Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

The cholinergic hypothesis of geriatric memory dysfunction

Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627

Theta oscillations in the hippocampus

Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332

Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962

The role of acetylcholine in learning and memory

Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693

Alzheimer's disease: Targeting the Cholinergic System

H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551

Molecular diversity and specializations among the cells of the adult mouse brain

Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404

Human Memory and the Cholinergic System

Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398

What is the amygdala?

Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

Cellular and organismal function of choline metabolism

Kenny, T. C., Scharenberg, S. G., Abu-Remaileh, M., & Birsoy, K. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01203-8 · Cited by 71

Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling

Lu, X., Xiong, W., Chen, Z., Li, Y.-M., Xu, F., Yang, X., Long, M., Guo, W., Wu, S., Sun, L. D., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01938-7 · Cited by 35

Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile

Huang, S., Yang, Z., Cheng, J., Li, H.-Y., Chen, S., Huang, Z.-H., Chen, J.-D., Xiong, R.-G., Yang, M.-T., Wang, C., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103578 · Cited by 33

Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation

Gargus, M., Ben‐Azu, B., Landwehr, A., Dunn, J., Errico, J. P., & Tremblay, M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1527842 · Cited by 32

Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model

Rabah, Y., Berwick, J.-P., Sagar, N., Pasquer, L., Plaçais, P.-Y., & Préat, T. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01189-3 · Cited by 26

Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks

Reynolds, L. M., Faure, P., & Barik, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03110-0 · Cited by 26

Cell-type-specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference

Zou, Y., Tong, C., Peng, W., Qiu, Y., Li, J., Xia, Y., Pei, M., Zhang, K., Li, W., Xu, M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.017 · Cited by 24

Impaired cognition in narcolepsy: clinical and neurobiological perspectives

Cano, C. A., Harel, B., & Scammell, T. E. (2024) · SLEEP · doi:10.1093/sleep/zsae150 · Cited by 23

The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease

Björklund, A., & Barker, R. A. (2024) · Brain · doi:10.1093/brain/awae026 · Cited by 21

Emerging Functions of Neuromodulation during Sleep

Sulaman, B. A., Zhang, Y., Matosevich, N., Kjærby, C., Foustoukos, G., Andersen, M., & Eban-Rothschild, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1277-24.2024 · Cited by 24

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Mousavi, H., Rimaz, M., & Zeynizadeh, B. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00055 · Cited by 21

Functionally refined encoding of threat memory by distinct populations of basal forebrain cholinergic projection neurons

Rajebhosale, P., Ananth, M. R., Kim, R., Crouse, R. B., Jiang, L., López‐Hernández, G. Y., Zhong, C., Arty, C., Wang, S., Jone, A., et al. (2024) · eLife · doi:10.7554/elife.86581 · Cited by 17

Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

Kim, R., Ananth, M. R., Desai, N. S., Role, L. W., & Talmage, D. A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114009 · Cited by 17

Cholinergic signaling to CA1 astrocytes controls fear extinction

Li, Y., Li, L., Wang, Y., Li, X., Ding, X., Li, L., Fei, F., Zheng, Y., Li, C., Duan, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads7191 · Cited by 16

Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT

Zheng, C., Liu, S., Modares, N. F., Paul, M. S., & Mak, T. W. (2025) · Nature Immunology · doi:10.1038/s41590-025-02144-4 · Cited by 16

Updating functional brain units: Insights far beyond Luria

Peña‐Casanova, J., Sánchez‐Benavides, G., & Sigg-Alonso, J. (2024) · Cortex · doi:10.1016/j.cortex.2024.02.004 · Cited by 16

Role of the Central Cholinergic Nervous System in Motor and Non-Motor Symptoms of Parkinson’s Disease

