Cited by 27Neuroscience and Neural EngineeringNeural dynamics and brain functionNeurological disorders and treatments

Large-scale, closed-loop interrogation of neural circuits underlying cognition.

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Khodagholy, Dion, Ferrero, Jose J., Park, Jaehyo, Zhao, Zifang, Gelinas, Jennifer N.·2022·Trends in Neurosciences

Abstract

Cognitive functions are increasingly understood to involve coordinated activity patterns between multiple brain regions, and their disruption by neuropsychiatric disorders is similarly complex. Closed-loop neurostimulation can directly modulate neural signals with temporal and spatial precision. How to leverage such an approach to effectively identify and target distributed neural networks implicated in mediating cognition remains unclear. We review current conceptual and technical advances in this area, proposing that devices that enable large-scale acquisition, integrated processing, and multiregion, arbitrary waveform stimulation will be critical for mechanistically driven manipulation of cognitive processes in physiological and pathological brain networks.

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  1. [47]Mankin EA (2021) Stimulation of the right entorhinal white matter enhances visual memory encoding in humans. Brain Stimul 14, 131– 140 33279717 PMC7855810
  2. [60]Heck CN (2014) Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia 55, 432– 41 24621228 PMC4233950

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Authors
Khodagholy, D., Ferrero, J. J., Park, J., Zhao, Z., & Gelinas, J. N.
Affiliations
  • Columbia University (US)
  • Columbia University Irving Medical Center (US)
Corresponding author
  • Khodagholy, Dion
  • Gelinas, Jennifer N.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2022-12
Volume
45
Issue
12
Pages
968-983
ISSN
0166-2236 (ISSN-L)
OpenAlex
W4307292466
Cited by
27
References
121
Citations by year
2026: 9 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 1
FWCI
0.64
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation (2219891, 1944415)
  • National Eye Institute (R21EY032381)
  • National Institute of Neurological Disorders and Stroke (R01NS118091, RF1NS128669)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
closed-loop neurostimulation, cognitive function, neural circuits, distributed neural networks, neuropsychiatric disorders, large-scale neural recording, brain-computer interface
MeSH terms
Brain, Cognition, Humans

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