More than just statics: temporal dynamics of intrinsic brain activity predicts the suicidal ideation in depressed patients

Li, Jiao; Duan, Xujun; Cui, Qian; Chen, Huafu; Liao, Wei

doi:10.1017/s0033291718001502

Cited by 208Functional Brain Connectivity StudiesTreatment of Major DepressionSuicide and Self-Harm Studies

More than just statics: temporal dynamics of intrinsic brain activity predicts the suicidal ideation in depressed patients

Li, Jiao, Duan, Xujun, Cui, Qian, Chen, Huafu, Liao, Wei·2019·Psychological Medicine

DOI 10.1017/s0033291718001502

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Abstract

Background: Major depressive disorder (MDD) is associated with high risk of suicide. Conventional neuroimaging works showed abnormalities of static brain activity and connectivity in MDD with suicidal ideation (SI). However, little is known regarding alterations of brain dynamics. More broadly, it remains unclear whether temporal dynamics of the brain activity could predict the prognosis of SI. Methods: We included MDD patients (n = 48) with and without SI and age-, gender-, and education-matched healthy controls (n = 30) who underwent resting-state functional magnetic resonance imaging. We first assessed dynamic amplitude of low-frequency fluctuation (dALFF) – a proxy for intrinsic brain activity (iBA) – using sliding-window analysis. Furthermore, the temporal variability (dynamics) of iBA was quantified as the variance of dALFF over time. In addition, the prediction of the severity of SI from temporal variability was conducted using a general linear model. Results: Compared with MDD without SI, the SI group showed decreased brain dynamics (less temporal variability) in the dorsal anterior cingulate cortex, the left orbital frontal cortex, the left inferior temporal gyrus, and the left hippocampus. Importantly, these temporal variabilities could be used to predict the severity of SI (r = 0.43, p = 0.03), whereas static ALFF could not in the current data set. Conclusions: These findings suggest that alterations of temporal variability in regions involved in executive and emotional processing are associated with SI in MDD patients. This novel predictive model using the dynamics of iBA could be useful in developing neuromarkers for clinical applications.

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Other studies have reported lower rs-fMRI activity and functional connectivity, probably due to different outcome measures and heterogeneity of suicidal ideation.
“However, other studies have reported lower rs-fMRI activity and functional connectivity (85, 86, 92, 93), probably due to use of different outcome measures of rs-fMRI activity, for example, regional homogeneity, fractional amplitude of low-frequency fluctuations among studies, and heterogeneity of suicidal ideation.”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [93]

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Temporal Changes in Local Functional Connectivity Density Reflect the Temporal Variability of the Amplitude of Low Frequency Fluctuations in Gray Matter
Tomasi, D. G., Kojori, E. S., & Volkow, N. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154407 · Cited by 39 · see citing works

