TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422

Molecular and cellular insights into T cell exhaustion

Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057

Super-enhancers in the control of cell identity and disease

Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978

Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata

Dai, Z., Sezin, T., Chang, Y., Lee, E. Y., Wang, E. H. C., & Christiano, A. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955038 · Cited by 35

Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

Künzli, M., Reuther, P., Pinschewer, D. D., & King, C. G. (2021) · eLife · doi:10.7554/elife.61869 · Cited by 35

Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies

Gálvez‐Cancino, F., Navarrete, M., Beattie, G., Puccio, S., Conde, E., Foster, K. A., Morris, Y., Sahwangarrom, T., Karagianni, D., Liu, J., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.03.021 · Cited by 37

The Underlying Mechanisms and Emerging Strategies to Overcome Resistance in Breast Cancer

Kannan, K., Srinivasan, A., Kannan, A., & Ali, N. (2025) · Cancers · doi:10.3390/cancers17172938 · Cited by 44

Immune Checkpoint Inhibitors in Transplantation—A Case Series and Comprehensive Review of Current Knowledge

Delyon, J., Zuber, J., Dorent, R., Poujol‐Robert, A., Péraldi, M., Anglicheau, D., & Lebbé, C. (2020) · Transplantation · doi:10.1097/tp.0000000000003292 · Cited by 34

Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

Pagé, N., Lemeille, S., Vincenti, I., Klimek, B., Mariotte, A., Wagner, I., Liberto, G. D., Kaye, J., & Merkler, D. (2021) · Nature Communications · doi:10.1038/s41467-021-21109-3 · Cited by 36

Increased frequency of TIGIT + CD73-CD8 + T cells with a TOX + TCF-1low profile in patients with newly diagnosed and relapsed AML

Brauneck, F., Haag, F., Woost, R., Wildner, N. H., Tolosa, E., Rissiek, A., Vohwinkel, G., Wellbrock, J., Bokemeyer, C., Wiesch, J. S. Z., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1930391 · Cited by 34

Active surveillance characterizes human intratumoral T cell exhaustion

You, R., Artichoker, J., Fries, A. C., Edwards, A. W., Combes, A. J., Reeder, G. C., Samad, B., & Krummel, M. F. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144353 · Cited by 35

Myeloid‑derived suppressor cell infiltration is associated with a poor prognosis in patients with hepatocellular carcinoma

Tomiyama, T., Itoh, S., Iseda, N., Toshida, K., Morinaga, A., Yugawa, K., Kosai‐Fujimoto, Y., Tomino, T., Kurihara, T., Nagao, Y., et al. (2022) · Oncology Letters · doi:10.3892/ol.2022.13213 · Cited by 33

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity

Hickman, T. L., Choi, E., Whiteman, K. R., Muralidharan, S., Pai, T., Johnson, T., Parikh, A. B., Friedman, T., Gilbert, M., Shen, B., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266980 · Cited by 36

Methionine cycle-dependent regulation of T cells in cancer immunity

Zhao, T., & Lum, J. J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.969563 · Cited by 34

A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function

Lo, W., Kuhlmann, M., Rizzuto, G. A., Ekiz, H. A., Kolawole, E. M., Revelo, M. P., Andargachew, R., Li, Z., Tsai, Y.-L., Marson, A., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01444-x · Cited by 31

Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity

Kang, S., Mansurov, A., Kurtanich, T. R., Chun, H. R., Slezak, A. J., Volpatti, L. R., Chang, K., Wang, T., Alpar, A. T., Refvik, K. C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh9879 · Cited by 34

Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Hu, D., Yang, R., Wang, G., Li, H., Fan, X., & Liang, G. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s445101 · Cited by 34

NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment

Hao, J., Li, R., Zhao, X., Liu, X., Chen, X., Xie, T., Li, X., Yao, C., Sun, Q., Wei, K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114301 · Cited by 35

Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence

Strongin, Z., Marchand, L. R., Deléage, C., Pampena, M. B., Cardenas, M. A., Beusch, C. M., Hoang, T. N., Urban, E., Gourvès, M., Nguyen, K., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01875-0 · Cited by 37

