The DOI matches its Crossref record; 62 of the 64 references it cites were found in a registry or an index.
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
Open accessAbstract
Innate immunity is associated with Alzheimer's disease 1, but the influence of immune activation on the production of amyloid-β is unknown 2,3. Here we identify interferon-induced transmembrane protein 3 (IFITM3) as a γ-secretase modulatory protein, and establish a mechanism by which inflammation affects the generation of amyloid-β. Inflammatory cytokines induce the expression of IFITM3 in neurons and astrocytes, which binds to γ-secretase and upregulates its activity, thereby increasing the production of amyloid-β. The expression of IFITM3 is increased with ageing and in mouse models that express familial Alzheimer's disease genes. Furthermore, knockout of IFITM3 reduces γ-secretase activity and the formation of amyloid plaques in a transgenic mouse model (5xFAD) of early amyloid deposition. IFITM3 protein is upregulated in tissue samples from a subset of patients with late-onset Alzheimer's disease that exhibit higher γ-secretase activity. The amount of IFITM3 in the γ-secretase complex has a strong and positive correlation with γ-secretase activity in samples from patients with late-onset Alzheimer's disease. These findings reveal a mechanism in which γ-secretase is modulated by neuroinflammation via IFITM3 and the risk of Alzheimer's disease is thereby increased.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Activated microglia may be involved in the generation of Aβ plaque by increasing the secretion of Aβ fragments; inducing the expression of interferon-induced transmembrane protein 3 (IFITM3), a γ-secretase modulatory protein; or releasing agents such as iron, which enhances the aggregation of soluble β-amyloid.37–39”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [39]
In the citing paper
“Brain inflammation can also trigger deposition of pathological amyloid proteins via upregulation of interferon‐induced transmembrane protein 3 (IFITM3). 104”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science · doi:10.1126/science.1262110 · Cited by 5,062
Self-citationOakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530
Self-citationTREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Self-citationVariant of TREM2 Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657
Self-citationProcessing of gene expression data generated by quantitative real-time RT-PCR.
Muller, P. Y., Janovjak, H., Miserez, A. R., & Dobbie, Z. (2002) · PubMed · Cited by 1,394
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004
Kumar, D. K. V., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1059 · Cited by 971
Research works printed but not linked: 1
- Placanica, L. et al. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J. Biol. Chem. 284, 2967–2977 (2009). · DOI
Cited by
Sorted by citations
Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668
Pan, R.-Y., He, L., Zhang, J., Liu, X., Liao, Y., Gao, J., Liao, Y., Yan, Y., Li, Q., Zhou, X., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.013 · Cited by 862
Self-citationFunction and therapeutic value of astrocytes in neurological diseases
Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662
Scinto, S. L., Bilodeau, D. A., Hincapie, R., Lee, W., Nguyen, S. S., Xu, M., Ende, C. W. A., Finn, M. G., Lang, K., Lin, Q., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00028-z · Cited by 654
Neuroinflammation in Alzheimer disease
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638
Pathogenesis and virulence of herpes simplex virus
Zhu, S., & Viejo‐Borbolla, A. (2021) · Virulence · doi:10.1080/21505594.2021.1982373 · Cited by 427
γ-Secretase in Alzheimer’s disease
Hur, J. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00754-8 · Cited by 339
Self-citationThe good, the bad, and the opportunities of the complement system in neurodegenerative disease
Schartz, N. D., & Tenner, A. J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02024-8 · Cited by 298
Cellular senescence at the crossroads of inflammation and Alzheimer's disease
Guerrero, A., De Strooper, B., & Arancibia-Cárcamo, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.007 · Cited by 236
Roy, E. R., Chiu, G., Li, S., Propson, N. E., Kanchi, R., Wang, B., Coarfa, C., Zheng, H., & Cao, W. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.018 · Cited by 236
Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Yang, G., Zhou, R., Guo, X., Yan, C., Lei, J., & Shi, Y. (2021) · Cell · doi:10.1016/j.cell.2020.11.049 · Cited by 189
Type-I-interferon-responsive microglia shape cortical development and behavior
Escoubas, C. C., Dorman, L. C., Nguyen, P. T., Lagares-Linares, C., Nakajo, H., Anderson, S. R., Barron, J. J., Wade, S. D., Cuevas, B., Vainchtein, I. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.020 · Cited by 179
