The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
Open accessAbstract
The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and prognostic markers of renal disease. Type I interferon (IFN)-response signatures in tubular cells and keratinocytes distinguished patients with LN from healthy control subjects. Moreover, a high IFN-response signature and fibrotic signature in tubular cells were each associated with failure to respond to treatment. Analysis of tubular cells from patients with proliferative, membranous and mixed LN indicated pathways relevant to inflammation and fibrosis, which offer insight into their histologic differences. In summary, we applied scRNA-seq to LN to deconstruct its heterogeneity and identify novel targets for personalized approaches to therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“two studies, focussing on populations of hypermethylated in cancer protein (Hic1)+Pdgfrα+ lymphocyte antigen 6 complex (LY6A)+ MP populations in heart and skeletal muscle, have elegantly demonstrated MP hierarchy, diversity in the pathophysiological roles of their progeny, and how fate determination of MP is context dependent31,32.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
In the citing paper
“although Hic1 inactivation in skeletal muscle also resulted in a marked expansion of Pdgfrα+LY6A+ cells during homeostasis, this did not increase skeletal muscle fibrosis and had no substantial effect on skeletal muscle regeneration31”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
In the citing paper
“Conditional genetic inactivation of Hic1 in mice led to activation and expansion of MPs in both heart and skeletal muscle, demonstrating that Hic1 is required for maintaining MP quiescence.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799
KEGG: new perspectives on genomes, pathways, diseases and drugs
Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1092 · Cited by 8,865
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814
Cited by
Sorted by citations
Items 101–200 of 402
A single‐cell survey of the human glomerulonephritis
Chen, Z., Zhang, T., Mao, K., Shao, X., Xu, Y., Zhu, M., Zhou, H., Wang, Q., Li, Z., Xie, Y., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16407 · Cited by 39
Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus
Tan, G., Baby, B., Zhou, Y., & Wu, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.808839 · Cited by 42
Gómez-Bañuelos, E., GOLDMAN, D. W., Andrade, V., Darrah, E., Petri, M., & Andrade, F. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101569 · Cited by 38
Itotagawa, E., Tomofuji, Y., Kato, Y., Konaka, H., Tsujimoto, K., Park, J., Nagira, D., Hirayama, T., Jo, T., Hirano, T., et al. (2022) · Rheumatology · doi:10.1093/rheumatology/keac528 · Cited by 39
Cheng, X., Lai, H., Luo, W., Zhang, M., Miao, J., Song, W., Xing, S., Wang, J., & Gao, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03740-6 · Cited by 37
High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis
Iwamoto, T., Dorschner, J. M., Selvaraj, S., Mezzano, V., Jensen, M. A., Vsetecka, D. M., Amin, S., Makol, A., Osborn, T. G., Moder, K. G., et al. (2021) · The Journal of Rheumatology · doi:10.3899/jrheum.210391 · Cited by 37
Self-citationGuoQi, L., Zhang, C., Li, Y., Yang, J., Wu, J., Shao, Y., Ma, K., Zhang, X., Zhu, S., Du, J., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.003 · Cited by 36
Application of single-cell RNA sequencing on human skin: Technical evolution and challenges
Kim, D., Chung, K. B., & Kim, T. (2020) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2020.06.002 · Cited by 38
Systemic lupus erythematosus: year in review 2019
Fan, Y., Hao, Y., & Zhang, Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000983 · Cited by 36
Mechanisms of Photosensitivity in Autoimmunity
Estadt, S. N., Maz, M. P., Musai, J., & Kahlenberg, J. M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.05.007 · Cited by 37
