The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
Open accessAbstract
The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and prognostic markers of renal disease. Type I interferon (IFN)-response signatures in tubular cells and keratinocytes distinguished patients with LN from healthy control subjects. Moreover, a high IFN-response signature and fibrotic signature in tubular cells were each associated with failure to respond to treatment. Analysis of tubular cells from patients with proliferative, membranous and mixed LN indicated pathways relevant to inflammation and fibrosis, which offer insight into their histologic differences. In summary, we applied scRNA-seq to LN to deconstruct its heterogeneity and identify novel targets for personalized approaches to therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“two studies, focussing on populations of hypermethylated in cancer protein (Hic1)+Pdgfrα+ lymphocyte antigen 6 complex (LY6A)+ MP populations in heart and skeletal muscle, have elegantly demonstrated MP hierarchy, diversity in the pathophysiological roles of their progeny, and how fate determination of MP is context dependent31,32.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
In the citing paper
“although Hic1 inactivation in skeletal muscle also resulted in a marked expansion of Pdgfrα+LY6A+ cells during homeostasis, this did not increase skeletal muscle fibrosis and had no substantial effect on skeletal muscle regeneration31”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
In the citing paper
“Conditional genetic inactivation of Hic1 in mice led to activation and expansion of MPs in both heart and skeletal muscle, demonstrating that Hic1 is required for maintaining MP quiescence.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799
KEGG: new perspectives on genomes, pathways, diseases and drugs
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1092 · Cited by 8,865
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814
Cited by
Sorted by citations
Items 201–300 of 402
The Advances of Single-Cell RNA-Seq in Kidney Immunology
Zeng, H., Yang, X., Luo, S., & Zhou, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752679 · Cited by 15
The role of non-coding RNA in lupus nephritis
Liang, H., & Liu, Q. (2023) · Human Cell · doi:10.1007/s13577-023-00883-w · Cited by 14
Clinical and histological significance of urinary CD11c+ macrophages in lupus nephritis
Kim, J., Lee, J. S., Go, H., Lim, J. S., Oh, J. S., Kim, Y., Lee, C., Yoo, B., & Hong, S. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02265-1 · Cited by 14
Genome editing to define the function of risk loci and variants in rheumatic disease
Baglaenko, Y., Macfarlane, D., Marson, A., Nigrovic, P. A., & Raychaudhuri, S. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00637-8 · Cited by 12
Self-citationLupus Susceptibility Loci Predispose Mice to Clonal Lymphocytic Responses and Myeloid Expansion
Akama‐Garren, E. H., & Carroll, M. C. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200098 · Cited by 12
Zheng, M., Hu, Z. Q., Zhou, W., Kong, Y., Wu, R., Zhang, B., Long, H., Jia, S., Lu, Q., & Zhao, M. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109172 · Cited by 13
Nordbø, O. P., Landolt, L. Z., Eikrem, Ø., Scherer, A., Leh, S. M., Furriol, J., Apeland, T., Mydel, P. M., & Marti, H. (2023) · Physiological Reports · doi:10.14814/phy2.15825 · Cited by 13
Shoffner, S. K., Close, L. A., Lazar, S., Ma, F., Gharaee‐Kermani, M., Hurst, A., Dobry, C. J., Pandian, D., Wasikowski, R., Victory, A. M., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.173437 · Cited by 13
Interferons and innate immune activation in autoimmune congenital heart block