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A brain-centric model of suicidal behavior
Mann, J. J., & Rizk, M. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081224 · Cited by 214 · see citing works
Dynamic changes of amplitude of low‐frequency fluctuations in patients with generalized anxiety disorder
Cui, Q., Sheng, W., Chen, Y., Pang, Y., Lu, F., Tang, Q., Han, S., Shen, Q., Wang, Y., Xie, A., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24902 · Cited by 159 · see citing works
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Endless Fluctuations: Temporal Dynamics of the Amplitude of Low Frequency Fluctuations
Liao, W., Chen, H., Li, J., Ji, G., Wu, G., Long, Z., Xu, Q., Duan, X., Cui, Q., & Biswal, B. B. (2019) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2019.2904555 · Cited by 143 · see citing works
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Local dynamic spontaneous brain activity changes in first-episode, treatment-naïve patients with major depressive disorder and their associated gene expression profiles
Xue, K., Liang, S., Yang, B., Zhu, D., Xie, Y., Qin, W., Liu, F., Zhang, Y., & Yu, C. (2020) · Psychological Medicine · doi:10.1017/s0033291720003876 · Cited by 112 · see citing works
White-matter functional topology: a neuromarker for classification and prediction in unmedicated depression
Li, J., Chen, H., Fan, F., Qiu, J., Du, L., Xiao, J., Duan, X., Chen, H., & Liao, W. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01053-4 · Cited by 69 · see citing works
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A neuromarker of individual general fluid intelligence from the white-matter functional connectome
Li, J., Biswal, B. B., Meng, Y., Yang, S., Duan, X., Cui, Q., Chen, H., & Liao, W. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0829-3 · Cited by 68 · see citing works
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Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders
Chen, G., Chen, P., Gong, J., Jia, Y., Zhong, S., Chen, F., Wang, J., Luo, Z., Qi, Z., Huang, L., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720002378 · Cited by 59 · see citing works
Functional network alterations differently associated with suicidal ideas and acts in depressed patients: an indirect support to the transition model
Wagner, G., Li, M., Sacchet, M. D., Richard‐Devantoy, S., Turecki, G., Bär, K., Gotlib, I. H., Walter, M., & Jollant, F. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01232-x · Cited by 58 · see citing works
Resting-state dynamic functional connectivity in major depressive disorder: A systematic review
Sun, S., Yan, C., Qu, S., Luo, G., Liu, X., Tian, F., Dong, Q., Li, X., & Hu, B. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111076 · Cited by 59 · see citing works
Resting-State Brain Network Dysfunctions Associated With Visuomotor Impairments in Autism Spectrum Disorder
Wang, Z., Wang, Y., Sweeney, J. A., Gong, Q., Lui, S., & Mosconi, M. W. (2019) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00017 · Cited by 56 · see citing works
Shared and specific dynamics of brain segregation and integration in bipolar disorder and major depressive disorder: A resting-state functional magnetic resonance imaging study
Luo, Z., Chen, G., Jia, Y., Zhong, S., Gong, J., Chen, F., Wang, J., Qi, Z., Liu, X., Huang, L., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.012 · Cited by 52 · see citing works
Abnormal dynamic functional connectivity density in patients with generalized anxiety disorder
Chen, Y., Cui, Q., Xie, A., Pang, Y., Sheng, W., Tang, Q., Li, D., Huang, J., He, Z., Wang, Y., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.09.084 · Cited by 51 · see citing works
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Altered dynamics of brain segregation and integration in poststroke aphasia
Guo, J., Biswal, B. B., Han, S., Li, J., Yang, S., Yang, M., & Chen, H. (2019) · Human Brain Mapping · doi:10.1002/hbm.24605 · Cited by 47 · see citing works
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Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia
Duan, X., Hu, M., Huang, X., Su, C., Zong, X., Dong, X., He, C., Xiao, J., Li, H., Tang, J., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz087 · Cited by 47 · see citing works
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Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation
Lan, M. J., Rizk, M. M., Pantazatos, S. P., Rubin‐Falcone, H., Miller, J. M., Sublette, M. E., Oquendo, M. A., Keilp, J. G., & Mann, J. J. (2019) · Depression and Anxiety · doi:10.1002/da.22888 · Cited by 48 · see citing works
Abnormal Dynamic Functional Network Connectivity Estimated from Default Mode Network Predicts Symptom Severity in Major Depressive Disorder
Sendi, M. S. E., Zendehrouh, E., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Fu, Z., Zhi, D., Lv, L., Ma, X., Ke, Q., Li, X., Wang, C., et al. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0748 · Cited by 44 · see citing works
