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Post-acute COVID-19 syndrome
Open accessAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.
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“Long COVID includes persisting symptoms, following directly after an infection with the COVID-19 virus”
From Health, well-being, and persisting symptoms in the pandemic: What is the role of psychological flexibility? (2022) · cites this paper as Nalbandian et al., 2021
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1 retracted
RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study
Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., Kang, L., Guo, L., Liu, M., Zhou, X., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32656-8 · Cited by 4,084
RetractedClinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30251-8 · Cited by 11,907
An interactive web-based dashboard to track COVID-19 in real time
Dong, E., Du, H., & Gardner, L. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30120-1 · Cited by 10,048
Factors associated with COVID-19-related death using OpenSAFELY
Williamson, E. J., Walker, A. J., Bhaskaran, K., Bacon, S., Bates, C., Morton, C. E., Curtis, H. J., Mehrkar, A., Evans, D., Inglesby, P., et al. (2020) · Nature · doi:10.1038/s41586-020-2521-4 · Cited by 6,674
Endothelial cell infection and endotheliitis in COVID-19
Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30937-5 · Cited by 6,358
Tang, N., Li, D., Wang, X., & Sun, Z. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14768 · Cited by 5,770
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., Vanstapel, A., Werlein, C., Stark, H., Tzankov, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2015432 · Cited by 5,613
Characteristics of SARS-CoV-2 and COVID-19
Hu, B., Guo, H., Zhou, P., & Shi, Z.-L. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00459-7 · Cited by 5,291
Research works printed but not linked: 2
- Zheng, Z., Chen, R. & Li, Y. The clinical characteristics of secondary infections of lower respiratory tract in severe acute respiratory syndrome. Chin. J. Respir. Crit. Care Med. 2, 270–274 (2003).
- Pozo-Rosich, P. Headache & COVID-19: a short-term challenge with long-term insights. In Proc. AHSAM 2020 Virtual Annual Scientific Meeting (Infomedica, 2020); https://www.ahshighlights.com/summaries-podcasts/article/headache-covid-19-a-short-term-challenge-with-long-term-insights
Cited by
Sorted by citations
The Global Burden of Cardiovascular Diseases and Risk
Vaduganathan, M., Mensah, G. A., Turco, J. V., Fuster, V., & Roth, G. A. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.11.005 · Cited by 2,413
Long-term cardiovascular outcomes of COVID-19
Xie, Y., Xu, E., Bowe, B. C., & Al‐Aly, Z. (2022) · Nature Medicine · doi:10.1038/s41591-022-01689-3 · Cited by 2,125
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: a systematic review and meta-analysis
Ceban, F., Ling, S., Lui, L. M. W., Lee, Y., Gill, H., Teopiz, K. M., Rodrigues, N. B., Subramaniapillai, M., Di Vincenzo, J. D., Cao, B., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.12.020 · Cited by 1,554
Chen, C., Haupert, S. R., Zimmermann, L., Shi, X., Fritsche, L. G., & Mukherjee, B. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac136 · Cited by 1,448
Long covid—mechanisms, risk factors, and management
Crook, H., Raza, S., Nowell, J., Young, M., & Edison, P. (2021) · BMJ · doi:10.1136/bmj.n1648 · Cited by 1,655
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
Yong, S. J. (2021) · Infectious Diseases · doi:10.1080/23744235.2021.1924397 · Cited by 1,339
Multiple early factors anticipate post-acute COVID-19 sequelae
Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.014 · Cited by 1,156
Symptoms and risk factors for long COVID in non-hospitalized adults
Subramanian, A., Nirantharakumar, K., Hughes, S., Myles, P. R., Williams, T., Gokhale, K. M., Taverner, T., Chandan, J. S., Brown, K. R., Simms-Williams, N., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01909-w · Cited by 1,108
Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection
Groff, D., Sun, A., Ssentongo, A. E., Ba, D. M., Parsons, N., Poudel, G. R., Lekoubou, A., Oh, J. S., Ericson, J. E., Ssentongo, P., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.28568 · Cited by 1,010
Diverse functional autoantibodies in patients with COVID-19
Wang, E. Y., Mao, T., Klein, J., Dai, Y., Huck, J. D., Jaycox, J. R., Liu, F., Zhou, T., Israelow, B., Wong, P., et al. (2021) · Nature · doi:10.1038/s41586-021-03631-y · Cited by 1,012
Collaborators, G. B. O. D. L. C., Hanson, S. W., Abbafati, C., Aerts, J. G. J. V., Al‐Aly, Z., Ashbaugh, C., Ballouz, T., Blyuss, O. B., Bobkova, P., Bonsel, G. J., et al. (2022) · JAMA · doi:10.1001/jama.2022.18931 · Cited by 1,015
Characterising long COVID: a living systematic review
Michelen, M., Cheng, V., Manoharan, L., Elkheir, N., Dagens, A., Hastie, C., O’Hara, M. E., Suett, J. C., Dahmash, D. T., Bugaeva, P., et al. (2021) · BMJ Global Health · doi:10.1136/bmjgh-2021-005427 · Cited by 1,004
Taquet, M., Dercon, Q., Luciano, S., Geddes, J. R., Husain, M., & Harrison, P. J. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003773 · Cited by 948
Long COVID after breakthrough SARS-CoV-2 infection
Al-Aly, Z., Bowe, B., & Xie, Y. (2022) · Nature Medicine · doi:10.1038/s41591-022-01840-0 · Cited by 866
Proal, A. D., & VanElzakker, M. B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.698169 · Cited by 921
Distinguishing features of long COVID identified through immune profiling
Klein, J., Wood, J., Jaycox, J. R., Dhodapkar, R. M., Lu, P., Gehlhausen, J. R., Tabachnikova, A., Greene, K., TABACOF, L. R., Malik, A. A., et al. (2023) · Nature · doi:10.1038/s41586-023-06651-y · Cited by 852
Risk Factors Associated With Post−COVID-19 Condition
Tsampasian, V., Elghazaly, H., Chattopadhyay, R., Dębski, M., Naing, T. K. P., Garg, P., Clark, A., Ntatsaki, E., & Vassiliou, V. S. (2023) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2023.0750 · Cited by 879
Premraj, L., Kannapadi, N. V., Briggs, J., Seal, S. M., Battaglini, D., Fanning, J. P., Suen, J. Y., Robba, C., Fraser, J. F., & Cho, S. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120162 · Cited by 817
Augustin, M., Schommers, P., Stecher, M., Dewald, F., Gieselmann, L., Gruell, H., Horn, C., Vanshylla, K., Cristanziano, V. D., Osebold, L., et al. (2021) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2021.100122 · Cited by 715
Therapeutic strategies for COVID-19: progress and lessons learned
Li, G., Hilgenfeld, R., Whitley, R. J., & Clercq, E. D. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00672-y · Cited by 714
A molecular single-cell lung atlas of lethal COVID-19
Melms, J. C., Biermann, J., Huang, H., Wang, Y., Nair, A., Tagore, S., Katsyv, I., Rendeiro, A. F., Amin, A. D., Schapiro, D., et al. (2021) · Nature · doi:10.1038/s41586-021-03569-1 · Cited by 685
REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19
Weinreich, D. M., Sivapalasingam, S., Norton, T. D., Ali, S., Gao, H., Bhore, R., Xiao, J., Hooper, A. T., Hamilton, J. D., Musser, B. J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2108163 · Cited by 662
Pathological sequelae of long-haul COVID
Mehandru, S., & Mérad, M. (2022) · Nature Immunology · doi:10.1038/s41590-021-01104-y · Cited by 675
Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
Raman, B., Bluemke, D. A., Lüscher, T. F., & Neubauer, S. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac031 · Cited by 717
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
Bowe, B. C., Xie, Y., & Al‐Aly, Z. (2022) · Nature Medicine · doi:10.1038/s41591-022-02051-3 · Cited by 656
Unexplained post-acute infection syndromes
Choutka, J., Jansari, V., Hornig, M., & Iwasaki, A. (2022) · Nature Medicine · doi:10.1038/s41591-022-01810-6 · Cited by 604