The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors

Gonzalez-Rellan, M. J., Riobello, C., Fang, S., da Silva, E. M., Koehler, J. A., Shang, R., Hammoud, R., Cao, X., Varela‐Rey, M., & Drucker, D. J. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.03.011 · Cited by 39

Reversal of T Cell Exhaustion in Chronic HCV Infection

Osuch, S., Metzner, K. J., & Cortés, K. C. (2020) · Viruses · doi:10.3390/v12080799 · Cited by 34

Adoptive T Cell Therapy with IL-12–Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity

Tucker, C., Mitchell, J. S., Martinov, T., Burbach, B. J., Beura, L. K., Wilson, J. C., Dwyer, A. J., Singh, L. M., Mescher, M. F., & Fife, B. T. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000007 · Cited by 34

NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Lewis, E. L., Xu, R., Beltra, J., Ngiow, S. F., Cohen, J. B., Telange, R., Crane, A., Sawinski, D. L., Wherry, E. J., & Porrett, P. M. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201599 · Cited by 32

Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma

Nguyen, R., Zhang, X., Sun, M., Abbas, S., Seibert, C., Kelly, M. C., Shern, J. F., & Thiele, C. J. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0717 · Cited by 34

TOX regulates T lymphocytes differentiation and its function in tumor

Niu, H., & Wang, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.990419 · Cited by 32

Biomechanics of T Cell Dysfunctions in Chronic Diseases

Gunasinghe, S. D., Peres, N. G., Goyette, J., & Gaus, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.600829 · Cited by 33

Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury

Hackstein, C.-P., Spitzer, J., Symeonidis, K., Horvatic, H., Bedke, T., Steglich, B., Klein, S., Assmus, L. M., Odainic, A., Szlapa, J., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.026 · Cited by 33

Systems analysis of innate and adaptive immunity in Long COVID

Peluso, M. J., Abdel‐Mohsen, M., Henrich, T. J., & Roan, N. R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101873 · Cited by 35

Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses

Oswald, B. M., DeCamp, L. M., Longo, J., Dahabieh, M. S., Bunda, N., Johnson, B. K., Watson, M. J., Ma, S., Preston, S. E. J., Sheldon, R. D., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01415-6 · Cited by 35

Immunotherapy for Hepatocellular Carcinoma: Current Limits and Prospects

Zhong, C. F., Li, Y., Yang, J., Jin, S., Chen, G., Li, D., Fan, X., & Lin, H. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.589680 · Cited by 32

γδ T cell exhaustion: Opportunities for intervention

Chen, D., Guo, Y., Jiang, J., Wu, P., Zhang, T., Wei, Q., Huang, J., & Wu, D. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0722-777r · Cited by 31

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8+ T cells

Riegel, D., Romero-Fernández, E., Simon, M., Adenugba, A., Singer, K., Mayr, R., Weber, F., Kleemann, M., Imbusch, C. D., Kreutz, M. P., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.029 · Cited by 35

Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice

Onyshchenko, K., Luo, R., Guffart, E., Gaedicke, S., Grosu, A., Firat, E., & Niedermann, G. (2023) · Nature Communications · doi:10.1038/s41467-023-37825-x · Cited by 31

Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

Kharel, A., Shen, J., Brown, R. J., Chen, Y., Nguyen, C. P., Alson, D., Bluemn, T., Fan, J., Gai, K., Zhang, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112649 · Cited by 32

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Collier, J. L., Pauken, K. E., Lee, C. A. A., Patterson, D. G., Markson, S. C., Conway, T. S., Fung, M. E., France, J. A., Mucciarone, K., Lian, C. G., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221920 · Cited by 33

Cytokine signaling in chimeric antigen receptor T-cell therapy

Kagoya, Y. (2023) · International Immunology · doi:10.1093/intimm/dxad033 · Cited by 31

Recent advances in understanding T cell activation and exhaustion during HBV infection

Wang, L., Zeng, X.-Q., Wang, Z., Fang, L.-C., & Liu, J. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.10.007 · Cited by 30