Temporal dynamic changes of intrinsic brain activity in schizophrenia with cigarette smoking
Yang, S., Meng, Y., Li, J., Fan, Y., Du, L., Chen, H., & Liao, W. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.06.012 · Cited by 43 · see citing works
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Identifying commonality and specificity across psychosis sub-groups via classification based on features from dynamic connectivity analysis
Du, Y., Hao, H., Wang, S., Pearlson, G. D., & Calhoun, V. D. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102284 · Cited by 43 · see citing works
Transition and Dynamic Reconfiguration of Whole-Brain Network in Major Depressive Disorder
Wang, S., Wen, H., Hu, X., Xie, P., Qiu, S., Qian, Y., Qiu, J., & He, H. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01995-2 · Cited by 44 · see citing works
Decreased Dynamic Segregation but Increased Dynamic Integration of the Resting-state Functional Networks During Normal Aging
He, L., Wang, X., Zhuang, K., & Qiu, J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.030 · Cited by 41 · see citing works
More than just statics: Temporal dynamic changes of intrinsic brain activity in cigarette smoking
Wen, M., Yang, Z., Wei, Y., Huang, H., Zheng, R., Wang, W., Gao, X., Zhang, M., Fang, K., Zhang, Y., et al. (2021) · Addiction Biology · doi:10.1111/adb.13050 · Cited by 41 · see citing works
Alterations of core structural network connectome associated with suicidal ideation in major depressive disorder patients
Liu, X., He, C., Fan, D., Zang, F., Zhu, Y., Zhang, H., Zhang, Z., Zhang, H., & Xie, C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01353-3 · Cited by 40 · see citing works
Dynamic Altered Amplitude of Low-Frequency Fluctuations in Patients With Major Depressive Disorder
Zheng, R., Chen, Y., Jiang, Y. B., Wen, M., Zhou, B., Li, S., Wei, Y., Yang, Z., Wang, C., Cheng, J., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.683610 · Cited by 40 · see citing works
Cross-network interaction for diagnosis of major depressive disorder based on resting state functional connectivity
Zhu, X., Yuan, F., Zhou, G., Nie, J., Wang, D., Hu, P., Ouyang, L., Kong, L., & Liao, W. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00326-2 · Cited by 38 · see citing works
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Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease
Shang, S., Ye, J., Wu, J., Zhang, H., Dou, W., Muthaiah, V. P. K., Tian, Y., Zhang, Y., Chen, Y., & Yin, X. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221098503 · Cited by 35 · see citing works
Shared and distinct patterns of dynamic functional connectivity variability of thalamo-cortical circuit in bipolar depression and major depressive disorder
Lu, F., Chen, Y., Cui, Q., Guo, Y., Pang, Y., Luo, W., Yu, Y., Chen, J., Gao, J., Sheng, W., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhac534 · Cited by 35 · see citing works
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Altered dynamic global signal topography in antipsychotic-naive adolescents with early-onset schizophrenia
Wang, X., Liao, W., Han, S., Li, J., Zhang, Y., Zhao, J., & Chen, H. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.01.035 · Cited by 35 · see citing works
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Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression
Shunkai, L., Su, T., Zhong, S., Chen, G., Zhang, Y., Zhao, H., Chen, P., Tang, G., Qi, Z., He, J., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721004906 · Cited by 35 · see citing works
Functional alterations of the suicidal brain: a coordinate-based meta-analysis of functional imaging studies
Chen, C.-F., Chen, W.-N., & Zhang, B. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00503-x · Cited by 35 · see citing works
Altered resting state dynamic functional connectivity of amygdala subregions in patients with autism spectrum disorder: A multi-site fMRI study
Gao, Y., Sun, J., Cheng, L. L., Yang, Q., Li, J., Hao, Z., Zhan, L., Shi, Y., Li, M., Jia, X., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.011 · Cited by 34 · see citing works
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Aberrant brain dynamics in major depressive disorder with suicidal ideation
Yang, J., Liu, Z., Tao, H., Cheng, Y., Fan, Z., Sun, F., Ouyang, X., & Yang, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.043 · Cited by 34 · see citing works
Structural and functional brain correlates of suicidal ideation and behaviors in depression: A scoping review of MRI studies
Vieira, R., Faria, A. R., Ribeiro, D., Picó‐Pérez, M., & Bessa, J. M. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110799 · Cited by 34 · see citing works
Reconfiguration of dynamic large‐scale brain network functional connectivity in generalized tonic–clonic seizures
Jia, X., Xie, Y., Dong, D., Pei, H., Jiang, S., Ma, S., Huang, Y., Zhang, X., Wang, Y., Zhu, Q. N., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24787 · Cited by 32 · see citing works
