The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
Open accessAbstract
The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and prognostic markers of renal disease. Type I interferon (IFN)-response signatures in tubular cells and keratinocytes distinguished patients with LN from healthy control subjects. Moreover, a high IFN-response signature and fibrotic signature in tubular cells were each associated with failure to respond to treatment. Analysis of tubular cells from patients with proliferative, membranous and mixed LN indicated pathways relevant to inflammation and fibrosis, which offer insight into their histologic differences. In summary, we applied scRNA-seq to LN to deconstruct its heterogeneity and identify novel targets for personalized approaches to therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“two studies, focussing on populations of hypermethylated in cancer protein (Hic1)+Pdgfrα+ lymphocyte antigen 6 complex (LY6A)+ MP populations in heart and skeletal muscle, have elegantly demonstrated MP hierarchy, diversity in the pathophysiological roles of their progeny, and how fate determination of MP is context dependent31,32.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
In the citing paper
“although Hic1 inactivation in skeletal muscle also resulted in a marked expansion of Pdgfrα+LY6A+ cells during homeostasis, this did not increase skeletal muscle fibrosis and had no substantial effect on skeletal muscle regeneration31”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
In the citing paper
“Conditional genetic inactivation of Hic1 in mice led to activation and expansion of MPs in both heart and skeletal muscle, demonstrating that Hic1 is required for maintaining MP quiescence.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799
KEGG: new perspectives on genomes, pathways, diseases and drugs
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1092 · Cited by 8,865
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814
Cited by
Sorted by citations
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
Self-citationFibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868
Confronting false discoveries in single-cell differential expression
Squair, J. W., Gautier, M., Kathe, C., Anderson, M. A., James, N. D., Hutson, T. H., Hudelle, R., Qaiser, T., Matson, K. J. E., Barraud, Q., et al. (2021) · doi:10.1101/2021.03.12.435024 · Cited by 1,086
Anders, H., Saxena, R., Zhao, M., Parodis, I., Salmon, J. E., & Mohan, C. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0141-9 · Cited by 1,018
Kidney fibrosis: from mechanisms to therapeutic medicines
Huang, R., Fu, P., & Ma, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01379-7 · Cited by 876
Autoimmunity and organ damage in systemic lupus erythematosus
Tsokos, G. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0677-6 · Cited by 589
Interferon target-gene expression and epigenomic signatures in health and disease
Barrat, F. J., Crow, M. K., & Ivashkiv, L. B. (2019) · Nature Immunology · doi:10.1038/s41590-019-0466-2 · Cited by 539
He, H., Suryawanshi, H., Morozov, P. S., Gay-Mimbrera, J., DUCA, E. D., Kim, H. J., Kameyama, N., Estrada, Y. D., Der, E. B., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.01.042 · Cited by 510
Self-citationApplications of single-cell RNA sequencing in drug discovery and development
de Sande, B. V., Lee, J. S., Mutasa-Gottgens, E., Naughton, B. J., Bacon, W., Manning, J. R., Wang, Y., Pollard, J. R., Mendez, M., Hill, J., et al. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00688-4 · Cited by 462
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
Crow, M. K. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223741 · Cited by 435
Peng, L., Li, W., Shi, Q.-F., Gao, F., Huang, B., Meng, J., Hu, C.-P., & Wang, C. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03178-2 · Cited by 387
Interferon pathway in SLE: one key to unlocking the mystery of the disease
