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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Open accessAbstract
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.
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“ACh signaling is essential for neuronal development, where it plays a trophic role in establishing and maintaining neuronal connectivity [111, 112].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [111]
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Metadata
- Authors
- Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ananth, Mala R.
- Role, Lorna W.
- Venue
- Nature Reviews Neuroscience
- Published
- 2023-02-23
- Volume
- 24
- Issue
- 4
- Pages
- 233-251
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC10439770
- OpenAlex
- W4321610346
- Semantic Scholar
- 87c380ffb1b9cea07172adcaa43cedaefb324e5a
- Cited by
- 148
- References
- 268
- Citations by year
- 2026: 44 · 2025: 63 · 2024: 36 · 2023: 5
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1zians009424-02, ZIA NS009424)
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- basal forebrain cholinergic neurons, acetylcholine, cholinergic neurotransmission, cognitive behavior
- MeSH terms
- Acetylcholine, Cognition, Humans, Signal Transduction, Cholinergic Agents, Basal Forebrain
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