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Evidence for improved DNA repair in the long-lived bowhead whale
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Long-lived animals share enhanced DNA repair, reduced molecular error rates and other processes.
“Long-lived animals share enhanced DNA repair3,5,9–11, reduced molecular error rates and other processes6,12–14.”
From A damage accumulation model identifies distinct aging regimes across species (2026) · cites this paper as [5]
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Somatic mutation rates scale with lifespan across mammals
Cagan, A., Baez-Ortega, A., Brzozowska, N., Abascal, F., Coorens, T. H. H., Sanders, M. A., Lawson, A. R. J., Harvey, L. M. R., Bhosle, S., Jones, D., et al. (2022) · Nature · doi:10.1038/s41586-022-04618-z · Cited by 481
SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species
Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.043 · Cited by 353
Self-citationOptimal enzymes for amplifying sequencing libraries
Quail, M. A., Otto, T. D., Gu, Y., Harris, S. R., Skelly, T. F., McQuillan, J. A., Swerdlow, H. P., & Oyola, S. O. (2012) · Nature Methods · doi:10.1038/nmeth.1814 · Cited by 196
Genomic discovery of potent chromatin insulators for human gene therapy
Liu, M., Maurano, M. T., Wang, H., Qi, H., Song, C.-Z., Navas, P. A., Emery, D. W., Stamatoyannopoulos, J. A., & Stamatoyannopoulos, G. (2015) · Nature Biotechnology · doi:10.1038/nbt.3062 · Cited by 121 · cited 1×
“The backbone was amplified from a pN1 plasmid without f1 bacteriophage origin of replication and modified by the addition of short insulator sequences 87 (E2, A2 and A4) purchased from Integrated DNA Technologies.”
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A damage accumulation model identifies distinct aging regimes across species
Raz, N., Yang, Y., Pridham, G., Shenhar, B., Frenkel, S., Levy, T., Tlusty, T., Mayo, A., & Alon, U. (2026) · Nature Aging · doi:10.1038/s43587-026-01138-7 · Cited by 7
Metadata
- Authors
- Firsanov, D., Zacher, M., Tian, X., Sformo, T. L., Zhao, Y., Tombline, G., Lu, J. Y., Zheng, Z., Perelli, L., Gurreri, E., Zhang, L., Guo, J., Korotkov, A., Volobaev, V., Biashad, S. A., Zhang, Z., Heid, J., Maslov, A. Y., Sun, S., Wu, Z., Gigas, J., Hillpot, E. C., Martinez, J. C., Lee, M., Williams, A., Gilman, A., Hamilton, N., Strelkova, E., Haseljic, E., Patel, A., Straight, M. E., Miller, N., Ablaeva, J., Tam, L. M., Couderc, C., Hoopmann, M. R., Moritz, R. L., Fujii, S., Pelletier, A., Hayman, D. J., Liu, H., Cai, Y., Leung, A. K. L., Zhang, Z., Nelson, C. B., Abegglen, L. M., Schiffman, J. D., Gladyshev, V. N., Maley, C. C., Modesti, M., Genovese, G., Simons, M. J. P., Vijg, J., Seluanov, A., & Gorbunova, V.
- ORCID
- Zacher, Max
- Sformo, Todd L.
- Zhao, Yang
- Lu, J. Yuyang
- Perelli, Luigi
- Gurreri, Enrico
- Zhang, Li
- Guo, Jing
- Volobaev, Valentin
- Zhang, Zhihui
- Heid, Johanna
- Maslov, Alexander Y.
- Sun, Shixiang
- Wu, Zhuoer
- Martinez, John C.
- Straight, Maggie E.
- Ablaeva, Julia
- Tam, Lok Ming
- Hoopmann, Michael R.
- Moritz, Robert L.
- Fujii, Shingo
- Hayman, Dan J.
- Liu, Hongrui
- Leung, Anthony K. L.
- Nelson, C. Bradley
- Abegglen, Lisa M.
- Schiffman, Joshua D.
- Gladyshev, Vadim N.
- Maley, Carlo C.
- Modesti, Mauro
- Genovese, Giannicola
- Simons, Mirre J. P.
- Vijg, Jan
- Gorbunova, Vera
- Venue
- Nature
- Published
- 2025-10-29
- Volume
- 648
- Issue
- 8094
- Pages
- 717-725
- ISSN
- 0028-0836
- 1476-4687
- PMC
- PMC12711569
- Cited by
- 61
- References
- 4
- Language
- en
- Update notices
- correction (2025-11-28)
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