Loss of microglial EED impairs synapse density, learning, and memory
Abstract
The embryonic ectoderm development (EED) is a core component of the polycomb-repressive complex 2 (PRC2) whose mutations are linked to neurodevelopmental abnormalities, intellectual disability, and neurodegeneration. Although EED has been extensively studied in neural stem cells and oligodendrocytes, its role in microglia is incompletely understood. Here, we show that microglial EED is essential for synaptic pruning during the postnatal stage of brain development. The absence of microglial EED at early postnatal stages resulted in reduced spines and impaired synapse density in the hippocampus at adulthood, accompanied by upregulated expression of phagocytosis-related genes in microglia. As a result, deletion of microglial Eed impaired hippocampus-dependent learning and memory in mice. These results suggest that microglial EED is critical for normal synaptic and cognitive functions during postnatal development.
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The EED gene codes for a core component of the polycomb-repressive complex 2, which has been linked to neurodevelopmental abnormalities, intellectual disability, and neurodegeneration, and microglial EED has been suggested to play a pivotal role in normal synaptic and cognitive functions.
“The embryonic ectoderm development gene (EED) codes for a core component of the polycomb-repressive complex 2, which has been linked to neurodevelopmental abnormalities, intellectual disability, and neurodegeneration, and microglial EED has been suggested to play a pivotal role in normal synaptic and cognitive functions (Wang et al., 2022).”
From Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response? (2024) · cites this paper as Wang et al., 2022
Cites
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 1× · see citing works
“As 5xFAD mice, a popular mouse model of Alzheimer’s disease (AD), have spatial learning and memory deficits from 2 months of age [31], and there are published transcriptomic profiles of microglia in 5xFAD mice [32].”
BackgroundKrasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works
Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works
Microglia and macrophages in brain homeostasis and disease
Li, Q., & Barres, B. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.125 · Cited by 1,999 · see citing works
Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works
The microglial sensome revealed by direct RNA sequencing
Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511 · see citing works
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution
Masuda, T., Sankowski, R., Staszewski, O., Böttcher, C., Amann, L., Sagar, Scheiwe, C., Nessler, S., Kunz, P., van Loo, G., et al. (2019) · Nature · doi:10.1038/s41586-019-0924-x · Cited by 1,310 · see citing works
Gosselin, D., Link, V. M., Romanoski, C. E., Fonseca, G. J., Eichenfield, D. Z., Spann, N. J., Stender, J. D., Chun, H. B., Garner, H., Geissmann, F., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.023 · Cited by 1,307 · see citing works
Zhan, Y., Paolicelli, R. C., Sforazzini, F., Weinhard, L., Bolasco, G., Pagani, F., Vyssotski, A. L., Bifone, A., Gozzi, A., Ragozzino, D., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3641 · Cited by 1,236 · see citing works
Role of the polycomb protein EED in the propagation of repressive histone marks
Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury, W. J., Voigt, P., Martin, S. R., Taylor, W. R., Marco, V. D., et al. (2009) · Nature · doi:10.1038/nature08398 · Cited by 1,203 · see citing works
Microglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180 · see citing works
Microglia development and function
Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154 · see citing works
Microglial brain region-dependent diversity and selective regional sensitivities to aging
Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151 · see citing works
Li, Q., Cheng, Z., Zhou, L., Darmanis, S., Neff, N. F., Okamoto, J., Gulati, G., Bennett, M. L., Sun, L. O., Clarke, L. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.006 · Cited by 1,129 · see citing works
Li, Q., Cheng, Z., Zhou, L., et al. (2018) · bioRxiv · doi:10.1101/406363 · Cited by 972 · see citing works
Microglia Heterogeneity in the Single-Cell Era
Masuda, T., Sankowski, R., Staszewski, O., & Prinz, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.010 · Cited by 784 · see citing works
Minocycline selectively inhibits M1 polarization of microglia
Kobayashi, K., Imagama, S., Ohgomori, T., Hirano, K., Uchimura, K., Sakamoto, K., Hirakawa, A., Takeuchi, H., Suzumura, A., Ishiguro, N., et al. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.54 · Cited by 742 · see citing works