Zhou, Y., Xu, J., Hou, Y., Leverenz, J. B., Kallianpur, A. R., Mehra, R., Liu, Y., Yu, H., Pieper, A. A., Jehi, L. E., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00850-3 · Cited by 165
Biswas, K. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578180 · Cited by 164
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
Qian, X.-H., Song, X.-X., Liu, X.-L., Chen, S.-D., & Tang, H.-D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101317 · Cited by 153
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
Gómez-Herranz, M., Taylor, J., & Sloan, R. D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102741 · Cited by 125
Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13490 · Cited by 117
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
Sudwarts, A., Ramesha, S., Gao, T., Ponnusamy, M., Wang, S., Hansen, M. T., Kozlova, A., Bitarafan, S., Kumar, P., Beaulieu‐Abdelahad, D., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00535-x · Cited by 110
Chung, S., Jeong, J.-H., Park, J.-C., Han, J. W., Lee, Y., Kim, J.-I., & Mook-Jung, I. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01295-y · Cited by 103
Alzheimer’s Disease and Inflammaging
Kosyreva, A., Sentyabreva, A., Tsvetkov, I., & Makarova, O. (2022) · Brain Sciences · doi:10.3390/brainsci12091237 · Cited by 98
Thadathil, N., Delotterie, D. F., Xiao, J., Hori, R., McDonald, M. P., & Khan, M. M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02109-8 · Cited by 94
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Čarná, M., Onyango, I. G., Katina, S., Holub, D., Novotný, J., Nezvedová, M., Jha, D., Nedelská, Z., Lacovich, V., Vyvere, T. V., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12970 · Cited by 101
Self-citationTsartsalis, S., Sleven, H., Fancy, N., Wessely, F., Smith, A. M., Willumsen, N., Cheung, T. K. D., Rokicki, M. J., Chau, V., Ifie, E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46630-z · Cited by 95
Vojtechova, I., Machacek, T., Kristofikova, Z., Stuchlik, A., & Petrasek, T. (2022) · PLOS Pathogens · doi:10.1371/journal.ppat.1010929 · Cited by 92
Revisiting the critical roles of reactive astrocytes in neurodegeneration
Qian, K., Jiang, X., Liu, Z., Zhang, J., Fu, P. F., Su, Y., Brazhe, N. A., Liu, D., & Zhu, L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02061-8 · Cited by 101
Alzheimer’s disease and its treatment–yesterday, today, and tomorrow
Kim, A. Y., Jerdi, S. A., MacDonald, R., & Triggle, C. R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1399121 · Cited by 99
Lactate and Lactylation in the Brain: Current Progress and Perspectives
Li, R., Yang, Y., Wang, H., Zhang, T., Duan, F., Wu, K., Yang, S., Xu, K., Jiang, X., & Sun, X. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01335-7 · Cited by 82
Zhao, Y., Zheng, Q., Hong, Y., Gao, Y., Hu, J., Lang, M., Zhang, H., Zhou, Y., Luo, H., Zhang, X., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01352-1 · Cited by 87
Are infections seeding some cases of Alzheimer’s disease?
Abbott, A. (2020) · Nature · doi:10.1038/d41586-020-03084-9 · Cited by 82
Amyloid beta acts synergistically as a pro-inflammatory cytokine
LaRocca, T. J., Cavalier, A. N., Roberts, C. M., Lemieux, M. R., Ramesh, P., Garcia, M. A., & Link, C. D. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105493 · Cited by 83
López‐Cerdán, A., Andreu, Z., Hidalgo, M. R., Grillo-Risco, R., Català-Senent, J. F., Soler-Sáez, I., Neva-Alejo, A., Gordillo, F., de la Iglesia-Vayá, M., & Garcia‐García, F. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00477-5 · Cited by 77
Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00236-x · Cited by 74
The viral hypothesis: how herpesviruses may contribute to Alzheimer’s disease
Wainberg, M., Luquez, T., Koelle, D. M., Readhead, B., Johnston, C., Darvas, M., & Funk, C. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01138-6 · Cited by 74
Yoo, J., Lee, J., Ahn, B., Han, J., & Lim, M. H. (2025) · Chemical Science · doi:10.1039/d4sc06762b · Cited by 78
Ribarič, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063245 · Cited by 77
Yang, H. S., Onos, K. D., Choi, K., Keezer, K. J., Skelly, D. A., Carter, G. W., & Howell, G. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108739 · Cited by 69
Alexander, C., Li, T., Hattori, Y., Chiu, D., Frost, G. R., Jonas, L., Liu, C., Anderson, C. J., Wong, E., Park, L., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01676-7 · Cited by 64
Self-citationReassessment of Pioglitazone for Alzheimer’s Disease
Saunders, A. M., Burns, D. K., & Gottschalk, W. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.666958 · Cited by 71
Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
Brown, M. R., Radford, S. E., & Hewitt, E. W. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.609073 · Cited by 67
Amyloid-β: A double agent in Alzheimer's disease?
