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Human germinal centres engage memory and naive B cells after influenza vaccination
Open accessAbstract
Influenza viruses remain a major public health threat. Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, which differentiate into a transient wave of circulating antibody-secreting plasmablasts 1-3. This recall response contributes to 'original antigenic sin'-the selective increase of antibody species elicited by previous exposures to influenza virus antigens 4. It remains unclear whether such vaccination can also induce germinal centre reactions in the draining lymph nodes, where diversification and maturation of recruited B cells can occur 5. Here we used ultrasound-guided fine needle aspiration to serially sample the draining lymph nodes and investigate the dynamics and specificity of germinal centre B cell responses after influenza vaccination in humans. Germinal centre B cells that bind to influenza vaccine could be detected as early as one week after vaccination. In three out of eight participants, we detected vaccine-binding germinal centre B cells up to nine weeks after vaccination. Between 12% and 88% of the responding germinal centre B cell clones overlapped with B cells detected among early circulating plasmablasts. These shared B cell clones had high frequencies of somatic hypermutation and encoded broadly cross-reactive monoclonal antibodies. By contrast, vaccine-induced B cell clones detected only in the germinal centre compartment exhibited significantly lower frequencies of somatic hypermutation and predominantly encoded strain-specific monoclonal antibodies, which suggests a naive B cell origin. Some of these strain-specific monoclonal antibodies recognized epitopes that were not targeted by the early plasmablast response. Thus, influenza virus vaccination in humans can elicit a germinal centre reaction that recruits B cell clones that can target new epitopes, thereby broadening the spectrum of vaccine-induced protective antibodies.
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“The detected plasmablasts were unlikely to be a contaminant of blood, because CD14+ monocyte and/or granulocyte frequencies were below 1% in all FNA samples (well below the 10% threshold that was previously established19)”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
In the citing paper
“Clones related to S-binding monoclonal antibodies had significantly increased mutation frequencies in their immunoglobulin heavy chain variable region (IGHV) genes compared to previously published naive B cells19, particularly those related to monoclonal antibodies that cross-reacted with seasonal betacoronaviruses”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
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“These responses to mRNA vaccination are superior to those seen after seasonal influenza virus vaccination in humans19, in whom haemagglutinin-binding germinal centre B cells were detected in only three out of eight participants.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
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“These data are consistent with previous findings from seasonal influenza virus vaccination in humans that show that the germinal centre reaction can engage pre-existing memory B cells directed against conserved epitopes as well as naive clones targeting novel epitopes19.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
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“Furthermore, the germinal centre responses after mRNA vaccination were superior to those seen after the seasonal influenza vaccination in humans204.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [204]
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Cites
UCSF Chimera—A visualization system for exploratory research and analysis
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20084 · Cited by 45,882
BLAST+: architecture and applications
Camacho, C., Coulouris, G., Avagyan, V., Ma, N., Papadopoulos, J., Bealer, K., & Madden, T. L. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-421 · Cited by 22,074
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
Scheres, S. H. W. (2012) · Journal of Structural Biology · doi:10.1016/j.jsb.2012.09.006 · Cited by 5,446
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Zivanov, J., Nakane, T., Forsberg, B., Kimanius, D., Hagen, W., Lindahl, E., & Scheres, S. (2018) · eLife · doi:10.7554/elife.42166 · Cited by 4,377
circlize implements and enhances circular visualization in R
Gu, Z., Gu, L., Eils, R., Schlesner, M., & Brors, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu393 · Cited by 4,290
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
