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Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
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“It has been proposed that TCL1A is aberrantly expressed in TET2MUT HSCs, and that this effect is reduced by the presence of the rs2887399 variant T allele.77”
From Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging (2024) · cites this paper as [77]
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“Most notably, a common inherited polymorphism in the TCL1A promoter has been associated with an increased risk of DNMT3A CH”
From Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy (2025) · cites this paper as [52]
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“but a decreased risk for other genes including TET2 (ref. 52).”
From Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy (2025) · cites this paper as [52]
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- Weinstock, J. S., Gopakumar, J., Burugula, B. B., Uddin, M. M., Jahn, N., Belk, J. A., Bouzid, H., Daniel, B., Miao, Z., Ly, N., Mack, T. M., Luna, S. E., Prothro, K. P., Mitchell, S. R., Laurie, C. A., Broome, J. G., Taylor, K. D., Guo, X., Sinner, M. F., von Falkenhausen, A. S., Kääb, S., Shuldiner, A. R., O’Connell, J. R., Lewis, J. P., Boerwinkle, E., Barnes, K. C., Chami, N., Kenny, E. E., Loos, R. J. F., Fornage, M., Hou, L., Lloyd-Jones, D. M., Redline, S., Cade, B. E., Psaty, B. M., Bis, J. C., Brody, J. A., Silverman, E. K., Yun, J. H., Qiao, D., Palmer, N. D., Freedman, B. I., Bowden, D. W., Cho, M. H., DeMeo, D. L., Vasan, R. S., Yanek, L. R., Becker, L. C., Kardia, S. L. R., Peyser, P. A., He, J., Rienstra, M., Van der Harst, P., Kaplan, R., Heckbert, S. R., Smith, N. L., Wiggins, K. L., Arnett, D. K., Irvin, M. R., Tiwari, H., Cutler, M. J., Knight, S., Muhlestein, J. B., Correa, A., Raffield, L. M., Gao, Y., de Andrade, M., Rotter, J. I., Rich, S. S., Tracy, R. 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- ORCID
- Gopakumar, Jayakrishnan
- Burugula, Bala Bharathi
- Uddin, Md Mesbah
- Daniel, Bence
- Mack, Taralynn M.
- Mitchell, Shaneice R.
- Bis, Joshua C.
- Vasan, Ramachandran S.
- Rienstra, Michiel
- Wiggins, Kerri L.
- Cutler, Michael J.
- Knight, Stacey
- Nilsson, Peter M.
- Marcus, Gregory M.
- Pullinger, Clive R.
- Smith, Albert V.
- Satpathy, Ansuman T.
- Kitzman, Jacob O.
- Whitsel, Eric A.
- Bick, Alexander G.
- Jaiswal, Siddhartha
- Venue
- Nature
- Published
- 2023-04-12
- Volume
- 616
- Issue
- 7958
- Pages
- 755-763
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC10360040
- Cited by
- 118
- References
- 20
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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