Cited by 148Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

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Ananth, Mala R., Rajebhosale, Prithviraj, Kim, Ronald, Talmage, David A., Role, Lorna W.·2023·Nature Reviews Neuroscience

DOI 10.1038/s41583-023-00677-xPMC PMC10439770

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Abstract

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have mapped the activity and functional connectivity of cholinergic neurons have shown that the axons of basal forebrain cholinergic neurons innervate the pallium with far more topographical and functional organization than was historically appreciated. Together with the results of studies using new probes that allow release of acetylcholine to be detected with high spatial and temporal resolution, these findings have implicated cholinergic networks in 'binding' diverse behaviours that contribute to cognition. Here, we review recent findings on the developmental origins, connectivity and function of cholinergic neurons, and explore the participation of cholinergic signalling in the encoding of cognition-related behaviours.

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Authors: Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W.
Affiliations: National Institutes of Health (US)
Corresponding author: Ananth, Mala R.
Role, Lorna W.
ORCID: Ananth, Mala R.
Rajebhosale, Prithviraj
Kim, Ronald
Talmage, David A.
Role, Lorna W.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2023-02-23
Volume: 24
Issue: 4
Pages: 233-251
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-023-00677-x
PMC: PMC10439770
OpenAlex: W4321610346
Semantic Scholar: 87c380ffb1b9cea07172adcaa43cedaefb324e5a
Cited by: 148
References: 268
Citations by year: 2026: 44 · 2025: 63 · 2024: 36 · 2023: 5
FWCI: 5.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1zians009424-02, ZIA NS009424)
National Institute of Neurological Disorders and Stroke
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: basal forebrain cholinergic neurons, acetylcholine, cholinergic neurotransmission, cognitive behavior
MeSH terms: Acetylcholine, Cognition, Humans, Signal Transduction, Cholinergic Agents, Basal Forebrain

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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

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