The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy
Open accessAbstract
SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune protection against COVID-19. However, little is known about SARS-CoV-2 mRNA vaccine-induced responses in immunosuppressed patients. We investigated induction of antigen-specific antibody, B cell and T cell responses longitudinally in patients with multiple sclerosis (MS) on anti-CD20 antibody monotherapy ( n = 20) compared with healthy controls ( n = 10) after BNT162b2 or mRNA-1273 mRNA vaccination. Treatment with anti-CD20 monoclonal antibody (aCD20) significantly reduced spike-specific and receptor-binding domain (RBD)-specific antibody and memory B cell responses in most patients, an effect ameliorated with longer duration from last aCD20 treatment and extent of B cell reconstitution. By contrast, all patients with MS treated with aCD20 generated antigen-specific CD4 and CD8 T cell responses after vaccination. Treatment with aCD20 skewed responses, compromising circulating follicular helper T (T FH ) cell responses and augmenting CD8 T cell induction, while preserving type 1 helper T (T H 1) cell priming. Patients with MS treated with aCD20 lacking anti-RBD IgG had the most severe defect in circulating T FH responses and more robust CD8 T cell responses. These data define the nature of the SARS-CoV-2 vaccine-induced immune landscape in aCD20-treated patients and provide insights into coordinated mRNA vaccine-induced immune responses in humans. Our findings have implications for clinical decision-making and public health policy for immunosuppressed patients including those treated with aCD20.
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Metadata
- Authors
- Apostolidis, S. A., Kakara, M., Painter, M. M., Goel, R. R., Mathew, D., Lenzi, K., Rezk, A., Patterson, K. R., Espinoza, D. A., Kadri, J. C., Markowitz, D. M., E. Markowitz, C., Mexhitaj, I., Jacobs, D., Babb, A., Betts, M. R., Prak, E. T. L., Weiskopf, D., Grifoni, A., Lundgreen, K. A., Gouma, S., Sette, A., Bates, P., Hensley, S. E., Greenplate, A. R., Wherry, E. J., Li, R., & Bar-Or, A.
- Venue
- Nature Medicine
- Published
- 2021-09-14
- Volume
- 27
- Issue
- 11
- Pages
- 1990-2001
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3200136047
- Cited by
- 507
- References
- 84
- FWCI
- 32.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Apostolidis, S. A., Kakara, M., Painter, M. M., Goel, R. R., Mathew, D., Lenzi, K., Rezk, A., Patterson, K. R., Espinoza, D. A., Kadri, J. C., Markowitz, D. M., E. Markowitz, C., Mexhitaj, I., Jacobs, D., Babb, A., Betts, M. R., Prak, E. T. L., Weiskopf, D., Grifoni, A., . . . Bar-Or, A. (2021). Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nature Medicine. https://doi.org/10.1038/s41591-021-01507-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
