Cited by 603Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

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Selective vulnerability in neurodegenerative diseases

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Fu, Hongjun, Hardy, John, Duff, Karen E.·2018·Nature Neuroscience

DOI 10.1038/s41593-018-0221-2PMC PMC6360529

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Abstract

Neurodegenerative diseases have two general characteristics that are so fundamental we usually take them for granted. The first is that the pathology associated with the disease only affects particular neurons ('selective neuronal vulnerability'); the second is that the pathology worsens with time and impacts more regions in a stereotypical and predictable fashion. The mechanisms underpinning selective neuronal and regional vulnerability have been difficult to dissect, but the recent application of whole-genome technologies, the development of mouse models that reproduce spatial and temporal features of the pathology, and the identification of intrinsic morphological, electrophysiological, and biochemical properties of vulnerable neurons are beginning to shed some light on these fundamental features of neurodegenerative diseases. Here we detail our emerging understanding of the underlying biology of selective neuronal vulnerability and outline some of the areas in which our understanding is incomplete.

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WGCNA: an R package for weighted correlation network analysis
Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Cryo-EM structures of tau filaments from Alzheimer’s disease
Fitzpatrick, A. W. P., Falcon, B., He, S., Murzin, A. G., Murshudov, G., Garringer, H. J., Crowther, R. A., Ghetti, B., Goedert, M., & Scheres, S. H. W. (2017) · Nature · doi:10.1038/nature23002 · Cited by 2,061
Ionic dependence of glutamate neurotoxicity
Choi, D. W. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00369.1987 · Cited by 1,854
A gene-based association method for mapping traits using reference transcriptome data
Gamazon, E. R., Wheeler, H. E., Shah, K. P., Mozaffari, S. V., Aquino-Michaels, K., Carroll, R. J., Eyler, A. E., Denny, J. C., Nicolae, D. L., Cox, N. J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3367 · Cited by 1,790
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,730
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2013) · Nature · doi:10.1038/nature12481 · Cited by 1,663
Rapid single-step induction of functional neurons from human pluripotent stem cells
Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., Marro, S., Patzke, C., Acuna, C., Covy, J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.029 · Cited by 1,644
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
Boillée, S., Velde, C. V., & Cleveland, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.018 · Cited by 1,476
The Biology of Proteostasis in Aging and Disease
Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472
APRIORITY
Asher, R. (1961) · The Lancet · doi:10.1016/s0140-6736(61)91217-x · Cited by 1,293
An environment-dependent transcriptional network specifies human microglia identity
Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science · doi:10.1126/science.aal3222 · Cited by 1,220
Ambra1 regulates autophagy and development of the nervous system
Fimia, G. M., Stoykova, A., Romagnoli, A., Giunta, L., Bartolomeo, S. D., Nardacci, R., Corazzari, M., Fuoco, C., Uçar, A., Schwartz, P. J., et al. (2007) · Nature · doi:10.1038/nature05925 · Cited by 1,082
Massively parallel single-nucleus RNA-seq with DroNc-seq
Habib, N., Avraham-Davidi, I., Basu, A., Burks, T., Shekhar, K., Hofree, M., Choudhury, S. R., Aguet, F., Gelfand, E., Ardlie, K., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4407 · Cited by 1,069
Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
Brettschneider, J., Del Tredici, K., Toledo, J. B., Robinson, J. L., Irwin, D. J., Grossman, M., Suh, E., Van Deerlin, V. M., Wood, E. M., Baek, Y., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23937 · Cited by 1,065
Fibril structure of amyloid-β(1–42) by cryo–electron microscopy
Gremer, L., Schölzel, D., Schenk, C., Reinartz, E., Labahn, J., Ravelli, R. B. G., Tusche, M., López‐Iglesias, C., Hoyer, W., Heise, H., et al. (2017) · Science · doi:10.1126/science.aao2825 · Cited by 1,055
Highly Multiplexed Subcellular RNA Sequencing in Situ
Lee, J. H., Daugharthy, E. R., Scheiman, J., Kalhor, R., Yang, J. L., Ferrante, T. C., Terry, R., Jeanty, S. S. F., Li, C., Amamoto, R., et al. (2014) · Science · doi:10.1126/science.1250212 · Cited by 973
Ageing and neuronal vulnerability
Mattson, M. P., & Magnus, T. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1886 · Cited by 957
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
Lake, B. B., Ai, R., Kaeser, G. E., Salathia, N. S., Yung, Y. C., Liu, R., Wildberg, A., Gao, D., Fung, H.-L., Chen, S., et al. (2016) · Science · doi:10.1126/science.aaf1204 · Cited by 957
Proteostasis and aging
Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 896
Differential loss of striatal projection neurons in Huntington disease.