Filipello, F., Morini, R., Corradini, I., Zerbi, V., Canzi, A., Michalski, B., Erreni, M., Markicevic, M., Starvaggi-Cucuzza, C., Otero, K., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.016 · Cited by 695 · see citing works
Microglia: Dynamic Mediators of Synapse Development and Plasticity
Wu, Y., Dissing-Olesen, L., MacVicar, B. A., & Stevens, B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.008 · Cited by 661 · see citing works
Microglia mediate forgetting via complement-dependent synaptic elimination
Wang, C., Yue, H., Hu, Z., Shen, Y., Ma, J., Li, J., Wang, X.-D., Wang, L., Sun, B., Shi, P., et al. (2020) · Science · doi:10.1126/science.aaz2288 · Cited by 629 · see citing works
Molecular mechanisms directing PRC2 recruitment and H3K27 methylation
Laugesen, A., Højfeldt, J. W., & Helin, K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.011 · Cited by 602 · see citing works
High‐yield isolation of murine microglia by mild trypsinization
Saura, J., Tusell, J. M., & Serratosa, J. (2003) · Glia · doi:10.1002/glia.10274 · Cited by 595 · see citing works
Microglial regional heterogeneity and its role in the brain
Tan, Y.-L., Yuan, Y., & Tian, L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0609-8 · Cited by 571 · see citing works
Epigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460 · see citing works
Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T. A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M., & Gotoh, Y. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.021 · Cited by 447 · see citing works
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease
Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.010 · Cited by 378 · see citing works
Mutations in EZH2 Cause Weaver Syndrome
Gibson, W. T., Hood, R. L., Zhan, S. H., Bulman, D. E., Fejes, A. P., Moore, R. A., Mungall, A. J. J., Eydoux, P., Babul‐Hirji, R., An, J., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.018 · Cited by 320 · see citing works
Microglia, Lifestyle Stress, and Neurodegeneration
Madore, C., Yin, Z., Leibowitz, J. A., & Butovsky, O. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.003 · Cited by 310 · see citing works
Inverse occurrence of cancer and Alzheimer disease: A population-based incidence study
Musicco, M., Adorni, F., Di Santo, S., Prinelli, F., Pettenati, C., Caltagirone, C., Palmer, K., & Russo, A. (2013) · Neurology · doi:10.1212/wnl.0b013e31829c5ec1 · Cited by 295 · see citing works
Positional cloning of a global regulator of anterior–posterior patterning in mice
Schumacher, A., Faust, C. J., & Magnuson, T. (1996) · Nature · doi:10.1038/383250a0 · Cited by 292 · see citing works
EZH2-Targeted Therapies in Cancer: Hype or a Reality
Eich, M., Athar, M., Ferguson, J. E., & Varambally, S. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2147 · Cited by 246 · see citing works
Lavarone, E., Barbieri, C., & Pasini, D. (2019) · Nature Communications · doi:10.1038/s41467-019-09624-w · Cited by 232 · see citing works
Functional antagonism of the polycomb-group genes eed and Bmi1 in hemopoietic cell proliferation
Lessard, J., Schumacher, A., Thorsteinsdottir, U., van Lohuizen, M., Magnuson, T., & Sauvageau, G. (1999) · Genes & Development · doi:10.1101/gad.13.20.2691 · Cited by 219 · see citing works
Ibáñez, K., Boullosa, C., Tabarés‐Seisdedos, R., Baudot, A., & Valencia, A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004173 · Cited by 203 · see citing works
Nikodemova, M., Kimyon, R. S., De, I., Small, A. L., Collier, L. S., & Watters, J. J. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.11.018 · Cited by 192 · cited 1× · see citing works
“The microglial population in the healthy brain is reduced by 50% and maintained in adulthood [45].”
BackgroundMicroglia regulate synaptic development and plasticity
Andoh, M., & Koyama, R. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22814 · Cited by 188 · see citing works
Cheng, Y., Wang, Z., Tan, W., Wang, X., Li, Y., Bai, B., Li, Y., Zhang, S.-F., Yan, H., Chen, Z.-L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0261-7 · Cited by 136 · see citing works
Self-citationLanni, C., Masi, M., Racchi, M., & Govoni, S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0760-2 · Cited by 130 · see citing works
Brain region-specific gene expression profiles in freshly isolated rat microglia
Doorn, K. J., Brevé, J. J. P., Drukarch, B., Boddeke, H. W. G. M., Huitinga, I., Lucassen, P. J., & van Dam, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00084 · Cited by 110 · see citing works
Gao, X., Enikolopov, G., & Chen, J. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.007 · Cited by 101 · see citing works
Peng, H., Geil, C., Chen, K. Y., McClain, J. A., & Nixon, K. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.02.175 · Cited by 95 · see citing works
Erratum: Positional cloning of a global regulator of anterior–posterior patterning in mice