Ambrosi, A., Thorlacius, G. E., Sonesson, S., & Wahren‐Herlenius, M. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12995 · Cited by 13
Fava, A., Raychaudhuri, S., & Rao, D. A. (2021) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2021.04.003 · Cited by 13
Self-citationUnderstand SLE heterogeneity in the era of omics, big data, and artificial intelligence
Puri, P., Jiang, S., Yang, Y., Mackay, F., & Yu, D. (2021) · Rheumatology & autoimmunity · doi:10.1002/rai2.12010 · Cited by 13
Neuroimmune system-mediated renal protection mechanisms
Inoue, T. (2021) · Clinical and Experimental Nephrology · doi:10.1007/s10157-021-02062-3 · Cited by 12
Perspectives in systems nephrology
Lindenmeyer, M. T., Alakwaa, F., Rose, M. P., & Kretzler, M. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03470-3 · Cited by 12
GBP2 acts as a member of the interferon signalling pathway in lupus nephritis
Zhang, Y., Liao, Y., Hang, Q., Sun, D., & Liu, Y. (2022) · BMC Immunology · doi:10.1186/s12865-022-00520-5 · Cited by 12
Single-cell transcriptomics: A new tool for studying diabetic kidney disease
Mao, Z., Gao, Z., Liu, Y., Liu, D., Liu, Z., & Wu, P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1053850 · Cited by 15
Common gene signatures and molecular mechanisms of diabetic nephropathy and metabolic syndrome
Zhang, C., Li, H., & Wang, S. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1150122 · Cited by 14
Experimental and computational technologies to dissect the kidney at the single-cell level
Kuppe, C., Perales-Patón, J., Sáez-Rodríguez, J., & Kramann, R. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa233 · Cited by 12
Promise and complexity of lupus mouse models
Moore, E., Reynolds, J. A., Davidson, A., Gallucci, S., Morel, L. M., Rao, D. A., Young, H. A., & Putterman, C. (2021) · Nature Immunology · doi:10.1038/s41590-021-00914-4 · Cited by 12
Self-citationDer, E. B., Suryawanshi, H., Morozov, P. S., Kustagi, M., Goilav, B., Ranabothu, S., Izmirly, P., Clancy, R. M., Belmont, M. H., Koenigsberg, M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0529-4 · Cited by 12
Self-citationLuo, H., Hussain, A., Abbas, M., Yuan, L., Shen, Y., Zhang, Z., Sun, G., Yin, X., & HUANG, S. H. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06996-0 · Cited by 12
Pandey, S. P., Bhaskar, R., Han, S. S., & Narayanan, K. B. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230915112642 · Cited by 12
Tumlin, J. A., Rovin, B. H., Anders, H., Mysler, E., Jayne, D. R. W., Takeuchi, T., Lindholm, C., Weiss, G., Sorrentino, A., Woollard, K. J., et al. (2024) · Kidney International Reports · doi:10.1016/j.ekir.2024.10.013 · Cited by 11
Urine proteomic insights from the belimumab in lupus nephritis trial
Weeding, E., Fava, A., Mohan, C., Magder, L. S., GOLDMAN, D. W., & Petri, M. (2022) · Lupus Science & Medicine · doi:10.1136/lupus-2022-000763 · Cited by 11
Studying Kidney Diseases at the Single-Cell Level
Jiang, M., Chen, H., & Guo, G. (2021) · Kidney Diseases · doi:10.1159/000517130 · Cited by 12
Danaher, P. J., Hasle, N., Nguyen, E. D., Hayward, K. N., Rosenwasser, N. L., Alpers, C. E., Reed, R. C., Okamura, D. M., Baxter, S. K., & Jackson, S. W. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.09.566503 · Cited by 11
Circulating and renal fibrocytes are associated with interstitial fibrosis in lupus nephritis
Kim, J., Go, H., Lim, J. S., Oh, J. S., Ahn, S. M., Kim, Y., Lee, C., Yoo, B., & Hong, S. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac345 · Cited by 10
Spinelli, F. R., Berti, R., Farina, G., Ceccarelli, F., Conti, F., & Crescioli, C. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103412 · Cited by 10
Lai, B., Luo, S., & Lai, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1489205 · Cited by 10
An inflammatory cytokine signature predicts IgA nephropathy severity and progression