Wu, L., Jiang, X., Qi, C., Zhang, C., Qu, B., & Shen, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653989 · Cited by 34
Tsai, C., Li, K., Shen, C., Lu, C., Lee, H.-T., Wu, T.-H., Ng, Y., Tsao, Y., Hsieh, S., & Yu, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210066 · Cited by 36
Management of Lupus Nephritis: New Treatments and Updated Guidelines
Avasare, R. S., Drexler, Y. R., Caster, D. J., Mitrofanova, A. V., & Jefferson, J. A. (2023) · Kidney360 · doi:10.34067/kid.0000000000000230 · Cited by 34
Chasset, F., Ribi, C., Trendelenburg, M., Huynh‐Do, U., Roux‐Lombard, P., Courvoisier, D. S., Chizzolini, C., & (SSCS, F. T. S. S. C. S. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa167 · Cited by 33
Li, D., Pan, Y., Xia, X., Liang, J., Liu, F., Dou, H., & Hou, Y. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173421 · Cited by 35
Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response
Stone, R. C., Chen, V., Burgess, J. L., Pannu, S., & Tomic‐Canic, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228590 · Cited by 35
Unlocking immune-mediated disease mechanisms with transcriptomics
de Jong, E., & Bosco, A. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200652 · Cited by 37
Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0528-5 · Cited by 33
Targeted Biologic Therapy for Systemic Lupus Erythematosus: Emerging Pathways and Drug Pipeline
Klavdianou, K., Lazarini, A., & Fanouriakis, A. (2020) · BioDrugs · doi:10.1007/s40259-020-00405-2 · Cited by 33
Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
Colli, M. L., Szymczak, F., & Eizirik, D. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.568446 · Cited by 33
Frangou, E. A., Garantziotis, P., Grigoriou, M., Banos, A., Nikolopoulos, D., Pieta, A., Doumas, S., Fanouriakis, A., Hatzioannou, A., Manolakou, T., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-222069 · Cited by 31
The immunoregulatory roles of non-haematopoietic cells in the kidney
Tsokos, G. C., Boulougoura, A., Kasinath, V., Endo, Y., Abdi, R., & Li, H. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00786-x · Cited by 32
Hoover, P., Der, E. B., Berthier, C. C., Arazi, A., Lederer, J. A., James, J. A., Buyon, J. P., Petri, M., Belmont, M. H., Izmirly, P., et al. (2019) · Arthritis Care & Research · doi:10.1002/acr.24066 · Cited by 30
Self-citationFollicular T Cells are Clonally and Transcriptionally Distinct in B Cell-Driven Autoimmune Disease
Akama‐Garren, E. H., van den Broek, T., Simoni, L., Castrillon, C. E., van der Poel, C. E., & Carroll, M. C. (2020) · Nature Communications · doi:10.1038/s41467-021-27035-8 · Cited by 32
Kenney, H. M., Wu, C., Loiselle, A. E., Xing, L., Ritchlin, C. T., & Schwarz, E. M. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02730-z · Cited by 32
Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts
Suryawanshi, H., Yang, H., Lubetzky, M., Morozov, P. S., Lagman, M., Thareja, G., Alonso, A., Li, C. Y., Snopkowski, C., Belkadi, A., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267704 · Cited by 30
Self-citationZheng, M., Zhou, W., Huang, C., Hu, Z. Q., Zhang, B., Lu, Q., & Zhao, M. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102989 · Cited by 29
Kim, J., Lee, J., Li, X., Kunjravia, N., Rambhia, D., Cueto, I., Kim, K., Chaparala, V., Ko, Y., Garcet, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250504 · Cited by 28
Zhang, Y., Chen, L., & Li, S. (2020) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2020.3017547 · Cited by 29
Regulation of cGAS-STING pathway - Implications for systemic lupus erythematosus
Hagiwara, A. M., Moore, R. E., Wallace, D. J., ISHIMORI, M. L., & Jefferies, C. A. (2021) · Rheumatology and Immunology Research · doi:10.2478/rir-2021-0023 · Cited by 27
Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis
Parodis, I., Lindblom, J., Dominguez, D. T., Beretta, L., Borghi, M. O., Castillo, J., Carnero‐Montoro, E., Enman, Y., Mohan, C., Alarcón-Riquelme, M. E., et al. (2024) · Kidney International Reports · doi:10.1016/j.ekir.2024.03.014 · Cited by 27
Bagyinszky, E., & An, S. S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158275 · Cited by 27
Common innate pathways to autoimmune disease
Langan, D., Rose, N. R., & Moudgil, K. D. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108361 · Cited by 31
Zhang, J., Chen, Y., Chen, T., Miao, B., Tang, Z., Hu, X., Luo, Y., Zheng, T., & Na, N. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.321 · Cited by 27
Circulating immune cell landscape and T‐cell abnormalities in patients with moyamoya disease
Ge, P., Tao, C., Wang, W., He, Q., Liu, C., Zheng, Z., Mou, S., Zhang, B., Liu, X., Zhang, Q., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1647 · Cited by 27
Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin
Hile, G. A., Coit, P., Xu, B., Victory, A. M., Gharaee‐Kermani, M., Estadt, S. N., Maz, M. P., Martens, J. W. S., Wasikowski, R., Dobry, C. J., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42460 · Cited by 26
Moysidou, G.-S., Garantziotis, P., Sentis, G., Nikoleri, D., Malissovas, N., Nikoloudaki, M., Stergioti, E.-M., Polia, S., Paschalidis, N., Filia, A., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2024-226051 · Cited by 27
Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes
Min, X., Zheng, M., Yu, Y., Wu, J., Kuang, Q., Hu, Z. Q., Ouyang, L., Lu, S., & Zhao, M. (2022) · Experimental Dermatology · doi:10.1111/exd.14568 · Cited by 23
Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice
Nishide, M., Shimagami, H., & Kumanogoh, A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01043-3 · Cited by 25
Recent advances in cutaneous lupus
Maz, M. P., Martens, J. W. S., Hannoudi, A., Reddy, A. L., Hile, G. A., & Kahlenberg, J. M. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102865 · Cited by 25
Type 1 interferons: A target for immune-mediated inflammatory diseases (IMIDs)
Mathian, A., Felten, R., Alarcón-Riquelme, M. E., Psarras, A., Mertz, P., Chasset, F., Vital, E. M. J., & Arnaud, L. (2023) · Joint Bone Spine · doi:10.1016/j.jbspin.2023.105627 · Cited by 27
Kuret, T., SodinŠemrl, S., Leskošek, B., & Ferk, P. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.822804 · Cited by 25
Decoding the complexity of delayed wound healing following Enterococcus faecalis infection
Celik, C., Lee, S. Y. T., Tanoto, F. R., Veleba, M., Kline, K. A., & Thibault, G. (2024) · eLife · doi:10.7554/elife.95113.3 · Cited by 28
Dysregulation in keratinocytes drives systemic lupus erythematosus onset
Tian, J., Shi, L., Zhang, D., Yao, X., Zhao, M., Kumari, S., Lü, J., Yu, D., & Lu, Q. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01240-z · Cited by 24
Tangtanatakul, P., Thumarat, C., Satproedprai, N., Kunhapan, P., Chaiyasung, T., Klinchanhom, S., Wang, Y., Wei, W., Wongshinsri, J., Chiewchengchol, D., et al. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02276-y · Cited by 26
Kunxian capsule alleviates renal damage by inhibiting the JAK1/STAT1 pathway in lupus nephritis
Cheng, C., Zhu, R., Liu, M., Yang, H., Guo, F., Du, Q., Wang, X., Li, M., Song, G., Qin, R., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116349 · Cited by 24
Single-cell RNA sequencing for the study of kidney disease
Zhu, J., Lu, J., & Weng, H. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00693-8 · Cited by 27
Immune Cell–Stromal Circuitry in Lupus Photosensitivity
Sim, J. H., Ambler, W. G., Sollohub, I. F., Howlader, M. J., Li, T. M., Lee, H. J., & Lu, T. T. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000905 · Cited by 25
Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2022
Winthrop, K. L., Isaacs, J. D., Mease, P. J., Boumpas, D. T., Baraliakos, X., Gottenberg, J., Siebert, S., Mosca, M., Basu, N., Orange, D. E., et al. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223528 · Cited by 23
