Cited by 695Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignNeural dynamics and brain function

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Novel electrode technologies for neural recordings

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Hong, Guosong, Lieber, Charles M.·2019·Nature Reviews Neuroscience

DOI 10.1038/s41583-019-0140-6PMC PMC6531316

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Abstract

Neural recording electrode technologies have contributed considerably to neuroscience by enabling the extracellular detection of low-frequency local field potential oscillations and high-frequency action potentials of single units. Nevertheless, several long-standing limitations exist, including low multiplexity, deleterious chronic immune responses and long-term recording instability. Driven by initiatives encouraging the generation of novel neurotechnologies and the maturation of technologies to fabricate high-density electronics, novel electrode technologies are emerging. Here, we provide an overview of recently developed neural recording electrode technologies with high spatial integration, long-term stability and multiple functionalities. We describe how these emergent neurotechnologies can approach the ultimate goal of illuminating chronic brain activity with minimal disruption of the neural environment, thereby providing unprecedented opportunities for neuroscience research in the future.

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Authors: Hong, G., & Lieber, C. M.
Affiliations: Harvard University (US)
Corresponding author: Lieber, Charles M.
ORCID: Hong, Guosong
Lieber, Charles M.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2019-03-04
Volume: 20
Issue: 6
Pages: 330-345
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-019-0140-6
PMC: PMC6531316
OpenAlex: W2920339115
Cited by: 695
References: 157
Citations by year: 2026: 58 · 2025: 104 · 2024: 101 · 2023: 117 · 2022: 108 · 2021: 110 · 2020: 77 · 2019: 19
FWCI: 10.45
Type: journal article
Language: en
Update notices: correction (2019-04-16)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (R00AG056636)
National Institute of Biomedical Imaging and Bioengineering (DP1EB025835)
Air Force Office of Scientific Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: neural recording electrodes, single-unit recording, chronic neural recording, multifunctional electrodes, extracellular recording, neurotechnology
MeSH terms: Action Potentials, Animals, Brain, Electrodes, Electrodes, Implanted, Humans, Neurons

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