Pathophysiology and mechanism of long COVID: a comprehensive review
Castanares‐Zapatero, D., Chalon, P. X., Kohn, L., Dauvrin, M., Detollenaere, J., de Noordhout, C. M., Jong, C. P.-D., Cleemput, I., & den Heede, K. V. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2076901 · Cited by 626
Swank, Z., Senussi, Y., Manickas-Hill, Z., Yu, X. G., Li, J. Z., Alter, G., & Walt, D. R. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac722 · Cited by 580
Carlini, V., Noonan, D. M., Abdalalem, E., Goletti, D., Sansone, C., Calabrone, L., & Albini, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1161067 · Cited by 590
Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Liu, Q., Mak, J. W. Y., Su, Q., Yeoh, Y. K., Lui, G. C.-Y., Ng, S. S., Zhang, F., Li, A. Y. L., Lu, W., Hui, D. S. C., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325989 · Cited by 540
Seeßle, J., Waterboer, T., Hippchen, T., Simon, J., Kirchner, M., Lim, A., Müller, B., & Merle, U. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab611 · Cited by 557
Long COVID science, research and policy
Al-Aly, Z., Davis, H., McCorkell, L., Soares, L., Wulf-Hanson, S., Iwasaki, A., & Topol, E. J. (2024) · Nature Medicine · doi:10.1038/s41591-024-03173-6 · Cited by 538
Alkodaymi, M. S., Omrani, O. A., Fawzy, N. A., Shaar, B. A., Almamlouk, R., Riaz, M. A., Obeidat, M. A., Obeidat, Y., Gerberi, D., Taha, R. M., et al. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.01.014 · Cited by 561
Long-term neurologic outcomes of COVID-19
Xu, E., Xie, Y., & Al-Aly, Z. (2022) · Nature Medicine · doi:10.1038/s41591-022-02001-z · Cited by 530
Long-COVID in children and adolescents: a systematic review and meta-analyses
Lopez-Leon, S., Wegman-Ostrosky, T., Ayuzo del Valle, N. C., Perelman, C., Sepulveda, R., Rebolledo, P. A., Cuapio, A., & Villapol, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-13495-5 · Cited by 528
Pathophysiology of COVID-19-associated acute kidney injury
Legrand, M. M., Bell, S., Forni, L. G., Joannidis, M., Koyner, J. L., Liu, K. D., & Cantaluppi, V. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00452-0 · Cited by 527
Tabacof, L., Tosto-Mancuso, J., Wood, J., Cortes, M., Kontorovich, A., McCarthy, D., Rizk, D., Rozanski, G., Breyman, E., Nasr, L., et al. (2021) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000001910 · Cited by 517
How COVID-19 shaped mental health: from infection to pandemic effects
Penninx, B. W. J. H., Benros, M. E., Klein, R. S., & Vinkers, C. H. (2022) · Nature Medicine · doi:10.1038/s41591-022-02028-2 · Cited by 480
The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
Schultheiß, C., Willscher, E., Paschold, L., Gottschick, C., Klee, B., Henkes, S.-S., Henkes, S.-S., Bosurgi, L., Sedding, D., Sedding, D., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100663 · Cited by 487
Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2
Molteni, E., Sudre, C. H., Canas, L. S., Bhopal, S., Hughes, R. C., Antonelli, M., Murray, B. A. K., Kläser, K., Kerfoot, E., Chen, L., et al. (2021) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(21)00198-x · Cited by 421
Natarajan, A., Zlitni, S., Brooks, E. F., Vance, S. E., Dahlen, A., Hedlin, H., Park, R. M., Han, A., Schmidtke, D. T., Verma, R., et al. (2022) · Med · doi:10.1016/j.medj.2022.04.001 · Cited by 420
Long-term complications of COVID-19
Desai, A. D., Lavelle, M. P., Boursiquot, B. C., & Wan, E. Y. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00375.2021 · Cited by 458
Self-citationPersistent complement dysregulation with signs of thromboinflammation in active Long Covid
Cervia, C., Brüningk, S. C., Hoch, T., Fan, B., Muzio, G., Thompson, R. C., Ceglarek, L., Meledin, R., Westermann, P., Emmenegger, M., et al. (2024) · Science · doi:10.1126/science.adg7942 · Cited by 437
Gluckman, T. J., Bhave, N. M., Allen, L. A., Chung, E. H., Spatz, E. S., Ammirati, E., Baggish, A. L., Bozkurt, B., Cornwell, W. K., Harmon, K. G., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.003 · Cited by 431