Defining the Skin Cellular Community Using Single-Cell Genomics to Advance Precision Medicine
Dubois, A., Gopee, N. H., Olabi, B., & Haniffa, M. A. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.05.104 · Cited by 23
Single-cell transcriptomics: a novel precision medicine technique in nephrology
Kim, J., & Park, J. (2020) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2020.415 · Cited by 22
Mavragani, C. P., Kirou, K. A., Seshan, S. V., & Crow, M. K. (2022) · Rheumatology · doi:10.1093/rheumatology/keac641 · Cited by 22
Targeted Small Molecules for Systemic Lupus Erythematosus: Drugs in the Pipeline
Mok, C. C. (2023) · Drugs · doi:10.1007/s40265-023-01856-x · Cited by 21
Targeted urine proteomics in lupus nephritis – a meta-analysis
Zhang, T., Duran, V., Vanarsa, K., & Mohan, C. (2020) · Expert Review of Proteomics · doi:10.1080/14789450.2020.1874356 · Cited by 21
Transcriptomic studies of systemic lupus erythematosus
Nakano, M., Iwasaki, Y., & Fujio, K. (2021) · Inflammation and Regeneration · doi:10.1186/s41232-021-00161-y · Cited by 20
Precision medicine in autoimmune diseases: fact or fiction
Dominguez, D. T., & Alarcón-Riquelme, M. E. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab448 · Cited by 21
The therapeutic potential of immunoengineering for systemic autoimmunity
McBride, D. A., Jones, R. M., Bottini, N., & Shah, N. J. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01084-x · Cited by 24
Yoshikawa, T., & Yanagita, M. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.07.008 · Cited by 22
Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics
Tang, C., Fang, M., Tan, G., Zhang, S., Yang, B., Li, Y., Zhang, T., Saxena, R., Mohan, C., & Wu, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.850015 · Cited by 20
The power of one: advances in single-cell genomics in the kidney
Clark, A. R., & Greka, A. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0237-1 · Cited by 17
Initial renal histology and early response predict outcomes of Brazilian lupus nephritis patients
Vajgel, G., de Oliveira, C. B. L., Costa, D. M., Cavalcante, M. A., Valente, L. M., Sesso, R., Crovella, S., Kirsztajn, G. M., & Sandrin‐Garcia, P. (2019) · Lupus · doi:10.1177/0961203319890681 · Cited by 19
Deonaraine, K., Carlucci, P. M., Fava, A., Li, J., Wofsy, D., James, J. A., Putterman, C., Diamond, B., Davidson, A., Fine, D. M., et al. (2021) · Lupus Science & Medicine · doi:10.1136/lupus-2021-000522 · Cited by 19
Self-citationAscensión, A. M., Araúzo-Bravo, M. J., & Izeta, A. (2022) · Life · doi:10.3390/life12010067 · Cited by 19
Yiu, G., Rasmussen, T. K., Tsai, B. L., Diep, V. K., Haddon, D. J., Tsoi, J., Miller, G. D., Comı́n-Anduix, B., Deleuran, B. W., Crooks, G. M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.833636 · Cited by 19
Garcia, L. P. W., Naderinabi, F., Gladman, D. D., Urowitz, M. B., Touma, Z., Konvalinka, A., & Wither, J. (2024) · Lupus Science & Medicine · doi:10.1136/lupus-2023-001038 · Cited by 19
Applying single‐cell technologies to clinical pathology: progress in nephropathology
Stewart, B. J., & Clatworthy, M. R. (2020) · The Journal of Pathology · doi:10.1002/path.5417 · Cited by 18
Update on the cellular pathogenesis of lupus
Gensous, N., Boizard-Moracchini, A., Lazaro, E., Richez, C., & Blanco, P. (2020) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000775 · Cited by 19
Horisberger, A., Griffith, A. M., Keegan, J., Arazi, A., Pulford, J. F., Murzin, E., Howard, K., Hancock, B. L., Fava, A., Sasaki, T., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci181034 · Cited by 27
Self-citationIshihara, R., Watanabe, R., Shiomi, M., Fujita, Y., Katsushima, M., Fukumoto, K., Yamada, S., & Hashimoto, M. (2025) · Biomolecules · doi:10.3390/biom15111586 · Cited by 20
