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Cited by 107Functional Brain Connectivity StudiesTreatment of Major DepressionMental Health Research Topics

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Reduced orbitofrontal-thalamic functional connectivity related to suicidal ideation in patients with major depressive disorder

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Kim, Kiwon, Kim, Sung-Woo, Myung, Woojae, Han, Cheol E., Fava, Maurizio, Mischoulon, David, Papakostas, George I., Seo, Sang Won, Cho, Hana, Seong, Joon-Kyung, Jeon, Hong Jin·2017·Scientific Reports
DOI 10.1038/s41598-017-15926-0PMC PMC5693996
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Abstract

Despite recent developments in neuroimaging, alterations of brain functional connectivity in major depressive disorder (MDD) patients with suicidal ideation are poorly understood. This study investigated specific changes of suicidal ideation in functional connectivity of MDD patients. Whole brain functional connectivity in 46 patients with MDD (23 with suicidal ideation and 23 without) and 36 age- and gender- matched healthy controls were compared using resting-state functional Magnetic Resonance Imaging (fMRI) analyzed with network-based statistics (NBS) and graph-theoretical methods. Decreased functional connectivity in a characterized sub-network was observed in patients with MDD and suicidal ideation (FDR-adjusted p < 0.05). The sub-network included the regions of the fronto-thalamic circuits in the left hemisphere. The network measures of the left superior frontal gyrus, pars orbitalis (r = −0.40, p = 0.009), left thalamus (r = −0.41, p = 0.009), and right thalamus (r = −0.51, p = −0.002) were shown, through graph theoretical analysis, to be significantly negatively correlated with severity of suicidal ideation. The reduced functional connectivity in left orbitofrontal-both thalamic regions with suicidal ideation in MDD were inversely proportional to the severity of suicidality independent from depression severity. These findings suggest problems with decision-making and information integration in MDD patients with suicidal ideation.

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Figure 1 Functional connectivities comparison between MDD patients with and without suicidal ideation. A sub-network shows significantly different functional connectivities between MDD patients with and without suicidal ideation analyzed by network-based statistics. (A–C) The sub-network mapped on a brain, which represent reduced functional connectivity in MDD patients in the lateral view of the left hemisphere (A), the transverse view (B), and the lateral view of the right hemisphere (C), respectively. The red circles represent the hub regions.
Figure 1 Functional connectivities comparison between MDD patients with and without suicidal ideation. A sub-network shows significantly different functional connectivities between MDD patients with and without suicidal ideation analyzed by network-based statistics. (A–C) The sub-network mapped on a brain, which represent reduced functional connectivity in MDD patients in the lateral view of the left hemisphere (A), the transverse view (B), and the lateral view of the right hemisphere (C), respectively. The red circles represent the hub regions.CC BY · PubMed Central
Figure 2 Functional connectivities comparison between healthy participants and MDD patients. A sub-network shows significantly different functional connectivities between healthy participants and MDD patients analyzed by network-based statistics. (A–C) The sub-network mapped on a brain, which represent reduced functional connectivity in MDD patients in the lateral view of the left hemisphere (A), the transverse view (B), and the lateral view of the right hemisphere (C), respectively. The red circles represent the hub regions.
Figure 2 Functional connectivities comparison between healthy participants and MDD patients. A sub-network shows significantly different functional connectivities between healthy participants and MDD patients analyzed by network-based statistics. (A–C) The sub-network mapped on a brain, which represent reduced functional connectivity in MDD patients in the lateral view of the left hemisphere (A), the transverse view (B), and the lateral view of the right hemisphere (C), respectively. The red circles represent the hub regions.CC BY · PubMed Central
Figure 3 Connectograms showing sub-networks related to suicidal ideation and major depressive disorder. Connectograms showing subnetworks related to suicidal ideation (A) and major depressive disorder (B). The thickness of connections represents the t-statistics of the network-based statistics test. Between two sub-networks, there is no overlapping brain region or connection, which could indicate neurological changes associated with suicidal ideation independent of depressive status. The classification and abbreviations of brain regions are referred to the references28.
Figure 3 Connectograms showing sub-networks related to suicidal ideation and major depressive disorder. Connectograms showing subnetworks related to suicidal ideation (A) and major depressive disorder (B). The thickness of connections represents the t-statistics of the network-based statistics test. Between two sub-networks, there is no overlapping brain region or connection, which could indicate neurological changes associated with suicidal ideation independent of depressive status. The classification and abbreviations of brain regions are referred to the references28.CC BY · PubMed Central

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Metadata

Authors
Kim, K., Kim, S.-W., Myung, W., Han, C. E., Fava, M., Mischoulon, D., Papakostas, G. I., Seo, S. W., Cho, H., Seong, J.-K., & Jeon, H. J.
Affiliations
  • Seoul National University (KR)
  • Korea University (KR)
  • CHA University Bundang Medical Center (KR)
  • Harvard University (US)
  • Samsung Medical Center (KR)
  • Samsung Biomedical Research Institute (KR)
Corresponding author
  • Seong, Joon-Kyung
  • Jeon, Hong Jin
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-11-17
Volume
7
Issue
1
Pages
15772-15772
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-15926-0
PMC
PMC5693996
OpenAlex
W2768253102
Cited by
107
References
75
Citations by year
2026: 3 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 11 · 2021: 36 · 2020: 7 · 2019: 12 · 2018: 6
FWCI
3.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Research Foundation
  • Ministry of Science, ICT and Future Planning (2017M3C7A1048092, 2016M3C7A1947307, NRF-2017M3A9F1027323)
  • National Research Foundation of Korea (NRF-2017M3A9F1027323, 2017M3A9F1027323, 2016M3C7A1947307, NRF-2016M3C7A1947307, No. NRF-2017M3A9F1027323; PI HJJ)
  • Ministry of Science ICT and Future Planning
  • Ministry of Education, Science and Technology (NRF-2017M3A9F1027323, 2011-0013064, 2016M3C7A1947307, NRF-2016M3C7A1947307)
  • Ministry of Science and ICT, South Korea
  • Samsung (SMO1161491)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
major depressive disorder, suicidal ideation, orbitofrontal cortex, thalamus, functional connectivity, resting-state fMRI, network-based statistics, graph theory, decision-making, information integration, suicide risk
MeSH terms
Adult, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Nerve Net, Thalamus, Prefrontal Cortex, Suicidal Ideation

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