Prevalence and Correlates of Long COVID Symptoms Among US Adults
Perlis, R. H., Santillana, M., Ognyanova, K., Safarpour, A., Trujillo, K. L., Simonson, M. D., Green, J., Quintana, A., Druckman, J. N., Baum, M., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.38804 · Cited by 391
Wang, S., Quan, L., Chavarro, J. E., Slopen, N. B., Kubzansky, L. D., Koenen, K. C., Kang, J. H., Weisskopf, M. G., Branch‐Elliman, W., & Roberts, A. L. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.2640 · Cited by 408
Onset and frequency of depression in post-COVID-19 syndrome: A systematic review
Renaud‐Charest, O., Lui, L. M. W., Eskander, S., Ceban, F., Ho, R., Vincenzo, J. D. D., Rosenblat, J. D., Lee, Y. L., Subramaniapillai, M., & McIntyre, R. S. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.09.054 · Cited by 393
Comorbidities, multimorbidity and COVID-19
Russell, C. D., Lone, N., & Baillie, J. K. (2023) · Nature Medicine · doi:10.1038/s41591-022-02156-9 · Cited by 373
Long-term effects of COVID-19 on mental health: a systematic review
Bourmistrova, N. W., Solomon, T., Braude, P., Strawbridge, R., & Carter, B. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.031 · Cited by 369
Understanding COVID-19-associated coagulopathy
Conway, E. M., Mackman, N., Warren, R. Q., Wolberg, A. S., Mosnier, L. O., Campbell, R. A., Gralinski, L. E., Rondina, M. T., van de Veerdonk, F. L., Hoffmeister, K. M., et al. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00762-9 · Cited by 380
Mechanisms of long COVID and the path toward therapeutics
Peluso, M. J., & Deeks, S. G. (2024) · Cell · doi:10.1016/j.cell.2024.07.054 · Cited by 399
Virus-induced senescence is a driver and therapeutic target in COVID-19
Lee, S., Yu, Y., Trimpert, J., Benthani, F., Mairhofer, M., Richter-Pechanska, P., Wyler, E., Belenki, D., Kaltenbrunner, S., Pammer, M., et al. (2021) · Nature · doi:10.1038/s41586-021-03995-1 · Cited by 350
Frequency, signs and symptoms, and criteria adopted for long COVID‐19: A systematic review
Martimbianco, A. L. C., Pacheco, R. L., Bagattini, Â. M., & Riera, R. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14357 · Cited by 370
Persistent Exertional Intolerance After COVID-19
Singh, I., Joseph, P., Heerdt, P. M., Cullinan, M., Lutchmansingh, D. D., Gulati, M., Possick, J. D., Systrom, D. M., & Waxman, A. B. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.08.010 · Cited by 338
Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study
Mizrahi, B., Sudry, T., Flaks‐Manov, N., Yehezkelli, Y., Kalkstein, N., Akiva, P., Ekka-Zohar, A., David, S. S. B., Lerner, U., Bivas‐Benita, M., et al. (2023) · BMJ · doi:10.1136/bmj-2022-072529 · Cited by 345
Morphological, cellular and molecular basis of brain infection in COVID-19 patients
Crunfli, F., Carregari, V. C., Veras, F. P., Vendramini, P. H., Valença, A. G. F., Antunes, A. S. L. M., Brandão-Teles, C., da Silva Zuccoli, G., Reis-de-Oliveira, G., Silva-Costa, L. C., et al. (2020) · doi:10.1101/2020.10.09.20207464 · Cited by 331
Peluso, M. J., Lu, S., Tang, A. F., Durstenfeld, M. S., Ho, H.-E., Goldberg, S. A., Forman, C. A., Munter, S. E., Hoh, R., Tai, V., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab490 · Cited by 332
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases
Zollner, A., Koch, R., Jukic, A., Pfister, A., Meyer, M., Rössler, A., Kimpel, J., Adolph, T. E., & Tilg, H. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.04.037 · Cited by 320
Post-acute sequelae of covid-19 six to 12 months after infection: population based study
Peter, R. S., Nieters, A., Kräusslich, H., Brockmann, S., Göpel, S., Kindle, G. R., Merle, U., Steinacker, J. M., Rothenbacher, D., Kern, W. V., et al. (2022) · BMJ · doi:10.1136/bmj-2022-071050 · Cited by 310
How Common is Long COVID in Children and Adolescents?
