The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron
Open accessAbstract
The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein 1 . Cellular immune responses, particularly CD8 + T cell responses, probably contribute to protection against severe SARS-CoV-2 infection 2–6 . Here we show that cellular immunity induced by current vaccines against SARS-CoV-2 is highly conserved to the SARS-CoV-2 Omicron spike protein. Individuals who received the Ad26.COV2.S or BNT162b2 vaccines demonstrated durable spike-specific CD8 + and CD4 + T cell responses, which showed extensive cross-reactivity against both the Delta and the Omicron variants, including in central and effector memory cellular subpopulations. Median Omicron spike-specific CD8 + T cell responses were 82–84% of the WA1/2020 spike-specific CD8 + T cell responses. These data provide immunological context for the observation that current vaccines still show robust protection against severe disease with the SARS-CoV-2 Omicron variant despite the substantially reduced neutralizing antibody responses 7,8 .
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Citations
Cites
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592
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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.
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Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19
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Self-citationAdaptive immunity to SARS-CoV-2 and COVID-19
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Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques
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Self-citationmRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
Goel, R. R., Painter, M. M., Apostolidis, S. A., Mathew, D., Meng, W., Rosenfeld, A. M., Lundgreen, K. A., Reynaldi, A., Khoury, D. S., Pattekar, A., et al. (2021) · Science · doi:10.1126/science.abm0829 · Cited by 873
Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa
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Cited by
Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and Monoclonal Antibodies
Wilhelm, A., Widera, M., Grikscheit, K., Toptan, T., Schenk, B., Pallas, C., Metzler, M., Kohmer, N., Hoehl, S., Helfritz, F. A., et al. (2021) · doi:10.1101/2021.12.07.21267432 · Cited by 440
Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines
Sette, A., & Crotty, S. (2022) · Immunological Reviews · doi:10.1111/imr.13089 · Cited by 269
Tenforde, M. W., Self, W. H., Gaglani, M., Ginde, A. A., Douin, D. J., Talbot, H. K., Casey, J. D., Mohr, N. M., Zepeski, A., McNeal, T., et al. (2022) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7112e1 · Cited by 170
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques
Liu, J., Yu, J., McMahan, K., Jacob-Dolan, C., He, X., Giffin, V., Wu, C., Sciacca, M., Powers, O., Nampanya, F., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abq7647 · Cited by 132
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Metadata
- Authors
- Liu, J., Chandrashekar, A., Sellers, D., Barrett, J., Jacob-Dolan, C., Lifton, M., McMahan, K., Sciacca, M., VanWyk, H., Wu, C., Yu, J., Collier, A.-R. Y., & Barouch, D. H.
- Venue
- Nature
- Published
- 2022-01-31
- Volume
- 603
- Issue
- 7901
- Pages
- 493-496
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4210272290
- Cited by
- 451
- References
- 17
- FWCI
- 49.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, J., Chandrashekar, A., Sellers, D., Barrett, J., Jacob-Dolan, C., Lifton, M., McMahan, K., Sciacca, M., VanWyk, H., Wu, C., Yu, J., Collier, A.-R. Y., & Barouch, D. H. (2022). Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron. Nature. https://doi.org/10.1038/s41586-022-04465-y
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