Rönnblom, L., & Leonard, D. (2019) · Lupus Science & Medicine · doi:10.1136/lupus-2018-000270 · Cited by 369
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost, S., Annusver, K., Jacob, T., Sun, X., Dalessandri, T., Sivan, U., Sequeira, I., Sandberg, R., & Kasper, M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.012 · Cited by 333
PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-21
Bocharnikov, A. V., Keegan, J., Wacleche, V. S., Cao, Y., Fonseka, C. Y., Wang, G., Muise, E. S., Zhang, K. X., Arazi, A., Keras, G., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130062 · Cited by 320
Self-citationType I interferon in the pathogenesis of systemic lupus erythematosus
Postal, M., Vivaldo, J. F., Fernandez‐Ruiz, R., Paredes, J. L., Appenzeller, S., & Niewold, T. B. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.10.014 · Cited by 309
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
Mahmoudi, S., Mancini, E., Xu, L., Moore, A., Jahanbani, F., Hebestreit, K., Srinivasan, R., Li, X., Devarajan, K., Prélot, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1658-5 · Cited by 285
XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury
Zhao, Z., Wu, J., Xu, H., Zhou, C., Han, B., Zhu, H. J., Hu, Z., Ma, Z., Ming, Z., Yao, Y., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02871-6 · Cited by 229
Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus
Yu, H., Nagafuchi, Y., & Fujio, K. (2021) · Biomolecules · doi:10.3390/biom11070928 · Cited by 228
Balzer, M. S., Doke, T., Yang, Y., Aldridge, D. L., Hu, H., Mai, H., Mukhi, D., Ma, Z., Shrestha, R., Palmer, M. B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31772-9 · Cited by 213
Jayne, D. R. W., Rovin, B. H., Mysler, E., Furie, R. A., Houssiau, F., Trasieva, T., Knagenhjelm, J., Schwetje, E., Chia, Y. L., Tummala, R., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221478 · Cited by 207
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2715-9 · Cited by 157
Billi, A. C., Ma, F., Plazyo, O., Gharaee‐Kermani, M., Wasikowski, R., Hile, G. A., Xing, X., Yee, C. M., Rizvi, S. M., Maz, M. P., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn2263 · Cited by 156
Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond
Kwon, Y.-C., Chun, S., Kim, K.-W., & Mak, A. (2019) · Cells · doi:10.3390/cells8101180 · Cited by 148
Kim, J., Lee, J., Kim, H. J., Kameyama, N., Nazarian, R. S., Der, E. B., Cohen, S. R., Guttman‐Yassky, E., Putterman, C., & Krueger, J. G. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.04.021 · Cited by 146
Self-citationTreatment of lupus nephritis: consensus, evidence and perspectives
Mok, C. C., Teng, Y. K. O., Saxena, R., & Tanaka, Y. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00925-5 · Cited by 141
Liu, X., Chen, W., Zeng, Q., Ma, B., Li, Z., Meng, T., Chen, J., Yu, N., Zhou, Z., & Long, X. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.06.010 · Cited by 140
Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus
Goel, R. R., Wang, X., O’Neil, L. J., Nakabo, S., Hasneen, K., Gupta, S., Wigerblad, G., Blanco, L. P., Kopp, J. B., Morasso, M. I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916897117 · Cited by 138
Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy
Zheng, Y., Lü, P., Deng, Y., Wen, L., Wang, Y., Ma, X., Wang, Z., Wu, L., Hong, Q., Duan, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108525 · Cited by 139
Prediction of prognosis and renal outcome in lupus nephritis
Parodis, I., Tamirou, F., & Houssiau, F. (2020) · Lupus Science & Medicine · doi:10.1136/lupus-2020-000389 · Cited by 137
Hong, X., Meng, S., Tang, D., Wang, T., Ding, L., Yu, H., Li, H., Liu, D. J., Dai, Y., & Yang, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594658 · Cited by 128
Skopelja‐Gardner, S., An, J., Tai, J., Tanaka, L., Sun, X., Hermanson, P., Baum, R., Kawasumi, M., Green, R. R., Gale, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64865-w · Cited by 130