Fan, X., Ng, C. T., Guo, D., Lim, F. T. W., Tan, J. C., Law, A. H. N., Goh, L. H., Poon, Z. Y., Cheung, A. M. S., Kong, S. L., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42383 · Cited by 18
Guo, X., Ning, J., Chen, Y., Liu, G., Zhao, L., Fan, Y., & Sun, S. (2023) · Briefings in Functional Genomics · doi:10.1093/bfgp/elad011 · Cited by 19
Kenney, H. M., Rangel‐Moreno, J., Peng, Y. H., Chen, K. L., Bruno, J. E., Embong, A. K., Pritchett, E. M., Fox, J. I., Becerril‐Villanueva, E., Gamboa‐Domínguez, A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1237498 · Cited by 17
Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study
Alduraibi, F. K., Fatima, H., Hamilton, J. A., Chatham, W. W., Hsu, H., & Mountz, J. D. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02766-1 · Cited by 17
Lessons From Transcriptome Analysis of Autoimmune Diseases
Nagafuchi, Y., Yanaoka, H., & Fujio, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.857269 · Cited by 19
Chen, J., Cui, L., Ouyang, J., Wang, J., & Xu, W. (2022) · Clinical Rheumatology · doi:10.1007/s10067-022-06214-y · Cited by 17
Li, T. M., Zyulina, V., Seltzer, E. S., Dacic, M., Chinenov, Y. V., Daamen, A. R., Veiga, K. R., Schwartz, N., Oliver, D. J., Zuckerman, P. C., et al. (2024) · eLife · doi:10.7554/elife.85914 · Cited by 15
Barrat, F. J., & Lu, T. T. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000659 · Cited by 17
Zhang, L., Zhang, M., Chen, X., He, Y., Chen, R., Zhang, J., Huang, J., Ouyang, C., & Shi, G. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-7507 · Cited by 17
Amo, L., Kole, H. K., Scott, B. L., Qi, C., Wu, J., & Bolland, S. M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148000 · Cited by 17
Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases
Rao, D. A. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01291-0 · Cited by 19
Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
Cai, S., Hu, Z., Chen, Y., Zhong, J., & Dong, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940581 · Cited by 16
McLaren, A. S., Fetit, R., Wood, C. S., Falconer, J., & Steele, C. W. (2023) · Chinese Clinical Oncology · doi:10.21037/cco-22-121 · Cited by 17
Titus, A. S. C. L. S., Tan, Y. C. R. S., Tran, P. T., Lindblom, J., Ivbievbiokun, M., Xu, Y., Zheng, J., Parodis, I., Cai, Q., Chang, A., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109713 · Cited by 17
Cheng, C., Li, B., Li, J., Wang, Y., Xiao, H., Lian, X., Chen, L., Wang, J., Wang, H., Qin, S., et al. (2024) · Kidney International · doi:10.1016/j.kint.2024.12.007 · Cited by 20
Bell, S. J., Merola, J. F., Webster, D. E., Pennington, S. R., Liao, W. J., Ogdie, A., FitzGerald, O., Ritchlin, C. T., & Scher, J. U. (2020) · Current Rheumatology Reports · doi:10.1007/s11926-020-00958-9 · Cited by 16
Hu, L., Chen, X., Narwade, N. P., Lim, M. G. L., Chen, Z., Tennakoon, C., Guan, P., Chan, U. I., Zhao, Z., Deng, M., et al. (2021) · Oncogene · doi:10.1038/s41388-021-02026-7 · Cited by 16
Zhao, X., Yang, S., Li, M., & Wang, Y. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2416605 · Cited by 15
Cai, M.-L., Gui, L., Huang, H., Zhang, Y., Zhang, L., Zhu, C. Y., & Sheng, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911997 · Cited by 15
Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus
Baxter, R. M., Wang, C. S., Garcia‐Perez, J. E., Kong, D. S. H., Coleman, B. M., Larchenko, V., Schuyler, R. P., Jackson, C. L., Ghosh, T., Rudra, P., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1208282 · Cited by 15
Loftus, S. N., Gharaee‐Kermani, M., Xu, B., Moore, T., Hannoudi, A., Mallbris, M. J., Klein, B., Gudjonsson, J. E., & Kahlenberg, J. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1384606 · Cited by 15
Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach
Omer, M. H., Shafqat, A., Ahmad, O., Nadri, J., AlKattan, K. M., & Yaqinuddin, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082339 · Cited by 15
Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research