Iuliano, A. D., Roguski, K. M., Chang, H. H., Muscatello, D. J., Palekar, R. S., Tempia, S., Cohen, C., Gran, J. M., Schanzer, D. L., Cowling, B. J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)33293-2 · Cited by 3,034
BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis
Durinck, S., Moreau, Y., Kasprzyk, A., Davis, S. R., Moor, B. D., Brāzma, A., & Huber, W. K. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti525 · Cited by 2,327
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Automated molecular microscopy: The new Leginon system
Suloway, C. J. M., Pulokas, J., Fellmann, D., Cheng, A., Guerra, F., Quispe, J. D., Stagg, S. M., Potter, C. S., & Carragher, B. O. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.03.010 · Cited by 1,695
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
Treutlein, B., Brownfield, D. G., Wu, A. R., Neff, N. F., Mantalas, G. L., Espinoza, F. H., Desai, T. J., Krasnow, M. A., & Quake, S. R. (2014) · Nature · doi:10.1038/nature13173 · Cited by 1,342
Yates, A. D., Achuthan, P., Akanni, W. A., Allen, J., Allen, J., Álvarez-Jarreta, J., Amode, M. R., Armean, I. M., Azov, A. G., Bennett, R., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz966 · Cited by 1,221
Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., et al. (2011) · Science · doi:10.1126/science.1205669 · Cited by 1,203
IgBLAST: an immunoglobulin variable domain sequence analysis tool
Ye, J., Ma, N., Madden, T., & Ostell, J. M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt382 · Cited by 1,161
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Wrammert, J., Smith, K., Miller, J., Langley, W. A., Kokko, K. E., Larsen, C. P., Zheng, N., Mays, I., Garman, L., Helms, C., et al. (2008) · Nature · doi:10.1038/nature06890 · Cited by 1,026
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
Gupta, N. T., Heiden, J. A. V., Uduman, M., Gadala-Maria, D., Yaari, G., & Kleinstein, S. H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv359 · Cited by 869
Self-citationAppion: An integrated, database-driven pipeline to facilitate EM image processing
Lander, G. C., Stagg, S. M., Voss, N. R., Cheng, A., Fellmann, D., Pulokas, J., Yoshioka, C., Irving, C., Mulder, A. M., Lau, P., et al. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2009.01.002 · Cited by 836
Lefranc, M., Pommie, C., Ruíz, M., Giudicelli, V., Foulquier, E., Truong, L., Contet, V., & Lefranc, G. (2002) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(02)00039-3 · Cited by 823
Lefranc, M., Pommie, C., Kaas, Q., Duprat, É., Bosc, N., Guiraudou, D., Jean, C., Ruíz, M., da Piedade, I., Rouard, M., et al. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.07.003 · Cited by 808
Wrammert, J., Koutsonanos, D., Li, G., Edupuganti, S., Sui, J., Michael, M., McCausland, M. M., Skountzou, I., Hornig, M., Lipkin, W. I., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101352 · Cited by 777
Multiple layers of B cell memory with different effector functions
Dogan, I., Bertocci, B., Vilmont, V., Delbos, F., Mégret, J., Storck, S., Reynaud, C.-A., & Weill, J.-C. (2009) · Nature Immunology · doi:10.1038/ni.1814 · Cited by 635
Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
Pape, K. A., Taylor, J. J., Maul, R. W., Gearhart, P. J., & Jenkins, M. K. (2011) · Science · doi:10.1126/science.1201730 · Cited by 572
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
Giudicelli, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki010 · Cited by 548
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 520
Heiden, J. A. V., Yaari, G., Uduman, M., Stern, J. N. H., O’Connor, K. C., Hafler, D. A., Vigneault, F., & Kleinstein, S. H. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu138 · Cited by 469
Self-citationRapid generation of fully human monoclonal antibodies specific to a vaccinating antigen
Smith, K., Garman, L., Wrammert, J., Zheng, N., Capra, J. D., Ahmed, R., & Wilson, P. C. (2009) · Nature Protocols · doi:10.1038/nprot.2009.3 · Cited by 467
Zuccarino-Catania, G., Sadanand, S., Weisel, F. J., Tomayko, M. M., Meng, H., Kleinstein, S. H., Good‐Jacobson, K. L., & Shlomchik, M. J. (2014) · Nature Immunology · doi:10.1038/ni.2914 · Cited by 449
Self-citationCorti, D., Suguitan, A. L., Pinna, D., Silacci, C., Fernandez-Rodriguez, B. M., Zatta, F., Santos, C. P., Luke, C. J., Torres-Velez, F. J., Temperton, N. J., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41902 · Cited by 433
Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.012 · Cited by 433
Self-citationEllebedy, A. H., Jackson, K., Kissick, H. T., Nakaya, H. I., Davis, C. W., Roskin, K. M., McElroy, A. K., Oshansky, C. M., Elbein, R., Thomas, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3533 · Cited by 396