The role of Ca2+-signaling in the regulation of epigenetic mechanisms

Hernández‐Oliveras, A., & Zarain‐Herzberg, Á. (2023) · Cell Calcium · doi:10.1016/j.ceca.2023.102836 · Cited by 32

Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy

Xiong, D., Yu, H., & Sun, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.04.022 · Cited by 31

Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy

Hou, Y., Žák, J., Shi, Y., Pratumchai, I., Dinner, B., Wang, W., Qin, K., Weber, E. W., Teijaro, J. R., & Wu, P. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0089 · Cited by 33

Lymph nodes fuel KLF2-dependent effector CD8+ T cell differentiation during chronic infection and checkpoint blockade

Tsui, C., Heyden, L., Wen, L., de Graça, C. G., Potemkin, N., Frolov, A., Rawlinson, D., Qin, L., Wimmer, V. C., Hadian-Jazi, M., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02276-7 · Cited by 37

Epigenetic regulation of T cell exhaustion in cancer

Kang, T. G., Johnson, J. T., Zebley, C. C., & Youngblood, B. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00883-y · Cited by 36

Clinical Relevance of CD4 Cytotoxic T Cells in High-Risk Neuroblastoma

Tang, X. X., Shimada, H., & Ikegaki, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.650427 · Cited by 33

Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment

Ring, S. S., Cupovic, J., Onder, L., Lütge, M., Perez‐Shibayama, C., Gil‐Cruz, C., Scandella, E., Martin, A. D., Mörbe, U., Hartmann, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25057-w · Cited by 31

Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells

LaPorte, K. M., Hernandez, R., Savio, A. S., & Malek, T. R. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006611 · Cited by 30

TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells

Collins, S. M., Alexander, K. A., Lundh, S. M., Dimitri, A. J., Zhang, Z., Good, C. R., Fraietta, J. A., & Berger, S. L. (2023) · Science Advances · doi:10.1126/sciadv.adh2605 · Cited by 33

Age-Related Alterations in Peripheral Immune Landscape with Magnified Impact on Post-Stroke Brain

Lü, J., Li, H., Zhang, G., Yang, F., Zhang, X., Ping, A., Xu, Z., Gu, Y., Wang, R., Ying, D., et al. (2023) · Research · doi:10.34133/research.0287 · Cited by 32

The effector program of human CD8 T cells supports tissue remodeling

Delacher, M., Schmidleithner, L., Simon, M., Stüve, P., Sanderink, L., Hotz‐Wagenblatt, A., Wuttke, M., Schambeck, K., Ruhland, B., Hofmann, V., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230488 · Cited by 30

Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer

Blise, K. E., Sivagnanam, S., Betts, C. B., Betre, K., Kirchberger, N. C., Tate, B. J., Furth, E. E., Costa, A. D., Nowak, J. A., Wolpin, B. M., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0873 · Cited by 31

Anti-CTLA-4 generates greater memory response than anti-PD-1 via TCF-1

Mok, S., Liu, H., Çobanoğlu, D. A., Anang, N.-A. A. S., Mancuso, J. J., Wherry, E. J., & Allison, J. P. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2418985122 · Cited by 30

Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer

Zhang, J., Pan, T., Lee, J., Goldberg, S., King, S. A., Tang, E., Hu, Y., Chen, L., Hoover, A., Zhu, L., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101920 · Cited by 33

CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy

Li, Z., Si, P., Meng, T., Zhao, X., Zhu, C., Zhang, D., Meng, S., Li, N., Liu, R., Ni, T., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.ado2463 · Cited by 35

Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy

Zou, D., Li, X. C., & Chen, W. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01321-7 · Cited by 30

Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 37

Explorations of CRISPR/Cas9 for improving the long-term efficacy of universal CAR-T cells in tumor immunotherapy

Naeem, M., Hazafa, A., Bano, N., Ali, R., Farooq, M., Razak, S. I. A., Lee, T. Y., & Devaraj, S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121409 · Cited by 32

CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes

Koyama‐Nasu, R., Kimura, M. Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0406 · Cited by 28

Glutamine deprivation impairs function of infiltrating CD8 + T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