Reiner, A., Albin, R. L., Anderson, K. D., D'Amato, C. J., Penney, J. B., & Young, A. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5733 · Cited by 839
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777
Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia
Bondareff, W., Mountjoy, C. Q., & Roth, M. (1982) · Neurology · doi:10.1212/wnl.32.2.164 · Cited by 683
Propagation of Tau aggregates and neurodegeneration
Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
Sulzer, D. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.009 · Cited by 602
Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease
Zeron, M. M., Hansson, O., Chen, N., Wellington, C. L., Leavitt, B. R., Brundin, P., Hayden, M. R., & Raymond, L. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00615-3 · Cited by 600
Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration
Saxena, S., & Caroni, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.031 · Cited by 578
Amyotrophic lateral sclerosis—a model of corticofugal axonal spread
Braak, H., Brettschneider, J., Ludolph, A. C., Lee, V. M., Trojanowski, J. Q., & Tredici, K. D. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.221 · Cited by 544
Aging as an event of proteostasis collapse
Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538
Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Milnerwood, A. J., Gladding, C. M., Pouladi, M. A., Kaufman, A. M., Hines, R. M., Boyd, J. D., Ko, R. W. Y., Vasuta, O. C., Graham, R. K., Hayden, M. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.008 · Cited by 533
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
Ryan, B. J., Hoek, S., Fon, E. A., & Wade-Martins, R. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.02.003 · Cited by 524
Oxidative stress and protein aggregation during biological aging
Squier, T. C. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00139-5 · Cited by 519
Motor Neuron Diversity in Development and Disease
Kanning, K. C., Kaplan, A., & Henderson, C. E. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135722 · Cited by 513
Excitatory amino acids and Alzheimer's disease
Greenamyre, J. T., & Young, A. B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90143-7 · Cited by 485
Invited review: Frontotemporal dementia caused by microtubule‐associated protein tau gene ( MAPT ) mutations: a chameleon for neuropathology and neuroimaging
Ghetti, B. F., Oblak, A. L., Boeve, B. F., Johnson, K. A., Dickerson, B. C., & Goedert, M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12213 · Cited by 458
Clinical correlates of selective pathology in the amygdala of patients with Parkinson’s disease
Harding, A. J., Stimson, E., Henderson, J. M., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf251 · Cited by 454
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Okamoto, S., Pouladi, M. A., Talantova, M. V., Yao, D., Xia, P., Ehrnhoefer, D. E., Zaidi, R., Clemente, A., Kaul, M., Graham, R. K., et al. (2009) · Nature Medicine · doi:10.1038/nm.2056 · Cited by 449
Living on the edge with too many mouths to feed: Why dopamine neurons die
Bolam, J. P., & Pissadaki, E. K. (2012) · Movement Disorders · doi:10.1002/mds.25135 · Cited by 439
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
Mendez, I. M., Sánchez‐Pernaute, R., Cooper, O., Viñuela, Á., Ferrari, D., Björklund, L., Dagher, A., & Ole Isacson, A. (2005) · Brain · doi:10.1093/brain/awh510 · Cited by 438
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
Soreq, L., Rose, J., Soreq, E., Hardy, J., Trabzuni, D., Cookson, M. R., Smith, C., Ryten, M., Patani, R., & Ule, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.011 · Cited by 419
Self-citation
Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease
Halliday, G. M., Li, Y. W., Blumbergs, P. C., JOH, T. H., Cotton, R. G. H., Howe, P. R. C., Blessing, W. W., & Geffen, L. B. (1990) · Annals of Neurology · doi:10.1002/ana.410270405 · Cited by 409
Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis
Braak, H., & Braak, E. (1996) · Acta Neuropathologica · doi:10.1007/s004010050508 · Cited by 406
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening
Wang, C., Ward, M. E., Chen, R., Liu, K., Tracy, T. E., Chen, X., Xie, M., Sohn, P. D., Ludwig, C., Meyer-Franke, A., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.019 · Cited by 400
What is the evidence that tau pathology spreads through prion-like propagation?
