5-HT release in nucleus accumbens rescues social deficits in mouse autism model

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The social motivation theory of autism

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Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

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Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism

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Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

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IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness

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Extrahippocampal Contributions to Social Memory: The Role of Septal Nuclei

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Effect of Aggressive Experience in Female Syrian Hamsters on Glutamate Receptor Expression in the Nucleus Accumbens

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Distinct Dynamics of Theta and Gamma Rhythmicity during Social Interaction Suggest Differential Mode of Action in the Medial Amygdala of Sprague Dawley Rats and C57BL/6J Mice

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Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance

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Oxytocin treatments or activation of the paraventricular nucleus-the shell of nucleus accumbens pathway reduce adverse effects of chronic social defeat stress on emotional and social behaviors in Mandarin voles

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Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene

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Gray areas: Neuropeptide circuits linking the Edinger-Westphal and Dorsal Raphe nuclei in addiction

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An Ascending Excitatory Circuit from the Dorsal Raphe for Sensory Modulation of Pain

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Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice

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Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion

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Galvanic Redox Potentiometry for Fouling‐Free and Stable Serotonin Sensing in a Living Animal Brain

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Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse

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Aptamer‐Based Galvanic Potentiometric Sensor for Real‐Time Monitoring of Serotonin Signaling Under Psychosocial Stress

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5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA

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Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder

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A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice

Kang, S. J., Kim, J., Kim, D., Roberts, B. Z., & Han, S. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01504-3 · Cited by 14

Fluorene-9-bisphenol acts on the gut-brain axis by regulating oxytocin signaling to disturb social behaviors in zebrafish

Zhang, S., Mi, P., Luan, J., Sun, M., Zhao, X. J., & Feng, X. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119169 · Cited by 13

Bioisosteric analogs of MDMA : Improving the pharmacological profile?

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DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice

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Intracranial mast cells contribute to the control of social behavior in male mice

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Acupuncture and oxytocinergic system: The promising treatment for autism

Su, T., & Pei, L. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2021-0011 · Cited by 13

Clinical and Neurobiological Aspects of TAO Kinase Family in Neurodevelopmental Disorders

Hu, C., Feng, P., Yang, Q., & Xiao, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.655037 · Cited by 13

Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder

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Sex-Specific Stress-Related Behavioral Phenotypes and Central Amygdala Dysfunction in a Mouse Model of 16p11.2 Microdeletion

Giovanniello, J. R., Ahrens, S., Yu, K., & Li, B. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.01.001 · Cited by 13

Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring

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Imaging neural circuit pathology of autism spectrum disorders: autism-associated genes, animal models and the application of in vivo two-photon imaging

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Maternal LPS Exposure Enhances the 5-HT Level in the Prefrontal Cortex of Autism-like Young Offspring

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A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens

Borland, J. M. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101175 · Cited by 13

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

Ni, R., Shu, Y., Li, T., & Zhou, J. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.763298 · Cited by 12

Autism Spectrum Disorder (ASD) : Definition, Contexts, Neural Correlates and Clinical Strategies

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Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish

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Serotonin and the neurobiology of anxious states

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Control of cortical synapse development and plasticity by MET receptor tyrosine kinase, a genetic risk factor for autism

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Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice

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Evolution of the acoustic startle response of Mexican cavefish

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Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse

Stilley, S. E., & Blakely, R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.677563 · Cited by 13

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a -deficiencyPreprint

Zhang, J., Eaton, M., Chen, X., Zhao, Y., Kant, S., Deming, B. A., Harish, K., Nguyen, H. P., Shu, Y. L., Lai, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.04.641498 · Cited by 10

Social deprivation substantially changes multi-structural neurotransmitter signature of social interaction: Glutamate concentration in amygdala and VTA as a key factor in social encounter-induced 50-kHz ultrasonic vocalization

Hamed, A., & Kursa, M. B. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.06.010 · Cited by 10

Sex-Dependent Effects of Chronic Social Defeat on Emotional and Social Behaviors, and Parameters of Oxytocin and Vasopressin Systems in Mandarin Voles (Microtus mandarinus)

Hou, W., Ma, H., Xun, Y., Zhang, X., Cai, W., Huang, S., He, Z., Tai, F., & Jia, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.625116 · Cited by 10

Dorsal Raphe Nucleus Serotoninergic Neurons Mediate Morphine Rewarding Effect and Conditioned Place Preference

Fu, B., Yao, J.-Q., Lu, C., Wang, B., Li, Z., Huang, M., Tian, T., Peng, H., & Liu, S. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.10.031 · Cited by 10

Acute Rapamycin Rescues the Hyperexcitable Phenotype of Accumbal Medium Spiny Neurons in the Valproic Acid Rat Model of Autism Spectrum Disorder

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5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice

Jiang, Y., Zhou, J., Song, B.-L., Wang, Y., Zhang, D.-L., Zhang, Z., Li, L., & Liu, Y.-J. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176027 · Cited by 11

Tryptophan hydroxylase 2 deficiency alters autism-related behavioural phenotypes in rats

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Serotonin modulates social responses to stressed conspecifics via insular 5-HT 2C receptors in rat

Ng, A. J., Vincelette, L. K., Li, J., Brady, B. H., & Christianson, J. P. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109598 · Cited by 9

Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus

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Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats

Olaniran, A., Garcia, K. T., Burke, M. A. M., Lin, H., Vènniro, M., & Li, X. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06280-9 · Cited by 11

A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant

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Is the efficacy of oxytocin for autism diminished at higher dosages or repeated doses?: Potential mechanisms and candidate solutions