Chen, L., Chen, X., Cai, G., Jiang, H., Chen, X., & Zhang, M. (2024) · MedComm · doi:10.1002/mco2.783 · Cited by 10
Interferon-α as a biomarker to predict renal outcomes in lupus nephritis
Garcia, L. P. W., Gladman, D. D., Urowitz, M. B., Bonilla, D., Schneider, R., Touma, Z., & Wither, J. (2024) · Lupus Science & Medicine · doi:10.1136/lupus-2024-001347 · Cited by 10
Organ-based characterization of B cells in patients with systemic lupus erythematosus
Wang, Y., Zhao, R. Z., Liang, Q., Ni, S., Yang, M., Qiu, L., Ji, J., Gu, Z., & Dong, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1509033 · Cited by 11
Shang, S., Xia, J., He, G., Zheng, Y., Zhang, J., Lu, H., Wang, H., Li, W., Li, Q., & Chen, X. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105785 · Cited by 10
New Mechanisms and Therapeutic Targets in Systemic Lupus Erythematosus
Tian, J., Zhou, H., Li, W., Yao, X., & Lu, Q. (2025) · MedComm · doi:10.1002/mco2.70246 · Cited by 12
Review: transcriptome and trans-omics analysis of systemic lupus erythematosus
Fujio, K., Takeshima, Y., Nakano, M., & Iwasaki, Y. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00123-w · Cited by 10
Treatment of lupus: more options after a long wait
Kostopoulou, M., Fanouriakis, A., Bertsias, G., & Boumpas, D. T. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-221817 · Cited by 10
Single-cell RNA sequencing for the study of lupus nephritis
Der, E. B., Suryawanshi, H., Buyon, J. P., Tuschl, T., & Putterman, C. (2019) · Lupus Science & Medicine · doi:10.1136/lupus-2019-000329 · Cited by 10
Self-citationSingle cell profiling of capillary blood enables out of clinic human immunity studies
Dobreva, T., Brown, D. A., Park, J. H., & Thomson, M. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-77073-3 · Cited by 10
Current Status of the Evaluation and Management of Lupus Patients and Future Prospects
Yavuz, Ş., & Lipsky, P. E. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.682544 · Cited by 10
Dong, Z., Dai, H., Liu, W., Jiang, H., Feng, Z., Liu, F., Zhao, Q., Rui, H., Liu, W. J., & Liu, B. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.770902 · Cited by 10
Wu, S., Ji, L., Fan, X., Fang, S., Bao, J., Yuan, X., Fan, Y., & Xie, G. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4987323 · Cited by 10
Xie, S., Titus, A. S. C. L. S., & Mohan, C. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109188 · Cited by 10
Yu, F., Teng, Y., Li, J., Yang, S., Zhang, Z., He, Y., Yang, H., Ding, C., & Zhou, P. (2023) · ACS Omega · doi:10.1021/acsomega.3c02200 · Cited by 10
O'Brien, P. J., Fletcher, T. F., Metz, A. L., Kurtz, H. J., Reed, B. K., Rempel, W. E., Clark, E. G., & Louis, C. F. (1987) · PubMed Central · Cited by 10
Elucidating the molecular circuitry of autoimmunity
Varadarajan, N., & Mohan, C. (2019) · Nature Immunology · doi:10.1038/s41590-019-0436-8 · Cited by 9
Nakajima, S., Tsuchiya, H., & Fujio, K. (2024) · Immunological Medicine · doi:10.1080/25785826.2024.2388343 · Cited by 11
Wang, Q., Dang, X., & Yang, W. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110367 · Cited by 9
Wong, C. C. Y., Gao, L. Y., Xu, Y., Chau, M. K. M., Zhang, D., Yap, D. Y. H., Ying, S. K., Lee, C. K., Yung, S., & Chan, T. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1443153 · Cited by 9
Wang, J., Zheng, A., Liu, N., Tan, Z. Y., Shi, Y., Ma, T., Luo, S., Zhu, L., Zhou, Z., Yuan, F., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.08.015 · Cited by 10
Single-cell biology to decode the immune cellular composition of kidney inflammation
Zhao, Y., Panzer, U., Bonn, S., & Krebs, C. F. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03483-y · Cited by 9