Protecting the kidney in systemic lupus erythematosus: from diagnosis to therapy
Maria, N. I., & Davidson, A. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0401-9 · Cited by 123
Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation
Skopelja‐Gardner, S., Tai, J., Sun, X., Tanaka, L., Kuchenbecker, J. A., Snyder, J. M., Kubes, P., Mustelin, T., & Elkon, K. B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019097118 · Cited by 123
The Mesangial cell — the glomerular stromal cell
Avraham, S., Korin, B., Chung, J.-J., Oxburgh, L. H., & Shaw, A. S. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00474-8 · Cited by 128
Kidney dendritic cells: fundamental biology and functional roles in health and disease
Kurts, C., Ginhoux, F., & Panzer, U. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0272-y · Cited by 121
Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block
Suryawanshi, H., Clancy, R. M., Morozov, P. S., Halushka, M. K., Buyon, J. P., & Tuschl, T. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz257 · Cited by 117
Self-citationDistinct transcriptome architectures underlying lupus establishment and exacerbation
Nakano, M., Ota, M., Takeshima, Y., Iwasaki, Y., Hatano, H., Nagafuchi, Y., Itamiya, T., Maeda, J., Yoshida, R., Yamada, S., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.021 · Cited by 110
The CD6/ALCAM pathway promotes lupus nephritis via T cell–mediated responses
Chalmers, S. A., Ramachandran, R. A., Garcia, S. J., Der, E. B., Herlitz, L., Ampudia, J., Chu, D., Jordan, N., Zhang, T., Parodis, I., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci147334 · Cited by 104
Self-citationStanley, S. K., Vanarsa, K., Soliman, S., Habazi, D., Pedroza, C., Gidley, G., Zhang, T., Mohan, S., Der, E. B., Suryawanshi, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15986-3 · Cited by 103
Self-citationSingle-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Zheng, M., Hu, Z. Q., Mei, X., Ouyang, L., Song, Y., Zhou, W., Kong, Y., Wu, R., Rao, S., Long, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35209-1 · Cited by 103
Fava, A., Buyon, J. P., Mohan, C., Zhang, T., Belmont, H. M., Izmirly, P., Clancy, R. M., Trujillo, J. M. M., Fine, D. M., Zhang, Y., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138345 · Cited by 101
Self-citationDesign and application of single-cell RNA sequencing to study kidney immune cells in lupus nephritis
Rao, D. A., Arazi, A., Wofsy, D., & Diamond, B. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0232-6 · Cited by 96
Pathogenic cellular and molecular mediators in lupus nephritis
Mohan, C., Zhang, T., & Putterman, C. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00722-z · Cited by 92
Self-citationZheng, W., Wang, X., Liu, J., Yu, X., Lu, L., Wang, H., Yu, J., Pei, X., Li, C., Wang, Z., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204289119 · Cited by 95
The role of neutrophils in rheumatic disease-associated vascular inflammation
Wang, L., Luqmani, R. A., & Udalova, I. A. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00738-4 · Cited by 92
Interferon lambda in inflammation and autoimmune rheumatic diseases
Goel, R. R., Kotenko, S. V., & Kaplan, M. J. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00606-1 · Cited by 90
Type I Interferons in Autoimmunity
Fernandez‐Ruiz, R., & Niewold, T. B. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.11.031 · Cited by 88
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies
Allen, M. E., Rus, V., & Szeto, G. L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.09.009 · Cited by 93
The lupus nephritis management renaissance
Mejia-Vilet, J. M., Malvar, A., Arazi, A., & Rovin, B. H. (2021) · Kidney International · doi:10.1016/j.kint.2021.09.012 · Cited by 89