Schumacher, A., Faust, C., & Magnuson, T. (1996) · Nature · doi:10.1038/384648a0 · Cited by 67 · see citing works
The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice
Tang, G.-B., Zeng, Y., Liu, P., Mi, T., Zhang, S.-F., Dai, S., Tang, Q.-Y., Yang, L. S., Xu, Y.-J., Yan, H.-L., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00267 · Cited by 65 · see citing works
Self-citationNovel EED mutation in patient with Weaver syndrome
Cooney, E., Bi, W., Schlesinger, A. E., Vinson, S. S., & Potocki, L. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38055 · Cited by 56 · see citing works
Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues
Biase, L. M. D., & Bonci, A. (2018) · The Neuroscientist · doi:10.1177/1073858418800996 · Cited by 55 · see citing works
EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms
Ueda, T., Sanada, M., Matsui, H., Yamasaki, N., Honda, Z.-I., Shih, L.-Y., Mori, H., Inaba, T., Ogawa, S., & Honda, H. (2012) · Leukemia · doi:10.1038/leu.2012.146 · Cited by 54 · see citing works
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters
Dai, S., Liu, P., Du, H., Liu, X., Xu, Y., Liu, C., Wang, Y.-Y., Teng, Z., & Liu, C. (2021) · EMBO Reports · doi:10.15252/embr.202052023 · Cited by 49 · see citing works
Self-citationRichie, E. R., Schumacher, A., Angel, J. M., Holloway, M., Rinchik, E. M., & Magnuson, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205051 · Cited by 46 · see citing works
Neurodegeneration and Cancer: Where the Disorder Prevails
Klus, P., Cirillo, D., Botta‐Orfila, T., & Tartaglia, G. G. (2015) · Scientific Reports · doi:10.1038/srep15390 · Cited by 46 · see citing works
Wang, J., Yang, L., Dong, C., Wang, J., Xu, L., Qiu, Y., Weng, Q., Zhao, C., Xin, M., & Lu, Q. R. (2020) · Science Advances · doi:10.1126/sciadv.aaz6477 · Cited by 42 · see citing works
Liu, P., Xu, Y., Dai, S., Du, H., Wang, Y., Li, X., Teng, Z., & Liu, C. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.05.010 · Cited by 41 · see citing works
Self-citationSauvageau, M., Miller, M., Lemieux, S., Lessard, J. A., Hébert, J., & Sauvageau, G. (2007) · Blood · doi:10.1182/blood-2007-07-098236 · Cited by 35 · see citing works
Liu, P., Tang, G.-B., Xu, Y., Zeng, Y.-Q., Zhang, S.-F., Du, H., Teng, Z., & Liu, C.-M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.007 · Cited by 29 · see citing works
Self-citationLocation, Location, Location: Microglia Are Where They Live
McCarthy, M. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.005 · Cited by 29 · see citing works
Zhang, F., Yan, Y., Cao, X., Zhang, J., Li, Y., & Guo, C. (2021) · Aging · doi:10.18632/aging.103822 · Cited by 29 · see citing works
Ueda, T., Nakata, Y., Nagamachi, A., Yamasaki, N., Kanai, A., Sera, Y., Sasaki, M., Matsui, H., Honda, Z., Oda, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600070113 · Cited by 27 · see citing works
Cheray, M., Stratoulias, V., Joseph, B., & Grabert, K. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00522 · Cited by 6 · see citing works
Flagged first, then by citations
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The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases
Tsuji, A., Ikeda, Y., Yoshikawa, S., Taniguchi, K., Sawamura, H., Morikawa, S., Nakashima, M., Asai, T. T., & Matsuda, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065742 · Cited by 153 · see citing works
Microglia-mediated synaptic pruning as a key deficit in neurodevelopmental disorders: Hype or hope?
Mordelt, A., & de Witte, L. D. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102674 · Cited by 95 · see citing works
Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell
Dermitzakis, I., Μanthou, M. E., Meditskou, S., Tremblay, M., Petratos, S., Zoupi, L., Boziki, M. K., Kesidou, E., Simeonidou, C., & Theotokis, P. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030171 · Cited by 48 · see citing works
Firdaus, Z., & Li, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042320 · Cited by 43 · see citing works
Microglial phagocytosis in Alzheimer disease
Brown, G. C., St George-Hyslop, P., Paolicelli, R. C., & Lemke, G. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-025-01162-y · Cited by 36 · see citing works
Yoshikawa, S., Taniguchi, K., Sawamura, H., Ikeda, Y., Tsuji, A., & Matsuda, S. (2022) · Metabolites · doi:10.3390/metabo12111052 · Cited by 25 · see citing works
You, Y., Chen, Z., & Hu, W. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108606 · Cited by 22 · see citing works
Dundee, J. M., Puigdellívol, M., Butler, R., & Brown, G. C. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1089-23.2023 · Cited by 23 · see citing works
Zhu, L., Mao, K., Liu, L., Xu, S., Zeng, M., Fu, Y., Huang, J., Li, T., Gao, G., Teng, Z., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113964 · Cited by 18 · see citing works