Carlé, C., Fortenfant, F., Tauber, M., Tournier, É., Paul, C. F., Bost, C., & Renaudineau, Y. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108908 · Cited by 9
Interferon blockade in lupus: effects on antiviral immunity
Steiger, S., & Anders, H. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00581-0 · Cited by 9
Tang, R., Lin, W., Shen, C., Hu, X., Yu, L., Meng, T., Zhang, L., Eggenhuizen, P. J., Ooi, J. D., Jin, P., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111104 · Cited by 9
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis
Cheng, C., Yang, H., Yang, C., Xie, J., Wang, J., Cheng, L., He, J., Li, H., Yuan, H., Guo, F., et al. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03292-y · Cited by 9
Mou, L., Zhang, F., Liu, X., Lu, Y., Yue, M., Lai, Y., Pu, Z., Huang, X., & Wang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1309447 · Cited by 9
Patterns of T‐Cell Phenotypes in Rheumatic Diseases From Single‐Cell Studies of Tissue
Gao, Y., Dunlap, G. S., Elahee, M., & Rao, D. A. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11296 · Cited by 10
Identification of a special cell type as a determinant of the kidney tropism of SARS‐CoV‐2
Lin, H., Ma, X., Xiao, F., Su, H., Shi, Y., Liu, Y., Song, L., Zhang, Z., Zhang, C., & Peng, H. (2021) · FEBS Journal · doi:10.1111/febs.16114 · Cited by 9
Hu, J., Huang, Z. J., Yu, M., Zhang, P., Xia, Z., & Gao, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038134 · Cited by 9
Omics technologies for kidney disease research
Wang, D., Yang, J., Fan, J., Chen, W., Nikolic‐Paterson, D. J., & Li, J. (2020) · The Anatomical Record · doi:10.1002/ar.24413 · Cited by 9
Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy
Yu, L., Lin, W., Shen, C., Meng, T., Jin, P., Ding, X., Eggenhuizen, P. J., Ooi, J. D., Tang, R., Nie, W., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.869284 · Cited by 9
Daamen, A. R., Wang, H., Bachali, P., Shen, N., Kingsmore, K. M., Robl, R. D., Grammer, A. C., Fu, S. M., & Lipsky, P. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147526 · Cited by 8
Pregizer, S. K., Vreven, T., Mathur, M., & Robinson, L. N. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1176856 · Cited by 9
Chen, Y., Gong, Y., Zou, J., Li, G., Zhang, F., Yang, Y., Liang, Y., Dai, W., He, L., & Lu, H. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101101 · Cited by 8
Molecular and Cellular Mediators of Renal Fibrosis in Lupus Nephritis
Ramasamy, A., & Mohan, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062621 · Cited by 8
Wang, Y., Afshari, K., Haddadi, N., Lopes, C. S., Eng, C.-H. L., Whiteman, L. M., Martinez, N., Kyawe, P. P., Anufrieva, K. S., Wei, K., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02502-w · Cited by 9
Targeting polo‐like kinase 1 to treat kidney diseases
Kulkarni, H. V., Dagar, N., & Gaikwad, A. B. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4099 · Cited by 8
Mou, L., Lu, Y., Wu, Z., Pu, Z., & Wang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1381445 · Cited by 8
Single-Cell Transcriptome Analysis as a Promising Tool to Study Pluripotent Stem Cell Reprogramming
Kim, H. K., Ha, T. W., & Lee, M. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115988 · Cited by 8
Identification of polo‐like kinase 1 as a therapeutic target in murine lupus
Li, Y., Wang, H., Zhang, Z., Tang, C., Zhou, X., Mohan, C., & Wu, T. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1362 · Cited by 8
Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allograftsPreprint
Suryawanshi, H., Yang, H., Lubetzky, M., Morozov, P. S., Lagman, M., Thareja, G., Alonso, A., Li, C. Y., Snopkowski, C., Belkadi, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.03.281733 · Cited by 8