Schepps, S., Xu, J., Yang, H. Y., Mandel, J. L., Mehta, J., Tolotta, J., Baker, N., Tekmen, V., Nikbakht, N., Fortina, P. M., et al. (2024) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-1245 · Cited by 18
Rethinking the Pathogenesis of Cutaneous Lupus
Kahlenberg, J. M. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.05.077 · Cited by 15
Dissecting the human kidney allograft transcriptome: single-cell RNA sequencing
Varma, E., Luo, X., & Muthukumar, T. (2020) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000840 · Cited by 15
Paek, S.-J., Lee, H., Lee, Y. J., Bang, S., Kim, D., Kang, B.-K., Park, D. J., Joo, Y. B., Kim, M., Kim, H., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01504-2 · Cited by 16
Sternhagen, E., Bettendorf, B. A., Lenert, A., & Lenert, P. S. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s275043 · Cited by 15
Single‐cell RNA sequencing in oral science: Current awareness and perspectives
Wu, J., Ding, Y., Wang, J., Lyu, F., Tang, Q., Song, J., Luo, Z., Wan, Q., Lan, X., Xu, Z., et al. (2022) · Cell Proliferation · doi:10.1111/cpr.13287 · Cited by 15
Global Phosphoproteomics Unveils Kinase-Regulated Networks in Systemic Lupus Erythematosus
Meng, S., Li, T., Wang, T., Li, D., Chen, J., Li, H., Cai, W., Zeng, Z., Liu, D. J., Tang, D., et al. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100434 · Cited by 14
Lupus Nephritis: Immune Cells and the Kidney Microenvironment
Chernova, I. (2024) · Kidney360 · doi:10.34067/kid.0000000000000531 · Cited by 14
Howlader, M. J., Ambler, W. G., Chalasani, M. L. S., Rathod, A., Seltzer, E. S., Sim, J. H., Shin, J., Schwartz, N., Shipman, W. D., Dasoveanu, D., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci168412 · Cited by 14
Metadata
- Authors
- the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Der, E., Suryawanshi, H., Morozov, P., Kustagi, M., Goilav, B., Ranabothu, S., Izmirly, P., Clancy, R., Belmont, H. M., Koenigsberg, M., Mokrzycki, M., Rominieki, H., Graham, J. A., Rocca, J. P., Bornkamp, N., Jordan, N., Schulte, E., Wu, M., Pullman, J., Slowikowski, K., Raychaudhuri, S., Guthridge, J., James, J., Buyon, J., Tuschl, T., & Putterman, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Rockefeller University (US)
- Arkansas Children's Hospital (US)
- New York University (US)
- Montefiore Medical Center (US)
- Broad Institute (US)
- Oklahoma Medical Research Foundation (US)
- Corresponding author
- Buyon, Jill
- Tuschl, Thomas
- Putterman, Chaim
- ORCID
- Venue
- Nature Immunology
- Published
- 2019-05-20
- Volume
- 20
- Issue
- 7
- Pages
- 915-927
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC6584054
- OpenAlex
- W2944872709
- Cited by
- 403
- References
- 52
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 61 · 2023: 44 · 2022: 86 · 2021: 56 · 2020: 64 · 2019: 25
- FWCI
- 44.01
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-10-11)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR003167, UL1TR000371)
- National Human Genome Research Institute (U01HG009379, T32HG002295)
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR067679, UH2AR067677, UH2AR067685, UH2AR067681, UH2AR067689, F31AR070582, UH2AR067676, UH2AR067694, UH2AR067691, UH2AR067690, UH2AR067688, UM2AR067678)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- lupus nephritis, type I interferon response, renal tubular epithelial cells, keratinocytes, renal fibrosis, treatment non-response, skin biopsy, disease heterogeneity, membranous lupus nephritis, proliferative lupus nephritis, single-cell transcriptomics, personalized treatment
- MeSH terms
- Biopsy, Fibrosis, Humans, Interferon Type I, Kidney Tubules, Lupus Nephritis, Protein Binding, Skin, Signal Transduction, Keratinocytes, Extracellular Matrix Proteins, Cell Lineage, Computational Biology, Gene Expression Profiling, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review