Dunlap, G. S., Billi, A. C., Xing, X., Ma, F., Maz, M. P., Tsoi, L. C., Wasikowski, R., Hodgin, J. B., Gudjonsson, J. E., Kahlenberg, J. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.156341 · Cited by 86
Clinical value of DNA methylation markers in autoimmune rheumatic diseases
Ballestar, E., Sawalha, A. H., & Lu, Q. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0470-9 · Cited by 84
Ramanujam, M., Steffgen, J., Visvanathan, S., Mohan, C., Fine, J. S., & Putterman, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102668 · Cited by 87
Self-citationIFN-I Mediates Lupus Nephritis From the Beginning to Renal Fibrosis
Ding, X., Ren, Y., & He, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676082 · Cited by 80
Alforaih, N., Whittall-García, L. P., & Touma, Z. (2022) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfac036 · Cited by 88
Immunology in the Era of Single-Cell Technologies
Efremova, M., Vento‐Tormo, R., Park, J.-E., Teichmann, S. A., & James, K. R. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090419-020340 · Cited by 80
The promise of precision medicine in rheumatology
Guthridge, J. M., Wagner, C. A., & James, J. A. (2022) · Nature Medicine · doi:10.1038/s41591-022-01880-6 · Cited by 80
Self-citationHong, S., Healy, H. G., & Kassianos, A. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.578952 · Cited by 79
Molecular mechanisms controlling age‐associated B cells in autoimmunity*
Phalke, S., Rivera‐Correa, J., Jenkins, D., Flores-Castro, D., Γιαννοπούλου, Ε., & Pernis, A. B. (2022) · Immunological Reviews · doi:10.1111/imr.13068 · Cited by 79
Lupus nephritis: challenges and progress
Davidson, A., Aranow, C. B., & Mackay, M. C. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000642 · Cited by 73
Mapping the human kidney using single-cell genomics
Schreibing, F., & Kramann, R. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00553-4 · Cited by 71
Transitioning single-cell genomics into the clinic
Lim, J. W. Y., Chin, V. T., Fairfax, K. A., Moutinho, C., Suan, D., Ji, H. P., & Powell, J. E. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00613-w · Cited by 74
Wang, R., Singaraju, A., Marks, K. E., Shakib, L., Dunlap, G. S., Adejoorin, I., Greisen, S. R., Chen, L., Tirpack, A., Aude, C. A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add1591 · Cited by 77
Vanarsa, K., Soomro, S., Zhang, T., Strachan, B. C., Pedroza, C., Nidhi, M., Cicalese, P. A., Gidley, G., Dasari, S., Mohan, S., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-216312 · Cited by 68
Self-citationRamaswamy, M., Tummala, R., Streicher, K. L., da Costa, A. N., & Brohawn, P. Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011286 · Cited by 69
Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis
Abraham, R., Durkee, M. S., Ai, J., Veselits, M., Casella, G., Asano, Y., Chang, A., Ko, K., Oshinsky, C., Peninger, E., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155350 · Cited by 63
Tertiary lymphoid structures in the choroid plexus in neuropsychiatric lupus
Stock, A. D., Der, E. B., Gelb, S., Huang, M. W., Weidenheim, K. M., Ben‐Zvi, A., & Putterman, C. (2019) · JCI Insight · doi:10.1172/jci.insight.124203 · Cited by 65
Self-citationCellular aspects of the pathogenesis of lupus nephritis
Chang, A., Clark, M. R., & Ko, K. (2020) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000777 · Cited by 64
Pathogenesis of lupus nephritis: the contribution of immune and kidney resident cells
Bhargava, R., Li, H., & Tsokos, G. C. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000887 · Cited by 66
Type I interferon–related kidney disorders
Lodi, L., Mastrolia, M. V., Bello, F., Rossi, G. M., Angelotti, M. L., Crow, Y. J., Romagnani, P., & Vaglio, A. (2022) · Kidney International · doi:10.1016/j.kint.2022.02.031 · Cited by 69
Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell, I. D., Steach, H. R., Gauld, S. B., Reinke-Breen, L., Kármán, J., Carr, T. L., Wetter, J. B., Phillips, L. A., Hinchcliff, M., & Flavell, R. A. (2022) · Science Immunology · doi:10.1126/sciimmunol.abq6691 · Cited by 72