Wang, W., Guo, M.-N., Li, N., Pang, D.-Q., & Wu, J. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i6.1124 · Cited by 29

Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes

Aljobaily, N. A., Allard, D., Perkins, B., Raugh, A., Galland, T., Jing, Y., Stephens, W. Z., Bettini, M. L., Hale, J. S., & Bettini, M. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.016 · Cited by 30

The epigenetic landscape of fate decisions in T cells

Jay, A., Pondevida, C. M., & Vahedi, G. (2025) · Nature Immunology · doi:10.1038/s41590-025-02113-x · Cited by 32

Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology

Guo, X., Ma, S., Wang, J., Fu, Y., & Ma, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1709852 · Cited by 29

Epigenetics of T cell fate decision

Pace, L., & Amigorena, S. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.01.002 · Cited by 30

Deep abscopal response to radiotherapy and anti-PD-1 in an oligometastatic melanoma patient with unfavorable pretreatment immune signature

Watanabe, T., Firat, E., Scholber, J., Gaedicke, S., Heinrich, C., Luo, R., Ehrat, N., Multhoff, G., Schmitt-Graeff, A. H., Grosu, A., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02587-8 · Cited by 30

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

Brenes, A. J., Vandereyken, M., James, O. J., Watt, H. J., Hukelmann, J. L., Spinelli, L., Dikovskaya, D., Lamond, A. I., & Swamy, M. (2021) · eLife · doi:10.7554/elife.70055 · Cited by 28

Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy

Martin, G. E., Sen, D. R., Pace, M. J., Robinson, N., Meyerowitz, J., Adland, E., Thornhill, J. P., Jones, M., Ogbe, A., Parolini, L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.647688 · Cited by 30

IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells

Dudek, M., Lohr, K., Donakonda, S., Baumann, T., Luedemann, M., Hegenbarth, S. I., Dübbel, L., Eberhagen, C., Michailidou, S., Yassin, A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110389 · Cited by 29

Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway

Zhang, S., Yu, F., Che, A., Tan, B., Huang, C., Chen, Y., Liu, X., Huang, Q., Zhang, W., Ma, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202104132 · Cited by 28

Comprehensive Analysis of HHLA2 as a Prognostic Biomarker and Its Association With Immune Infiltrates in Hepatocellular Carcinoma

Ding, L., Yu, Q., Yang, S., Yang, W., Liu, T., Xian, J., Tian, T., Li, T., Chen, W., Wang, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.831101 · Cited by 30

Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies

Beider, K., Itzhaki, O., Schachter, J., Grushchenko-Polaq, A. H., Voevoda-Dimenshtein, V., Rosenberg, E., Ostrovsky, O., Devillers, O., Frommer, R. S., Zeltzer, L., et al. (2022) · Cells · doi:10.3390/cells11071140 · Cited by 30

Coengineering specificity, safety, and function into T cells for cancer immunotherapy

Attianese, G. M. P. G., Ash, S., & Irving, M. B. (2023) · Immunological Reviews · doi:10.1111/imr.13252 · Cited by 29

Charting the Roadmap of T Cell Exhaustion

Chu, T., & Zehn, D. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.019 · Cited by 30

Determinants of anti-PD1 response and resistance in clear cell renal cell carcinomaPreprint

Au, L., Hatipoglu, E., de Massy, M. R., Litchfield, K., Rowan, A., Thompson, R. H., Schnidrig, D., Byrne, F., Beattie, G., Horswell, S. D., et al. (2021) · medRxiv · doi:10.1101/2021.03.19.21253661 · Cited by 29

Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response

Kang, K., Wu, Y., Chang, H., Wang, L., Wang, Z., & Zhao, A. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106836 · Cited by 30

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

Byl, W. V. D., Nüssing, S., Peters, T. J., Ahn, A., Li, H., Ledergor, G., David, E., Koh, A. S., Wagle, M. V., Deguit, C. D. T., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.026 · Cited by 32

Targeting Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer: Beyond PD-1/PD-L1 Monoclonal Antibodies

Roussot, N., Kaderbhaï, C., & Ghiringhelli, F. (2025) · Cancers · doi:10.3390/cancers17050906 · Cited by 29