Yu, H., & Wu, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111575 · Cited by 62
IFITM protein regulation and functions: Far beyond the fight against viruses
Friedlová, N., Kokas, F. Z., Hupp, T. R., Vojtěšek, B., & Nekulová, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1042368 · Cited by 62
Protein S -palmitoylation in immunity
Das, T., Yount, J. S., & Hang, H. C. (2021) · Open Biology · doi:10.1098/rsob.200411 · Cited by 61
Li, H., Cai, R., Zhou, Y., Jiang, Y., & Tan, S. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03563-8 · Cited by 72
Turning the tide on Alzheimer’s disease: modulation of γ-secretase
Luo, J. E., & Li, Y.-M. (2022) · Cell & Bioscience · doi:10.1186/s13578-021-00738-7 · Cited by 59
Self-citationIn situ spatial glycomic imaging of mouse and human Alzheimer's disease brains
Hawkinson, T. R., Clarke, H. A., Young, L. E. A., Conroy, L. R., Markussen, K. H., Kerch, K. M., Johnson, L. A., Nelson, P. T., Wang, C., Allison, D. B., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12523 · Cited by 55
Chandra, S., Di Meco, A., Dodiya, H. B., Popovic, J., Cuddy, L. K., Weigle, I. Q., Zhang, X., Sadleir, K., Sisodia, S. S., & Vassar, R. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00635-2 · Cited by 58
Self-citationPannexin-1 Channels as Mediators of Neuroinflammation
Seo, J. H., Dalal, M. S., & Contreras, J. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105189 · Cited by 61
Epigenetic Regulation of Neuroinflammation in Alzheimer’s Disease
Ma, Y., Wang, W., Liu, S., Qiao, X., Xing, Y., Zhou, Q., & Zhang, Z. (2023) · Cells · doi:10.3390/cells13010079 · Cited by 58
Tsatsanis, A., McCorkindale, A. N., Wong, B. X. W., Patrick, E., Ryan, T. M., Evans, R. W., Bush, A. I., Sutherland, G. T., Sivaprasadarao, A., Guennewig, B., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01248-1 · Cited by 57
The 2020 Yearbook of Neurorestoratology
Huang, H., Chen, L., Chopp, M., Young, W., Bach, J. R., He, X., Sarnowaska, A., Xue, M., Zhao, R. C., Shetty, A. K., et al. (2021) · Journal of Neurorestoratology · doi:10.26599/jnr.2021.9040002 · Cited by 56
Ding, M., Ding, S., Du, D., Wang, X., Hu, X., Guan, P., Lyu, Z., & Lin, Y. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117087 · Cited by 56
Promoting Alzheimer’s disease research and therapy with stem cell technology
Cao, Z., Kong, F., Ding, J., Chen, C., He, F., & Deng, W. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03737-w · Cited by 60
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases
Wang, H., Fleishman, J. S., Wu, S., Wang, G., Du, L., Li, J., & Du, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102691 · Cited by 55
Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection
Duff, E. P., Zetterberg, H., Heslegrave, A., Dehghan, A., Elliott, P., Allen, N. E., Runz, H., Laban, R., Veleva, E., Whelan, C. D., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03426-4 · Cited by 61
Nanotechnology for the diagnosis and treatment of Alzheimer's disease: A bibliometric analysis
Li, L., He, R., Yan, H., Leng, Z., Zhu, S., & Gu, Z. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101654 · Cited by 49
Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer's disease
Zheng, L., Wu, S., Jin, H., Wu, J., Wang, X., Cao, Y., Zhou, Z., Jiang, Y., Li, L., Yang, X., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154890 · Cited by 48
Chen, L., van Zijl, P. C. M., Wei, Z., Lu, H., Duan, W., Wong, P. C., Li, T., & Xu, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118071 · Cited by 48
Self-citationLang, R., Li, H., Luo, X., Liu, C., Zhang, Y., Guo, S., Xu, J., Bao, C., Dong, W., & Yu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1008072 · Cited by 53