Pregnancy-related complications in systemic lupus erythematosus
Tan, Y., Yang, S., Liu, Q., Li, Z., Mu, R., Qiao, J., & Cui, L. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102864 · Cited by 67
Using single-cell technologies to map the human immune system — implications for nephrology
Stewart, B. J., Ferdinand, J. R., & Clatworthy, M. R. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0227-3 · Cited by 61
Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus
Bolouri, N., Akhtari, M., Farhadi, E., Mansouri, R., Faezi, S. T., Jamshidi, A., & Mahmoudi, M. (2022) · Inflammation Research · doi:10.1007/s00011-022-01554-6 · Cited by 62
Schnepp, P. M., Shelley, G., Dai, J., Wakim, N. I., Jiang, H., Mizokami, A., & Keller, E. T. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0051 · Cited by 59
A hitchhiker's guide to single-cell transcriptomics and data analysis pipelines
Nayak, R., & Hasija, Y. (2021) · Genomics · doi:10.1016/j.ygeno.2021.01.007 · Cited by 62
Longitudinal Immune Cell Profiling in Patients With Early Systemic Lupus Erythematosus
Sasaki, T., Bracero, S., Keegan, J., Chen, L., Cao, Y., Stevens, E. F., Qu, Y., Wang, G., Nguyen, J. P., Sparks, J. A., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42248 · Cited by 55
Renal Fibrosis in Lupus Nephritis
Sciascia, S., Cozzi, M., Barinotti, A., Radin, M., Cecchi, I., Fenoglio, R., Mancardi, D., Jones, G. W., Rossi, D., & Roccatello, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214317 · Cited by 61
Martínez, B. A., Shrotri, S., Kingsmore, K. M., Bachali, P., Grammer, A. C., & Lipsky, P. E. (2022) · Science Advances · doi:10.1126/sciadv.abn4776 · Cited by 56
Leyva-Castillo, J. M., Sun, L., Wu, S.-Y., Rockowitz, S., Piotr Sliz, A., & Geha, R. S. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.03.002 · Cited by 57
Systemic lupus erythematosus genetics: insights into pathogenesis and implications for therapy
Ghodke‐Puranik, Y., Olferiev, M., & Crow, M. K. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01152-2 · Cited by 58
Zhao, M., Jiang, J., Zhao, M., Chang, C., Wu, H., & Lu, Q. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08813-6 · Cited by 50
Lupus Nephritis Risk Factors and Biomarkers: An Update
Renaudineau, Y., Brooks, W. H., & Bellière, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914526 · Cited by 61
Risk of Renal Failure Within 10 or 20 Years of Systemic Lupus Erythematosus Diagnosis
Petri, M., Barr, E. A., & Magder, L. S. (2020) · The Journal of Rheumatology · doi:10.3899/jrheum.191094 · Cited by 50
Liu, X., Yuan, M., Xiang, Q., Li, Z., Xu, F., Chen, W., Chen, J., Huang, J., Yu, N., Zhou, Z., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00402-5 · Cited by 55
Xu, J., Shen, C., Lin, W., Meng, T., Ooi, J. D., Eggenhuizen, P. J., Tang, R., Xiao, G., Jin, P., Ding, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683330 · Cited by 50
Update on the cellular and molecular aspects of lupus nephritis
Frangou, E. A., Georgakis, S., & Bertsias, G. K. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108445 · Cited by 50
Lupus Nephritis Biomarkers: A Critical Review
Alduraibi, F. K., & Tsokos, G. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020805 · Cited by 53
Anti-Cytokine Autoantibodies in Systemic Lupus Erythematosus
Howe, H. S., & Leung, B. P. L. (2019) · Cells · doi:10.3390/cells9010072 · Cited by 48
Theocharidis, G., Tekkela, S., Veves, A., McGrath, J. A., & Onoufriadis, A. (2022) · Experimental Dermatology · doi:10.1111/exd.14547 · Cited by 50
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
Chen, W., Jin, B., Cheng, C., Peng, H., Zhang, X., Tan, W., Tang, R., Lian, X., Diao, H., Luo, N., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224788 · Cited by 48
Deleersnijder, D., Callemeyn, J., Arijs, I., Naesens, M., Craenenbroeck, A. H. V., Lambrechts, D., & Sprangers, B. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021020157 · Cited by 49