Self-citationMesin, L., Schiepers, A., Ersching, J., Barbulescu, A., Cavazzoni, C. B., Angelini, A., Okada, T., Kurosaki, T., & Victora, G. D. (2019) · Cell · doi:10.1016/j.cell.2019.11.032 · Cited by 352
Complex Antigens Drive Permissive Clonal Selection in Germinal Centers
Kuraoka, M., Schmidt, A. G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S. C., Kepler, T. B., & Kelsoe, G. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.010 · Cited by 315
Structural and genetic basis for development of broadly neutralizing influenza antibodies
Lingwood, D., McTamney, P. M., Yassine, H. M., Whittle, J. R. R., Guo, X., Boyington, J. C., Wei, C., & Nabel, G. J. (2012) · Nature · doi:10.1038/nature11371 · Cited by 269
Broadly protective human antibodies that target the active site of influenza virus neuraminidase
Stadlbauer, D., Zhu, X., McMahon, M., Turner, J. S., Wohlbold, T. J., Schmitz, A. J., Strohmeier, S., Yu, W., Nachbagauer, R., Mudd, P. A., et al. (2019) · Science · doi:10.1126/science.aay0678 · Cited by 265
Self-citationEngineered immunogen binding to alum adjuvant enhances humoral immunity
Moyer, T. J., Kato, Y., Abraham, W. D., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0753-3 · Cited by 259
Self-citationBianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M. G., Bastidas, R. B., Nedellec, R., McCoy, L. E., Wilson, I. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.009 · Cited by 198
Self-citationGadala-Maria, D., Yaari, G., Uduman, M., & Kleinstein, S. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417683112 · Cited by 188
Self-citationHavenar‐Daughton, C., Carnathan, D. G., de la Peña, A. T., Pauthner, M. G., Briney, B. S., Reiss, S. M., Wood, J., Kaushik, K., van Gils, M. J., Rosales, S. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.085 · Cited by 180
Margine, I., Palese, P., & Krammer, F. (2013) · Journal of Visualized Experiments · doi:10.3791/51112 · Cited by 169
Self-citationVallania, F., Tam, A., Lofgren, S., Schaffert, S. A., Azad, T. D., Bongen, E., Haynes, W. A., Alsup, M., Alonso, M. N., Davis, M. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07242-6 · Cited by 161
Gupta, N. T., Adams, K., Briggs, A. W., Timberlake, S. C., Vigneault, F., & Kleinstein, S. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601850 · Cited by 159
Self-citationHoehn, K. B., Heiden, J. A. V., Zhou, J. Q., Lunter, G. A., Pybus, O. G., & Kleinstein, S. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906020116 · Cited by 114
Self-citationNogal, B., Bianchi, M., Cottrell, C. A., Kirchdoerfer, R. N., Sewall, L. M., Turner, H. L., Zhao, F., Sok, D., Burton, D. R., Hangartner, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.061 · Cited by 89
Self-citationA Phylogenetic Codon Substitution Model for Antibody Lineages
Hoehn, K. B., Lunter, G. A., & Pybus, O. G. (2017) · Genetics · doi:10.1534/genetics.116.196303 · Cited by 78
Basic human anatomy : a regional study of human structure
O’Rahilly, R., & Müller, F. (1983) · Medical Entomology and Zoology · Cited by 74
Gilchuk, I. M., Bangaru, S., Gilchuk, P., Irving, R. P., Kose, N., Bombardi, R. G., Thornburg, N. J., Creech, C. B., Edwards, K. M., Li, S., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.10.003 · Cited by 69
Self-citationMeade, P. S., Kuan, G. M., Strohmeier, S., Maier, H. E., Amanat, F., Balmaseda, Á., Ito, K., Roubidoux, E. K., Javier, A., Gresh, L., et al. (2020) · mBio · doi:10.1128/mbio.03243-19 · Cited by 67
Self-citationRe-Engaging Cross-Reactive Memory B Cells: The Influenza Puzzle
Ellebedy, A. H., & Ahmed, R. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00053 · Cited by 55
Self-citationHavenar‐Daughton, C., Newton, I. G., Zare, S., Reiss, S. M., Schwan, B., Suh, M. J., Hasteh, F., Levi, G., & Crotty, S. (2020) · Journal of Immunological Methods · doi:10.1016/j.jim.2020.112746 · Cited by 50
Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs
Brozy, J., Schlaepfer, E., Mueller, C. K. S., Rochat, M.-A., Rampini, S. K., Myburgh, R., Raum, T., Kufer, P., Baeuerle, P. A., Muenz, M., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00491-18 · Cited by 48
Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships
Zhou, J. Q., & Kleinstein, S. H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900666 · Cited by 47
Self-citationNachbagauer, R., Shore, D. A., Yang, H., Johnson, S. K., Gabbard, J. D., Tompkins, S. M., Wrammert, J., Wilson, P. C., Stevens, J., Ahmed, R., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00949-18 · Cited by 38
Self-citationMeade, P. S., Latorre‐Margalef, N., Stallknecht, D. E., & Krammer, F. (2017) · Emerging Microbes & Infections · doi:10.1038/emi.2017.98 · Cited by 25
Self-citation
Research works printed but not linked: 2
- Francis, T. On the doctrine of original antigenic sin. Proc. Am. Phil. Soc. 104, 572–578 (1953).