Interactions between sleep disturbances and Alzheimer’s disease on brain function: a preliminary study combining the static and dynamic functional MRI
Li, K., Luo, X., Zeng, Q., Jiaerken, Y., Wang, S., Xu, X., Xu, X., Xu, J., Wang, C., Zhou, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55452-9 · Cited by 31 · see citing works
Resting‐State Functional Connectivity and Brain Network Abnormalities in Depressive Patients with Suicidal Ideation
Chen, V. C., Chou, Y.-S., Tsai, Y., Huang, Y.-C., McIntyre, R. S., & Weng, J. (2021) · Brain Topography · doi:10.1007/s10548-020-00817-x · Cited by 32 · see citing works
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review
Demchenko, I., Tassone, V. K., Kennedy, S. H., Dunlop, K., & Bhat, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864902 · Cited by 29 · see citing works
“For depression, studies have identified unique CFPs that predicted suicidal ideation (211), treatment response to the serotonin selective reuptake inhibitor (SSRI) sertraline (151, 212), and general antidepressant response independent of treatment modality (31).”
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Gray matter voxel-based morphometry in mania and remission states of children with bipolar disorder
Xiao, Q., Zhong, Y., Jiao, Q., Lu, G., & Su, Y. E. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.042 · Cited by 31 · see citing works
Machine Learning-Based Identification of Suicidal Risk in Patients With Schizophrenia Using Multi-Level Resting-State fMRI Features
Bohaterewicz, B., Sobczak, A. M., Podolak, I. T., Wójcik, B., Mętel, D., Chrobak, A. A., Fąfrowicz, M., Siwek, M., Dudek, D., & Marek, T. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.605697 · Cited by 31 · see citing works
Aberrant integrity of the cortico-limbic-striatal circuit in major depressive disorder with suicidal ideation
Yang, J., Palaniyappan, L. K., Xi, C., Cheng, Y., Fan, Z., Chen, C., Zhang, M., Pan, Y., Tao, H., Ouyang, X., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.003 · Cited by 30 · see citing works
Altered dynamic brain activity and functional connectivity in thyroid‐associated ophthalmopathy
Jiang, W., Liu, J., Zhou, J., Wu, Q., Pu, X., Chen, H., Xu, X., Wu, F., & Hu, H. (2023) · Human Brain Mapping · doi:10.1002/hbm.26437 · Cited by 28 · see citing works
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Abnormal functional connectivity as neural biological substrate of trait and state characteristics in major depressive disorder
He, Z., Lu, F., Sheng, W., Han, S., Pang, Y., Chen, Y., Tang, Q., Yang, Y., Luo, W., Yu, Y., et al. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109949 · Cited by 28 · see citing works
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Temporal dynamics alterations of spontaneous neuronal activity in anterior cingulate cortex predict suicidal risk in bipolar II patients
Tian, S., Zhu, R., Chattun, M. R., Wang, H., Chen, Z., Zhang, S., Shao, J., Wang, X., Yao, Z., & Lü, Q. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00448-7 · Cited by 28 · see citing works
Dynamic Functional Connectivity Alterations and Their Associated Gene Expression Pattern in Autism Spectrum Disorders
Ma, L., Yuan, T., Li, W., Guo, L., Zhu, D., Wang, Z., Liu, Z., Xue, K., Wang, Y., Liu, J., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.794151 · Cited by 28 · see citing works
Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder
Zhou, B., Chen, Y., Zheng, R., Jiang, Y. B., Li, S., Wei, Y., Zhang, M., Gao, X., Wen, B., Han, S., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.877417 · Cited by 26 · see citing works
Connectomics-based resting-state functional network alterations predict suicidality in major depressive disorder
Wáng, Q., He, C., Wang, Z., Fan, D., Zhang, Z., Xie, C., Yan, C., Chen, X., Li, L., Castellanos, F. X., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02655-4 · Cited by 26 · see citing works
Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes
Jiang, S., Luo, C., Huang, Y., Li, Z., Chen, Y., Li, X., Pei, H., Wang, P., Wang, X., & Yao, D. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00361 · Cited by 25 · see citing works
Dynamics and Concordance Abnormalities Among Indices of Intrinsic Brain Activity in Individuals With Subjective Cognitive Decline: A Temporal Dynamics Resting-State Functional Magnetic Resonance Imaging Analysis
Yang, Y., Zha, X., Zhang, X., Ke, J., Hu, S., Wang, X., Su, Y., & Hu, C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.584863 · Cited by 25 · see citing works
Three major psychiatric disorders share specific dynamic alterations of intrinsic brain activity
Zhang, L., Zhang, R., Han, S., Womer, F. Y., Wei, Y., Duan, J., Chang, M., Li, C., Feng, R., Liu, J., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.06.014 · Cited by 25 · see citing works
Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder
Ding, Z., Ding, Z., Chen, Y., Lv, D., Li, T., Shang, T., Ma, J., Zhan, C., Yang, X., Xiao, J., et al. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04740-w · Cited by 25 · see citing works
Frequency-dependent and time-variant alterations of neural activity in post-stroke depression: A resting-state fMRI study
Wu, X., Wang, L., Jiang, H., Fu, Y., Wang, T., Ma, Z., Wu, X., Wang, Y., Fan, F., Song, Y., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103445 · Cited by 24 · see citing works
Characteristics of temporal dynamics of intrinsic brain activity in unmedicated bipolar disorder with suicidality
Gong, J., Chen, G., Zhou, M., Jia, Y., Zhong, S., Chen, F., Lai, S., Luo, Z., Wang, J., Xu, H., et al. (2020) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420948960 · Cited by 25 · see citing works
Aberrant state-related dynamic amplitude of low-frequency fluctuations of the emotion network in major depressive disorder
Zhao, L., Wang, D., Xue, S., Tan, Z., Wang, Y., & Lian, Z. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.003 · Cited by 24 · see citing works
Shared and distinct changes in local dynamic functional connectivity patterns in major depressive and bipolar depressive disorders
Tang, Q., Cui, Q., Chen, Y., Deng, J. S., Sheng, W., Yang, Y., Lu, F., Zeng, Y., Jiang, K., & Chen, H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.109 · Cited by 24 · see citing works
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Prediction of suicidality in bipolar disorder using variability of intrinsic brain activity and machine learning
Tian, S., Zhu, R., Chen, Z., Wang, H., Chattun, M. R., Zhang, S., Shao, J., Wang, X., Yao, Z., & Lü, Q. (2023) · Human Brain Mapping · doi:10.1002/hbm.26243 · Cited by 24 · see citing works
Mental Health Difficulties Related to Suicidal Behavior in Adolescents: The Moderating Role of Self-Esteem
de la Barrera, U., Montoya‐Castilla, I., Pérez‐Albéniz, A., Lucas‐Molina, B., & Fonseca‐Pedrero, E. (2020) · Archives of Suicide Research · doi:10.1080/13811118.2020.1823918 · Cited by 24 · see citing works
Aberrant functional brain network dynamics in patients with functional constipation
Yin, T., He, Z., Ma, P., Sun, R., Xie, K., Liu, T., Chen, L., Chen, J., Hou, L., Teng, Y., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25663 · Cited by 22 · see citing works
Hippocampal neuropathology in suicide: Gaps in our knowledge and opportunities for a breakthrough
Zhang, L., Lucassen, P. J., Salta, E., Verhaert, P. D. E. M., & Swaab, D. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.023 · Cited by 22 · see citing works
Electroconvulsive therapy changes temporal dynamics of intrinsic brain activity in depressed patients
Nie, J., Wei, Q., Bai, T., Zhang, T., Lv, H., Zhang, L., Ji, G., Yu, F., Tian, Y., & Wang, K. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114732 · Cited by 21 · see citing works
Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts
Cheng, X., Chen, J., Zhang, X., Wang, T., Sun, J., Zhou, Y., Yang, R., Xiao, Y., Chen, A., Song, Z., et al. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02242-4 · Cited by 22 · see citing works
Electroconvulsive Therapy Regulates Brain Connectome Dynamics in Patients With Major Depressive Disorder
Guo, Y., Xia, M., Ye, R., Bai, T., Wu, Y., Ji, Y., Yu, Y., Ji, G., Wang, K., Yong He, A., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.03.012 · Cited by 22 · see citing works
More than just statics: Abnormal dynamic amplitude of low-frequency fluctuation in adolescent patients with pure conduct disorder
Lu, F., Liu, P., Chen, H., Wang, M., Xu, S., Yuan, Z., Wang, X., Wang, S., & Zhou, J. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.08.027 · Cited by 21 · see citing works
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Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder
Fan, S., Nemati, S., Akiki, T. J., Roscoe, J., Averill, C. L., Fouda, S., Averill, L. A., & Abdallah, C. G. (2020) · Chronic Stress · doi:10.1177/2470547020984726 · Cited by 21 · see citing works
Abnormal dynamic brain activity and functional connectivity of primary motor cortex in blepharospasm
Luo, Y., Guo, Y., Zhong, L., Liu, Y., Dang, C., Wang, Y., Zeng, J., Zhang, W., Peng, K., & Liu, G. (2021) · European Journal of Neurology · doi:10.1111/ene.15233 · Cited by 21 · see citing works
Abnormal Dynamics of Functional Connectivity Density Associated With Chronic Neck Pain
Ni, X., Zhang, J., Sun, M., Wang, L., Xu, T., Zeng, Q., Wang, X., Wang, Z., Liao, H., Hu, Y., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.880228 · Cited by 21 · see citing works
Altered Static and Dynamic Interhemispheric Resting-State Functional Connectivity in Patients With Thyroid-Associated Ophthalmopathy
Chen, W., Hu, H., Wu, Q., Chen, L., Zhou, J., Chen, H., Xu, X., & Wu, F. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.799916 · Cited by 20 · see citing works
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Variability and concordance among indices of brain activity in major depressive disorder with suicidal ideation: A temporal dynamics resting-state fMRI analysis.