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TAAR1 and 5-HT1B receptor agonists attenuate autism-like irritability and aggression in rats prenatally exposed to valproic acid

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Targeting 5-HT as a Potential Treatment for Social Deficits in Autism

Yang, G.-Y., Geng, H.-Y., & Hu, C. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00876-z · Cited by 8

Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons

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Circuits underlying social function and dysfunction

Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 9

The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents

Borland, J. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105809 · Cited by 8

Oxytocin predicts positive affect gains in a role-play interaction

Berceanu, A. I., Papasteri, C., Sofonea, A., Boldasu, R., Nita, D. E., Poalelungi, C., Froemke, R. C., & Carcea, I. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1258254 · Cited by 8

Mesocorticolimbic circuit mechanisms of social dominance behavior

Choi, T.-Y., Jeong, S., & Koo, J. W. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01299-8 · Cited by 7

Deciphering the Functions of Raphe–Hippocampal Serotonergic and Glutamatergic Circuits and Their Deficits in Alzheimer’s Disease

Yu, W., Zhang, R., Zhang, A., & Mei, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031234 · Cited by 7

Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics

Heifets, B. D., & Malenka, R. C. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00803-8 · Cited by 7

Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice

Fujiwara, T., Kofuji, T., & Akagawa, K. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113447 · Cited by 6

Optogenetic Approaches to Understand the Neural Circuit Mechanism of Social Deficits Seen in Autism Spectrum Disorders

Nakai, N., Overton, E. T. N., & Takumi, T. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-8763-4_36 · Cited by 7

Integrated single-cell atlases unveil the operation principles of whole-brain 5-HT neuronal subsystems

Song, Z., Huang, C.-X., Zhang, H., Ye, C., Guan, N. N., & Song, J. (2025) · Science Advances · doi:10.1126/sciadv.adv8128 · Cited by 9

Supplementation with stigma maydis polysaccharide attenuates autism‐like behaviors and improves gut function in valproic acid‐induced autism model male rats

Yang, X., Li, H., Yang, C., & Ge, J. (2024) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10354 · Cited by 6

Scopolamine affects fear learning and social recognition in adult zebrafish

Fu, C., Tong, S., Liu, M.-X., Liao, B., & Chou, M.-Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.041 · Cited by 5

Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder

Wang, B. M., Mills, Z., Jones, H. F., Montgomery, J. M., & Lee, K. Y. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70088 · Cited by 7

Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward

Pinto, D. F. C., Guo, M. Y., Pomrenze, M. B., Morishita, W., Li, M. X., Zweifel, L. S., Eshel, N., & Malenka, R. C. (2026) · Nature Communications · doi:10.1038/s41467-026-70519-8 · Cited by 4

Serotonin and aggression

Tricklebank, M. D., & Petrinovic, M. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813323-1.00009-8 · Cited by 5

Reward learning improves social signal processing in autism model mice

Kim, J., Jung, M. W., & Lee, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113228 · Cited by 6

Meso-Py: Dual Brain Cortical Calcium Imaging in Mice during Head-Fixed Social Stimulus Presentation

Michelson, N. J., Bolaños, F., Bolaños, L. A., Balbi, M., LeDue, J. M., & Murphy, T. H. (2023) · eNeuro · doi:10.1523/eneuro.0096-23.2023 · Cited by 12

Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury

O’Connell, C. J., Reeder, E. L., Hymore, J. A., Brown, R. S., Notorgiacomo, G. A., Collins, S. M., Gudelsky, G. A., & Robson, M. J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114695 · Cited by 5

Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociabilityPreprint

Li, L.-F., Zhang, L.-Z., He, Z.-X., Zhang, Y.-T., Ma, H., Xun, Y.-F., Yuan, W., Hou, W.-J., Li, Y.-T., Lv, Z.-J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.21.307280 · Cited by 5

Alcohol inhibits sociability via serotonin inputs to the nucleus accumbensPreprint

Wang, R., Khan, K. M., Balasubramanian, N., James, T. D., Selvakumar, G. P., Kim, D., Pierson, S. R., Wu, Q., Niciu, M. J., Hefti, M. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.29.542761 · Cited by 5

Gut microbiota characteristics and therapeutic effects of fecal microbiota transplantation in children with autism spectrum disorder in central China: a combined cross-sectional and prospective study

Wu, R., Teng, X., Guo, Y., Cai, Y., Lv, Y., Gao, H., Zhang, W., Shen, H., & Fan, J. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1648471 · Cited by 4

Indoleamine 2,3‐dioxygenase 2 deficiency associates with autism‐like behavior via dopaminergic neuronal dysfunction

Ishikawa, M., Yamamoto, Y., Wulaer, B., Kunisawa, K., Fujigaki, H., Ando, T., Kimura, H., Kushima, I., Arioka, Y., Torii, Y., et al. (2023) · FEBS Journal · doi:10.1111/febs.17019 · Cited by 4

Gut microbiome is associated with personality traits of free-ranging Tibetan macaques (Macaca thibetana)

Xia, M., Xia, Y., Sun, Y., Wang, J., Lu, J., Wang, X., Xia, D., Xu, X., & Sun, B. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1381372 · Cited by 5

A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice

Maloney, S. E., McCullough, K. B., Chaturvedi, S. M., Selmanovic, D., Chase, R., Chen, J., Wu, S., Granadillo, J. L., Kroll, K. L., & Dougherty, J. D. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105796 · Cited by 4

Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivation

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Autism and arousal

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Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism

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Aptamer‐Based Galvanic Potentiometric Sensor for Real‐Time Monitoring of Serotonin Signaling Under Psychosocial Stress

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