Large-scale, closed-loop interrogation of neural circuits underlying cognition.
Open accessAbstract
Cognitive functions are increasingly understood to involve coordinated activity patterns between multiple brain regions, and their disruption by neuropsychiatric disorders is similarly complex. Closed-loop neurostimulation can directly modulate neural signals with temporal and spatial precision. How to leverage such an approach to effectively identify and target distributed neural networks implicated in mediating cognition remains unclear. We review current conceptual and technical advances in this area, proposing that devices that enable large-scale acquisition, integrated processing, and multiregion, arbitrary waveform stimulation will be critical for mechanistically driven manipulation of cognitive processes in physiological and pathological brain networks.
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Closed-loop circuits exist in just about every part of the nervous system.
“In this framework, we should consider that closed-loop circuits exist in just about every part of the nervous system (Farkhondeh Tale Navi et al., 2022; Khodagholy et al., 2022).”
From Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges (2022) · cites this paper as Khodagholy et al., 2022
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Flagged first, then by citations
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Self-citation
- Authors
- Khodagholy, D., Ferrero, J. J., Park, J., Zhao, Z., & Gelinas, J. N.
- Affiliations
- Columbia University (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Khodagholy, Dion
- Gelinas, Jennifer N.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 45
- Issue
- 12
- Pages
- 968-983
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC10437206
- OpenAlex
- W4307292466
- Cited by
- 27
- References
- 121
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Neurosciences (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (2219891, 1944415)
- National Eye Institute (R21EY032381)
- National Institute of Neurological Disorders and Stroke (R01NS118091, RF1NS128669)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- closed-loop neurostimulation, cognitive function, neural circuits, distributed neural networks, neuropsychiatric disorders, large-scale neural recording, brain-computer interface
- MeSH terms
- Brain, Cognition, Humans
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