Belimumab or anifrolumab for systemic lupus erythematosus? A risk-benefit assessment
Kirou, K. A., Dall’Era, M., Aranow, C. B., & Anders, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.980079 · Cited by 48
Burja, B., Paul, D., Tastanova, A., Edalat, S. G., Gerber, R., Houtman, M., Elhaï, M., Bürki, K., Staeger, R., Restivo, G., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.872688 · Cited by 48
Zeng, L., Yang, K., Zhang, T., Zhu, X., Hao, W., Chen, H., & Ge, J. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102919 · Cited by 47
Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus
Xiong, H., Cui, M., Kong, N., Jing, J., Xu, Y., Liu, X., Yang, F., Xu, Z., Yan, Y., Zhao, D., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104507 · Cited by 43
Fenton, K. A., & Pedersen, H. L. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1183535 · Cited by 43
Danaher, P. J., Hasle, N., Nguyen, E. D., Roberts, J. E., Rosenwasser, N. L., Rickert, C., Hsieh, E. W. Y., Hayward, K. N., Okamura, D. M., Alpers, C. E., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adl1666 · Cited by 43
Insights into rheumatic diseases from next-generation sequencing
Donlin, L. T., Park, S. H., Γιαννοπούλου, Ε., Ivovic, A., Park‐Min, K., Siegel, R. M., & Ivashkiv, L. B. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0217-7 · Cited by 42
Wu, C., Jiang, S., Chen, Z., Li, T., Gu, X., Dai, M., Du, F., Ye, Y., Tang, L., Wang, M., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-225876 · Cited by 40
Are lupus animal models useful for understanding and developing new therapies for human SLE?
Moore, E., & Putterman, C. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102490 · Cited by 40
Self-citation
Metadata
- Authors
- the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Der, E., Suryawanshi, H., Morozov, P., Kustagi, M., Goilav, B., Ranabothu, S., Izmirly, P., Clancy, R., Belmont, H. M., Koenigsberg, M., Mokrzycki, M., Rominieki, H., Graham, J. A., Rocca, J. P., Bornkamp, N., Jordan, N., Schulte, E., Wu, M., Pullman, J., Slowikowski, K., Raychaudhuri, S., Guthridge, J., James, J., Buyon, J., Tuschl, T., & Putterman, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Rockefeller University (US)
- Arkansas Children's Hospital (US)
- New York University (US)
- Montefiore Medical Center (US)
- Broad Institute (US)
- Oklahoma Medical Research Foundation (US)
- Corresponding author
- Buyon, Jill
- Tuschl, Thomas
- Putterman, Chaim
- ORCID
- Venue
- Nature Immunology
- Published
- 2019-05-20
- Volume
- 20
- Issue
- 7
- Pages
- 915-927
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC6584054
- OpenAlex
- W2944872709
- Cited by
- 403
- References
- 52
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 61 · 2023: 44 · 2022: 86 · 2021: 56 · 2020: 64 · 2019: 25
- FWCI
- 44.01
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-10-11)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR003167, UL1TR000371)
- National Human Genome Research Institute (U01HG009379, T32HG002295)
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR067679, UH2AR067677, UH2AR067685, UH2AR067681, UH2AR067689, F31AR070582, UH2AR067676, UH2AR067694, UH2AR067691, UH2AR067690, UH2AR067688, UM2AR067678)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- lupus nephritis, type I interferon response, renal tubular epithelial cells, keratinocytes, renal fibrosis, treatment non-response, skin biopsy, disease heterogeneity, membranous lupus nephritis, proliferative lupus nephritis, single-cell transcriptomics, personalized treatment
- MeSH terms
- Biopsy, Fibrosis, Humans, Interferon Type I, Kidney Tubules, Lupus Nephritis, Protein Binding, Skin, Signal Transduction, Keratinocytes, Extracellular Matrix Proteins, Cell Lineage, Computational Biology, Gene Expression Profiling, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review