Mudher, A., Colin, M., Dujardin, S., Medina, M., Dewachter, I., Alavi Naini, S. M., Mandelkow, E.-M., Mandelkow, E., Buée, L., Goedert, M., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0488-7 · Cited by 384
Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)
Dickson, D. W., Kouri, N., Murray, M. E., & Josephs, K. A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9589-0 · Cited by 380
The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
Alexianu, M. E., Ho, B., Mohamed, A. H., Bella, V. L., Smith, R. G., & Appel, S. H. (1994) · Annals of Neurology · doi:10.1002/ana.410360608 · Cited by 374
Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff
Braak, H., & Del Tredici, K. (2017) · Journal of Parkinson’s Disease · doi:10.3233/jpd-179001 · Cited by 372
Staging TDP-43 pathology in Alzheimer’s disease
Josephs, K. A., Murray, M. E., Whitwell, J. L., Parisi, J. E., Petrucelli, L., Jack, C. R., Petersen, R. C., & Dickson, D. W. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1211-9 · Cited by 366
Early frontotemporal dementia targets neurons unique to apes and humans
Seeley, W. W., Carlin, D. A., Allman, J. M., Macedo, M. N., Bush, C., Miller, B. L., & DeArmond, S. J. (2006) · Annals of Neurology · doi:10.1002/ana.21055 · Cited by 364
Neurodegenerative Diseases: Expanding the Prion Concept
Walker, L. C., & Jucker, M. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033828 · Cited by 361
Post mortem studies in Parkinson’s disease — is it possible to detect brain areas for specific symptoms?
Jellinger, K. A. (1999) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6360-3_1 · Cited by 359
Platelet mitochondria function in Parkinson's disease
Krige, D., Carroll, M. T., Cooper, J. A. D., MARSDEN, C. D., & Schapira, A. H. V. (1992) · Annals of Neurology · doi:10.1002/ana.410320612 · Cited by 358
Generation of pure GABAergic neurons by transcription factor programming
Yang, N., Chanda, S., Marro, S., Ng, Y.-H., Janas, J. A., Haag, D., Ang, C. E., Tang, Y., Flores, Q., Mall, M., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4291 · Cited by 341
Pathogenesis of Parkinson's disease
Hirsch, E. C., Jenner, P., & Przedborski, S. (2013) · Movement Disorders · doi:10.1002/mds.25032 · Cited by 336
SELECTIVE LOSS OF NEURONES OF ORIGIN OF ADRENERGIC PROJECTION TO CEREBRAL CORTEX (NUCLEUS LOCUS COERULEUS) IN SENILE DEMENTIA
Bondareff, W. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92657-x · Cited by 332
Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling
Nichterwitz, S., Chen, G., Benitez, J. A., Yilmaz, M., Storvall, H., Cao, M., Sandberg, R., Deng, Q., & Hedlund, E. (2016) · Nature Communications · doi:10.1038/ncomms12139 · Cited by 331
Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions
Swistowski, A., Peng, J., Liu, Q., Mali, P., Rao, M. S., Cheng, L., & Zeng, X. (2010) · Stem Cells · doi:10.1002/stem.499 · Cited by 317
NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum
Landwehrmeyer, G. B., Standaert, D. G., Testa, C. M., Penney, J., & Young, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05297.1995 · Cited by 316
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00242.2007 · Cited by 309
Calcium ions in neuronal degeneration
Wojda, U., Salińska, E., & Kuźnicki, J. (2008) · IUBMB Life · doi:10.1002/iub.91 · Cited by 303
A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology
Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., Nahaboo Solim, M. A., Moens, T. G., Paublete, R. M., Ali, S. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.041 · Cited by 290
Self-citation
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins
Ciryam, P., Tartaglia, G. G., Morimoto, R. I., Dobson, C. M., & Vendruscolo, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.09.043 · Cited by 270
Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration
Rabinovici, G. D., Seeley, W. W., Kim, E. J., Gorno‐Tempini, M. L., Rascovsky, K., Pagliaro, T. A., Allison, S. C., Halabi, C., Kramer, J. H., Johnson, J. K., et al. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507308779 · Cited by 264
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
Fu, H., Rodriguez, G. A., Herman, M., Emrani, S., Nahmani, E., Barrett, G., Figueroa, H. Y., Goldberg, E., Hussaini, S. A., & Duff, K. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.023 · Cited by 264
Self-citation
Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis
Shaw, P. J., & Eggett, C. J. (2000) · Journal of Neurology · doi:10.1007/bf03161151 · Cited by 262
Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes
Victor, M. B., Richner, M., Olsen, H. E., Lee, S. W., Monteys, A. M., Ma, C., Huh, C. J., Zhang, B., Davidson, B. L., Yang, X. W., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0075-7 · Cited by 246
Calcium homeostasis, selective vulnerability and Parkinson's disease
Chan, C. S., Gertler, T. S., & Surmeier, D. J. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.006 · Cited by 245
Chapter 37 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease
Morrison, J. H., & Hof, P. R. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36039-4 · Cited by 241
Selective functional, regional, and neuronal vulnerability in frontotemporal dementia
Seeley, W. W. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283168e2d · Cited by 235
Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update
Brichta, L., & Greengard, P. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00152 · Cited by 227
Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease
Surmeier, D. J., Guzmán, J. N., & Sánchez-Padilla, J. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.003 · Cited by 224
Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM
Schmidt, M., Rohou, A. L., Lasker, K., Yadav, J. K., Schiene‐Fischer, C., Fändrich, M., & Grigorieff, N. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503455112 · Cited by 222
Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons
Sundberg, M., Bogetofte, H., Lawson, T., Jansson, J. P., Smith, G. A., Astradsson, A., Moore, M. A., Osborn, T. M., Cooper, O., Spealman, R. D., et al. (2013) · Stem Cells · doi:10.1002/stem.1415 · Cited by 222
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Sun, S., Sun, Y., Ling, S., Ferraiuolo, L., McAlonis‐Downes, M., Zou, Y., Drenner, K., Wang, Y., Ditsworth, D., Tokunaga, S., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520639112 · Cited by 201
Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease
Stranahan, A. M., & Mattson, M. P. (2010) · Neural Plasticity · doi:10.1155/2010/108190 · Cited by 198
Parkinson's Disease Is Not Simply a Prion Disorder
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1787-16.2017 · Cited by 197
Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease
Chin, J., Massaro, C. M., Palop, J. J., Thwin, M. T., Yu, G.-Q., Bien-Ly, N., Bender, A., & Mucke, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3758-06.2007 · Cited by 188
Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS
von Lewinski, F., & Keller, B. U. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.001 · Cited by 186
Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9
Bussière, T., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10760 · Cited by 185
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
Tsvetkov, A. S., Arrasate, M., Barmada, S., Ando, D. M., Sharma, P., Shaby, B. A., & Finkbeiner, S. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1308 · Cited by 178
Differential vulnerability of neurons in Huntington’s disease: the role of cell type‐specific features
Han, I., You, Y., Kordower, J. H., Brady, S. T., & Morfini, G. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06672.x · Cited by 176
Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases
Ciryam, P., Kundra, R., Morimoto, R. I., Dobson, C. M., & Vendruscolo, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.12.004 · Cited by 175
Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism
Greene, J. G., Dingledine, R. J., & Greenamyre, J. T. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.003 · Cited by 174
Calretinin-immunoreactive neocortical interneurons are unaffected in Alzheimer's disease
Hof, P. R., Nimchinsky, E. A., Celio, M. R., Bouras, C., & Morrison, J. H. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90504-e · Cited by 172
Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: Reciprocal networks and neuronal evolution
Seeley, W. W., Allman, J. M., Carlin, D. A., Crawford, R. K., Macedo, M. N., Greicius, M. D., DeArmond, S. J., & Miller, B. L. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815c0f14 · Cited by 165
A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease
Morrison, J. H., Lewis, D. A., Campbell, M. J., Huntley, G. W., Benson, D. L., & Bouras, C. (1987) · Brain Research · doi:10.1016/0006-8993(87)90914-0 · Cited by 164
Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology
Mishizen-Eberz, A. J., Rissman, R. A., Carter, T. L., Ikonomovic, M. D., Wolfe, B. B., & Armstrong, D. M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.09.016 · Cited by 156