Biomaterials-based anti-inflammatory treatment strategies for Alzheimer’s disease
Chu, J., Zhang, W., Liu, Y., Gong, B., Ji, W., Yin, T., Gao, C., Liangwen, D., Hao, M., Chen, C., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.374137 · Cited by 48
SARS‐COV‐2 infection and Parkinson's disease: Possible links and perspectives
Al-Kuraishy, H. M., Al-Gareeb, A. I., Kaushik, A. K., Kujawska, M., Ahmed, E., & Batiha, G. E. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25171 · Cited by 47
Alzheimer’s genes in microglia: a risk worth investigating
Sudwarts, A., & Thinakaran, G. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00679-4 · Cited by 52
Photoaffinity labelling with small molecules
Homan, R. A., Lapek, J. D., Woo, C. M., Niessen, S., Jones, L. H., & Parker, C. G. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00308-4 · Cited by 60
Wu, Z., Tang, W., Ibrahim, F. E. E. M., Chen, X., Yan, H., Tao, C., Wang, Z., Guo, Y., Fu, Y., Wang, Q., et al. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03945-5 · Cited by 45
Monda, A., Torre, M. E. L., Messina, A., Maio, G. D., Monda, V., Moscatelli, F., Stefano, M. D., Marra, M. L., di Padova, M., Dipace, A., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1425816 · Cited by 50
Chang, R. R., Trushina, E. V., Zhu, K., Zaidi, S. S. A., Lau, B. M., Kueider‐Paisley, A., Moein, S., He, Q., Alamprese, M. L., Vagnerova, B., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12675 · Cited by 42
Astrocyte and oligodendrocyte pathology in Alzheimer's disease
Ziar, R., Tesar, P. J., & Clayton, B. L. L. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00540 · Cited by 47
SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk
Green, R. J., Mayilsamy, K., McGill, A. R., Martinez, T. E., Chandran, B., Blair, L. J., Bickford, P. C., Mohapatra, S. S., & Mohapatra, S. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.09.007 · Cited by 42
Gut microbiota and its metabolites in Alzheimer’s disease: from pathogenesis to treatment
Zou, X., Zou, G., Zou, X., Wang, K., & Chen, Z. (2024) · PeerJ · doi:10.7717/peerj.17061 · Cited by 51
Bashir, S., Uzair, M., Abualait, T., Arshad, M. M. U. D., Khallaf, R. A., Niaz, A., Thani, Z., Yoo, W., Túnez, I., Demirtaş-Tatlıdede, A., et al. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12625 · Cited by 42
Recent progress of nanomedicine in the treatment of Alzheimer’s disease
Hu, L., Tao, Y., Jiang, Y., & Qin, F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1228679 · Cited by 49
Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Alves, S. S., da Silva-Júnior, R. M. P., Servilha‐Menezes, G., Homolak, J., Šalković‐Petrišić, M., & Garcia‐Cairasco, N. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210234 · Cited by 39
Kaygisiz, K., Rauch‐Wirth, L., Dutta, A., Yu, X., Nagata, Y., Bereau, T., Münch, J., Synatschke, C. V., & Weil, T. (2023) · Nature Communications · doi:10.1038/s41467-023-40663-6 · Cited by 37
Kloske, C. M., Dugan, A. J., Weekman, E. M., Winder, Z., Patel, E., Nelson, P. T., Fardo, D. W., & Wilcock, D. M. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab085 · Cited by 37
S ‑Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs
Das, T., Yang, X., Lee, H.-Y., Garst, E. H., Valencia, E., Chandran, K., Im, W., & Hang, H. C. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00176 · Cited by 37
De Strooper, B., & Karran, E. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00057-w · Cited by 36
The Potential of NLRP3 Inflammasome as a Therapeutic Target in Neurological Diseases
He, W., Hu, Z., Zhong, Y., Wu, C., & Li, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03229-7 · Cited by 38
The role of lysosomal membrane proteins in autophagy and related diseases
