.-Y., Liu, P.-P., Liu, C., He, B.-D., He, X.-C., Du, H.-Z., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01576-w · Cited by 32

High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils

Capetillo‐Zarate, E., Gracia, L., Yu, F., Banfelder, J. R., Lin, M. T. S., Tampellini, D., & Gouras, G. K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.045 · Cited by 31

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer’s Disease Brain

Korvatska, O., Kiianitsa, K., Ratushny, A. V., Matsushita, M. M., Beeman, N. E., Chien, W., Satoh, J., Dorschner, M. O., Keene, C. D., Bammler, T. K., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.559342 · Cited by 31

Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor–NLRP3 inflammasome–caspase-1 signalling axis

Pampuščenko, K., Morkūnienė, R., Krasauskas, L., Smirnovas, V., Brown, G. C., & Borutaitė, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-37887-3 · Cited by 31

The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human Microglia

Mishra, S., Morshed, N., Sidhu, S. B., Kinoshita, C., Stevens, B., Jayadev, S., & Young, J. E. (2025) · Glia · doi:10.1002/glia.70009 · Cited by 31

The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10

Zheng, Y., Prince, N., Marzal, L. N. P., Ahmed, S., Garssen, J., Perez‐Pardo, P., & Kraneveld, A. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911013 · Cited by 30

Phagocytosis by Human Monocyte-Derived Macrophages

Newman, S. L., Devery-Pocius, J. E., Ross, G. D., & Henson, P. M. (2017) · Complement · doi:10.1159/000467840 · Cited by 28

DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation

Lv, J., Wang, W., Zhu, X., Xu, X., Yan, Q., Lu, J., Shi, X., Wang, Z., Zhou, J., Huang, X., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.041 · Cited by 28

Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures

Pampuščenko, K., Morkūnienė, R., Krasauskas, L., Smirnovas, V., Tomita, T., & Borutaitė, V. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02150-7 · Cited by 28

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss

Feng, T., Luan, L., Katz, I. I., Ullah, M., Deerlin, V. M. V., Trojanowski, J. Q., Lee, E. B., & Hu, F. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01334-7 · Cited by 28

Uptake of Aβ 1–40- and Aβ 1–42-coated yeast by microglial cells: a role for LRP

Laporte, V., Lombard, Y., Levy-Benezra, R., Tranchant, C., Poindron, P., & Warter, J.-M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1203620 · Cited by 27

Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms

Falkon, K. F., Danford, L., Kuri, E. G., Esquinca‐Moreno, P., Señeriz, Y. L. P., Smith, S. A., Wickline, J. L., Louwrier, A., McPhail, J. A., Sayre, N. L., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14418 · Cited by 26

Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer’s disease through PI3K-Akt signaling

Jiang, M., Zhao, D., Zhou, Y., Kong, W., Xie, Z., Xiong, Y., Li, Y., Zhao, S., Kou, X., Zhang, S., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01994-0 · Cited by 24

Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease

Meyer, C., Niedermeier, T., Feyen, P., Struebing, F. L., Rauchmann, B., Karali, K., Gentz, J., Tillmann, Y., Landgraf, N. F., Rumpf, S.-L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62500-8 · Cited by 24

The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia

Wang, K., Wang, C., Chen, D., Huang, Y., Li, J., Wei, P., Shi, Z., Zhang, Y., & Gao, Y. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04465-1 · Cited by 23

TMEM106B regulates microglial proliferation and survival in response to demyelination

Zhang, T., Pang, W., Feng, T., Guo, J. D., Wu, K., Santos, M. N., Arthanarisami, A., Nana, A. L., Nguyen, Q., Kim, P. J., et al. (2023) · Science Advances · doi:10.1126/sciadv.add2676 · Cited by 23

Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Guan, Z., Chen, Z., Fu, S., Dai, L., & Shen, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00260 · Cited by 22

Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling

Huang, Y., & Lemke, G. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204306119 · Cited by 22

N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia

Condic, M., Oberstein, T. J., i, M. H., Reimann, M. C., Kornhuber, J., Maler, J. M., & Spitzer, P. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.003 · Cited by 20

Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer’s disease

Li, Y., Xu, M., Xiang, B.-L., Li, X., Zhang, D.-F., Zhao, H., Bi, R., & Yao, Y.-G. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01542-2 · Cited by 20

Distinct patterns of plaque and microglia glycosylation in Alzheimer's disease

Fastenau, C., Bunce, M., Keating, M., Wickline, J. L., Hopp, S. C., & Bieniek, K. F. (2024) · Brain Pathology · doi:10.1111/bpa.13267 · Cited by 20

Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases

Zhang, S., Shu, H., Zhou, J., Rubin-Sigler, J., Yang, X. J., Liu, Y., Cooper‐Knock, J., Monte, E., Zhu, C., Tu, S., et al. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02725-6 · Cited by 20

Author Correction: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Morizawa, Y. M., Hirayama, Y., Ohno, N., Shibata, S., Shigetomi, E., Sui, Y., Nabekura, J., Sato, K., Okajima, F., Takebayashi, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01594-1 · Cited by 17

SHIP inhibition mediates select TREM2-induced microglial functions

Ramakrishnan, G. S., Berry, W. L., Pacherille, A., Kerr, W. G., Chisholm, J. D., Pedicone, C., & Humphrey, M. B. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.04.002 · Cited by 17

Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models

Hu, W., Chen, M., Lin, Y., Zhang, H., Sun, L., Shao, W., Ye, Y., Cheng, Y., Zhou, S., Hu, P., et al. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01378-x · Cited by 17

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease

Zhu, B., Wangzhou, A., Yu, D., Li, T., Schmidt, R., Florencio, S. L. D., Chao, L., Thurber, A. L., Zhou, M., Msheik, Z., et al. (2024) · Neuron · doi:10.1016/j.neuron.2025.06.020 · Cited by 17

β-Amyloid (Aβ40, Aβ42) binding to modified LDL accelerates macrophage foam cell formation

Schulz, B., Liebisch, G., Grandl, M., Werner, T., Barlage, S., & Schmitz, G. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.08.002 · Cited by 16

Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge

Cousins, O., Schubert, J. J., Chandra, A., Veronese, M., Valkimadi, P., Creese, B., Khan, Z., Arathimos, R., Hampshire, A., Rosenzweig, I., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02945-0 · Cited by 16

Complement receptor 4 mediates the clearance of extracellular tau fibrils by microglia

Yoo, C. J., Choi, Y., Bok, E., Lin, Y., Cheon, M., Lee, Y., & Kim, J. (2024) · FEBS Journal · doi:10.1111/febs.17150 · Cited by 16

The microglial P2Y6 receptor as a therapeutic target for neurodegenerative diseases

Dundee, J. M., & Brown, G. C. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00438-5 · Cited by 16

The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage

Butler, C. A., Mendoza‐Arvilla, A., Milinkeviciute, G., Cunha, C. D., Kawauchi, S., Rezaie, N., Liang, H. Y., Javonillo, D. I., Thach, A., Wang, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13783 · Cited by 15

An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathology

Sokolova, D., Puletti, F., Ghansah, S. A., Georgiades, T., Zheng, Y., Wu, L., Schepper, S. D., Lange, J., Ferreira, L. S. S., Sierksma, A., et al. (2026) · Neuron · doi:10.1101/2024.08.31.606944 · Cited by 15

Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells

Boudesco, C., Nonneman, A., Cinti, A., Picardi, P., Redaelli, L., Swijsen, S., Roewe, J., Reinhardt, P., Ibach, M., Walter, J., et al. (2022) · Glia · doi:10.1002/glia.24252 · Cited by 14

Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis

Chidambaram, H., Desale, S. E., Qureshi, T., & Chinnathambi, S. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3662-6_16 · Cited by 14

Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model

Lee, J., Mizuno, K., Watanabe, H., Lee, I., Tsumita, T., Hida, K., Yawaka, Y., Kitagawa, Y., Hasebe, A., Iimura, T., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03192-7 · Cited by 14

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau

Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Schache, K. J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03073-2 · Cited by 14

Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis

Zhang, L., Huang, L., Zhou, Y., Meng, J., Zhang, L., Zhou, Y., Zheng, N., Guo, T., Zhao, S., Wang, Z., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00789-7 · Cited by 13

Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer’s disease in 5xFAD mice

Gomez, A. R., Byun, H. R., Wu, S., Muhammad, A. K. M. G., Ikbariyeh, J., Chen, J., Muro, A., Li, L., Bernstein, K. E., Ainsworth, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00879-1 · Cited by 13

Impaired Hematopoiesis and Disrupted Monocyte/Macrophage Homeostasis in Mucopolysaccharidosis Type I Mice

Viana, G. M., Buri, M. V., Paredes‐Gamero, E. J., Martins, A. M., & D’Almeida, V. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25120 · Cited by 11

Three‐dimensional view of microglia—amyloid plaque interactions

Gotkiewicz, M., Capra, J., Miettinen, P. O., Natunen, T., & Tanila, H. (2024) · Glia · doi:10.1002/glia.24628 · Cited by 11

Cerebrospinal fluids from Alzheimer's disease patients exhibit neurotoxic effects on neuronal cell cultures

Jankevičiūtė, S., Pšemeneckienė, G., Morkūnienė, R., Grušauskienė, E., Petrikonis, K., Rastenytė, D., & Borutaitė, V. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14389 · Cited by 9

Characterisation of molecular mechanisms for PLCγ2 disease-linked variants

Bunney, T. D., Kampyli, C., Gregory, A., & Katan, M. (2024) · Advances in Biological Regulation · doi:10.1016/j.jbior.2024.101053 · Cited by 8

Synaptic pruning genes networks in Alzheimer’s disease: correlations with neuropathology and cognitive decline

Sanfilippo, C., Castrogiovanni, P., Imbesi, R., Fagone, P., Scuderi, G., Vinciguerra, M., & Rosa, M. D. (2025) · GeroScience · doi:10.1007/s11357-025-01740-4 · Cited by 8

Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer’s and Nasu-Hakola disease

Swain, P. S., Panda, S., Pati, S., & Dehury, B. (2023) · Journal of Molecular Modeling · doi:10.1007/s00894-023-05770-7 · Cited by 6

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk

Dodd, R. B., Enomoto, M., Zhou, Y., Satoh, K., Zhang, Y., Chen, F., Acheson, B., Ghaffari, D., Sayn-Wittgenstein, E., Manning, J. J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75140-3 · Cited by 4

Ramp Sequence May Explain Synonymous Variant Association with Alzheimer’s Disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA)

Miller, J. B., Brandon, J. A., Harmon, L. M., Sabra, H. W., Lucido, C. C., Murcia, J. D. G., Nations, K. A., Payne, S. H., Ebbert, M., Kauwe, J. S. K., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13030739 · Cited by 3

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk

Dodd, R. B., Enomoto, M., Zhou, Y., Satoh, K., Zhang, Y., Chen, F., Acheson, B., Ghaffari, D., Sayn-Wittgenstein, E., Manning, J. J., et al. (2025) · doi:10.1101/2025.07.29.667318 · Cited by 3

Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deußing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01752-x · Cited by 2

Microglia and neuroinflammation: function, heterogeneity, and crosstalk

Zong, S., Cui, X., Wu, S., & Lu, Z. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01438-3 · Cited by 28

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Ivanova, M. I., Rosa, C. L., & Ramamoorthy, A. (2026) · Protein Science · doi:10.1002/pro.70519 · Cited by 6

Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation

Gaudet, A. D., & Fonken, L. K. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.01.002 · Cited by 3

Effects of environmental enrichment on the hippocampal microglial profile under neuroinflammatory conditions: A systematic review

Gonçalves, C. B., Costa, M. R., Kanashiro, A., Pereira, D. D., Fernandes, M. S. D. S., & Souto, F. O. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106645 · Cited by 2

Targeting microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and therapeutic approaches

Bang-feng, L., Chen, X., Xie, R., Mo, Y.-F., Wu, Y.-Z., Meng, Y., Han, X.-L., Chen, M., & Peng, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1818802 · Cited by 2

Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, Pharmacological, Nanoparticle, and Gene Therapy Approaches

Raghuvanshi, S., Mazumder, A., & Das, S. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273378092250623064748

How brain ‘cleaners’ fail: Mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease

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