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Cited by 4,862Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

The DOI matches its Crossref record; 230 of the 233 references it cites were found in a registry or an index.

Post-acute COVID-19 syndrome

Open access
Nalbandian, Ani, Sehgal, Kartik, Gupta, Aakriti, Madhavan, Mahesh V., McGroder, Claire, Stevens, Jacob S., Cook, Joshua R., Nordvig, Anna S., Shalev, Daniel, Sehrawat, Tejasav S., Ahluwalia, Neha, Bikdeli, Behnood, Dietz, Donald, Der-Nigoghossian, Caroline, Liyanage-Don, Nadia, Rosner, Gregg F., Bernstein, Elana J., Mohan, Sumit, Beckley, Akinpelumi A., Seres, David S., Choueiri, Toni K., Uriel, Nir, Ausiello, John C., Accili, Domenico, Freedberg, Daniel E., Baldwin, Matthew, Schwartz, Allan, Brodie, Daniel, Garcia, Christine Kim, Elkind, Mitchell S. V., Connors, Jean M., Bilezikian, John P., Landry, Donald W., Wan, Elaine Y.·2021·Nature Medicine
DOI 10.1038/s41591-021-01283-zPMC PMC8893149
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.

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  1. Zheng, Z., Chen, R. & Li, Y. The clinical characteristics of secondary infections of lower respiratory tract in severe acute respiratory syndrome. Chin. J. Respir. Crit. Care Med. 2, 270–274 (2003).
  2. Pozo-Rosich, P. Headache & COVID-19: a short-term challenge with long-term insights. In Proc. AHSAM 2020 Virtual Annual Scientific Meeting (Infomedica, 2020); https://www.ahshighlights.com/summaries-podcasts/article/headache-covid-19-a-short-term-challenge-with-long-term-insights

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Metadata

Authors
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., Ahluwalia, N., Bikdeli, B., Dietz, D., Der-Nigoghossian, C., Liyanage-Don, N., Rosner, G. F., Bernstein, E. J., Mohan, S., Beckley, A. A., Seres, D. S., Choueiri, T. K., Uriel, N., Ausiello, J. C., Accili, D., Freedberg, D. E., Baldwin, M., Schwartz, A., Brodie, D., Garcia, C. K., Elkind, M. S. V., Connors, J. M., Bilezikian, J. P., Landry, D. W., & Wan, E. Y.
Affiliations
  • Columbia University Irving Medical Center (US)
  • Brigham and Women's Hospital (US)
  • Yale New Haven Hospital (US)
  • Mayo Clinic (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • NewYork–Presbyterian Hospital (US)
Corresponding author
  • Sehgal, Kartik
  • Wan, Elaine Y.
ORCID
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2021-03-22
Volume
27
Issue
4
Pages
601-615
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/s41591-021-01283-z
PMC
PMC8893149
OpenAlex
W3136955306
Cited by
4,862
References
233
Citations by year
2026: 324 · 2025: 502 · 2024: 827 · 2023: 1161 · 2022: 1379 · 2021: 666
FWCI
129.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Health & Human Services | National Institutes of Health (T32 HL007854, 5T32 NS007153, R01-DK114893, R01-MD014161, U01-DK116066, K23 DK111847, R01 HL152236, R03 HL146881)
  • National Science Foundation (2032726)
  • U.S. Department of Defense (PR181960)
  • The Esther Aboodi Endowed Professorship at Columbia University, and the Wu Family Research fund
Topics
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
long COVID, SARS-CoV-2, COVID-19 survivors, persistent symptoms, late complications, pathophysiology, multidisciplinary care, risk identification, patient advocacy
MeSH terms
COVID-19, SARS-CoV-2, Acute Disease, Cardiovascular Diseases, Humans, Patient Advocacy, Syndrome, Systemic Inflammatory Response Syndrome, Venous Thromboembolism

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