Zimmermann, P., Pittet, L. F., & Curtis, N. C. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003328 · Cited by 294
Lam, S. M., Zhang, C., Wang, Z., Zhen, N., Zhang, S., Yang, S., Huang, X., Mo, L., Li, J., Lee, B. T. K., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00425-4 · Cited by 285
Nopp, S., Moik, F., Klok, F. A., Gattinger, D., Petrovic, M., Vonbank, K., Koczulla, A. R., Ay, C., & Zwick, R. H. (2022) · Respiration · doi:10.1159/000522118 · Cited by 303
Koc, H. C., Xiao, J., Liu, W., Li, Y., & Chen, G. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.75056 · Cited by 310
Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort
Tran, V.-T., Porcher, R., Pane, I., & Ravaud, P. (2022) · Nature Communications · doi:10.1038/s41467-022-29513-z · Cited by 290
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Ryan, F. J., Hope, C. M., Masavuli, M. G., Lynn, M. A., Mekonnen, Z. A., Yeow, A. E. L., García-Valtanen, P., Al-Delfi, Z., Gummow, J., Ferguson, C. C., et al. (2022) · BMC Medicine · doi:10.1186/s12916-021-02228-6 · Cited by 288
Kell, D. B., Laubscher, G. J., & Pretorius, E. (2022) · Biochemical Journal · doi:10.1042/bcj20220016 · Cited by 278
Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications
Zhang, F., Lau, R. I., Liu, Q., Su, Q., Chan, F. K. L., & Ng, S. C. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00698-4 · Cited by 282
Monocytes and Macrophages in COVID-19
Knoll, R., Schultze, J. L., & Schulte-Schrepping, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720109 · Cited by 279
Behnood, S. A., Shafran, R., Bennett, S. D., Zhang, A. X. D., O’Mahoney, L. L., Stephenson, T. J., Ladhani, S. N., Stavola, B. L. D., Viner, R., & Swann, O. V. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.11.011 · Cited by 288
Matta, J., Wiernik, E., Robineau, O., Carrat, F., Touvier, M., Severi, G., de Lamballerie, X., Blanché, H., Deleuze, J.-F., Gouraud, C., et al. (2022) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2021.6454 · Cited by 266
Parotto, M., Gyöngyösi, M., Howe, K. L., Myatra, S. N., Ranzani, O., Shankar‐Hari, M., & Herridge, M. S. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00239-4 · Cited by 282
Neurological manifestations of long-COVID syndrome: a narrative review
Stefanou, M., Palaiodimou, L., Bakola, E., Smyrnis, N., Papadopoulou, Μ., Paraskevas, G. P., Rizos, E., Boutati, E. I., Grigoriadis, N., Krogias, C., et al. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221076890 · Cited by 267
Montani, D., Savale, L., Noël, N., Meyrignac, O., Colle, R., Gasnier, M., Corruble, E., Beurnier, A., Jutant, E., Pham, T. O., et al. (2022) · European Respiratory Review · doi:10.1183/16000617.0185-2021 · Cited by 277
Chronic viral coinfections differentially affect the likelihood of developing long COVID
Peluso, M. J., Deveau, T., Munter, S. E., Ryder, D., Buck, A. M., Beck‐Engeser, G., Chan, F., Lu, S., Goldberg, S. A., Hoh, R., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci163669 · Cited by 275
Zazhytska, M., Kodra, A. L., Hoagland, D. A., Frere, J. J., Fullard, J. F., Shayya, H. J., McArthur, N. G., Møller, R., Uhl, S. A., Omer, A. D., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.024 · Cited by 260
Peluso, M. J., Deitchman, A. N., Torres, L., Iyer, N. S., Munter, S. E., Nixon, C. C., Donatelli, J. L., Thanh, C., Takahashi, S., Hakim, J. M. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109518 · Cited by 251
Wenzel, J., Lampe, J., Müller‐Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00926-1 · Cited by 259
Sex differences in sequelae from COVID-19 infection and in long COVID syndrome: a review