Li, W.-C., Wang, C.-Y., Lan, X.-F., Fu, L., Zhang, F., Ye, Y., Liu, H., Wu, K., Zhou, Y.-L., & Ning, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.122 · Cited by 20 · see citing works
The effects of antipsychotics on interactions of dynamic functional connectivity in the triple-network in first episode schizophrenia
Wang, Y., Jiang, Y., Collin, G., Liu, D., Su, W., Xu, L., Wei, Y., Tang, Y., Zhang, T., Tang, X., et al. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.07.038 · Cited by 19 · see citing works
Static and dynamic resting-state brain activity patterns of table tennis players in 7-Tesla MRI
Li, Y., Zhao, M., Cao, Y., Gao, Y., Wang, Y., Yun, B., Luo, L., Liu, W., & Zheng, C.-Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1202932 · Cited by 19 · see citing works
Altered dynamic regional homogeneity in patients with conduct disorder
Lu, F., Zhao, Y., He, Z., Ma, X., Yao, X., Liu, P., Wang, X., Yang, G., & Zhou, J. (2021) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2021.107865 · Cited by 19 · see citing works
Dynamic Functional Connectivity Reveals Abnormal Variability in the Amygdala Subregions of Children With Attention-Deficit/Hyperactivity Disorder
Yang, Y., Yang, B., Zhang, L., Peng, G., & Fang, D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.648143 · Cited by 18 · see citing works
Thyroid hormones disturbances, cognitive deficits and abnormal dynamic functional connectivity variability of the amygdala in unmedicated bipolar disorder
Chen, P., Chen, G., Zhong, S., Chen, F., Ye, T., Gong, J., Tang, G., Pan, Y., Luo, Z., Qi, Z., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.023 · Cited by 18 · see citing works
The cumulative therapeutic effect of acupuncture in patients with migraine without aura: Evidence from dynamic alterations of intrinsic brain activity and effective connectivity
Chen, Y., Kang, Y., Luo, S., Liu, S., Wang, B., Gong, Z., Huang, Y., Wang, H., Zhan, S., & Tan, W. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.925698 · Cited by 18 · see citing works
Static and dynamic alterations in the amplitude of low-frequency fluctuation in patients with amyotrophic lateral sclerosis
Ma, X., Lu, F., Chen, H., Hu, C., Wang, J., Zhang, S., Zhang, S., Yang, G., & Zhang, J. (2020) · PeerJ · doi:10.7717/peerj.10052 · Cited by 18 · see citing works
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Altered dynamic functional connectivity of insular subregions could predict symptom severity of male patients with autism spectrum disorder
Zhao, L., Xue, S., Sun, Y., Lan, Z., Zhang, Z., Xue, Y., Wang, X., & Jin, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.12.093 · Cited by 18 · see citing works
Effects of risperidone monotherapy on the default-mode network in antipsychotic-naïve first-episode schizophrenia: Posteromedial cortex heterogeneity and relationship with the symptom improvements
Duan, X., Hu, M., Huang, X., Dong, X., Zong, X., He, C., Xiao, J., Tang, J., Chen, X., & Chen, H. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.01.001 · Cited by 19 · see citing works
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The role of frontal-subcortical connectivity in the relation between coping styles and reactivity and downregulation of negative emotion
Wang, X., Blain, S. D., Wei, D., Yang, W., Yang, J., Zhuang, K., He, L., DeYoung, C. G., & Qiu, J. (2020) · Brain and Cognition · doi:10.1016/j.bandc.2020.105631 · Cited by 17 · see citing works
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Authors: Li, J., Duan, X., Cui, Q., Chen, H., & Liao, W.
Affiliations: University of Electronic Science and Technology of China (CN)
Corresponding author: Liao, Wei
ORCID: Duan, Xujun
Cui, Qian
Chen, Huafu
Liao, Wei
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2018-06-18
Volume: 49
Issue: 5
Pages: 852-860
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291718001502
OpenAlex: W2809054788
Cited by: 208
References: 80
Citations by year: 2026: 14 · 2025: 26 · 2024: 17 · 2023: 30 · 2022: 31 · 2021: 36 · 2020: 37 · 2019: 15 · 2018: 2
FWCI: 13.40
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Higher Education Discipline Innovation Project
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Keywords: suicidal ideation, major depressive disorder, intrinsic brain activity, dynamic amplitude of low-frequency fluctuation, temporal dynamics of brain activity, resting-state functional connectivity, dorsal anterior cingulate cortex, orbitofrontal cortex, hippocampus, inferior temporal gyrus, neuromarkers, suicide risk prediction
MeSH terms: Adult, Brain Mapping, Cerebral Cortex, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Linear Models, Young Adult, Suicidal Ideation

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More than just statics: temporal dynamics of intrinsic brain activity predicts the suicidal ideation in depressed patients

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