PreprintCited by 519RNA Research and SplicingRNA and protein synthesis mechanismsCancer-related molecular mechanisms research

What Are 3′ UTRs Doing?

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Mayr, Christine·2019·Cold Spring Harbor Perspectives in Biology

Abstract

3' untranslated regions (3' UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. In addition, 3' UTRs can establish 3' UTR-mediated protein-protein interactions (PPIs), and thus can transmit genetic information encoded in 3' UTRs to proteins. This function has been shown to regulate diverse protein features, including protein complex formation or posttranslational modifications, but is also expected to alter protein conformations. Therefore, 3' UTR-mediated information transfer can regulate protein features that are not encoded in the amino acid sequence. This review summarizes both 3' UTR functions-the regulation of mRNA and protein-based processes-and highlights how each 3' UTR function was discovered with a focus on experimental approaches used and the concepts that were learned. This review also discusses novel approaches to study 3' UTR functions in the future by taking advantage of recent advances in technology.

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  • Adenylate-uridylate-rich elements are involved in mRNA degradation, and degradation rate and translation life cycle can be adjusted by replacing adenylate-uridylate-rich sequences found in the 3′ UTR.

    “Studies have shown that adenylate-uridylate-rich elements are involved in mRNA degradation. Degradation rate and translation life cycle can be adjusted by replacing adenylate-uridylate-rich sequences found in the 3′ UTR.137–139”

    From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [137]

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Research works printed but not linked: 1

  1. Lee SH, Mayr C. 2017. 3 ′ UTR-dependent signalosome assembly deter- mines substrate specificity of BIRC3 E3 ligase during B cell migration. In EMBO conference, RNA localisation and local translation. Barga, Italy.

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Authors
Mayr, C.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Mayr, Christine
Venue
Cold Spring Harbor Perspectives in Biology
Published
2018-09-04
Volume
11
Issue
10
Pages
a034728
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2890344905
Cited by
519
References
120
Citations by year
2026: 71 · 2025: 86 · 2024: 101 · 2023: 83 · 2022: 84 · 2021: 47 · 2020: 29 · 2019: 15 · 2018: 3
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Damon Runyon Cancer Research Foundation (P30 CA008748)
  • Pershing Square Sohn Cancer Research Alliance (P30 CA008748)
  • National Institutes of Health (CA008748)
  • National Cancer Institute (U01CA164190, CA008748, P30CA008748)
  • National Institute of General Medical Sciences (DP1GM123454)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
3' untranslated region, mRNA regulation, mRNA stability, mRNA localization, translational regulation, protein-protein interaction, post-translational modification, protein complex formation, protein conformation, non-coding RNA
MeSH terms
Protein Binding, RNA, Messenger, Protein Biosynthesis, RNA-Binding Proteins, 3' Untranslated Regions, RNA Stability

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