Sylvester, S. V., Rusu, R., Chan, B., Bellows, M., O’Keefe, C., & Nicholson, S. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2081454 · Cited by 290
Long COVID: pathophysiological factors and abnormalities of coagulation
Turner, S., Khan, A., Putrino, D. F., Woodcock, A. A., Kell, D. B., & Pretorius, E. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.03.002 · Cited by 247
Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)
Sherif, Z. A., Gómez, C. R., Connors, T. J., Henrich, T. J., Reeves, W. B., & RECOVER Mechanistic Pathway Task Force (2023) · eLife · doi:10.7554/elife.86002 · Cited by 248
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
Ramakrishnan, R. K., Kashour, T., Hamid, Q. A., Halwani, R., & Tleyjeh, I. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686029 · Cited by 246
Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19
Soares, M. N., Eggelbusch, M., Naddaf, E., Gerrits, K. H. L., van der Schaaf, M., van den Borst, B., Wiersinga, W. J., van Vugt, M., Weijs, P. J. M., Murray, A. J., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12896 · Cited by 247
Frere, J. J., Serafini, R. A., Pryce, K. D., Zazhytska, M., Oishi, K., Golynker, I., Panis, M., Zimering, J. H., Horiuchi, S., Hoagland, D. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq3059 · Cited by 239
Post-COVID Syndrome: An Insight on Its Pathogenesis
Maltezou, H. C., Pavli, A., & Tsakris, A. (2021) · Vaccines · doi:10.3390/vaccines9050497 · Cited by 253
Identifying who has long COVID in the USA: a machine learning approach using N3C data
Pfaff, E., Girvin, A. T., Bennett, T. D., Bhatia, A., Brooks, I. M., Deer, R., Dekermanjian, J., Jolley, S. E., Kahn, M. G., Kostka, K., et al. (2022) · The Lancet Digital Health · doi:10.1016/s2589-7500(22)00048-6 · Cited by 223
Edlow, A. G., Castro, V. M., Shook, L. L., Kaimal, A. J., & Perlis, R. H. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.15787 · Cited by 232
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Cusi, K. J., Hilliard, M. E., Isaacs, D. M., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s004 · Cited by 242
Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment
Mazza, M. G., Palladini, M., Poletti, S., & Benedetti, F. (2022) · CNS Drugs · doi:10.1007/s40263-022-00931-3 · Cited by 248
Glynne, P. A., Tahmasebi, N., Gant, V. A., & Gupta, R. (2021) · Journal of Investigative Medicine · doi:10.1136/jim-2021-002051 · Cited by 215
Rehabilitation Interventions for Post-Acute COVID-19 Syndrome: A Systematic Review
Fugazzaro, S., Contri, A., Esseroukh, O., Kaleci, S., Croci, S., Massari, M., Facciolongo, N. C., Besutti, G., Iori, M., Salvarani, C., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095185 · Cited by 235
Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex
Hugon, J., Msika, E.-F., Queneau, M., Farid, K., & Paquet, C. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10655-x · Cited by 216
CT of Post-Acute Lung Complications of COVID-19
Solomon, J. J., Heyman, B., Ko, J. P., Condos, R., & Lynch, D. A. (2021) · Radiology · doi:10.1148/radiol.2021211396 · Cited by 212
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
Kaplan, C. M., Kelleher, E. M., Irani, A., Schrepf, A., Clauw, D. J., & Harte, S. E. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00966-8 · Cited by 231
Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms
Son, K., Jamil, R., Chowdhury, A., Mukherjee, M., Venegas, C., Miyasaki, K., Zhang, K., Patel, Z., Salter, B., Yuen, A. C. Y., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.00970-2022 · Cited by 221
Notarte, K. I., de Oliveira, M. H. S., Peligro, P. J., Velasco, J. V., Macaranas, I., Ver, A. T., Pangilinan, F. C., Pastrana, A., Goldrich, N., Kavteladze, D., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247314 · Cited by 209