Xu, J., Gu, J., Pei, W., Zhang, Y., Wang, L., & Gao, J. (2023) · FEBS Journal · doi:10.1111/febs.16820 · Cited by 38
Giridharan, V. V., Catumbela, C. S. G., Catalão, C. H. R., Lee, J., Ganesh, B. P., Petronilho, F. C., Dal‐Pizzol, F., Morales, R., & Barichello, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02172-2 · Cited by 38
Zhang, S.-S., Gao, Z., Feng, L., & Li, M. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s483412 · Cited by 39
Therapeutic Targeting Strategies for Early- to Late-Staged Alzheimer’s Disease
Kang, Y. J., Diep, Y. N., Tran, M., & Cho, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249591 · Cited by 36
Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
Hu, R., Yu, Q., Zhou, S.-D., Yin, Y., Hu, R.-G., Lu, H.-P., & Hu, B.-L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.605961 · Cited by 35
Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
Tan, J. M. J., Garner, M. E., Regeimbal, J. M., Greene, C. J., Márquez, J. D. R., Ammendolia, D. A., McCluggage, A. R. R., Li, T., Wu, K. J., Cemma, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24982-0 · Cited by 35
Self-citationNanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms
Cheng, G., Xie, A., Yan, Z., Zhu, X., Song, Y., & Chen, T. (2023) · Brain‐X · doi:10.1002/brx2.27 · Cited by 35
Liu, Y., Tan, Y., Zhang, Z., Li, H., Yi, M., Zhang, Z., Hui, S., & Peng, W. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101831 · Cited by 34
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease
Xu, P., Chang, J. C., Zhou, X., Wang, W., Bamkole, M. A., Wong, E., Bettayeb, K., Jiang, L.-L., Huang, T. Y., Luo, W., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202446 · Cited by 36
Self-citation[Retracted] A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction‐Related Diseases
Weng, Z.-B., Chen, Y.-R., Lv, J.-T., Wang, M.-X., Chen, Z.-Y., Zhou, W., Shen, X.-C., Zhan, L.-B., & Wang, F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4289383 · Cited by 32
“…studies, it is considered that the main pathogenesis of AD includes the degeneration of A β [90 – 92], hyperphosphorylation of Tau protein [93], the imbalance of choline [94], neuroin fl ammation [95, 96], abnormalities in neurotransmitters, and dysfunction of mitochondrial autophagy [97, 98].”
Self-citationRetractedMahaman, Y. A. R., Huang, F., Salissou, M. T. M., Yacouba, M. B. M., Wang, J., Liu, R., Zhang, B., Li, H., Zhu, F., & Wang, X. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01356-6 · Cited by 34
Self-citationBi, D., Bao, H., Yang, X., Wu, Z., Yang, X., Xu, G., Liu, X., Wan, Z., Liu, J., He, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.030 · Cited by 32
Vavougios, G. D., Nday, C. M., Pelidou, S., Gourgoulianis, K. I., Stamoulis, G. I., Doskas, T. K., & Zarogiannis, S. G. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100243 · Cited by 33
Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease
Chan, H. J., Yanshree, Roy, J., Tipoe, G. L., Fung, M., & Lim, L. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810151 · Cited by 33
Razazan, A. P., Karunakar, P., Mishra, S. P., Sharma, S., Miller, B. C., Jain, S., & Yadav, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.735933 · Cited by 34
Glial interference: impact of type I interferon in neurodegenerative diseases
Roy, E. R., & Cao, W. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00583-3 · Cited by 31
Ma, G., Zhang, D.-F., Zou, Q.-C., Xie, X., Xu, L., Feng, X.-L., Li, X., Han, J.-B., Yu, D., Deng, Z.-H., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00458-3 · Cited by 30
Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform
Tran, V. T. A., Kang, Y. J., Kim, H., Cho, H., & Cho, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136925 · Cited by 35
The γ-secretase substrate proteome and its role in cell signaling regulation
Hou, P., Zielonka, M., Serneels, L., Martínez‐Muriana, A., Fattorelli, N., Wolfs, L., Poovathingal, S. K., T’Syen, D., Balusu, S., Theys, T., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.029 · Cited by 29
The Role of PKM2 in Multiple Signaling Pathways Related to Neurological Diseases
Zhang, X., Lei, Y., Zhou, H., Liu, H., & Xu, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03901-y · Cited by 30
Sullivan, J. M., Bagnell, A. M., Alevy, J., Avila, E. M., Mihaljević, L., Saavedra-Rivera, P. C., Kong, L., Huh, J. S., McCray, B. A., Aisenberg, W. H., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk1358 · Cited by 29
Hao, W., Luo, Q., Tomic, I., Quan, W., Hartmann, T., Menger, M. D., Fassbender, K. C., & Liu, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363014 · Cited by 29
Khan, S., Delotterie, D. F., Xiao, J., Thangavel, R., Hori, R. T., Koprich, J. B., Alway, S. E., McDonald, M. P., & Khan, M. M. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106065 · Cited by 33
Xu, Z.-J., Li, Q., Ding, L., Shi, H.-H., Xue, C., Mao, X., Wang, Y., & Zhang, T. (2021) · Food & Function · doi:10.1039/d1fo00286d · Cited by 30
Metadata
- Authors
- Hur, J.-Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., Barros, M., Li, T., Nie, P., Zhai, Y., Wang, J. C., TCW, J., Guo, L., McKenzie, A., Ming, C., Zhou, X., Wang, M., Sagi, Y., Renton, A. E., Esposito, B. T., Kim, Y., Sadleir, K. R., Trinh, I., Rissman, R. A., Vassar, R., Zhang, B., Johnson, D. S., Masliah, E., Greengard, P., Goate, A., & Li, Y.-M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- Rockefeller University (US)
- Northwestern University (US)
- University of California San Diego (US)
- Pfizer (United States) (US)
- Corresponding author
- Li, Yue-Ming
- ORCID
- Hur, Ji-Yeun
- Frost, Georgia R.
- Wong, Eitan
- Barros, Marilia
- Li, Thomas
- Zhai, Yujia
- TCW, Julia
- Guo, Lei
- McKenzie, Andrew
- Ming, Chen
- Zhou, Xianxiao
- Wang, Minghui
- Sagi, Yotam
- Renton, Alan E.
- Kim, Yong
- Sadleir, Katherine R.
- Trinh, Ivy
- Rissman, Robert A.
- Vassar, Robert
- Zhang, Bin
- Johnson, Douglas S.
- Masliah, Eliezer
- Greengard, Paul
- Goate, Alison
- Li, Yue-Ming
- Venue
- Nature
- Published
- 2020-09-02
- Volume
- 586
- Issue
- 7831
- Pages
- 735-740
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7919141
- OpenAlex
- W3082942379
- Cited by
- 382
- References
- 64
- Citations by year
- 2026: 53 · 2025: 51 · 2024: 53 · 2023: 68 · 2022: 77 · 2021: 65 · 2020: 15
- FWCI
- 34.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (1s10od018522-01, 1s10od026880-01)
- National Institute on Aging (R01AG057907, R01AG026660, U01AG046170, R01AG018440, R01AG006170, RF1AG057440, K01AG062683, RF1AG057593, R01AG061350, P30AG062429)
- National Cancer Institute (P30CA008748)
- National Institute of Neurological Disorders and Stroke (R01NS096275)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- IFITM3, gamma-secretase, Alzheimer's disease, amyloid-beta, innate immunity, neuroinflammation, inflammatory cytokines, presenilin, amyloid plaques, 5xFAD mice, late-onset Alzheimer's disease, aging, familial Alzheimer's disease
- MeSH terms
- Aged, 80 and over, Aging, Alzheimer Disease, Animals, Astrocytes, Disease Models, Animal, Female, Humans, Immunity, Innate, Inflammation, Male, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Risk, Up-Regulation, Amyloid beta-Protein Precursor, RNA-Binding Proteins, Age of Onset, Catalytic Domain, Mice, Presenilin-1, Amyloid Precursor Protein Secretases, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