Self-citationHorisberger, A., Griffith, A., Keegan, J., Arazi, A., Pulford, J. F., Murzin, E., Howard, K., Hancock, B., Fava, A., Sasaki, T., et al. (2024) · bioRxiv · doi:10.1101/2024.01.14.575609 · Cited by 2
Self-citationInsights into future management of lupus nephritis
Askanase, A., Dall’Era, M., & Almaani, S. J. (2024) · Frontiers in Lupus · doi:10.3389/flupu.2024.1334932 · Cited by 7
Brilland, B., Despré, M., Khatri, R., Quéméneur, T., Vandenbussche, C., Merillon, N., Boizard-Moracchini, A., Roy, M., Preisser, L., Riou, J., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.07.034 · Cited by 7
Souz, J. A. A., Wei, Y., Cui, C., Qu, R., Choi, J.-Y., Wang, F., Moioffer, S. J., Barrett, J., Chernova, I., Nadella, M., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.022 · Cited by 8
Self-citationXu, H., Ye, Y., Duan, R., Gao, Y., Hu, Y., & Gao, L. (2024) · Advanced Science · doi:10.1002/advs.202306770 · Cited by 6
‘-Omics’ shed light on B cells in lupus
Pernis, A. B., & Ivashkiv, L. B. (2019) · Nature Immunology · doi:10.1038/s41590-019-0446-6 · Cited by 7
Cellular and molecular heterogeneity in systemic lupus erythematosus
Fava, A., & Rao, D. A. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2022.101653 · Cited by 8
Karmakar, A., Kumar, U., Prabhu, S. S., Ravindran, V. K., Nagaraju, S. P., Suryakanth, V. B., Prabhu, M. M., & Karmakar, S. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01484-z · Cited by 6
Single-cell RNA sequencing in autoimmune diseases: New insights and challenges
Huang, J., Hu, Y., Wang, S., Liu, Y., Sun, X., Wang, X., & Yu, H. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108807 · Cited by 7
Decoding tryptophan: Pioneering new frontiers in systemic lupus erythematosus
Huang, F., Sun, K., Zhou, J., Bao, J., Xie, G., Lu, K., & Fan, Y. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103809 · Cited by 6
Chapelle, N., Fantou, A., Marron, T., Kenigsberg, E., Mérad, M., & Martin, J. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006944 · Cited by 6
Keratinocytes: From passive targets to active mediators of systemic autoimmunity
Psarras, A., & Vital, E. M. J. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo3961 · Cited by 6
Single-Cell Sequencing in Rheumatic Diseases: New Insights from the Perspective of the Cell Type
Ding, L., Li, X., Zhu, H., & Luo, H. (2022) · Aging and Disease · doi:10.14336/ad.2022.0323 · Cited by 6
Palla, G., & Ferrero, E. (2020) · iScience · doi:10.1016/j.isci.2020.101451 · Cited by 8
Chen, Y.-Y., Ding, Y., Li, L., Han, S., Huang, M., Wong, C. C. L., Yu, F., & Zhao, M. (2022) · Lupus · doi:10.1177/09612033221094711 · Cited by 6
Li, S., Lu, C., Zhang, Y., Zhao, X., Lin, K., Kong, X., Fox, D., Xue, L., Sun, L., Liu, Y., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104631 · Cited by 6
Lymphocytes in the neighborhood: good or bad for the kidney?
Li, H., Tsokos, M., & Tsokos, G. C. (2022) · Journal of Clinical Investigation · doi:10.1172/jci160657 · Cited by 6
Qing, J., Zheng, F., Zhi, H., Yaigoub, H., Tirichen, H., Li, Y., Zhao, J., Qiang, Y., & Li, Y. (2022) · Biomolecules · doi:10.3390/biom12091276 · Cited by 6
Ichinose, K., Hagiwara, H., Kitamura, M., Nishino, T., & Kawakami, A. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf211 · Cited by 5
Yamamoto, S., Saito, Y., Sato, T., Nakano, S., Kasseki, D., Nagao, A., Miura, N., Nagaoka, K., Kita, A., Miyajima, M., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43244 · Cited by 6
Interferons in HIV-1 infection: mechanisms, antiviral potentials, and therapeutic challenges
Zhu, L., Ji, J., Xiao, J., Wang, F., Yu, J., Liu, Y., Zhang, Y., Wu, H., Su, B., Lu, X., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1736658 · Cited by 7
Liu, Y., Wang, F., Zhang, Y., Pei, Z., & Chen, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1721954 · Cited by 5