Transcriptional and epigenetic regulation of memory NK cell responses

Beaulieu, A. M. (2021) · Immunological Reviews · doi:10.1111/imr.12947 · Cited by 29

TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer

Yang, M., Huang, Q., Li, C., Jiang, Z., Sun, J. P., Wang, Z., Liang, R., Li, D., Li, B., & Zhao, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.647540 · Cited by 29

Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue

Dornieden, T., Sattler, A., Reguant, A. P., Ruhm, A. H., Thiel, L. G., Bergmann, Y., Thole, L. M. L., Köhler, R., Kühl, A. A., Hauser, A. E., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020101528 · Cited by 32

Identification of a T-bethi Quiescent Exhausted CD8 T Cell Subpopulation That Can Differentiate into TIM3+CX3CR1+ Effectors and Memory-like Cells

Raju, S., Xia, Y., Dániel, B., Yost, K. E., Bradshaw, E., Tonc, E., Verbaro, D., Kometani, K., Yokoyama, W. M., Kurosaki, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001348 · Cited by 31

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Ronen, D., Bsoul, A., Lotem, M., Abedat, S., Yarkoni, M., Amir, O., & Asleh, R. (2022) · Vaccines · doi:10.3390/vaccines10040540 · Cited by 29

Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis

Chaudhary, O., Trotta, D., Wang, K., Wang, X., Chu, X., Bradley, C., Okulicz, J. F., Maves, R. C., Kronmann, K., Schofield, C. M., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004564 · Cited by 29

Delineating the transcriptional landscape and clonal diversity of virus-specific CD4+ T cells during chronic viral infection

Zander, R., Khatun, A., Kasmani, M. Y., Chen, Y., & Cui, W. (2022) · eLife · doi:10.7554/elife.80079 · Cited by 28

Metabolic Control of Memory T-Cell Generation and StemnessPreprint

Raynor, J. L., Chapman, N. M., & Chi, H. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037770 · Cited by 28

Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction

Witt, M., Oliveira‐Ferrer, L., Koch‐Nolte, F., Menzel, S., Hell, L., Sturmheit, T., Seubert, E., Weimer, P., Ding, Y., Qi, M., et al. (2024) · OncoImmunology · doi:10.1080/2162402x.2024.2346359 · Cited by 29

Hepatitis E virus: from innate sensing to adaptive immune responses

Brüggemann, Y., Klöhn, M., Wedemeyer, H. H., & Steinmann, E. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00950-z · Cited by 26

Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy

Wu, M., Wu, Y., Jin, Y., Mao, X., Zeng, S., Yu, H., Zhang, J., Jin, Y., Wu, Y., Xu, T., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00644 · Cited by 27

Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming

Lawton, M. L., Inge, M. M., Blum, B. C., Smith-Mahoney, E. L., Bolzan, D., Lin, W., McConney, C., Porter, J., Moore, J., Youssef, A., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002943 · Cited by 25

Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

Clark, M. L., Simeonov, K. P., Mowel, W. K., Michieletto, M. F., Joannas, L. D., Wright, J. M., Erickson, I., Johnson, L. R., Krishnan, R., de la Fuente‐Núñez, C., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.006 · Cited by 29

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program

Rome, K., Stein, S. J., Kurachi, M., Petrovic, J., Schwartz, G. W., Mack, E. A., Uljon, S., Wu, W. W., DeHart, A. G., McClory, S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190888 · Cited by 26

Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis

Yu, X., Zhang, L., Chaudhry, A., Rapaport, A. S., & Ouyang, W. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0320-234r · Cited by 25

Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging

Nagai, N., Kudo, Y., Aki, D., Nakagawa, H., & Taniguchi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052238 · Cited by 30

Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes: A Rational Indicator of Antitumor Response and Immune Checkpoint Blockade

Kanda, Y., Okazaki, T., & Katakai, T. (2021) · Cancers · doi:10.3390/cancers13184616 · Cited by 30

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Ou, K., Hamo, D., Schulze, A. S., Roemhild, A., Kaiser, D., Gasparoni, G., Salhab, A., Zarrinrad, G., Amini, L., Schlickeiser, S., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.751590 · Cited by 25

MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection

Stelekati, E., Cai, Z., Manne, S., Chen, Z., Beltra, J., Buchness, L. A., Leng, X., Ristin, S., Nzingha, K., Ekshyyan, V., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106083119 · Cited by 24

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

Perdomo-Celis, F., Passaes, C., Monceaux, V., Volant, S., Boufassa, F., de Truchis, P., Marcou, M., Bourdic, K., Weiss, L., Jung, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 27

Exhaustion of CD39-Expressing CD8+ T Cells in Crohn’s Disease Is Linked to Clinical Outcome

Globig, A.-M., Mayer, L., Heeg, M., Andrieux, G., Ku, M., Otto-Mora, P., Hipp, A. V., Zoldan, K., Pattekar, A., Rana, N., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.045 · Cited by 30

Empowering the Potential of CAR-T Cell Immunotherapies by Epigenetic Reprogramming

Alvanou, M., Lysandrou, M., Christofi, P., Psatha, N., Spyridonidis, A., Παπαδοπούλου, Α., & Yannaki, E. (2023) · Cancers · doi:10.3390/cancers15071935 · Cited by 28

Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A Literature Review

Zhu, W., Li, Y., Han, M., & Jiang, J. (2023) · Biology · doi:10.3390/biology12040541 · Cited by 28

Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8 + T Cell Immunity against Tumor

Yu, A., Fu, J., Yin, Z. Q., Yan, H. M., Xiao, X., Zou, D., Zhang, X., Zu, X., Li, X. C., & Chen, W. (2023) · Research · doi:10.34133/research.0271 · Cited by 28

Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion

Munter, S. D., Buhl, J. L., Cock, L. D., Parys, A. V., Daneels, W., Pascal, E., Deseins, L., Ingels, J., Goetgeluk, G., Jansen, H., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0677 · Cited by 28

Harnessing CD8+ T cell dynamics in hepatitis B virus‐associated liver diseases: Insights, therapies and future directions

Yue, B., Gao, Y., Hu, Y., Zhan, M., Wu, Y., & Lu, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1731 · Cited by 26

Stem-like CD8+ T cells in cancer

Steiner, C., Denlinger, N., Huang, X., & Yang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1426418 · Cited by 28

Role of kynurenine in promoting the generation of exhausted CD8+ T cells in colorectal cancer.

Wu, D., & Zhu, Y. (2021) · PubMed · Cited by 26

Epigenetic Regulation of Cancer Immune Cells

Patino, D. M. A., Radhakrishnan, V., Suvilesh, K. N., Manjunath, Y., Li, G., Kimchi, E. T., Staveley-O’Carroll, K. F., Warren, W. C., Kaifi, J. T., & Mitchem, J. B. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.022 · Cited by 26

The HMG Transcription Factor TOX Induces a Transcriptional and Epigenetic Program of CD8+ T Cell Exhaustion in Chronic Infection and Cancer

Khan, O. (2019) · ScholarlyCommons (University of Pennsylvania)

1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX

Huang, Y., Giles, J. R., Ngiow, S. F., Baxter, A. E., Manne, S., Khan, O., Park, S. L., Wu, J. E., & Wherry, E. J. (2023) · Regular and Young Investigator Award Abstracts · doi:10.1136/jitc-2023-sitc2023.1016

Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate

Huang, Y., Ngiow, S. F., Baxter, A. E., Manne, S., Park, S. L., Wu, J. E., Khan, O., Giles, J. R., & Wherry, E. J. (2025) · Science Immunology · doi:10.1126/sciimmunol.ado3032 · Cited by 57

Role, function and regulation of the thymocyte selection-associated high mobility group box protein in CD8+ T cell exhaustion

Cheng, Y., Shao, Z., Chen, L., Zheng, Q., Zhang, Q., Ding, W., Zhang, M., Yu, Q., & Gao, D. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.11.004 · Cited by 20

Tick-TOX, it’s time for T cell exhaustion

Mann, T. H., & Kaech, S. M. (2019) · Nature Immunology · doi:10.1038/s41590-019-0478-y · Cited by 70