Pooled genetic perturbation screens with image-based phenotypes

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Pooled CRISPR screening with single-cell transcriptome readout.

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Genetically encoded indicators of neuronal activity

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Spatial organization of the somatosensory cortex revealed by osmFISH

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Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method

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High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

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Highly parallel identification of essential genes in cancer cells

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Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells

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Multiplexed protein maps link subcellular organization to cellular states

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Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

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Image-based genome-wide siRNA screen identifies selective autophagy factors

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Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues

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Highly multiplexed <i>in situ</i> protein imaging with signal amplification by Immuno-SABER

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Systems survey of endocytosis by multiparametric image analysis

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A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

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In situ detection and genotyping of individual mRNA molecules

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Optical Pooled Screens in Human Cells

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Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

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Image Data Resource: a bioimage data integration and publication platform

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Genome-Wide RNAi Screen for Host Factors Required for Intracellular Bacterial Infection

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Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips

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Highly Parallel Profiling of Cas9 Variant Specificity

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Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

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Machine learning and computer vision approaches for phenotypic profiling

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The phenotypic landscape of essential human genes

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A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

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RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

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Mixed-culture assays for analyzing neuronal synapse formation

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Self-supervised deep learning encodes high-resolution features of protein subcellular localization

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CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens

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Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization

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Weakly Supervised Learning of Single-Cell Feature Embeddings

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Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors

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Time-resolved imaging-based CRISPRi screening

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High-content imaging-based pooled CRISPR screens in mammalian cells

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In situ genotyping of a pooled strain library after characterizing complex phenotypes

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CRISPR/Cas9 screening using unique molecular identifiers

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Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes

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High-throughput, image-based screening of pooled genetic-variant libraries

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Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens

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High‐throughput, microscope‐based sorting to dissect cellular heterogeneity

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Versatile phenotype-activated cell sorting

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Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infectionPreprint

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Lentiviral co-packaging mitigates the effects of intermolecular recombination and multiple integrations in pooled genetic screens

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Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networksPreprint

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Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real timePreprint

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High-content analysis screening for cell cycle regulators using arrayed synthetic crRNA libraries

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High-content Imaging-based Pooled CRISPR Screens in Mammalian CellsPreprint

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Perturb-map enables CRISPR genomics with spatial resolution and identifies regulators of tumor immune compositionPreprint

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feldman4/OpticalPooledScreens: Another Zenodo release, maybe this time it'll work.

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How to build the virtual cell with artificial intelligence: Priorities and opportunities

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Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas

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Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView

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Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular, intercellular, and functional transcriptional circuits

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High-throughput Sequencing Technology and Its Application

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The Optimal Sequencing Depth of Tumor Biopsies for Identifying Clonal Cell Populations

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