Tian, S.-Y., Cao, X., Liu, G.-J., Zi, Y., Zhu, H.-X., Jiang, Y.-M., Lou, W.-W., Fang, X.-X., Ling, S., Liu, Z., et al. (2025) · Current Neuropharmacology · doi:10.2174/011570159x368923250313045859 · Cited by 7

Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory

Mei, F., Zhao, C. F., Li, S., Xue, Z., Zhao, Y., Xu, Y., Ye, R., You, H., Yu, P., Han, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51707-w · Cited by 12

Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain

Li, H., Li, Y., Wang, T., Li, S., Liu, H., Ning, S., Shen, W., Zhao, Z., & Wu, H. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01296-x · Cited by 15

Design and synthesis of new 1,2,3-triazole-methoxyphenyl-1,3,4-oxadiazole derivatives: selective butyrylcholinesterase inhibitors against Alzheimer’s disease

Iraji, A., Hariri, R., Hashempur, M. H., Ghasemi, M., Pourtaher, H., Saeedi, M., & Akbarzadeh, T. (2025) · BMC Chemistry · doi:10.1186/s13065-025-01475-5 · Cited by 12

Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology

Rennie, K. (2025) · Life · doi:10.3390/life15071032 · Cited by 11

Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training

Abdulla, Z. I., Mineur, Y. S., Crouse, R. B., Etherington, I. M., Yousuf, H., Na, J. J., & Picciotto, M. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02003-0 · Cited by 11

Cholinergic degeneration in prodromal and early Parkinson’s disease: a link to present and future disease states

Eisenstein, T., Groenewald, K., van Hillegondsberg, L., Alhajraf, F., Zerenner, T., Lawton, M., Ben‐Shlomo, Y., Griffanti, L., Hu, M. T., & Klein, J. C. (2025) · Brain · doi:10.1093/brain/awaf168 · Cited by 11

Neural Correlates of Early-Life Urbanization and Their Spatial Relationships with Gene Expression, Neurotransmitter, and Behavioral Domain Atlases

Huang, W., Sun, X., Zhang, X., Xu, R., Qian, Y., & Zhu, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03962-7 · Cited by 10

The Modulation of Neuroimmune Responses in Peripheral Inflammation

Wang, J., Ji, D., Dai, N., Chang, Q., Gong, M., & Fu, B. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s533106 · Cited by 12

Acetylcholine chemotaxis in global bacterial plant pathogens

Gavira, J. A., Gilabert, M. J., Santamaría‐Hernando, S., Molina-Ollero, A., Rico‐Jiménez, M., Cabrera, J. J., López‐Solanilla, E., & Matilla, M. A. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128294 · Cited by 9

Unlocking the neuroprotective secrets of natural products: a focus on the gut-brain axis

Yang, X., Hu, D., Cheng, R., Bao, Q., Jiang, H., Zhao, B., & Zhang, Y. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10081-1 · Cited by 11

Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes

Chen, Z., Liu, Y., Yang, Y., Wang, L., Qin, M., Jiang, Z., Xu, M., & Zhang, S. (2025) · Science Advances · doi:10.1126/sciadv.adt1617 · Cited by 10

The cholinergic basal forebrain and its role in neurodegeneration

Cykowski, M. D., & Masdeu, J. C. (2025) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaf112 · Cited by 8

Whole Genome Sequencing and Extracellular Metabolite Profiling of Lactiplantibacillus plantarum FRT4: Insights into Probiotic Functionality

Huang, Y., Meng, K., Liu, G., Chen, Z., Han, Y., Yang, P., Zhang, R., & Cai, H. (2025) · Biology · doi:10.3390/biology14091167 · Cited by 7

Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways

Chen, J., Li, Q., Ji, B., Zhang, K., Ren, M., Li, A., Gong, H., Wang, J., Cao, G., Luo, Q., et al. (2025) · Brain · doi:10.1093/brain/awaf060 · Cited by 7

Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders

Abraham, S. M., Suresh, S., & Komal, P. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01586-6 · Cited by 8

Rethinking early Alzheimer’s disease: An impaired internal model updating disorder?