- Carati, C., Gannon, B. & Piller, N. Anatomy and physiology in relation to compression of the upper limb and thorax. J. Lymphoedema 5, 58–67 (2010).
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Cell2location maps fine-grained cell types in spatial transcriptomics
Kleshchevnikov, V., Shmatko, A., Dann, E., Aivazidis, A., King, H. W., Li, T., Elmentaite, R., Lomakin, A., Kedlian, V., Gayoso, A., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01139-4 · Cited by 1,279
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
Turner, J. S., O’Halloran, J. A., Kalaidina, E., Kim, W., Schmitz, A. J., Zhou, J. Q., Lei, T., Thapa, M., Chen, R. E., Case, J. B., et al. (2021) · Nature · doi:10.1038/s41586-021-03738-2 · Cited by 831
Self-citationVictora, G. D., & Nussenzweig, M. C. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-120419-022408 · Cited by 893
Goel, R. R., Apostolidis, S. A., Painter, M. M., Mathew, D., Pattekar, A., Kuthuru, O., Gouma, S., Hicks, P., Meng, W., Rosenfeld, A. M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abi6950 · Cited by 655
Metadata
- Authors
- Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T., Amor, M., McIntire, K. M., Meade, P., Strohmeier, S., Brent, R. I., Richey, S. T., Haile, A., Yang, Y. R., Klebert, M. K., Suessen, T., Teefey, S., Presti, R. M., Krammer, F., Kleinstein, S. H., Ward, A. B., & Ellebedy, A. H.
- Affiliations
- Washington University in St. Louis (US)
- Yale University (US)
- Scripps Research Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Ellebedy, Ali H.
- ORCID
- Turner, Jackson S.
- Zhou, Julian Q.
- Han, Julianna
- Schmitz, Aaron J.
- Alsoussi, Wafaa B.
- Lei, Tingting
- McIntire, Katherine M.
- Meade, Philip
- Strohmeier, Shirin
- Brent, Rafael I.
- Richey, Sara T.
- Yang, Yuhe R.
- Klebert, Michael K.
- Teefey, Sharlene
- Presti, Rachel M.
- Krammer, Florian
- Kleinstein, Steven H.
- Ward, Andrew B.
- Ellebedy, Ali H.
- Venue
- Nature
- Published
- 2020-08-31
- Volume
- 586
- Issue
- 7827
- Pages
- 127-132
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7566073
- OpenAlex
- W3082694457
- Cited by
- 304
- References
- 54
- Citations by year
- 2026: 46 · 2025: 40 · 2024: 53 · 2023: 58 · 2022: 51 · 2021: 50 · 2020: 5
- FWCI
- 29.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000448, UL1TR002345)
- National Cancer Institute (T32CA009547, P30CA091842)
- National Institute of Allergy and Infectious Diseases (HHSN272201400008C), AI117287, R01AI128821, R01AI117287, R01AI104739, AI128821, R01AI104732, R56AI117287, 75N93019C00051, T32AI007244, R21AI139813, U01AI141990, U19AI089992, HHSN 272201400006C)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- influenza vaccination, germinal center, memory B cells, naive B cells, somatic hypermutation, original antigenic sin, plasmablasts, monoclonal antibodies, cross-reactive antibodies, strain-specific antibodies, draining lymph nodes, vaccine-induced antibody response
- MeSH terms
- Adult, Animals, B-Lymphocytes, Clone Cells, Female, Humans, Immunologic Memory, Influenza, Human, Influenza Vaccines, Male, Epitope Mapping, Germinal Center, Mice
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