SARS-CoV-2-specific T cells in infection and vaccination
Open accessAbstract
During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic.
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T cell responses play a vital role as a second layer of defense, in particular in the prevention of severe COVID-19.
“T cell responses play a vital role as a second layer of defense, in particular in the prevention of severe COVID-19 (26).”
From Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera (2022) · cites this paper as [26]
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Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination
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Next-generation nanovaccine induces durable immunity and protects against SARS-CoV-2
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Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
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Developing dendritic cell for SARS-CoV-2 vaccine: Breakthrough in the pandemic
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Longitudinal Dynamics of Cellular Responses in Recovered COVID-19 Patients
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Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization
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Self-citationA Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients
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Antigen-specific T cell responses in SARS-CoV-2 mRNA-vaccinated children
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- Authors
- Bertoletti, A., Le Bert, N., Qui, M., & Tan, A. T.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Duke-NUS Medical School (SG)
- Corresponding author
- Bertoletti, Antonio
- Venue
- Cellular & Molecular Immunology
- Published
- 2021-09-01
- Volume
- 18
- Issue
- 10
- Pages
- 2307-2312
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC8408362
- OpenAlex
- W3196516725
- Cited by
- 159
- References
- 102
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 20 · 2023: 23 · 2022: 84 · 2021: 11
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cellular and Molecular Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- MOH | National Medical Research Council (COVID19RF3-0060, MOH-StaR17Nov-0001)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, virus-specific T cells, T cell immunity, COVID-19 vaccination, adaptive immunity, inflammation, pathogenesis, protective immunity, COVID-19 vaccines
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Humans, T-Lymphocytes, Spike Glycoprotein, Coronavirus
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