Antonioni, A. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106790 · Cited by 8

Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice

Zheng, F., Wess, J., & Alzheimer, C. (2023) · Cells · doi:10.3390/cells12141890 · Cited by 7

Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

Li, C., Xiao, L., Lin, W., Li, M., Liu, J., Qiu, X., Li, M., Zheng, Y., Xu, C., Wang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50042-4 · Cited by 7

Decoding the long-term impacts of genetic modifications in hormone pathways on plant physiology and ecosystem stability

Khan, N. (2025) · Environmental Reviews · doi:10.1139/er-2025-0081 · Cited by 6

Developing personalized treatment strategies for Parkinson’s disease based on disease subtypes

Hey, G. E., Eisinger, R. S., Guarín, D. L., Safarpour, D., Rodríguez‐Violante, M., & Ramirez‐Zamora, A. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2552784 · Cited by 7

Neuroscience in prostate cancer

Liu, Z., Peng, Q., Wang, Y., Chiu, P. K., Teoh, J. Y., Wang, R., Liu, X., Wu, D., & Ng, C. (2025) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-025-01042-y · Cited by 5

Distinct Neural Mechanisms Between Anesthesia Induction and Emergence: A Narrative Review

Zhang, D., & Wei, Y. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007114 · Cited by 7

Long‐range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse

Ren, M., Li, Y., Jiang, T., Liu, B., Li, X., Jia, X., Li, A., Luo, Q., Gong, H., & Li, X. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14552 · Cited by 5

A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice

Ananth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Záborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C., & Role, L. W. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115249 · Cited by 8

Molecular organization of central cholinergic synapses

Rosenthal, J., Zhang, D., Yin, J., Long, C., Yang, G., Li, Y., Lu, Z., Li, W., Yu, Z., Li, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422173122 · Cited by 6

Efficient separation and quantitative sleep evaluation of phospholipids and glycerides of Antarctic krill

Liang, Y., Jiang, K., Tu, J., Liu, Z., Hu, Y., Gong, W., Li, J., Dong, X., Hardiman, G., Guo, X., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144529 · Cited by 6

Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

Manjila, S. B., Son, S., Parmaksiz, D., Kline, H. L., Betty, R., Wu, Y.-T., Pi, H.-J., Shin, D., Liwang, J. K., Kronman, F. N., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115827 · Cited by 8

The complex relationship between the microbiota-gut-brain axis and neurodegenerative diseases and future perspectives

Chen, Y., Wang, D., Liao, Y., Zuo, G., & Lu, X. (2024) · Discover Medicine · doi:10.1007/s44337-024-00135-2 · Cited by 5

The Central Cholinergic Synapse: A Primer

Klein, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199670 · Cited by 5

Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input

Xie, L., Wang, X., Lin, X., Wen, J., Ma, T., Leong, A. T. L., & Wu, E. X. (2025) · Nature Communications · doi:10.1038/s41467-025-66104-0 · Cited by 8

Effects of Ficus exasperata on neurotransmission and expression of BDNF, tau, ACHE and BACE in diabetic rats

Adeyomoye, O., Adetunji, J. B., Olaniyan, O. T., Adetunji, C. O., & Ogunmiluyi, O. E. (2024) · Metabolism Open · doi:10.1016/j.metop.2024.100333 · Cited by 5

Basal forebrain cholinergic input mediates adaptive attention allocation to enhance olfactory discrimination

Garg, R., Qiu, Q., & Yu, C. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003374 · Cited by 5

Enhanced TrkA signaling impairs basal forebrain-dependent behavior

Calvo-Enrique, L., Lisa, S., Vicente‐García, C., Deogracias, R., & Arévalo, J. C. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1266983 · Cited by 4

Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention

Xu, X., Anayiti, X., Chen, P., Xie, Z., Tao, M., Xiang, Y., Tan, M., Liu, Y., Yue, L., Xiao, S., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100298 · Cited by 4

Amygdala‐Dependent Signaling Pathways and Regulating Circuits in Fear Memory

Huang, M.-Q., Liang, X., Lin, X., Li, W., Jiang, Y., & Geng, F. (2025) · Synapse · doi:10.1002/syn.70026 · Cited by 4

Recent Advances and Future Directions in Alzheimer’s Disease Genetic Research

Stancheva, M., Toncheva, D. I., & Karachanak-Yankova, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167819 · Cited by 4

Design of N-salicyltryptamines-based highly selective BChE inhibitors to elevate brain acetylcholine, improve learning, and reduce amyloid-β in Alzheimer's disease

Wu, K., Yang, C., Zeng, J., Wu, Q., Zhao, Y., Hu, C., Zhao, Y., Wu, J., Wang, Z., Wang, Z., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118273 · Cited by 4

Acetylcholine Neurons Become Cholinergic during Three Time Windows in the Developing Mouse Brain

Goral, R. O., Lamb, P. W., & Yakel, J. L. (2024) · eNeuro · doi:10.1523/eneuro.0542-23.2024 · Cited by 5

Cholinergic modulation of reinforcement learning and prefrontal value computations under uncertaintyPreprint

Kurtenbach, H., Froböse, M. I., Ort, E., Bahners, B. H., Butz, M., Schnitzler, A., Hirschmann, J., & Jocham, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.20.614105 · Cited by 4

Comparative Physiology and Morphology of BLA‐Projecting NBM/SI Cholinergic Neurons in Mouse and Macaque

Luo, F., Jiang, L., Desai, N. S., Li, B., Watkins, G. V., Eldridge, M. A. G., Plotnikova, A. S., Mohanty, A., Cummins, A. C., Averbeck, B. B., et al. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.70001 · Cited by 3

Acetylcholine and muscarinic receptor targeting in bipolar disorder: does xanomeline-trospium chloride and other investigational muscarinic agonists hold promise as mechanistically informed treatments for manic episodes, mixed features and cognitive deficits in bipolar disorder?

McIntyre, R. S. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2522885 · Cited by 3

Cholinergic white matter pathways integrity in prodromal and early manifest Lewy body disease

Eisenstein, T., Groenewald, K., van Hillegondsberg, L., Alhajraf, F., Zerenner, T., Lawton, M., Ben‐Shlomo, Y., Griffanti, L., Hu, M. T. M., & Klein, J. C. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf421 · Cited by 3

Cholinergic Phenotypes of Acetyl-CoA with ATP-Citrate Lyase Link

Gul‐Hinc, S., Jankowska-Kulawy, A., & Szutowicz, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020782 · Cited by 4

Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain

Jia, L., Li, X., Yan, Y., Xu, L., Guo, J., Wang, W., Zhang, W., Li, L., Shang, B., Zhang, Y., et al. (2026) · Science · doi:10.1126/science.adw1803 · Cited by 4

Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex

Vattino, L. G., Clayton, K. K., Hackett, T. A., Polley, D. B., & Takesian, A. E. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf338 · Cited by 5

Analysis of the Efficacy of Acetylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease, Literature Review

Petrov, W., Ślebioda, D., Kozińska, R. B., Kukla, K., Petrov, P., Sroka, M., Tesyna, J., Puźniak, G., Kudliński, M., Rejda, T., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135733 · Cited by 4

Nicotinic acetylcholine receptors in the brain

Barrantes, F. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00004-4 · Cited by 3

Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo

Xie, S., Miao, X., Li, G., Zheng, Y. R., Li, M., Ji, E., Wang, J., Li, S., Cai, R., Geng, L., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02325-w · Cited by 4

The therapeutic potential of naringenin, a natural citrus flavonoid, on pulpal pain and pain‐related cognitive dysfunction