Post-acute COVID-19 outcomes in children with mild and asymptomatic disease
Say, D. F., Crawford, N. W., McNab, S., Wurzel, D. F., Steer, A. C., & Tosif, S. (2021) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(21)00124-3 · Cited by 204
The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection
Moghimi, N., Napoli, M. D., Biller, J., Siegler, J. E., Shekhar, R., McCullough, L. D., Harkins, M. S., Hong, E., Alaouieh, D., Mansueto, G., et al. (2021) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-021-01130-1 · Cited by 202
Incidence of newly diagnosed diabetes after Covid-19
Rathmann, W., Kuß, O., & Kostev, K. (2022) · Diabetologia · doi:10.1007/s00125-022-05670-0 · Cited by 192
Prognostic Factors for Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis
Maglietta, G., Diodati, F., Puntoni, M., Lazzarelli, S., Marcomini, B., Patrizi, L., & Caminiti, C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061541 · Cited by 198
Vijayakumar, B., Boustani, K., Ogger, P. P., Papadaki, A., Tonkin, J., Orton, C. M., Ghai, P., Suveizdytė, K., Hewitt, R. J., Desai, S. R., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.017 · Cited by 188
Metadata
- Authors
- Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., Ahluwalia, N., Bikdeli, B., Dietz, D., Der-Nigoghossian, C., Liyanage-Don, N., Rosner, G. F., Bernstein, E. J., Mohan, S., Beckley, A. A., Seres, D. S., Choueiri, T. K., Uriel, N., Ausiello, J. C., Accili, D., Freedberg, D. E., Baldwin, M., Schwartz, A., Brodie, D., Garcia, C. K., Elkind, M. S. V., Connors, J. M., Bilezikian, J. P., Landry, D. W., & Wan, E. Y.
- Affiliations
- Columbia University Irving Medical Center (US)
- Brigham and Women's Hospital (US)
- Yale New Haven Hospital (US)
- Mayo Clinic (US)
- Icahn School of Medicine at Mount Sinai (US)
- NewYork–Presbyterian Hospital (US)
- Corresponding author
- Sehgal, Kartik
- Wan, Elaine Y.
- ORCID
- Nalbandian, Ani
- Sehgal, Kartik
- Gupta, Aakriti
- Madhavan, Mahesh V.
- McGroder, Claire
- Stevens, Jacob S.
- Cook, Joshua R.
- Nordvig, Anna S.
- Shalev, Daniel
- Sehrawat, Tejasav S.
- Ahluwalia, Neha
- Bikdeli, Behnood
- Der-Nigoghossian, Caroline
- Liyanage-Don, Nadia
- Bernstein, Elana J.
- Mohan, Sumit
- Beckley, Akinpelumi A.
- Seres, David S.
- Choueiri, Toni K.
- Uriel, Nir
- Ausiello, John C.
- Accili, Domenico
- Freedberg, Daniel E.
- Baldwin, Matthew
- Schwartz, Allan
- Brodie, Daniel
- Garcia, Christine Kim
- Elkind, Mitchell S. V.
- Connors, Jean M.
- Bilezikian, John P.
- Landry, Donald W.
- Wan, Elaine Y.
- Venue
- Nature Medicine
- Published
- 2021-03-22
- Volume
- 27
- Issue
- 4
- Pages
- 601-615
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC8893149
- OpenAlex
- W3136955306
- Cited by
- 4,862
- References
- 233
- Citations by year
- 2026: 324 · 2025: 502 · 2024: 827 · 2023: 1161 · 2022: 1379 · 2021: 666
- FWCI
- 129.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (T32 HL007854, 5T32 NS007153, R01-DK114893, R01-MD014161, U01-DK116066, K23 DK111847, R01 HL152236, R03 HL146881)
- National Science Foundation (2032726)
- U.S. Department of Defense (PR181960)
- The Esther Aboodi Endowed Professorship at Columbia University, and the Wu Family Research fund
- Topics
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- long COVID, SARS-CoV-2, COVID-19 survivors, persistent symptoms, late complications, pathophysiology, multidisciplinary care, risk identification, patient advocacy
- MeSH terms
- COVID-19, SARS-CoV-2, Acute Disease, Cardiovascular Diseases, Humans, Patient Advocacy, Syndrome, Systemic Inflammatory Response Syndrome, Venous Thromboembolism
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