Genetic interrogation for sequence and copy number variants in systemic lupus erythematosus
Yeo, N. K., Lim, C. K., Yaung, K. N., Khoo, N. K. H., Arkachaisri, T., Albani, S., & Yeo, J. G. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1341272 · Cited by 6
LncRNA XIST/miR-381-3P/STAT1 axis as a potential biomarker for lupus nephritis
Chen, J., Li, M., Shang, S., Cheng, L., Tang, Z., & Huang, C. (2024) · Lupus · doi:10.1177/09612033241273072 · Cited by 5
Bulusu, S. N., Bavikatte, A. N., Shah, S. S., Murthy, S. S. N., Kommoju, V., Mariaselvam, C. M., Kavadichanda, C. G., Vembar, S. S., Thabah, M. M., & Negi, V. S. (2025) · Immunology · doi:10.1111/imm.13891 · Cited by 6
Liu, B., Li, A., Xu, J., & Cui, Y. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.935107 · Cited by 7
Epigenomic and transcriptomic analysis of chronic inflammatory diseases
Tam, S. K. M., & Leung, D. C. Y. (2021) · Genes & Genomics · doi:10.1007/s13258-021-01045-8 · Cited by 5
Glomerular Kidney Diseases in the Single-Cell Era
Latt, K. Z., Heymann, J. A. W., Yoshida, T., & Kopp, J. B. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.761996 · Cited by 5
Association of Immune-Related Genetic and Epigenetic Alterations with Lupus Nephritis
Mei, X., Jin, H., Zhao, M., & Lu, Q. (2022) · Kidney Diseases · doi:10.1159/000524937 · Cited by 6
Billi, A. C., Ma, F., Plazyo, O., Gharaee‐Kermani, M., Wasikowski, R., Hile, G. A., Xing, X., Yee, C. M., Rizvi, S. M., Maz, M. P., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460124 · Cited by 5
Soyfoo, M. S., & Sarrand, J. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010077 · Cited by 4
Metadata
- Authors
- the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Der, E., Suryawanshi, H., Morozov, P., Kustagi, M., Goilav, B., Ranabothu, S., Izmirly, P., Clancy, R., Belmont, H. M., Koenigsberg, M., Mokrzycki, M., Rominieki, H., Graham, J. A., Rocca, J. P., Bornkamp, N., Jordan, N., Schulte, E., Wu, M., Pullman, J., Slowikowski, K., Raychaudhuri, S., Guthridge, J., James, J., Buyon, J., Tuschl, T., & Putterman, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Rockefeller University (US)
- Arkansas Children's Hospital (US)
- New York University (US)
- Montefiore Medical Center (US)
- Broad Institute (US)
- Oklahoma Medical Research Foundation (US)
- Corresponding author
- Buyon, Jill
- Tuschl, Thomas
- Putterman, Chaim
- ORCID
- Venue
- Nature Immunology
- Published
- 2019-05-20
- Volume
- 20
- Issue
- 7
- Pages
- 915-927
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC6584054
- OpenAlex
- W2944872709
- Cited by
- 403
- References
- 52
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 61 · 2023: 44 · 2022: 86 · 2021: 56 · 2020: 64 · 2019: 25
- FWCI
- 44.01
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-10-11)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR003167, UL1TR000371)
- National Human Genome Research Institute (U01HG009379, T32HG002295)
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR067679, UH2AR067677, UH2AR067685, UH2AR067681, UH2AR067689, F31AR070582, UH2AR067676, UH2AR067694, UH2AR067691, UH2AR067690, UH2AR067688, UM2AR067678)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- lupus nephritis, type I interferon response, renal tubular epithelial cells, keratinocytes, renal fibrosis, treatment non-response, skin biopsy, disease heterogeneity, membranous lupus nephritis, proliferative lupus nephritis, single-cell transcriptomics, personalized treatment
- MeSH terms
- Biopsy, Fibrosis, Humans, Interferon Type I, Kidney Tubules, Lupus Nephritis, Protein Binding, Skin, Signal Transduction, Keratinocytes, Extracellular Matrix Proteins, Cell Lineage, Computational Biology, Gene Expression Profiling, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review