Hashemi, M., Raouf, F. H., Dogani, M., Shahsavari, F., Abasnejad, M., Esmaeili‐Mahani, S., Khezri, A., Mirmohammadi, H., & Omid Dianat, A. (2025) · International Endodontic Journal · doi:10.1111/iej.14267 · Cited by 2

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Ma, P., Zhang, K., Yi, L., Yang, C., Lang, H., Sun, J., Li, J., Bai, Q., He, Y., Dai, S., et al. (2025) · Advanced Science · doi:10.1002/advs.202500177 · Cited by 2

Improving Visual Working Memory with Cholinergic Deep Brain Stimulation

Bava, J., Wang, Z., Bick, S. K. B., Englot, D. J., & Constantinidis, C. (2023) · Brain Sciences · doi:10.3390/brainsci13060917 · Cited by 2

Effects of Aging and Nerve Growth Factor on Neuropeptide Expression and Cholinergic Innervation of the Rat Basolateral Amygdala

Pereira, P. A., Tavares, M., Laires, M., Mota, B., Madeira, M. D., Paula-Barbosa, M. M., & Cardoso, A. (2024) · Biology · doi:10.3390/biology13030155 · Cited by 1

Cholinergic System Structure and Function Changes in Individuals with Down Syndrome During the Development of Alzheimer’s Disease

Russell, J. K., Conley, A. C., Wilson, J. E., & NEWHOUSE, P. A. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_523 · Cited by 3

Brain glucose metabolism as a neuronal substrate of the abnormal behavioral response to stress in the mdx mouse, a model of Duchenne muscular dystrophy

Goutal, S., Lancien, M., Rivier, F., Tournier, N., & Vaillend, C. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106771 · Cited by 2

Hierarchical organization of the forebrain cholinergic system in rats

Varsanyi, P., Alloway, K. D., Chavez, C. M., Gielow, M. R., Gombkötő, P., Kondo, H., Nádasdy, Z., & Záborszky, L. (2025) · iScience · doi:10.1016/j.isci.2025.112001 · Cited by 3

Mechanisms of the Pathogenesis of Alzheimer’s Disease: The Role of the Basal Forebrain

Kitchigina, V. F., Popova, I. Y., & Shubina, L. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01784-1 · Cited by 2

Novel opportunities for treating complex neuropsychiatric and neurocognitive conditions based on recent developments with xanomeline

Pavlov, V. A. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1593341 · Cited by 2

Cognitive Impairment in Temporal Lobe Epilepsy: Alterations in the Basal Forebrain Cholinergic System

Shen, B., Jiang, L., Shi, Y., Guo, J., Chen, B., Qiu, Z., Wang, S., Yuan, Z., & Fang, J. (2025) · Brain and Behavior · doi:10.1002/brb3.71090 · Cited by 2

Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neuronsPreprint

Brahmia, B., Naaldijk, Y., Sarkar, P., Parisiadou, L., & Hilfiker, S. (2024) · eLife · doi:10.7554/elife.101135.1 · Cited by 3

Cholinergic recruitment of Chandelier cells during arousalPreprint

Martinez-Marquez, E., Reyes-León, S., Garcia-San-Jose, F., López-Begines, S., Nieto-González, J. L., & García‐Junco‐Clemente, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.18.633708 · Cited by 2

The Neural Basis of AgingPreprint

Jackson, B. (2025) · doi:10.33774/coe-2025-fcg76-v3 · Cited by 1

The activity of cholinergic neurons in the basal forebrain interferes with anesthesia-arousal process of propofol

Feng, C.-H., Du, X., Wang, Z., Wu, T., & Zhang, L.-N. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102449 · Cited by 1

Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice

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Jackson, B. (2025) · doi:10.33774/coe-2025-fcg76-v2

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Richardson, R. T. (1991) · Medical Entomology and Zoology · Cited by 70

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