Cited by 56SARS-CoV-2 and COVID-19 ResearchVaccine Coverage and HesitancyCOVID-19 Clinical Research Studies

The Importance of Advancing Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Children

Open access
Kao, Carol M, Orenstein, Walter A, Anderson, Evan J·2021·Clinical Infectious Diseases

Abstract

While the role of children in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains to be defined, children likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2. Thus, our current estimates are likely under-representative of the true burden of SARS-CoV-2 in children. Given the potential direct benefit of a SARS-CoV-2 vaccine in children and the substantial indirect benefit through community protection, or “herd immunity,” we argue that planning and implementation of SARS-CoV-2 vaccines should include children. Furthermore, community protection occurred after widespread implementation of prior childhood vaccines against Streptococcus pneumoniae, rubella, and rotavirus. We detail considerations for vaccine clinical trials, potential barriers to the implementation of widespread vaccination and argue why children would be an ideal target population for vaccination.

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Crossref · 10.1093/cid/ciaa712

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  • Vaccination of adolescents is likely to confer the direct benefit of preventing disease along with indirect benefits, including community protection.

    “Vaccination of adolescents is likely to confer the direct benefit of preventing disease along with indirect benefits, including community protection.24”

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Authors
Kao, C. M., Orenstein, W. A., & Anderson, E. J.
Affiliations
Emory University (US)
Venue
Clinical Infectious Diseases
Published
2020-06-03
Volume
72
Issue
3
Pages
515-518
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W3029543140
Cited by
56
References
32
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 25 · 2021: 15 · 2020: 3
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • AbbVie
  • Pfizer
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
SARS-CoV-2, COVID-19 vaccines, children, childhood immunization, asymptomatic transmission, herd immunity, community protection, vaccine clinical trials
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, Child, Humans, Viral Vaccines, Immunity, Herd

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