TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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Molecular and cellular insights into T cell exhaustion

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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

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Restoring function in exhausted CD8 T cells during chronic viral infection

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Super-enhancers in the control of cell identity and disease

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Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

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CAR T Cell Immunotherapy Beyond Haematological Malignancy

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On-treatment derived neutrophil-to-lymphocyte ratio and survival with palbociclib and endocrine treatment: analysis of a multicenter retrospective cohort and the PALOMA-2/3 study with immune correlates

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Immunotherapy Targeting CCR8+ Regulatory T Cells Induces Antitumor Effects via Dramatic Changes to the Intratumor CD8+ T Cell Profile

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XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

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CD8+ T-cell exhaustion: Impediment to triple-negative breast cancer (TNBC) immunotherapy

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Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity

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Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells

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Unravelling T cell exhaustion through co‐inhibitory receptors and its transformative role in cancer immunotherapy

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Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion

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Persistent antigen exposure via the eryptotic pathway drives terminal T cell dysfunction

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Epigenetic Modifiers: Anti-Neoplastic Drugs With Immunomodulating Potential

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Prospects and Challenges for T Cell-Based Therapies of HCC

Woller, N., Engelskircher, S. A., Wirth, T. C., & Wedemeyer, H. H. (2021) · Cells · doi:10.3390/cells10071651 · Cited by 25

Increased TOX expression concurrent with PD ‐1, Tim‐3, and CD244 expression in T cells from patients with acute myeloid leukemia

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Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16+ cancer

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PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

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Fundamentals to therapeutics: Epigenetic modulation of CD8+ T Cell exhaustion in the tumor microenvironment

Blake, M. K., O’Connell, P. M., & Aldhamen, Y. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1082195 · Cited by 28

Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection

Quezada, L. K., Jin, W., Liu, Y. C., Kim, E. S., He, Z., Indralingam, C. S., Tysl, T., Labarta-Bajo, L., Wehrens, E. J., Jo, Y., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001983 · Cited by 24

MetaTiME integrates single-cell gene expression to characterize the meta-components of the tumor immune microenvironment

Zhang, Y., Xiang, G., Jiang, A. Y., Lynch, A. W., Zeng, Z., Wang, C., Zhang, W., Fan, J., Kang, J., Gu, S. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38333-8 · Cited by 27

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Anderson-Crannage, M., Ascensión, A. M., Ibáñez-Solé, O., Zhu, H., Schaefer, E., Ottomanelli, D., Hochberg, B., Pan, J. G., Luo, W., Tian, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1211505 · Cited by 30

Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma

Manfredi, G. F., Celsa, C., John, C., Jones, C., Acuti, N., Scheiner, B., Fulgenzi, C. A. M., Korolewicz, J., Pinter, M., Gennari, A., et al. (2023) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s291553 · Cited by 30

Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC

Shi, J., Li, G., Liu, L., Yuan, X., Wang, Y., Gong, M., Li, C., Ge, X., & Lu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166052 · Cited by 28

A T cell receptor β chain–directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity

Hsu, J., Donahue, R. N., Katragadda, M., Lowry, J., Huang, W., Srinivasan, K., Guntas, G., Tang, J., Servattalab, R., Moisan, J., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0258 · Cited by 26

T cell exhaustion and senescence for ovarian cancer immunotherapy

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Phenotypic and spatial heterogeneity of CD8+ tumour infiltrating lymphocytes

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The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation

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The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion

Dahabieh, M. S., DeCamp, L. M., Oswald, B. M., Kitchen-Goosen, S. M., Fu, Z. F., Vos, M., Compton, S. E., Longo, J., Foy, N. M., Williams, K. S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02185-9 · Cited by 24

Yangyin Fuzheng Jiedu Prescription exerts anti-tumor immunity in hepatocellular carcinoma by alleviating exhausted T cells

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Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers

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Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy

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Gene Regulatory Circuits in Innate and Adaptive Immune Cells

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Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications

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The implication of anti-PD-1 therapy in cancer patients for the vaccination against viral and other infectious diseases.

Retnakumar, S. V., Chauvin, C., & Bayry, J. (2023) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2023.108399 · Cited by 21

Enhancing personalized immune checkpoint therapy by immune archetyping and pharmacological targeting

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Translational Frontiers and Clinical Opportunities of Immunologically Fitted Radiotherapy

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Back to the Future: Effector Fate during T Cell Exhaustion

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Regulatory T-cell dysfunction and its implication for cell therapy

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Molecular insight into T cell exhaustion in hepatocellular carcinoma

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Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis/chronic fatigue syndrome

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Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer

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Expression pattern, regulation, and clinical significance of TOX in breast cancer

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Epigenetic Regulation of Immune Checkpoints and T Cell Exhaustion Markers in Tumor-Infiltrating T Cells of Colorectal Cancer Patients

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Increased TOX expression concurrent with PD‐1, Tim‐3, and CD244 in T cells from patients with non‐Hodgkin lymphoma

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Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma

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Single-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease

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Early DNA methylation changes in children developing beta cell autoimmunity at a young age

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AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunity

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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

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A subset of immune-system T cells branded as seeds for type 1 diabetes

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Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy

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BATF targets T cell exhaustion for termination

Boi, S. K., Lan, X., & Youngblood, B. (2021) · Nature Immunology · doi:10.1038/s41590-021-00978-2 · Cited by 22

Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells

Alavi, S., Emran, A. A., Tseng, H., Tiffen, J. C., McGuire, H. M., & Hersey, P. (2022) · Cancers · doi:10.3390/cancers14020323 · Cited by 22

Non-coding RNAs: Key players in T cell exhaustion

Li, K., & Wang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.959729 · Cited by 22

Light-Activated Assembly of Connexon Nanopores in Synthetic Cells

Sihorwala, A. Z., Lin, A. J., Stachowiak, J. C., & Belardi, B. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12491 · Cited by 21

Canine peripheral blood TCRαβ T cell atlas: Identification of diverse subsets including CD8A+ MAIT-like cells by combined single-cell transcriptome and V(D)J repertoire analysis

Eschke, M., Moore, P. F., Chang, H., Alber, G., & Keller, S. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1123366 · Cited by 22

mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

Nirschl, C. J., Brodkin, H. R., Domonkos, C., Dwyer, C. J., Hicklin, D. J., Ismail, N. S., Seidel‐Dugan, C., Steiner, P., Steuert, Z., Sullivan, J. M., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0705 · Cited by 22

Applying causal discovery to single-cell analyses using CausalCell

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Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation

Fu, Y., Wang, J., Liu, C., Liao, K., Gao, X., Tang, R., Binbin, F., Hong, Y., Xiao, N., Xiao, C., et al. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01075-0 · Cited by 21

The nexus of dynamic T cell states and immune checkpoint blockade therapy in the periphery and tumor microenvironment

Luo, H., Wang, W., Mai, J., Yin, R., Cai, X., & Li, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1267918 · Cited by 22

Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

Tang, L., Huang, Z., Mei, H., & Hu, Y. (2023) · Military Medical Research · doi:10.1186/s40779-023-00486-4 · Cited by 24

Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

Wang, X., Lu, L., Hong, X., Wu, L., Yang, C., Wang, Y., Li, W., Yang, Y., Cao, D., Di, W. J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113712 · Cited by 22

Targeting Oncoimmune Drivers of Cancer Metastasis

Kudo‐Saito, C., Ozaki, Y., Imazeki, H., Hayashi, H., Masuda, J., Ozawa, H., & Ogiwara, Y. (2021) · Cancers · doi:10.3390/cancers13030554 · Cited by 21

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

Lin, C., Levy, P. L., Alflen, A., Apriamashvili, G., Ligtenberg, M. A., Vredevoogd, D. W., Bleijerveld, O. B., Alkan, F., Malka, Y., Hoekman, L., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.016 · Cited by 21

Elucidating the role of S100A10 in CD8+ T cell exhaustion and HCC immune escape via the cPLA2 and 5-LOX axis

Wang, G., Shen, X., Jin, W., Song, C., Dong, M., Zhou, Z., & Wang, X. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06895-0 · Cited by 22

Focusing on CD8+ T-cell phenotypes: improving solid tumor therapy

Yao, Z., Zeng, Y., Liu, C., Jin, H., Wang, H., Zhang, Y., Ding, C., Chen, G., & Wu, D. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03195-5 · Cited by 27

Overcoming Resistance Mechanisms to Melanoma Immunotherapy

Zheng, D. X., Bozym, D. J., Tarantino, G., Sullivan, R. J., Liu, D., & Jenkins, R. W. (2024) · American Journal of Clinical Dermatology · doi:10.1007/s40257-024-00907-7 · Cited by 25

Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia

Pham‐Danis, C., Novak, A. J., Danis, E. P., McClellan, S. M., Leach, L., Yarnell, M. C., Ebmeier, C. C., Tasian, S. K., & Kohler, M. E. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.02.008 · Cited by 23

Cancer systems immunology

Reticker-Flynn, N. E., & Engleman, E. G. (2020) · eLife · doi:10.7554/elife.53839 · Cited by 23

Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades

Zhang, J., Liu, D., Liu, J., Han, Y., Xu, H., Leng, X., Kong, D., & Liu, L. (2020) · Biomaterials Science · doi:10.1039/d0bm00908c · Cited by 21

Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas

Zhang, H., Fan, F., Yu, Y., Wang, Z., Liu, F., Dai, Z., Zhang, L., Liu, Z., & Cheng, Q. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02460-3 · Cited by 21

Dynamics of Circulating Immune Cells During Chemoradiotherapy in Patients with Non-Small Cell Lung Cancer Support Earlier Administration of Anti-PD-1/PD-L1 Therapy

Kim, K. H., Pyo, H., Lee, H., Oh, D., Noh, J. M., Ahn, Y. C., Yoon, H. I., Moon, H., Lee, J., Park, S., et al. (2022) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2022.02.003 · Cited by 21

LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade

Yoo, K. J., Johannes, K., Gonzalez, L. E., Patel, A., Shuptrine, C. W., Opheim, Z., Lenz, K. L., Campbell, K., Nguyen, T., Miriyala, J., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101175 · Cited by 22

Modulation of T cell function and survival by the tumor microenvironment

Mani, N. L., Andrews, D., & Obeng, R. C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1191774 · Cited by 22

Stem‐like T cells in cancer and autoimmunity

Schnell, A. (2024) · Immunological Reviews · doi:10.1111/imr.13356 · Cited by 22

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD

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Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints

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