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains
Walker, D. G., Lue, L., Adler, C. H., Shill, H. A., Caviness, J. N., Sabbagh, M. N., Akiyama, H., Serrano, G. E., Sue, L. I., & Beach, T. G. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.11.020 · Cited by 153
Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients
Richfield, E. K., Maguire‐Zeiss, K. A., Vonkeman, H. E., & Voorn, P. (1995) · Annals of Neurology · doi:10.1002/ana.410380605 · Cited by 153
Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model
Kingsbury, A. E., Bandopadhyay, R., Silveira‐Moriyama, L., Ayling, H., Kallis, C., Sterlacci, W., Maeir, H., Poewe, W. H., & Lees, A. J. (2010) · Movement Disorders · doi:10.1002/mds.23305 · Cited by 152
Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging
Magnusson (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00011 · Cited by 130
The natural history of central motor abnormalities in amyotrophic lateral sclerosis
Mills, K. R. (2003) · Brain · doi:10.1093/brain/awg260 · Cited by 124
Determinants of neuronal vulnerability in neurodegenerative diseases
Morrison, B. M., Hof, P. R., & Morrison, J. H. (1998) · Annals of Neurology · doi:10.1002/ana.410440706 · Cited by 120
Mitochondrial dynamics and quality control in Huntington's disease
Guedes-Dias, P., Pinho, B. R., Soares, T. R., de Proença, J., Duchen, M. R., & Oliveira, J. M. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.09.008 · Cited by 119
From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases
Roselli, F., & Caroni, P. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.063 · Cited by 117
Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells
Sun, A. X., Yuan, Q., Tan, S., Xiao, Y., Wang, D., Khoo, A., Sani, L., Tran, H.-D., Kim, P., Chiew, Y. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.035 · Cited by 115
The neglected constituent of the basal forebrain corticopetal projection system: GABAergic projections
Sarter, M. F., & Bruno, J. P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02004.x · Cited by 113
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
Ciryam, P., Lambert-Smith, I. A., Bean, D. M., Freer, R., Cid, F., Tartaglia, G. G., Saunders, D. N., Wilson, M. R., Oliver, S. G., Morimoto, R. I., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613854114 · Cited by 107
Mitochondrial function in Parkinson's disease
Schapira, A. H. V., Mann, V. M., Cooper, J. A. D., Krige, D., Jenner, P. G., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320720 · Cited by 106
Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ‘permissive templating’ as a general mechanism underlying neurodegeneration
Hardy, J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330578 · Cited by 105
Self-citation
Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum
K�ppenbender, K. D., Standaert, D. G., Feuerstein, T. J., Penney, J. B., Young, A. B., & Landwehrmeyer, G. B. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000417)419:4 · Cited by 104
Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability
Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., Zhang, Z., Huang, Y., Temple, S., Coppola, G., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.001 · Cited by 103
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
Freer, R., Sormanni, P., Vecchi, G., Ciryam, P., Dobson, C. M., & Vendruscolo, M. (2016) · Science Advances · doi:10.1126/sciadv.1600947 · Cited by 101
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family
Spina, S., Farlow, M. R., Unverzagt, F. W., Kareken, D. A., Murrell, J. R., Fraser, G. M., Epperson, F., Crowther, R. A., Spillantini, M. G., Goedert, M., et al. (2007) · Brain · doi:10.1093/brain/awm280 · Cited by 98
Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease
Kundra, R., Ciryam, P., Morimoto, R. I., Dobson, C. M., & Vendruscolo, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618417114 · Cited by 93
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
Imamura, K., Sahara, N., Kanaan, N. M., Tsukita, K., Kondo, T., Kutoku, Y., Ohsawa, Y., Sunada, Y., Kawakami, K., Hotta, A., et al. (2016) · Scientific Reports · doi:10.1038/srep34904 · Cited by 88
Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions
Bender, A., Schwarzkopf, R.-M., McMillan, A., Krishnan, K. J., Rieder, G., Neumann, M., Elstner, M., Turnbull, D. M., & Klopstock, T. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0892-9 · Cited by 87
A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation
Ciryam, P., Kundra, R., Freer, R., Morimoto, R. I., Dobson, C. M., & Vendruscolo, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516604113 · Cited by 85
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
Muratore, C., Zhou, C. Q., Liao, M., Fernandez, M. A., Taylor, W. M., Lagomarsino, V. N., Pearse, R. V., Rice, H. C., Negri, J. M., He, A., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.015 · Cited by 82
Localization of immunoreactivity for Deleted in Colorectal Cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents
Osborne, P. B., Halliday, G. M., Cooper, H. M., & Keast, J. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.043 · Cited by 77
Single cell gene expression profiling in Alzheimer’s disease
Ginsberg, S. D., Che, S., Counts, S., & Mufson, E. J. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.05.007 · Cited by 76
Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
Morigaki, R., & Goto, S. (2017) · Brain Sciences · doi:10.3390/brainsci7060063 · Cited by 76
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner
Wang, Y., & Mattson, M. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.007 · Cited by 72
Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease
Mattsson, N., Schott, J. M., Hardy, J., Turner, M. R., & Zetterberg, H. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311321 · Cited by 72
Self-citation
Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease
Ginsberg, S. D., Malek‐Ahmadi, M. H., Alldred, M. J., Che, S., Elarova, I., Chen, Y., Jeanneteau, F. D., Kranz, T. M., Chao, M. V., Counts, S., et al. (2017) · Hippocampus · doi:10.1002/hipo.22802 · Cited by 69
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer’s disease
Lee, H., Ogawa, O., Zhu, X., O’Neill, M. J., Petersen, R. B., Castellani, R. J., Ghanbari, H., Perry, G. L., & Smith, M. A. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0820-8 · Cited by 68
Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTR interaction
Fombonne, J., Rabizadeh, S., Banwait, S., Mehlen, P., & Bredesen, D. E. (2009) · Annals of Neurology · doi:10.1002/ana.21578 · Cited by 68
Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases
Walker, L. C. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-034943 · Cited by 60
Differential expression of GABAA and glycine receptors in ALS‐resistant vs. ALS‐vulnerable motoneurons: possible implications for selective vulnerability of motoneurons
Lorenzo, L.-É., Barbe, A., Portalier, P., Fritschy, J., & Bras, H. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04863.x · Cited by 60
Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks
Varrone, A., Pappatà, S., Caracò, C., Soricelli, A., Milan, G., Quarantelli, M., Alfano, B., Postiglione, A., & Salvatore, M. (2002) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0883-5 · Cited by 59
Neuronal vulnerability in Parkinson's disease
Double, K. L. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70018-9 · Cited by 59
On the origin of Alzheimerʼs disease
Roberts, G. W., Nash, M., Ince, P. G., Royston, M. C., & Gentleman, S. M. (1993) · Neuroreport · doi:10.1097/00001756-199301000-00001 · Cited by 58
Functional Differences Between Direct and Indirect Striatal Output Pathways in Huntington's Disease
Galvan, L., André, V. M., Wang, E. A., Cepeda, C., & Levine, M. S. (2012) · Journal of Huntington's Disease · doi:10.3233/jhd-2012-120009 · Cited by 56
Involvement of Onuf's nucleus in amyotrophic lateral sclerosis
Kihira, T., Yoshida, S., YOSHIMASU, F., WAKAYAMA, I., & YASE, Y. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)05313-0 · Cited by 55
Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1
Shu, S., Zhu, H., Tang, N., Chen, W., Li, X., Li, H., Pei, L., Liu, D., Mu, Y., Tian, Q., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-16.2016 · Cited by 51
Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease
Perez, S. E., Getova, D. P., He, B., Counts, S., Geula, C., Désiré, L., Coutadeur, S., Peillon, H., Ginsberg, S. D., & Mufson, E. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.027 · Cited by 43
Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability
Giovannantonio, L. G. D., Salvio, M. D., Acampora, D., Prakash, N., Wurst, W., & Simeone, A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.10.022 · Cited by 42
Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice
Götz, J., Schönrock, N., Vissel, B., & Ittner, L. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1143 · Cited by 38
Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease
Tiernan, C. T., Ginsberg, S. D., Guillozet-Bongaarts, A. L., Ward, S., He, B., Kanaan, N. M., Mufson, E. J., Binder, L. I., & Counts, S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.031 · Cited by 38
Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis
Tomiyama, M., Kimura, T., Maeda, T., Tanaka, H., Furusawa, K., Kurahashi, K., & Matsunaga, M. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00561-5 · Cited by 38
Neuron-Specific Alterations in Signal Transduction Pathways associated with Alzheimer's Disease
Gerschütz, A., Heinsen, H., Grünblatt, E., Wagner, A. K., Bartl, J., Meißner, C., Fallgatter, A. J., Al‐Sarraj, S., Troakes, C., Ferrer, I., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131280 · Cited by 37
Differential vulnerability, connectivity, and cell typology
Morrison, J. H. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90021-3 · Cited by 36
Demonstration of neurofibrillary tangles in parvalbumin-immunoreactive interneurones in the cerebral cortex of Alzheimer-type dementia brain
Iwamoto, N., & Emson, P. C. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90764-k · Cited by 32
Differential expression of Group I metabotropic glutamate receptors in motoneurons at low and high risk for degeneration in ALS
Laslo, P., Lipski, J., & Funk, G. D. (2001) · Neuroreport · doi:10.1097/00001756-200107030-00027 · Cited by 32
Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1
Grand, J. N. L., Bon, K., Fraîchard, A., Zhang, J., Jouvenot, M., Risold, P., Boyer‐Guittaut, M., & Delage-Mourroux, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063133 · Cited by 29
Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease
McKeever, P. M., Kim, T. P., Hesketh, A. R., MacNair, L., Miletic, D., Favrin, G., Oliver, S. G., Zhang, Z., George‐Hyslop, P. S., & Robertson, J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.014 · Cited by 27
Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice
Johnson, N. R., Condello, C., Guan, S., Oehler, A., Becker, J., Gavidia, M., Carlson, G. A., Giles, K., & Prusiner, S. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717193114 · Cited by 25
Embryonic development of selectively vulnerable neurons in Parkinson’s disease
Oliveira, M. A. P., Balling, R., Smidt, M. P., & Fleming, R. M. T. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0022-4 · Cited by 24
Functional alterations in neural circuits in Alzheimer's disease
Simonian, N. A., & Hyman, B. T. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00034-c · Cited by 22
Literacy as a determining factor for brain organization: from Lecours' contribution to the present day
Parente, M. A. D. M. P., Fonseca, R. P., & Scherer, L. C. (2008) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642009dn20300002 · Cited by 19
Decreased expression of calretinin in the cerebral cortex and hippocampus of SOD1G93A transgenic mice
Chung, Y. H., Joo, K. M., Nam, R. H., Cho, M. H., Kim, D. J., Lee, W. B., & Ik, C. (2005) · Brain Research · doi:10.1016/j.brainres.2004.12.022 · Cited by 16
Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases
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Self-citation
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Untitled work
Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3

Research works printed but not linked: 1

Nitrini, R. Selective vulnerability of von Economo neurons in frontotemporal dementia. Dement. Neuropsychol. 2, 164 (2008).

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Authors: Fu, H., Hardy, J., & Duff, K. E.
Affiliations: Columbia University Irving Medical Center (US)
UCL Queen Square Institute of Neurology (GB)
Corresponding author: Duff, Karen E.
ORCID: Fu, Hongjun
Hardy, John
Duff, Karen E.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-09-24
Volume: 21
Issue: 10
Pages: 1350-1358
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-018-0221-2
PMC: PMC6360529
OpenAlex: W2890004445
Cited by: 585
References: 154
Citations by year: 2026: 87 · 2025: 78 · 2024: 85 · 2023: 67 · 2022: 83 · 2021: 82 · 2020: 60 · 2019: 39 · 2018: 3
FWCI: 6.05
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institute on Aging (RF1AG056151, K01AG056673)
National Institute of Neurological Disorders and Stroke (R01NS074874)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: neurodegenerative diseases, selective neuronal vulnerability, regional vulnerability, disease progression
MeSH terms: Animals, Humans, Neurons, Neurodegenerative Diseases, Genome-Wide Association Study

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