Self-citationZhang, F., Wang, Q.-Y., Zhou, J., Zhou, X., Xia, W., Hu, L., Cheng, H., Yu, Q., & Cai, R.-L. (2023) · iScience · doi:10.1016/j.isci.2023.107645 · Cited by 18 · see citing works
Shi, R., Liu, C., Xu, Y., Wang, Y., He, B., He, X., Du, H., Hu, B., Jiao, J., Liu, C., et al. (2023) · Cells · doi:10.3390/cells12040558 · Cited by 17 · see citing works
Self-citationLiu, C., Gao, X., Shi, R., Wang, Y., He, X., Du, H., Hu, B., Jiao, J., Liu, C., & Teng, Z. (2023) · Cell Proliferation · doi:10.1111/cpr.13439 · Cited by 16 · see citing works
Self-citationSchiele, M. A., Crespo Salvador, O., Lipovsek, J., Schwarte, K., Schlosser, P., Zwanzger, P., Arolt, V., Baune, B. T., Köttgen, A., & Domschke, K. (2024) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae045 · Cited by 13 · see citing works
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Choi, Y., & Chung, W. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00870-9 · Cited by 12 · see citing works
Huang, L., Li, F., Ye, L., Yu, F., & Wang, C. (2023) · Cell Proliferation · doi:10.1111/cpr.13413 · Cited by 10 · see citing works
Yoshikawa, S., Taniguchi, K., Sawamura, H., Ikeda, Y., Tsuji, A., & Matsuda, S. (2022) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2022.00114 · Cited by 10 · see citing works
Cardona, C. L., Wei, L., Kim, J., Angeles, E., Singh, G., Chen, S., Patel, R., Ifediora, N., Canoll, P., Teich, A. F., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03562-9 · Cited by 8 · see citing works
Emerging non-proinflammatory roles of microglia in healthy and diseased brains
Sun, Y., Che, J., & Zhang, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110664 · Cited by 8 · see citing works
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Shen, F.-S., Liu, C., Sun, H.-Z., Chen, X., Xue, Y., & Chen, L. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae098 · Cited by 8 · see citing works
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Wang, J., Xiao, X., He, X., He, B., Liu, C., & Teng, Z. (2023) · Cells · doi:10.3390/cells12202429 · Cited by 6 · see citing works
Self-citationKe, J.-P., He, B., Gong, M., Yan, Z.-Z., Du, H., Teng, Z., & Liu, C. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01852-y · Cited by 5 · see citing works
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Self-citationDong, J., Chen, W., Chang, S., Liu, N., Zhu, W. J., Ma, L., Qiao, J., Wang, Y., Mao, Z., & Kang, J. (2025) · The FASEB Journal · doi:10.1096/fj.202402934r · Cited by 3 · see citing works
Self-citationKirikae, H., Kimura, K., Fu, J., Sun, Z., Wang, H., SHIBUYA, H., Kasahara, Y., Miyazaki, H., Yamamoto, Y., Sakai, M., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106534 · Cited by 2 · see citing works
Nakashima, M. (2024) · International Journal of Physiology Pathophysiology and Pharmacology · doi:10.62347/wazh2090 · Cited by 1 · see citing works
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Ye, L., Shen, Z., Yang, Q. Z. C., Wu, X., Ye, J., Li, Z., Xiong, F., Che, S., Zhao, C., & Wang, Z. (2025) · Research Square · doi:10.21203/rs.3.rs-6582362/v1
Ye, L., Shen, Z., Yang, Q., Wu, X., Ye, J., Li, Z., Xiong, F., Che, S., Zhao, C., & Wang, Z. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107236
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Adaptive Immune Signals Shape Neural Circuit Development Through CNS Border-Glia Pathways.
Wei, X., Liu, F.-X., & Shi, Z.-G. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106201
Zhang, K., Zheng, Y., Liu, X., Pan, J., Qi, H., Wang, A., Li, X., Wu, F., Shen, X., Liu, H., et al. (2026) · Environment International · doi:10.1016/j.envint.2026.110482
- Authors
- Wang, Y.-Y., Deng, Y.-S., Dai, S.-K., Mi, T.-W., Li, R.-Y., Liu, P.-P., Liu, C., He, B.-D., He, X.-C., Du, H.-Z., Yang, H.-C., Tang, Y., Liu, C.-M., & Teng, Z.-Q.
- Affiliations
- Chinese Academy of Sciences (CN)
- Capital Medical University (CN)
- Corresponding author
- Liu, Cong
- Tang, Yi
- Liu, Chang-Mei
- Teng, Zhao-Qian
- Venue
- Molecular Psychiatry
- Published
- 2022-04-28
- Volume
- 27
- Issue
- 7
- Pages
- 2999-3009
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W4225015717
- Cited by
- 32
- References
- 62
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 3
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the National Key Research and Development Program of China Project
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- EED, microglia, polycomb repressive complex 2, synaptic pruning, synaptic density, dendritic spines, hippocampus, learning and memory, phagocytosis, postnatal brain development, intellectual disability, neurodevelopmental disorders
- MeSH terms
- Animals, Hippocampus, Synapses, Microglia, Mice, Neural Stem Cells, Polycomb Repressive Complex 2
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